CN1342466A - Medicine for treating cardiovascular disease and its preparing process - Google Patents
Medicine for treating cardiovascular disease and its preparing process Download PDFInfo
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- CN1342466A CN1342466A CN 00113176 CN00113176A CN1342466A CN 1342466 A CN1342466 A CN 1342466A CN 00113176 CN00113176 CN 00113176 CN 00113176 A CN00113176 A CN 00113176A CN 1342466 A CN1342466 A CN 1342466A
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- aconiti lateralis
- lateralis preparata
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Abstract
A medicine for treating cardiovascular disease is prepared from 3 Chinese medicinal materials including sliced aconite root (5-10 wt. portions), notoginseng (0.5-2) and cinnamon bark (0.5-2) through extracting and proportionally mixing. Its advantages include high curative effect, low toxic by-effect, and broad spectruna.
Description
The present invention relates to field of pharmaceutical technology, specifically treat medicine of cardiovascular disease and preparation method thereof.
Relevant cardiovascular diseases's clinical treatment drug development at present is more, and is single with regard to the development of Chinese medicine, also obtained the considerable length of advancing, and played certain effect as single medicinal material and polypharmaceutic development etc. for cardiovascular control.But there is no Radix Aconiti Lateralis Preparata both at home and abroad and make capsular compound preparation, be used for the treatment of the bibliographical information of cardiovascular disease.
Radix Aconiti Lateralis Preparata is that tcm clinical practice is used one of wide, that history is longer medicine, this medicine to clinical deficiency of YANG QI a little less than, cold extremities faint pulse, trusted subordinate's cold type of pain, the critical illness of sympotoms caused by cold factors such as yang deficiency diseases caused by exogenous pathogenic factor has significant curative effect, by successive dynasties traditional Chinese medical science doctor family is generally acknowledged, in recent years, along with the further investigation to herbal pharmacology, drug effect confirms, it is in cardiovascular system, the refreshing smart system of maincenter and endocrine, and aspects such as immunologic function adjusting have significant curative effect.Yet unsatisfactory is, Radix Aconiti Lateralis Preparata has stronger toxic and side effects again, needs the decoction of long period when taking, and decocting time is difficult to grasp, and it is improper to decoct, easily produces toxic and side effects, even generation poisoning disastrous accident.Owing to these reasons, make many doctors and patient both want to use for Radix Aconiti Lateralis Preparata, the sense of fear is arranged again.So how to grasp Chinese medicine Radix Aconiti Lateralis Preparata decoction process, can shorten the decocting time of Radix Aconiti Lateralis Preparata, keep back rescuing the significant curative effect of contrary, cold relieving pain relieving, stomach warming and YANG enhancing, can reduce and overcome its toxic and side effects again, become the problem that vast hospitalized patients is looked forward to solution jointly.
The objective of the invention is provides a kind of safe, effective, stable, cheap for clinical, can treat the clinical new drug of cardiovascular disease and the preparation method of this medicine.
The object of the present invention is achieved like this: with raw material (weight portion) Radix Aconiti Lateralis Preparata 5-10, Radix Notoginseng 0.5-2, Cortex Cinnamomi 0.5-2, three kinds of raw materials extract active ingredient by certain process respectively and merge and make.
Manufacturing method for above mentioned medicine is:
1) add water 8-14 with Radix Aconiti Lateralis Preparata and doubly decoct three times, boiled 2-5 hour at every turn, filter, merge three times and decoct filtrate, decompression or normal pressure are condensed into paste, and 80 ℃ of oven dry down, it is standby to make Radix Aconiti Lateralis Preparata extract dry powder through pulverizing;
2) add 3-5 times of 95% alcohol reflux three times with Radix Notoginseng, each reflux, extract, 3-5 hour, reducing concentration of alcohol for the third time was 75% reflux, extract,, three times extracting solution merges, be evaporated to paste, 80 ℃ of oven dry down, it is standby that pulverizing makes Radix Notoginseng extract dry powder;
3) add water 5-8 doubly with Cortex Cinnamomi, use steam distillation, it is standby that separation obtains Cortex Cinnamomi volatile oil;
4) with above-mentioned three kinds of standby material mix homogeneously, sieve, encapsulated by specification.
Radix Aconiti Lateralis Preparata capsule of the present invention is to administer by being guidance with the differential diagnosis in tcm opinion, designs for the basis with clinical practice.Outstanding feature of the present invention is that the conventional amount used of Radix Aconiti Lateralis Preparata is the 3-15 gram, and more than the 5-10 that Radix Aconiti Lateralis Preparata consumption of the present invention is a conventional amount used times, this is extremely rare in successive dynasties tcm clinical practice treatment, also is the outstanding remarkable place of its clinical efficacy.The present invention is through processing drug test to Radix Aconiti Lateralis Preparata in a large number, make di esters alkaloid hydrolysis in the process that processing is concocted that contained toxicity is very strong in the living Radix Aconiti Lateralis Preparata, generate the less monoesters class alkali of toxicity, its toxicity only is di esters alkaloidal 1/200, as continue hydrolysis, then generate toxicity littler not with the amine alcohols alkali of ester bond, its toxicity only is di esters alkaloidal 1/2000.So in the course of processing of Radix Aconiti Lateralis Preparata, add water, heating, pressurization, the height of temperature, with most important, according to this principle, the present invention has carried out variance, quadrature has realized that best production technology is preferred on a large amount of bases of testing during decoction.Both keep the pharmacological action and the clinical efficacy of Chinese medicine Radix Aconiti Lateralis Preparata with the compound recipe Radix Aconiti Lateralis Preparata medicine of explained hereafter of the present invention, significantly reduced the toxic and side effects of Radix Aconiti Lateralis Preparata itself simultaneously again.The extraction of the arasaponin in the Radix Notoginseng, the effective ingredient in the Cortex Cinnamomi in addition makes this curative effect of medication better, and indication is wider.Medicine medicine of the present invention source abundance, technology is simple and direct rationally, patent medicine is the pure medicine of no any additives, patient's taking convenience is cheap, realized safety, effectively, stablize, purpose easily.
