CN1336196A - Transdermal absorbed medicine for treating periarthritis of shoulder joint - Google Patents
Transdermal absorbed medicine for treating periarthritis of shoulder joint Download PDFInfo
- Publication number
- CN1336196A CN1336196A CN 00121155 CN00121155A CN1336196A CN 1336196 A CN1336196 A CN 1336196A CN 00121155 CN00121155 CN 00121155 CN 00121155 A CN00121155 A CN 00121155A CN 1336196 A CN1336196 A CN 1336196A
- Authority
- CN
- China
- Prior art keywords
- radix
- rhizoma
- medicine
- substrate
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to an external use medicinal plaster capable of skin permeable and adsorption for treating omitis. It is composed of 16 traditional Chinese medicinal herbs including radix ledebouriellae, radix anglicae dahuricae, rhizoma seu radix notopterygii, herba aseri, radix clematidis, radix aconiti, safflower, radix paeoniae, rubra, ligusticum root, myrrhae, boneol etc. and with adhesive, filler being added. It is spread on supporting material to form plaster after mixed and homogenized.
Description
The invention belongs to medical technical field, is a kind of external used medicine and production method thereof for the treatment of scapulohumeral periarthritis.
Scapulohumeral periarthritis is the aseptic inflammation that betides shoulder joint surrounding soft tissue, shows as shoulder pain and shoulder joint kinesitherapy dysfunction.This disease betided after the middle age, and 50-60 year is an onset peak, and its sickness rate accounts for the 2-5% of total population.Injection adrenal gland's glucocorticoid partial closure's therapy and physical therapy are generally adopted in the treatment of scapulohumeral periarthritis, still do not have the special-purpose medicaments of single-minded treatment scapulohumeral periarthritis at present both at home and abroad.
The present invention is according to Chinese medical theory, select for use have expelling wind and cold, the Chinese medicine of eliminating blood stasis and promoting blood circulation, promoting the flow of QI in the collateral by warming the meridian, analgesia effect.The Chinese medicine that the present invention selects is Radix Clematidis, Radix Saposhnikoviae, Ramulus Cinnamomi, Herba Asari, Flos Carthami, Olibanum, Myrrha, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Caulis Piperis Kadsurae, Borneolum Syntheticum, Fructus Zanthoxyli.
In order to improve drug effect, must utilize modern crafts to extract selected Effective Components of Chinese Herb.For this reason, the inventor of this work has carried out a large amount of research work, through experiment is definite repeatedly, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari, Ramulus Cinnamomi, Flos Carthami, Rhizoma Chuanxiong, Olibanum, Myrrha, Fructus Zanthoxyli, the employing alcohol-water flow extracts, and the extracting solution concentration of alcohol is 30-95%, is preferably 50-75%, reflux, extract, 1-4 time is preferably 2 times.Remove by filter medicinal residues, merging filtrate is through concentrating, obtaining Chinese medicine extract respectively behind the vacuum drying.
Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Clematidis, Radix Paeoniae Rubra are defined as decocting in water and extract 2 times, remove by filter filtering residue, merging filtrate, obtain extract separately behind concentrate drying.
After the Chinese medicine extracts active ingredients, mix by a certain percentage, get medicine material, mix with substrate, medicine and substrate blended ratio 10-50: 90-50, optimal proportion are 25-45: 75-55.Fully behind mixing, the homogenizing, on coating machine, be coated with, after the drying, cut into 10 * 12cm
2Paster, through the packing after be finished product.
, should by a certain percentage substrate be prepared with before substrate is mixed at medicine.Substrate is made up of polyisobutylene, glycerol, Polyethylene Glycol, liquid Paraffin, azone and water, and the polyisobutylene ratio is 5-20%, is preferably 7-15%; Glycerol is 5-30%, is preferably 10-20%; Polyethylene Glycol is 1-20%, is preferably 5-10%; Liquid Paraffin is 20-40%, is preferably 25-30%; The azone ratio is 1-5%, is preferably 2-3%; All the other are moisture content.Because therefore the Borneolum Syntheticum poorly water-soluble, before substrate and medicament mixed, gets required Borneolum Syntheticum in proportion,, join in the substrate, fully mix homogeneously with an amount of 95% ethanol dissolving.
