CN102755595A - Bone fracture medicinal patch and preparation method thereof - Google Patents
Bone fracture medicinal patch and preparation method thereof Download PDFInfo
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- CN102755595A CN102755595A CN2012102662233A CN201210266223A CN102755595A CN 102755595 A CN102755595 A CN 102755595A CN 2012102662233 A CN2012102662233 A CN 2012102662233A CN 201210266223 A CN201210266223 A CN 201210266223A CN 102755595 A CN102755595 A CN 102755595A
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Abstract
The invention discloses a bone fracture medicinal patch and a preparation method thereof, which belong to the field of external Chinese patent medicaments. The bone fracture medicinal patch comprises a Chinese medicinal formula, a substrate material, a back lining layer and a supporting layer, wherein the formula consists of the following components in parts by weight: 10 parts of Chinese angelica, 10 parts of szechuan lovage rhizome, 10 parts of common bletilla tuber, 10 parts of ground beetle, 20 parts of pseudo-ginseng root, 10 parts of cortex eucommiae, 10 parts of tree peony root-bark, 20 parts of sappan wood, 10 parts of suberect spatholobus stem, 20 parts of fortune's drynaria rhizome, 10 parts of himalayan teasel root, 20 parts of astragalus, 20 parts of sealwort, 10 parts of double-teeth pubescent angelica root, 20 parts of frankincense, 80 parts of myrrh, 20 parts of safflower, 20 parts of twotooth achyranthes root, 5 parts of native copper, 2 parts of dragon's blood, 20 parts of common selfheal fruit-spike, 20 parts of fenugreek seed, 20 parts of epimedium herb, 20 parts of south dodder seed, 10 parts of ainsliaea, 10 parts of corydalis tuber, 10 parts of peach kernel, 10 parts of common burreed rhizome and 10 parts of curcuma zedoary. The preparation method comprises the following steps of: preparing Chinese medicinal fine powder; preparing an extract; preparing a substrate material; preparing paste; and making a plaster. The bone fracture medicinal patch has the effects of relieving pain, stopping bleeding, diminishing swelling quickly and healing quickly, is free from harmful substances such as mercury, lead and the like, is nonirritant, is non-allergic to skin, does not pollute skin, is easy to strip, can be removed and stuck repeatedly, does not hurt hairs, and is mainly applied to patients with bone fractures and bone fracture injuries and whose tendons and bones are manually straightened or set, or people for which poroma is not formed a long time after bone fractures.
Description
Affiliated technical field
The present invention relates to a kind of external Chinese patent medicine, especially bone injury is used plaster, belongs to the external technical field of Chinese patent medicine.
Background technology
At present, the traditional plaster, black plaster, the rubber plaster that are used for bone healing contain harmful materials such as hydrargyrum, lead, and be big to the skin viscous force, can cause chaeta impaired, peels off difficulty, causes the patient suffering, and be disposable use; Black plaster must heat when using, and the adhesive tape chaeta also pollutes skin.Cause administration time to be restricted thus, the effective ingredient of medicine can not fully absorb, and bioavailability is low, and the allergic phenomena incidence rate is high.Bring very big inconvenience for patient's use; And the existing Chinese medicine mud cream that is used for orthopedics department treatment, black plaster etc. make the patient treatment cycle long because the effective ingredient of medicine can not discharge fully and cause effective rate of utilization low.
Summary of the invention
To the problems referred to above, the present invention provides a kind of convenient and practical bone injury plaster.
The technical solution adopted for the present invention to solve the technical problems is:
The bone injury plaster; Comprise Chinese medicine preparation, host material, backing layer and supporting layer; Chinese medicine preparation is made up of following composition by weight: Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Eupolyphaga Seu Steleophaga 10, Radix Notoginseng 20, the Cortex Eucommiae 10, Cortex Moutan 10, Lignum Sappan 20, Caulis Spatholobi 10, Rhizoma Drynariae 20, Radix Dipsaci 10, the Radix Astragali 20, Rhizoma Polygonati 20, Radix Angelicae Pubescentis 10, Olibanum 20, Myrrha 80, Flos Carthami 20, Radix Achyranthis Bidentatae 20, Pyritum 5, Sanguis Draxonis 2, Spica Prunellae 20, reed Ba Zi 20, Herba Epimedii 20, field dobber 20, Ainsliaea fragrans Champ. 10, Rhizoma Corydalis 10, Semen Persicae 10, triangular 10, Rhizoma Curcumae 10; Host material is made up of following components in weight percent: adhesive agent 10-20%, wetting agent 20-40%, filler 5-20%, transdermal enhancer 1-5%, purified water 30-50%.
The method for preparing of bone injury plaster may further comprise the steps:
A. Chinese medicine fine powder preparation:
With following raw material of Chinese medicine and composition by weight: Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Eupolyphaga Seu Steleophaga 10, Radix Notoginseng 20, the Cortex Eucommiae 10 are ground into fine powder, and mix homogeneously is subsequent use;
B. ethanol stream extractum preparation:
The ethanol of getting 70% usefulness 60% of Chinese medicine fine powder is heated to 80 ℃ of reflux, extract, ethanol stream extractum, and is subsequent use;
C. aqueous extract preparation:
With following raw material of Chinese medicine and composition by weight: Cortex Moutan 10, Lignum Sappan 20, Caulis Spatholobi 10, Rhizoma Drynariae 20, Radix Dipsaci 10, the Radix Astragali 20, Rhizoma Polygonati 20 Radix Angelicae Pubescentiss 10, Olibanum 20, Myrrha 80, Flos Carthami 20, Radix Achyranthis Bidentatae 20, Pyritum 5, Spica Prunellae 20, reed Ba Zi 20, Herba Epimedii 20, field dobber 20, Ainsliaea fragrans Champ. 10, Rhizoma Corydalis 10, Semen Persicae 10, triangular 10, Rhizoma Curcumae 10 are used purified water extraction; Decoct three times, decocted 2 hours for the first time, add 10 times of water; Decocted 1 hour for the second time, add 8 times of water; Decocted for the third time one hour, and added 8 times of water, merge three times decoction liquor, filtering and heating is concentrated to the aqueous extract that relative density is 1.3-1.4, and is subsequent use;
D. host material preparation:
With adhesive agent 10-20%, wetting agent 20-40%, filler 5-20%, transdermal enhancer 1-5%, purified water 30-50% mix homogeneously, subsequent use;
E. mastic preparation: will remain 30% Chinese medicine fine powder at normal temperatures and add Sanguis Draxonis 2 weight portions, ethanol stream extractum, extractum, and add the surplus host material again and stir by weight 10-15%, 0.5-1%, 1-3% mixing;
F. plaster is made:
The mastic of processing is coated on the supporting layer medicine non-woven fabrics uniformly, and thickness is 2-3mm, on paste layer, covers the backing layer polyethylene film, cutting, is packaged into finished product.
The invention has the beneficial effects as follows that pain relieving, hemostasis, detumescence are fast, healing is fast, nontoxic (harmful substances such as hydrargyrum, lead), nonirritant do not have irritated phenomenon to skin, do not pollute skin.Peel off easily, and can take off subsides repeatedly, do not injure chaeta.Has the effect of mending bone, bone strengthening, promotion osteanagenesis; Osteoblastic differentiation there is obvious facilitation; Thereby the formation that adds bone strengthening is had good effect, can promote the immediate union of fracturing, the problem that makes fracture back callus not form (bone does not connect) has for a long time obtained good solution.After being mainly used in fracture, fracture and injury, muscles and bones made or connect positive patient in order for maneuver, or the crowd that fracture back callus does not form for a long time uses.
The specific embodiment
Below in conjunction with embodiment the present invention is further specified.
The bone injury plaster; Comprise Chinese medicine preparation, host material, backing layer and supporting layer; Chinese medicine preparation is made up of following composition by weight: Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Eupolyphaga Seu Steleophaga 10, Radix Notoginseng 20, the Cortex Eucommiae 10, Cortex Moutan 10, Lignum Sappan 20, Caulis Spatholobi 10, Rhizoma Drynariae 20, Radix Dipsaci 10, the Radix Astragali 20, Rhizoma Polygonati 20 Radix Angelicae Pubescentiss 10, Olibanum 20, Myrrha 80, Flos Carthami 20, Radix Achyranthis Bidentatae 20, Pyritum 5, Sanguis Draxonis 2, Spica Prunellae 20, reed Ba Zi 20, Herba Epimedii 20, field dobber 20, Ainsliaea fragrans Champ. 10, Rhizoma Corydalis 10, Semen Persicae 10, triangular 10, Rhizoma Curcumae 10; Host material is made up of following components in weight percent: adhesive agent 10-20%, wetting agent 20-40%, filler 5-20%, transdermal enhancer 1-5%, purified water 30-50%.
Adhesive agent in the host material is sodium polyacrylate or polyvinylpyrrolidone, and wetting agent is glycerol or propylene glycol, and filler is a calcium carbonate, and transdermal enhancer is an azone.
The method for preparing of bone injury plaster may further comprise the steps:
A. Chinese medicine fine powder preparation:
With following raw material of Chinese medicine and composition by weight: Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Eupolyphaga Seu Steleophaga 10, Radix Notoginseng 20, the Cortex Eucommiae 10 are ground into fine powder, and mix homogeneously is subsequent use;
B. ethanol stream extractum preparation:
The ethanol of getting 70% usefulness 60% of Chinese medicine fine powder is heated to 80 ℃ of reflux, extract, ethanol stream extractum, and is subsequent use;
C. extractum preparation:
With following raw material of Chinese medicine and composition by weight: Cortex Moutan 10, Lignum Sappan 20, Caulis Spatholobi 10, Rhizoma Drynariae 20, Radix Dipsaci 10, the Radix Astragali 20, Rhizoma Polygonati 20 Radix Angelicae Pubescentiss 10, Olibanum 20, Myrrha 80, Flos Carthami 20, Radix Achyranthis Bidentatae 20, Pyritum 5, Spica Prunellae 20, reed Ba Zi 20, Herba Epimedii 20, field dobber 20, Ainsliaea fragrans Champ. 10, Rhizoma Corydalis 10, Semen Persicae 10, triangular 10, Rhizoma Curcumae 10 are used purified water extraction; Decoct three times, decocted 2 hours for the first time, add 10 times of water; Decocted 1 hour for the second time, add 8 times of water; Decocted for the third time one hour, and added 8 times of water, merge three times decoction liquor, filtering and heating is concentrated to the aqueous extract that relative density is 1.3-1.4, and is subsequent use;
D. host material preparation:
With sodium polyacrylate or polyvinylpyrrolidone 10-20%, glycerol or propylene glycol 20-40%, calcium carbonate 5-20%, azone 1-5%, purified water 30-50% mix homogeneously, subsequent use;
E. mastic preparation: will remain 30% Chinese medicine fine powder at normal temperatures and add Sanguis Draxonis 2 weight portions, ethanol stream extractum, extractum, and add the surplus host material again and stir by weight 10-15%, 0.5-1%, 1-3% mixing;
F. plaster is made:
The mastic of processing is coated on the supporting layer medicine non-woven fabrics uniformly, and thickness is 2-3mm, on paste layer, covers the backing layer polyethylene film, cutting, is packaged into finished product.
Flos Carthami in the prescription, Cortex Moutan, Radix Achyranthis Bidentatae, Caulis Spatholobi, Olibanum, Myrrha, be blood circulation promoting and blood stasis dispelling; Pyritum, Rhizoma Drynariae are blood-activating and trauma-curing medicinal; The Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Drynariae, Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening; The Radix Astragali, Radix Angelicae Sinensis circulation of qi promoting are enriched blood.Radix Notoginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), Sanguis Draxonis have hemostasis by removing blood stasis, reducing swelling and alleviating pain, the effect of granulation promoting.Eupolyphaga Seu Steleophaga is a promoting blood circulation to remove blood stasis, reunion of fractured tendons and bones, dredge the meridian passage.Du is swollen, and Rhizoma Polygonati, Radix Achyranthis Bidentatae are blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, sharp joint.All medicines are synthetic to play QI and blood regulating, and the meridian dredging is invigorated blood circulation, enriched blood, blood stasis dispelling; Bone and muscle strengthening, invigorating the liver and kidney; The generation of callus when short, tranquilizing the mind.
The present invention is raw material with Chinese medicine, extracts the cataplasma of processing with the preparation process technology in conjunction with modern Chinese medicine.Compare with traditional unguentum, it has following characteristics:
This product adopts extractum, Chinese medicine fine powder and host material to prepare according to corresponding proportion, and the ratio of medicine and host material is improved greatly, reaches 40: 60; The ordinary rubber unguentum then only can reach 10: 90, and the thick 2-3mm that reaches of mastic has guaranteed that medicine effectively discharges and the unit dosage, reaches lasting therapeutic effect.
The host material that adopts is a major ingredients with water solublity (hydrophilic) macromolecular material, and is strong with the medicine affinity, nontoxic through the preparation of science, nonirritant.Human body skin there is not irritated phenomenon.Skin whiting, scratchy, erythema can not occur, not pollute skin, avoid traditional rubber and high dimerization host material shortcoming.Scalable viscosity affinity makes it to accomplish with the human body adherence force moderate, peels off easily, and can take off subsides repeatedly, does not injure chaeta.
Hydrophilic high molecular material in the host material makes medicine be in activated state all the time, has improved the penetrating power of medicament active composition to skin, make the through rapidly focus of medicine, and the control slow release effect of medicine is obvious.Can in 24 hours to 120 hours, discharge medicine uniformly, avoid the peak valley phenomenon of medicine, improve the effective rate of utilization of pharmaceutical compositions.
In the host material process for preparation, adopt temperature production.Avoided destruction to the aromatic substance effective ingredient.Guarantee the bioavailability of the effective ingredient of medicine to greatest extent.
Prescription has further strengthened the affinity to human body skin, and ingredient is permeated in human body by the human body temperature induction.Efficiency of drugs can receive the adjusting of skin temperature, stops after taking off discharging.Other plaster then can't reach, and loses efficacy easily in the serious volatilization short time to such an extent as to take the effective ingredient of back medicine off.
The present invention learns modern Chinese medicine with the Chinese medicine preparation technology and organically combines on the basis of Chinese medicine, on the basis of the former curative effect of assurance, improves and innovates.Utilization Chinese medicine principle: Liver and kidney is ruled together, vital essence with mend, QI and blood is laid equal stress on and take liver, spleen into account, it is unimpeded to reach blood circulation promoting and blood stasis dispelling, collateral dredging, mechanism of qi.Make and be able to recovery from illness in the therapeutic process that patient with bone fracture can be more convenient, safer, more comfortable.
Claims (3)
1. bone injury plaster; Comprise Chinese medicine preparation, host material, backing layer and supporting layer; It is characterized in that; Chinese medicine preparation is made up of following composition by weight: Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Eupolyphaga Seu Steleophaga 10, Radix Notoginseng 20, the Cortex Eucommiae 10, Cortex Moutan 10, Lignum Sappan 20, Caulis Spatholobi 10, Rhizoma Drynariae 20, Radix Dipsaci 10, the Radix Astragali 20, Rhizoma Polygonati 20, Radix Angelicae Pubescentis 10, Olibanum 20, Myrrha 80, Flos Carthami 20, Radix Achyranthis Bidentatae 20, Pyritum 5, Sanguis Draxonis 2, Spica Prunellae 20, reed Ba Zi 20, Herba Epimedii 20, field dobber 20, Ainsliaea fragrans Champ. 10, Rhizoma Corydalis 10, Semen Persicae 10, triangular 10, Rhizoma Curcumae 10; Host material is made up of following components in weight percent: adhesive agent 10-20%, wetting agent 20-40%, filler 5-20%, transdermal enhancer 1-5%, purified water 30-50%.
2. synthetism analgesic ointment according to claim 1 is characterized in that, the adhesive agent in the described host material is sodium polyacrylate or polyvinylpyrrolidone, and wetting agent is glycerol or propylene glycol, and filler is a calcium carbonate, and transdermal enhancer is an azone.
3. the method for preparing of a bone injury plaster is characterized in that, may further comprise the steps:
A. Chinese medicine fine powder preparation
With following raw material of Chinese medicine and composition by weight: Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Eupolyphaga Seu Steleophaga 10, Radix Notoginseng 20, the Cortex Eucommiae 10 are ground into the Chinese medicine fine powder, and mix homogeneously is subsequent use;
B. ethanol stream extractum preparation:
The ethanol of getting 70% usefulness 60% of above-mentioned Chinese medicine fine powder is heated to 80 ℃ of reflux, extract, ethanol stream extractum, and is subsequent use;
C. aqueous extract preparation:
With following raw material of Chinese medicine and composition by weight: Cortex Moutan 10, Lignum Sappan 20, Caulis Spatholobi 10, Rhizoma Drynariae 20, Radix Dipsaci 10, the Radix Astragali 20, Rhizoma Polygonati 20, Radix Angelicae Pubescentis 10, Olibanum 20, Myrrha 80, Flos Carthami 20, Radix Achyranthis Bidentatae 20, Pyritum 5, Spica Prunellae 20, reed Ba Zi 20, Herba Epimedii 20, field dobber 20, Ainsliaea fragrans Champ. 10, Rhizoma Corydalis 10, Semen Persicae 10, triangular 10, Rhizoma Curcumae 10 are used purified water extraction; Decoct three times, decocted 2 hours for the first time, add 10 times of water; Decocted 1 hour for the second time, add 8 times of water; Decocted for the third time one hour, and added 8 times of water, merge three times decoction liquor, filtering and heating is concentrated to the extractum that relative density is 1.3-1.4, and is subsequent use;
D. host material preparation:
With adhesive agent 10-20%, wetting agent 20-40%, filler 5-20%, transdermal enhancer 1-5%, purified water 30-50% mix homogeneously, subsequent use;
E. mastic preparation: will remain 30% Chinese medicine fine powder at normal temperatures and add Sanguis Draxonis 2 weight portions, ethanol stream extractum, extractum, and add the surplus host material again and stir by weight 10-15%, 0.5-1%, 1-3% mixing;
F. plaster is made:
The mastic of processing is coated on the supporting layer medicine non-woven fabrics uniformly, and thickness is 2-3mm, on paste layer, covers the backing layer polyethylene film, cutting, is packaged into finished product.
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| CN2012102662233A CN102755595A (en) | 2012-07-18 | 2012-07-18 | Bone fracture medicinal patch and preparation method thereof |
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| CN2012102662233A CN102755595A (en) | 2012-07-18 | 2012-07-18 | Bone fracture medicinal patch and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356893A (en) * | 2012-03-27 | 2013-10-23 | 上海卫生材料厂有限公司 | Method for extracting traditional Chinese medicines such as frankincense, myrrh and rhizoma bletillae |
| CN103877556A (en) * | 2014-04-17 | 2014-06-25 | 崔贵成 | Traditional Chinese medicine plaster for bone injury and fracture |
| CN104225413A (en) * | 2014-10-23 | 2014-12-24 | 张相才 | Orthopedic patch for external application and preparation method thereof |
| CN105233191A (en) * | 2015-11-30 | 2016-01-13 | 济南舜祥医药科技有限公司 | Medicine treating bone fracture and preparation method |
| CN108578676A (en) * | 2018-05-08 | 2018-09-28 | 广州湘喜生物科技有限公司 | A kind of patch for having effects that orthopaedics is promoted to heal |
-
2012
- 2012-07-18 CN CN2012102662233A patent/CN102755595A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356893A (en) * | 2012-03-27 | 2013-10-23 | 上海卫生材料厂有限公司 | Method for extracting traditional Chinese medicines such as frankincense, myrrh and rhizoma bletillae |
| CN103877556A (en) * | 2014-04-17 | 2014-06-25 | 崔贵成 | Traditional Chinese medicine plaster for bone injury and fracture |
| CN104225413A (en) * | 2014-10-23 | 2014-12-24 | 张相才 | Orthopedic patch for external application and preparation method thereof |
| CN105233191A (en) * | 2015-11-30 | 2016-01-13 | 济南舜祥医药科技有限公司 | Medicine treating bone fracture and preparation method |
| CN108578676A (en) * | 2018-05-08 | 2018-09-28 | 广州湘喜生物科技有限公司 | A kind of patch for having effects that orthopaedics is promoted to heal |
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Application publication date: 20121031 |