Embodiment 1:
1) with 10 kilograms of RADIX ACONITI LATERALIS PREPARATA, add water and decoct three times for 80 kilograms, boiled 5 hours for the first time, filter, boiled 3 hours for the second time, filter, boiled for the third time 1 hour, filter, merge three times and decoct filtrate, normal pressure is condensed into paste, and 80 ℃ of oven dry down, it is standby to make Radix Aconiti Lateralis Preparata extract dry powder through pulverizing;
2) add 2 kilograms with Radix Notoginseng, add 10 kilogram of 95% alcohol reflux three times, reflux, extract, is 5 hours for the first time, reflux, extract, is 3 hours for the second time, reducing concentration of alcohol for the third time is 75% reflux, extract, 2 hours, three extracting solution merge, and are evaporated to paste, 80 ℃ of oven dry down, pulverize that to make Radix Notoginseng extract dry powder standby;
3) with 1 kilogram of Cortex Cinnamomi, add 8 kilograms in water, use steam distillation, oil-water separation obtains Cortex Cinnamomi volatile oil standby (or adopting commercially available Oleum Cinnamomi);
4) with above-mentioned three kinds of standby material mix homogeneously, sieve, encapsulated by specification.
Embodiment 2:
1) with 10 kilograms of RADIX ACONITI LATERALIS PREPARATA, add water and decoct three times for 120 kilograms, boiled 4 hours for the first time, filter, boiled 3 hours for the second time, filter, boiled for the third time 3 hours, filter, merge three times and decoct filtrate, concentrating under reduced pressure becomes paste, and 80 ℃ of oven dry down, it is standby to make Radix Aconiti Lateralis Preparata extract dry powder through pulverizing;
2) add 2 kilograms with Radix Notoginseng, add 20 kilogram of 95% alcohol reflux three times, reflux, extract, is 4 hours for the first time, reflux, extract, is 3 hours for the second time, reducing concentration of alcohol for the third time is 75% reflux, extract, 1 hour, three extracting solution merge, and are evaporated to paste, 80 ℃ of oven dry down, pulverize that to make Radix Notoginseng extract dry powder standby;
3) with 1 kilogram of Cortex Cinnamomi, add 12 kilograms in water, use steam distillation, it is standby to obtain Cortex Cinnamomi volatile oil through oil-water separation;
4) with above-mentioned three kinds of standby material mix homogeneously, sieve, encapsulated by specification.
Claims (2)
1, a kind of medicine for the treatment of cardiovascular disease is characterized in that raw material contains (weight portion) Radix Aconiti Lateralis Preparata 5-10, and Radix Notoginseng 0.5-2, Cortex Cinnamomi 0.5-2, three kinds of raw materials extract active ingredient by certain process respectively and merge and make.
2, the preparation method of the medicine of treatment cardiovascular disease according to claim 1 is characterized in that:
1) add water 8-14 with Radix Aconiti Lateralis Preparata and doubly decoct three times, boiled 2-5 hour at every turn, filter, merge three times and decoct filtrate, decompression or normal pressure are condensed into paste, and 80 ℃ of oven dry down, it is standby to make Radix Aconiti Lateralis Preparata extract dry powder through pulverizing;
2) add 3-10 times of 95% alcohol reflux three times with Radix Notoginseng, each reflux, extract, 3-5 hour, reducing concentration of alcohol for the third time was 75% reflux, extract,, three times extracting solution merges, be evaporated to paste, 80 ℃ of oven dry down, it is standby that pulverizing makes Radix Notoginseng extract dry powder;
3) add water 5-12 doubly with Cortex Cinnamomi, use steam distillation, it is standby that separation obtains Cortex Cinnamomi volatile oil;
4) with above-mentioned three kinds of standby material mix homogeneously, sieve, encapsulated by specification.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 00113176 CN1131043C (en) | 2000-09-08 | 2000-09-08 | Medicine for treating cardiovascular disease and its preparing process |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN 00113176 CN1131043C (en) | 2000-09-08 | 2000-09-08 | Medicine for treating cardiovascular disease and its preparing process |
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CN1342466A true CN1342466A (en) | 2002-04-03 |
CN1131043C CN1131043C (en) | 2003-12-17 |
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CN 00113176 Expired - Fee Related CN1131043C (en) | 2000-09-08 | 2000-09-08 | Medicine for treating cardiovascular disease and its preparing process |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105076571A (en) * | 2015-08-25 | 2015-11-25 | 云南省林业科学院 | Pu'er healthcare tea and method for manufacturing same |
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2000
- 2000-09-08 CN CN 00113176 patent/CN1131043C/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105076571A (en) * | 2015-08-25 | 2015-11-25 | 云南省林业科学院 | Pu'er healthcare tea and method for manufacturing same |
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Granted publication date: 20031217 Termination date: 20091009 |