The paster of making according to the present invention, after being affixed on patient's painful area, can promote that synovial fluid absorbs in the shoulder joint synovial bursa, connective tissue is secreted synovial fluid around reducing articular cavity, scapulohumeral periarthritis characteristics of lesion such as articular cavity adhesion, capacity dwindle are disappeared, finally make pain disappear the shoulder joint kinesitherapy functional rehabilitation.
Hereinafter, will be example with some optimum implementation, this invention is done more specifically introduced.Example 1:
Get Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari, Ramulus Cinnamomi, Flos Carthami, Rhizoma Chuanxiong, Myrrha, Olibanum, each 1kg of Fructus Zanthoxyli, add 8 liter of 60% alcoholic solution reflux, extract, respectively 2 times, each 2 hours, filter, remove medicinal residues, merging filtrate, vacuum concentration also reclaims ethanol, concentrate at 50 ℃ of following vacuum dryings to dry powder, weigh, the effective component extracts that various medical materials obtain is as follows: heavy (g) 89.52 94.68 91.18 86.80 90.73 97.14 105.30 110.02 96.28 of medical material (1kg) Radix Saposhnikoviae Radix Angelicae Dahuricae Herba Asari Ramulus Cinnamomi Flos Carthami Rhizoma Chuanxiong Olibanum Myrrha Fructus Zanthoxyli extract
Get Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Clematidis, each 1kg of Radix Paeoniae Rubra, adding 8 times of water boils respectively extracted 2 hours, filter, discard medicinal residues, merging filtrate, vacuum concentration to extractum ratio weighs about 1.40, put in the vacuum drying oven dry, to moisture less than till 10%, pulverize, weigh, effective ingredient (extract) weight that every kind of medical material obtains is as follows: medical material (1kg) Caulis Piperis Kadsurae Rhizoma Et Radix Notopterygii Radix Aconiti Radix Aconiti Kusnezoffii Radix Clematidis Radix Paeoniae Rubra extract (g) 105.22 103.76 91.50 93.20 98.32 101.18
After the extracts active ingredients, by following prescription proportioning extract is fully mixed with substrate, homogenize, typical proportion is as follows: (Chinese medicine extract replaces with the Chinese medicine title)
Radix Saposhnikoviae 60g Radix Angelicae Dahuricae 60g Herba Asari 30g Ramulus Cinnamomi 30g
Flos Carthami 30g Rhizoma Chuanxiong 50g Olibanum 30g Myrrha 30g
Fructus Zanthoxyli 50g Radix Paeoniae Rubra 60g Caulis Piperis Kadsurae 30g Rhizoma Et Radix Notopterygii 30g
Radix Aconiti 30g Radix Aconiti Kusnezoffii 30g Radix Clematidis 30g Borneolum Syntheticum 15g
Substrate composition is:
Polyisobutylene 120g glycerol 200g Polyethylene Glycol 100g
Liquid Paraffin 300g azone 30g water 800g
According to the above ratio medicine is fully mixed with substrate, homogenizing, wherein Borneolum Syntheticum joins in the mixture after with the dissolving of an amount of 95% ethanol, then the medicine that mixes is applied on the medical cloth of support material.Be coated with on the even rearmounted tunnel drier and dry.Be cut into 10 * 12cm
2The paster of size, above-mentioned prescription is made 1000 of pasters altogether, the every about 565mg of effective ingredient content, every square centimeter of about 4.7mg of pastille.Example 2:
The plaster that adopts example 1 to make carries out clinical trial, is affixed on the shoulder arthralgia position, and paste every day 1, and 7 days is a course of treatment.
Observe case totally 50 examples, male's 18 examples wherein, women's 32 examples, 58 years old mean age, average course of disease 1.2 years.
Curative effect determinate standard: clinical cure: pain disappears, and functional rehabilitation can recover former work.Produce effects: pain disappears substantially, and function of joint is normal substantially, does not influence work.Effectively: pain relief, functional activity makes moderate progress.Invalid: as to compare no change or alleviate slightly before the pain, functional activity and treatment.
