CN1348362A - 磁响应组合物 - Google Patents

磁响应组合物 Download PDF

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Publication number
CN1348362A
CN1348362A CN99803728A CN99803728A CN1348362A CN 1348362 A CN1348362 A CN 1348362A CN 99803728 A CN99803728 A CN 99803728A CN 99803728 A CN99803728 A CN 99803728A CN 1348362 A CN1348362 A CN 1348362A
Authority
CN
China
Prior art keywords
compositions
carbon
ferrum
granule
weight ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99803728A
Other languages
English (en)
Chinese (zh)
Inventor
V·A·沃尔孔斯基
S·D·久克舍尔斯特诺夫
S·V·切尔尼亚科夫
L·M·阿伦
T·B·肯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FeRx Inc
Original Assignee
FeRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FeRx Inc filed Critical FeRx Inc
Publication of CN1348362A publication Critical patent/CN1348362A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN99803728A 1998-01-06 1999-01-06 磁响应组合物 Pending CN1348362A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/003,286 US6200547B1 (en) 1994-01-26 1998-01-06 Magnetically responsive compositions for carrying biologically active substances and methods of production and use

Publications (1)

Publication Number Publication Date
CN1348362A true CN1348362A (zh) 2002-05-08

Family

ID=21705076

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99803728A Pending CN1348362A (zh) 1998-01-06 1999-01-06 磁响应组合物

Country Status (11)

Country Link
US (1) US6200547B1 (https=)
EP (1) EP1043975A4 (https=)
JP (1) JP2002500177A (https=)
KR (1) KR20010024836A (https=)
CN (1) CN1348362A (https=)
AU (1) AU744205B2 (https=)
BR (1) BR9906786A (https=)
CA (1) CA2317019C (https=)
IL (2) IL137033A (https=)
NZ (1) NZ505408A (https=)
WO (1) WO1999034779A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006015520A1 (fr) * 2004-08-11 2006-02-16 Yangde Zhang Procédé de préparation de nanoparticules magnétiques de galactosyle-has contenant de l’adriamycine
CN100384475C (zh) * 2002-10-29 2008-04-30 德州科隆载体研究所 磁引导抗癌药剂的制备方法

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US6482436B1 (en) * 1993-01-29 2002-11-19 Ferx Incorporated Magnetically responsive composition
NZ521255A (en) * 2000-03-06 2007-01-26 Univ Kentucky Res Found Methods to impair hematologic cancer progenitor cells and compounds related thereto
US6488615B1 (en) 2000-03-31 2002-12-03 Ferx Incorporated Permanent magnet keeper-shield assembly
US7090636B2 (en) * 2000-03-31 2006-08-15 Fe Rx Incorporated Permanent magnet keeper-shield assembly
MXPA02011092A (es) 2000-05-10 2004-08-19 David A Sirbasku Composiciones y metodos para demostrar la regulacion del sistema inmune secretor del crecimiento de la celula de cancer que responde a la hormona esteroidea.
US20030072812A1 (en) 2001-05-10 2003-04-17 Sirbasku David A Breast cancer eradication program
US8119138B2 (en) * 2000-05-10 2012-02-21 Signe Biopharma Inc. Anti-estrogen and immune modulator combinations for treating breast cancer
US7863011B2 (en) * 2000-05-10 2011-01-04 Signe Biopharma, Inc. Screening method for predicting susceptibility to breast cancer
US6921283B2 (en) * 2001-08-27 2005-07-26 Trompeter Electronics, Inc. BNC connector having visual indication
US6679827B2 (en) * 2001-10-11 2004-01-20 Robert E. Sandstrom Magnetic field enhancement of tumor treatment
EP2299265A1 (en) * 2001-11-13 2011-03-23 Signe BioPharma Inc. Cancer eradication program
US7249604B1 (en) 2002-05-10 2007-07-31 Vasmo, Inc. Medical devices for occlusion of blood flow
WO2004066975A1 (en) * 2002-12-18 2004-08-12 Hough Ear Institute Otologic nanotechnology
US20050155779A1 (en) * 2003-04-08 2005-07-21 Xingwu Wang Coated substrate assembly
US20050240100A1 (en) * 2003-04-08 2005-10-27 Xingwu Wang MRI imageable medical device
US20050261763A1 (en) * 2003-04-08 2005-11-24 Xingwu Wang Medical device
US20050278020A1 (en) * 2003-04-08 2005-12-15 Xingwu Wang Medical device
US20050025797A1 (en) * 2003-04-08 2005-02-03 Xingwu Wang Medical device with low magnetic susceptibility
US20050244337A1 (en) * 2003-04-08 2005-11-03 Xingwu Wang Medical device with a marker
US7344491B1 (en) 2003-11-26 2008-03-18 Nanobiomagnetics, Inc. Method and apparatus for improving hearing
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
DE10359252A1 (de) * 2003-12-17 2005-07-28 Siemens Ag Navigierte Wärmebehandlung von Tumoren mit enzymumhüllten Eisenpartikeln
US20070027532A1 (en) * 2003-12-22 2007-02-01 Xingwu Wang Medical device
US9028829B2 (en) * 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US7846201B2 (en) * 2004-02-20 2010-12-07 The Children's Hospital Of Philadelphia Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex
US8562505B2 (en) * 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US20070100457A1 (en) * 2004-03-04 2007-05-03 Hyde Edward R Jr Paramagnetic liquid interface
GB0405552D0 (en) * 2004-03-12 2004-04-21 Magnet Attraction Ltd Methods for the targetted delivery of biological molecules
WO2005110395A1 (en) * 2004-05-19 2005-11-24 University Of South Carolina System and device for magnetic drug targeting with magnetic drug carrier particles
WO2006002365A2 (en) * 2004-06-24 2006-01-05 Angiotech International Ag Microparticles with high loadings of a bioactive agent
WO2007035871A1 (en) * 2005-09-21 2007-03-29 Massachusetts Institute Of Technology Systems and methods for tuning properties of nanoparticles
US20070255086A1 (en) * 2006-04-26 2007-11-01 Nehls Robert J Medical Device Including Magnetic Particles
US8163279B2 (en) 2007-04-13 2012-04-24 Stemline Therapeutics, Inc. IL3Rα antibody conjugates and uses thereof
US9034387B2 (en) * 2007-10-03 2015-05-19 Jawaharlal Nehru Centre For Advanced Scientific Research Intrinsically fluorescent carbon nanospheres and a process thereof
US20090169484A1 (en) 2007-12-28 2009-07-02 Ihi Corporation Iron-salen complex
JP2009274962A (ja) * 2008-05-12 2009-11-26 Yoshihiro Ishikawa 鉄サレン錯体、磁性を有する薬剤、薬剤の誘導システム、並びに磁気検出装置
CN104800195A (zh) 2008-11-20 2015-07-29 株式会社Ihi 自磁性金属salen络合物
US9744235B2 (en) 2010-10-19 2017-08-29 The Board Of Regents Of The University Of Oklahoma Treatment of cardiovascular disorders with targeted nanoparticles
US10398668B2 (en) 2010-10-19 2019-09-03 The Board Of Regents Of The University Of Oklahoma Glutamate treatment of cardiovascular disorders
US8740872B2 (en) 2010-10-19 2014-06-03 The Board Of Regents Of The University Of Oklahoma Magnetically-targeted treatment for cardiac disorders
US9005757B2 (en) 2010-12-21 2015-04-14 Ihi Corporation Metal-salen complex compound and method for producing the same
JP2012176905A (ja) * 2011-02-25 2012-09-13 Ihi Corp 金属サレン錯体化合物
WO2022034176A2 (en) * 2020-08-13 2022-02-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Delivery device
WO2025118073A1 (en) * 2023-12-04 2025-06-12 Rocket Science Health Corp. Magnetic formulations for biomarker sampling and enhanced drug delivery

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US4871716A (en) 1986-02-04 1989-10-03 University Of Florida Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof
JPH01122037U (https=) 1988-02-12 1989-08-18
SU1722256A3 (ru) 1989-11-02 1992-03-23 Viktor A Volkonskij Cпocoб пoлучehия maгhиtoупpabляemoй диcпepcии
ATE210967T1 (de) 1993-01-29 2002-01-15 Ferx Inc Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung
US5776925A (en) * 1996-01-25 1998-07-07 Pharmacyclics, Inc. Methods for cancer chemosensitization
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100384475C (zh) * 2002-10-29 2008-04-30 德州科隆载体研究所 磁引导抗癌药剂的制备方法
WO2006015520A1 (fr) * 2004-08-11 2006-02-16 Yangde Zhang Procédé de préparation de nanoparticules magnétiques de galactosyle-has contenant de l’adriamycine

Also Published As

Publication number Publication date
NZ505408A (en) 2003-04-29
AU2027999A (en) 1999-07-26
IL137033A (en) 2005-12-18
JP2002500177A (ja) 2002-01-08
CA2317019C (en) 2003-10-14
EP1043975A1 (en) 2000-10-18
EP1043975A4 (en) 2007-05-02
BR9906786A (pt) 2000-10-17
AU744205B2 (en) 2002-02-21
IL137033A0 (en) 2001-06-14
KR20010024836A (ko) 2001-03-26
CA2317019A1 (en) 1999-07-15
WO1999034779A1 (en) 1999-07-15
US6200547B1 (en) 2001-03-13

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