The result: through a course of therapy, part is through among two course of therapy, the 50 routine patients, and cured person 8 examples account for 16%, and produce effects person's 16 examples account for 32%, and responder's 24 examples account for 48%, and nonresponder's 2 examples account for 4%, total effective rate 96%.
Claims (6)
1, a kind of Transdermal absorption medicine preparation for the treatment of scapulohumeral periarthritis is characterized in that said preparation contains effective ingredient and substrate and Percutaneous absorption enhancer that plurality of Chinese is extracted, coats on the medical support material, cuts into the external used medicine of certain specification.
2,, comprise Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Caulis Piperis Kadsurae, Herba Asari, Ramulus Cinnamomi, Radix Clematidis, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Olibanum, Myrrha, Fructus Zanthoxyli, Borneolum Syntheticum according to the Chinese medicine of claim 1.
3, according to the Chinese medicine extraction method of claim 1, wherein Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari, Ramulus Cinnamomi, Flos Carthami, Rhizoma Chuanxiong, Myrrha, Olibanum, Fructus Zanthoxyli, adopt the ethanol water reflux, extract, respectively 2 times, concentration of alcohol is 30-95%, extracting the back concentrates, reclaim ethanol,, obtain effective ingredient through vacuum drying.Caulis Piperis Kadsurae, Rhizoma Et Radix Notopterygii, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Clematidis, Radix Paeoniae Rubra decocting in water respectively extract 2 times, obtain effective ingredient through concentrated, vacuum drying.
4, according to claim 1, substrate is made up of filler and binding agent, and filler is glycerol, liquid Paraffin, Polyethylene Glycol, and binding agent is a polyisobutylene, and transdermal enhancer is an azone.Its proportioning is: polyisobutylene 5-20%, glycerol 5-30%, Polyethylene Glycol 1-20%, liquid Paraffin 20-40%, azone 1-5%.
5, according to claim 3, after each Chinese medicine extracts active ingredients drying, after mixing by a certain percentage, to mix with substrate, the ratio of medicine and substrate is 10-50: 90-50.
6, according to claim 5, the ratio of pharmaceutically active ingredient is in each: Radix Saposhnikoviae (in extract, down together) 0-60mg, Radix Clematidis 0-30mg, Radix Angelicae Dahuricae 0-60mg, Ramulus Cinnamomi 0-30mg, Herba Asari 0-30mg, Rhizoma Chuanxiong 0-40mg, Radix Paeoniae Rubra 0-60mg, Caulis Piperis Kadsurae 0-50mg, Flos Carthami 0-50mg, Olibanum 0-50mg, Myrrha 0-50mg, Fructus Zanthoxyli 0-60mg, Radix Aconiti 0-50mg, Radix Aconiti Kusnezoffii 0-50mg, Rhizoma Et Radix Notopterygii 0-50mg, Borneolum Syntheticum 0-20mg.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00121155 CN1336196A (en) | 2000-07-28 | 2000-07-28 | Transdermal absorbed medicine for treating periarthritis of shoulder joint |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00121155 CN1336196A (en) | 2000-07-28 | 2000-07-28 | Transdermal absorbed medicine for treating periarthritis of shoulder joint |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1336196A true CN1336196A (en) | 2002-02-20 |
Family
ID=4588618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 00121155 Pending CN1336196A (en) | 2000-07-28 | 2000-07-28 | Transdermal absorbed medicine for treating periarthritis of shoulder joint |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1336196A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102048926A (en) * | 2011-01-07 | 2011-05-11 | 河南中医学院 | Chinese medicinal pain-relieving spray for externally treating osteoarthrosis |
CN102133362A (en) * | 2011-03-14 | 2011-07-27 | 山东省千佛山医院 | Traditional Chinese medicine composition for treating arthritis |
CN102526308A (en) * | 2011-12-27 | 2012-07-04 | 李承平 | Chinese medicinal formulation for external treatment by hot compression, fumigation and medicated bath |
CN104208299A (en) * | 2014-08-13 | 2014-12-17 | 蚌埠火鹤制药有限公司 | Plaster for treating periarthritis of shoulder and manufacturing method thereof |
CN105232665A (en) * | 2015-11-04 | 2016-01-13 | 李连欣 | Traditional Chinese medicine honey bolus for treating periarthritis of shoulder and preparation method thereof |
CN110898144A (en) * | 2019-11-29 | 2020-03-24 | 菏泽市圣医医疗科技有限公司 | Black plaster for treating scapulohumeral periarthritis and preparation method thereof |
-
2000
- 2000-07-28 CN CN 00121155 patent/CN1336196A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102048926A (en) * | 2011-01-07 | 2011-05-11 | 河南中医学院 | Chinese medicinal pain-relieving spray for externally treating osteoarthrosis |
CN102133362A (en) * | 2011-03-14 | 2011-07-27 | 山东省千佛山医院 | Traditional Chinese medicine composition for treating arthritis |
CN102133362B (en) * | 2011-03-14 | 2011-12-28 | 山东省千佛山医院 | Traditional Chinese medicine composition for treating arthritis |
CN102526308A (en) * | 2011-12-27 | 2012-07-04 | 李承平 | Chinese medicinal formulation for external treatment by hot compression, fumigation and medicated bath |
CN104208299A (en) * | 2014-08-13 | 2014-12-17 | 蚌埠火鹤制药有限公司 | Plaster for treating periarthritis of shoulder and manufacturing method thereof |
CN105232665A (en) * | 2015-11-04 | 2016-01-13 | 李连欣 | Traditional Chinese medicine honey bolus for treating periarthritis of shoulder and preparation method thereof |
CN110898144A (en) * | 2019-11-29 | 2020-03-24 | 菏泽市圣医医疗科技有限公司 | Black plaster for treating scapulohumeral periarthritis and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1362256A (en) | Osteological Chinese medicine prepn. | |
CN103316192B (en) | Traditional Chinese medicine foot-bathing liquid for treating lumbocrural pain and preparation method thereof | |
CN113768975A (en) | Traditional Chinese medicine composition for treating arthralgia, traditional Chinese medicine patch, and preparation method and use method thereof | |
CN103127438A (en) | Chinese medicinal preparation for treating rheumatic bone pain and preparation method | |
CN1336196A (en) | Transdermal absorbed medicine for treating periarthritis of shoulder joint | |
CN102755595A (en) | Bone fracture medicinal patch and preparation method thereof | |
CN102178811B (en) | Medicament for treating skin ulcer and preparation method thereof | |
CN108403932B (en) | Traditional Chinese medicine compound external preparation for treating hormone-dependent dermatitis and preparation method and application thereof | |
CN101020019A (en) | Dogskin plaster and its prepn process | |
CN105796640A (en) | Traditional Chinese medicine composition and preparation with acne treatment function | |
CN103341013B (en) | A kind of Chinese medicine for the treatment of lumbago and skelalgia | |
CN102343028B (en) | Chinese medicinal composition for treating cyclomastopathy and preparation method thereof | |
CN115381912A (en) | External traditional Chinese medicine compound preparation for reducing cancer pain and preparation method thereof | |
CN103585568A (en) | Traditional Chinese medicine composition for treating dermatophytosis | |
CN110141622B (en) | Traditional Chinese medicine composition for treating pain and preparation method and application thereof | |
CN102784129A (en) | Preparation process of traditional Chinese medicine plaster | |
CN1116892C (en) | Bagged blood circulation-activating and obstruction-dredging granule and its preparation | |
CN105641128A (en) | Traditional Chinese medicine composition for treating herpes zoster | |
CN111067985A (en) | External traditional Chinese medicine composition and traditional Chinese medicine plaster for easing pain as well as preparation method and application | |
CN101129678A (en) | Externally used formulated product for treating empyrosis and method of preparing the same | |
CN116370529B (en) | A topical Chinese medicinal composition for treating rheumatism, and its preparation method and application | |
CN1061546C (en) | Preparation for treating burns and empyrosis and its preparing process | |
CN115887601B (en) | A composition for treating hemorrhoid and its preparation method | |
CN110141621B (en) | Traditional Chinese medicine composition for treating pain and preparation method and application thereof | |
CN101020003A (en) | Wind evil expelling sea horse plaster and its prepn |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |