CN1328853A - Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique - Google Patents
Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique Download PDFInfo
- Publication number
- CN1328853A CN1328853A CN 01123976 CN01123976A CN1328853A CN 1328853 A CN1328853 A CN 1328853A CN 01123976 CN01123976 CN 01123976 CN 01123976 A CN01123976 A CN 01123976A CN 1328853 A CN1328853 A CN 1328853A
- Authority
- CN
- China
- Prior art keywords
- quick
- solution
- blood vessel
- support
- anastomosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003872 anastomosis Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 238000000034 method Methods 0.000 title claims description 24
- 230000002792 vascular Effects 0.000 title claims description 23
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 6
- 229920000642 polymer Polymers 0.000 claims abstract description 4
- 108010010803 Gelatin Proteins 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
- 235000019322 gelatine Nutrition 0.000 claims description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims description 8
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 6
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 6
- 235000019800 disodium phosphate Nutrition 0.000 claims description 6
- 230000035479 physiological effects, processes and functions Effects 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 4
- 235000010413 sodium alginate Nutrition 0.000 claims description 4
- 229940005550 sodium alginate Drugs 0.000 claims description 4
- 239000000661 sodium alginate Substances 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 abstract description 32
- 150000001875 compounds Chemical class 0.000 abstract description 9
- 239000013078 crystal Substances 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- ZRWPUFFVAOMMNM-UHFFFAOYSA-N Patulin Chemical compound OC1OCC=C2OC(=O)C=C12 ZRWPUFFVAOMMNM-UHFFFAOYSA-N 0.000 abstract 2
- 239000012154 double-distilled water Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 15
- 210000000988 bone and bone Anatomy 0.000 description 14
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 238000004108 freeze drying Methods 0.000 description 6
- 239000000155 melt Substances 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- 238000012856 packing Methods 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 238000010417 needlework Methods 0.000 description 4
- 239000004830 Super Glue Substances 0.000 description 3
- FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 description 3
- 238000009958 sewing Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000004026 tunica intima Anatomy 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 230000001194 anti-hemostatic effect Effects 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 150000002148 esters Chemical group 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000001365 lymphatic vessel Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002406 microsurgery Methods 0.000 description 1
- 210000004083 nasolacrimal duct Anatomy 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
Abstract
A preparation method of the invented quick-soluble scaffold for anastomosis of blood vessel includes the following steps: firstly, preparing double-distilled water solution by using dissolvable polymer, heating the above-mentioned solution, quickly stirring and adding physiological salt powder to form ropy compound, using mould to extrude or draw the said compound to make it into claviform or hollow tube which is identical to vassel of human body in diameter so as to obtain the invented soluble scaffold material. This blood vessel scaffold possesses micrometer level porosity in structure, after it is compounded with physiological salt crystal, its mechanical strength is increased, in the course of application, it features proper dissolving time, smooth surface, good elasticity and does not damage endangium, and it is non-toxic, and has no residual. It is quick in anastomosis speed, simple and easy to implement.
Description
Technical field:
The present invention relates to a kind of preparation method that is used for the instant bracket of microtraumatic quick vascular anastomosis technique,, simplify the operation, improve the identical speed of blood vessel, belong to technical field of biological materials to improve the identical quality of blood vessel.
Background technology:
The vascular anastomosis technology is the basic fundamental of surgery, it produces the development that has directly promoted whole surgery with development, traditional needlework vascular suture technology remains the vascular anastomosis technology that is most widely used at present, can obtain higher vascular anastomosis patency rate through screwing up discipline of long period, but the deficiency of its existence can not be ignored also: the doctor must could grasp this technology through strict professional skill training; Surgical condition requires high; Complicated operation; Difficulty is bigger; And it is time-consuming.The participation of needlework in sewing process be inevitably for the damage of blood vessel wall, and the damage of blood vessel wall is to cause the anastomotic stoma oozing of blood, anastomotic stricture, and there is certain identical mortality in thrombotic main cause so needlework are sewed up blood vessel.
Along with the further raising of surgical intervention level, the vascular anastomosis technology is had higher requirement.At first, under the condition that war wound and extensive disaster are hindered, produce a large amount of wounded in the short time, time this moment is deciding factor, under traditional this condition of vascular suture technology early stage repair blood vessel become impossible.Secondly, along with the thorough solution of immunologic rejection problem and organ origin problem, the novel vascular anastomosis can be applied in the organ transplantation process.The 3rd, blood vessel is a kind of in the numerous biological ducts of body, other body biological duct also comprises: deferent duct, fallopian tube, ureter, lymphatic vessel, biliary tract, urethra, intestinal, nasolacrimal duct or the like, coincideing of other biological pipeline also equally adopted the needlework sewing with blood vessel at present, it is also very similar that it sews up requirement, and method can further be applied in the kiss termination process of other biological duct of body so novel vascular of the present invention coincide.
People have successively invented multiple vascular anastomosis method, as: heat coagulable pipe method (method of laser welding, bipolar coagulation coincide method or the like), sleeve pipe or collar method and the apparatus method or the like of coincideing of coincideing of coincideing, because all there is the shortcoming of self in these methods, so do not obtain clinical practice always.The vascular anastomosis that adopts mainly is esters support, saccharide support, Polyethylene Glycol support with support at present, all there is weak point in all kinds of supports, as: meet water after-poppet intensity and obviously descend, can not play a supporting role in the overall process of coincideing, have potential cytology's toxicity, tunica intima is produced damage or the like.
Summary of the invention:
The objective of the invention is to propose a kind of preparation method that is used for the instant bracket of microtraumatic quick vascular anastomosis technique, a kind of quick to prepare, the easy used timbering material of vascular anastomosis method, solvable inner support is combined with adhesive technology, body biological duct kiss is connect method to be made improvements, coincide fast to be used for operating pipeline-like tissue, particularly the vascular anastomosis of microsurgery.
The preparation method of the instant bracket that is used for microtraumatic quick vascular anastomosis technique that the present invention proposes comprises following each step:
1, the resolvability polymer is configured to the DDW solution of 5%-30% concentration, this solution can solidify at 10~25 ℃, and the soluble polymeric thing can be a gelatin here, sodium alginate, but metabolism polymer such as aminopolysaccharide.
2. above-mentioned solution is heated to 50~90 ℃, adding accounts for solution quality than the physiology salt powder that is 3~25% under stirring fast, forms the thickness complex.The physiology salt here can be sodium hydrogen phosphate, sodium chloride etc.
3. under 0~20 ℃, utilize mould to extrude or be drawn into the bar-shaped or hollow pipe suitable above-mentioned complex, be trimmed to length 5~20mm, be the solubility timbering material with the human vas diameter.
In actual production, use, can be with above-mentioned timbering material pre-freeze 8~24 hours under-10~-80 ℃ low temperature, then in lyophilizing on the freezer dryer more than 24 hours.Demarcate size, the quality of support, ethylene oxide or cobalt-60 sterilization packagings, stored refrigerated is standby.When using in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone.Outside blood vessel that the broken ends of fractured bone is bonding with adhesive of medical, open vascular clamp, support melts rapidly in blood, and anastomotic stoma is led to blood.
Novel vascular stent with method of the present invention preparation structurally has micron-sized porous, and mechanical strength increases behind compound physiology salt crystal, and it is suitable to have dissolution time in the use, smooth surface, good springiness, arterial intima not, the characteristics of nontoxic residue-free.The present invention assists solubility inner support in the above-mentioned blood vessel when bonding, anti-hemostatic tube bonding is narrow, and there is not the seepage phenomenon in anastomotic stoma, and the speed of coincideing is fast, and little blood vessel is bonding simple, does not need special installation and special experience thereof, is specially adapted to basic hospital.The present invention can substitute traditional sewing method in being applied to vascular anastomosis, be a kind of fast, easy vascular anastomosis method will improve the success rate of vascular anastomosis greatly.
The specific embodiment: The raw material sources that use among the present invention are: gelatin, Beijing chemical reagents corporation, chemical pure. Sodium alginate is for connecting Produce at the cloud port, and shitosan is the Qingdao product. Physiology salt is pure for analyzing, and water uses distilled water.
Embodiment 1:
With gelatin in 90 ℃ of solution that are configured to 20% (mass ratio), this solution can solidify at 20 degrees centigrade.
2. heat this solution to 80 ℃, add 10% sodium hydrogen phosphate under the rapid stirring, stirs be incubated after 10 minutes for subsequent use
3. under 10 ℃ external environment, utilize proper mold to extrude or be drawn into the bar-shaped of suitable thickness or hollow tube support the compound of melting, be trimmed to length 5~20nm
4. timbering material is in-40 ℃ of lower pre-freezes 12 hours, then freeze-drying 24 hours on freeze drier
5. demarcate size, the quality of support, cobalt-60 sterilization packing, 4 ℃ save backup
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with medical adhesive, open blood vessel clip, support melts rapidly in blood, coincide The logical blood of mouth.
Embodiment 2:
With gelatin in 90 ℃ the configuration 20% mass ratioes) solution, this solution can solidify at 20 degrees centigrade.
2. heat this solution, add the sodium hydrogen phosphate of 20% quality under the rapid stirring, stirs be incubated after 10 minutes for subsequent use
3. under 10 ℃ external environment, the bar-shaped of suitable thickness or hollow tube support are extruded or be drawn into to the compound of melting, be trimmed to length 5~20 mm
4. timbering material is in-20 ℃ of lower pre-freezes 12 hours, then freeze-drying 30 hours on freeze drier
5. demarcate size, the quality of support, cobalt-60 sterilization packing, 40 save backup
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with medical adhesive, open blood vessel clip, support melts rapidly in blood, coincide The logical blood of mouth.
Embodiment 3:
1. with the solution of gelatin in 90 ℃ of configurations 20% (mass ratio), this solution can solidify at 20 degrees centigrade.
2. heat this solution, add the sodium chloride of 20% quality under the rapid stirring, stirs be incubated after 10 minutes for subsequent use
3. under 0 ℃ of environment, the bar-shaped of suitable thickness or hollow tube support are extruded or be drawn into to the compound of melting, be trimmed to length 5~20 mm
4. timbering material is in-40 ℃ of lower pre-freezes 24 hours, then freeze-drying 30 hours on freeze drier
5. demarcate size, the quality of support, cobalt-60 sterilization packing, 4 ℃ save backup
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with medical adhesive, open blood vessel clip, support melts rapidly in blood, and a mouthful logical blood coincide
Embodiment 4:
With gelatin in 90 ℃ the configuration 30% mass ratioes) solution, this solution can solidify at 17 ℃.
2. heat this solution, with the powder of the sodium chloride of the porphyrize of adding 20% quality under the rapid stirring
3. under 0 ℃ of environment, the bar-shaped of suitable thickness or hollow tube support are extruded or be drawn into to the compound of melting, be trimmed to length 5M20 mm
4. in-40 ℃ of lower pre-freezes 12 hours, then freeze-drying 30 hours on freeze drier
5. demarcate size, the quality of support, cobalt-60 sterilization packing, 4 ℃ save backup
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with the medical grade cyanoacrylate adhesive, open blood vessel clip, support melt rapidly in Blood, a mouthful logical blood coincide.
Embodiment 5:
With sodium alginate in 90 ℃ the configuration 20% (mass ratio) solution, can solidify at 20 ℃.
2. heat this solution, with the powder of the sodium hydrogen phosphate of the porphyrize of adding 20% quality under the rapid stirring
3. under 0 ℃ of environment, the bar-shaped of suitable thickness extruded or be drawn into to the compound of melting
4. in-20 ℃ of lower pre-freezes 12 hours, then freeze-drying 30 hours on freeze drier
5. demarcate size, the quality of support, cobalt-60 sterilization packing, 4 ℃ save backup
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with the medical grade cyanoacrylate adhesive, open blood vessel clip, support melts rapidly Solution is in blood, and a mouthful logical blood coincide.
Embodiment 6:
1. with shitosan and gelatin (1: the 1 wt/wt) solution in 90 ℃ of configurations 20% (mass ratio), this solution is 20 ℃ can solidify.
2. heat this solution, with the powder of the sodium hydrogen phosphate of the porphyrize of adding 10% quality under the rapid stirring
3. under 0 ℃ of environment, the bar-shaped of suitable thickness extruded or be drawn into to the compound of melting
4. in-20 ℃ of lower pre-freezes 12 hours, then freeze-drying 24 hours on freeze drier
5. demarcate size, the quality of support, cobalt-60 sterilization packing, 4 ℃ save backup
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with the medical grade cyanoacrylate adhesive, open blood vessel clip, support melts rapidly Solution is in blood, and a mouthful logical blood coincide.
Claims (1)
1, a kind of preparation method that is used for the instant bracket of microtraumatic quick vascular anastomosis technique is characterized in that this method comprises following each step:
(1), the resolvability polymer is configured to the DDW solution of 5%-30% concentration, this solution can solidify at 10~25 ℃, and soluble polymeric thing wherein is any in gelatin, sodium alginate or the aminopolysaccharide;
(2), above-mentioned solution is heated to 50~90 ℃, stir fast to add down and account for solution quality than the physiology salt powder that is 3~25%, formation thickness complex, physiology salt wherein is sodium hydrogen phosphate or sodium chloride;
(3) under 0~20 ℃, utilize mould to extrude or be drawn into the bar-shaped or hollow pipe suitable above-mentioned complex with the human vas diameter, be trimmed to length 5~20mm, be the solubility timbering material.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01123976 CN1131074C (en) | 2001-08-10 | 2001-08-10 | Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01123976 CN1131074C (en) | 2001-08-10 | 2001-08-10 | Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1328853A true CN1328853A (en) | 2002-01-02 |
CN1131074C CN1131074C (en) | 2003-12-17 |
Family
ID=4665407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 01123976 Expired - Fee Related CN1131074C (en) | 2001-08-10 | 2001-08-10 | Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1131074C (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101732111A (en) * | 2008-11-27 | 2010-06-16 | 梁向党 | Method for preparing T-shaped instant stent for end-to-side adhesion of biological duct |
US8182890B2 (en) | 2007-01-19 | 2012-05-22 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
CN101678153B (en) * | 2007-05-16 | 2013-04-17 | 格利达股份公司 | Vessel stent |
US8636792B2 (en) | 2007-01-19 | 2014-01-28 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
US8814930B2 (en) | 2007-01-19 | 2014-08-26 | Elixir Medical Corporation | Biodegradable endoprosthesis and methods for their fabrication |
US9259339B1 (en) | 2014-08-15 | 2016-02-16 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9480588B2 (en) | 2014-08-15 | 2016-11-01 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9730819B2 (en) | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9855156B2 (en) | 2014-08-15 | 2018-01-02 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9943426B2 (en) | 2015-07-15 | 2018-04-17 | Elixir Medical Corporation | Uncaging stent |
US10918505B2 (en) | 2016-05-16 | 2021-02-16 | Elixir Medical Corporation | Uncaging stent |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101077424B (en) * | 2006-05-25 | 2011-04-06 | 范恒华 | Blood vessel bonding anastomosis sealant and kit |
-
2001
- 2001-08-10 CN CN 01123976 patent/CN1131074C/en not_active Expired - Fee Related
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9566371B2 (en) | 2007-01-19 | 2017-02-14 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
US8182890B2 (en) | 2007-01-19 | 2012-05-22 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
US8323760B2 (en) | 2007-01-19 | 2012-12-04 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
US8636792B2 (en) | 2007-01-19 | 2014-01-28 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
US8814930B2 (en) | 2007-01-19 | 2014-08-26 | Elixir Medical Corporation | Biodegradable endoprosthesis and methods for their fabrication |
US9119905B2 (en) | 2007-01-19 | 2015-09-01 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
CN101678153B (en) * | 2007-05-16 | 2013-04-17 | 格利达股份公司 | Vessel stent |
CN101732111A (en) * | 2008-11-27 | 2010-06-16 | 梁向党 | Method for preparing T-shaped instant stent for end-to-side adhesion of biological duct |
US9730819B2 (en) | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9480588B2 (en) | 2014-08-15 | 2016-11-01 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9259339B1 (en) | 2014-08-15 | 2016-02-16 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9855156B2 (en) | 2014-08-15 | 2018-01-02 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9943426B2 (en) | 2015-07-15 | 2018-04-17 | Elixir Medical Corporation | Uncaging stent |
US10076431B2 (en) | 2016-05-16 | 2018-09-18 | Elixir Medical Corporation | Uncaging stent |
US10271976B2 (en) | 2016-05-16 | 2019-04-30 | Elixir Medical Corporation | Uncaging stent |
US10383750B1 (en) | 2016-05-16 | 2019-08-20 | Elixir Medical Corporation | Uncaging stent |
US10786374B2 (en) | 2016-05-16 | 2020-09-29 | Elixir Medical Corporation | Uncaging stent |
US10918505B2 (en) | 2016-05-16 | 2021-02-16 | Elixir Medical Corporation | Uncaging stent |
US11622872B2 (en) | 2016-05-16 | 2023-04-11 | Elixir Medical Corporation | Uncaging stent |
US12011378B2 (en) | 2016-05-16 | 2024-06-18 | Elixir Medical Corporation | Uncaging stent |
Also Published As
Publication number | Publication date |
---|---|
CN1131074C (en) | 2003-12-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105641753B (en) | A kind of 3D printing biodegradable stent of the achievable blood vessel transfer of compound rhBMP-2 | |
CN1131074C (en) | Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique | |
US3620218A (en) | Cylindrical prosthetic devices of polyglycolic acid | |
CN110665061A (en) | Acellular scaffold solution-GelMA hydrogel composite material and preparation method thereof | |
CN108744055B (en) | Silk fibroin bone cement biological adhesive and preparation method thereof | |
JP5406915B2 (en) | Biocompatible implant | |
CN101708344B (en) | Nanofiber vascular prostheses and preparation method | |
CN101057979A (en) | Injectable self-curable calcium phosphate bone tissue repairing material and its preparation method and application | |
BR112012009560A2 (en) | composition production method to induce tissue regeneration by activating platelet-rich plasma (prp) | |
CN106139246A (en) | A kind of regenerated silk azelon support and preparation method thereof | |
CN102133432A (en) | Preparation method of silk fibroin micropore bracket | |
CN109182249B (en) | Preparation method of scaffold material for cell transplantation for in vivo repair | |
US11744917B2 (en) | Tissular formulation or adhesive obtained from a blood composition containing platelets, and method for the preparation of said formulation | |
WO2023143334A1 (en) | Implant for preventing anastomotic leak | |
Hoseini et al. | Manufacturing and properties of poly vinyl alcohol/fibrin nanocomposite used for wound dressing | |
CN1215818C (en) | Double layer hollow blood vessel internal support used for vascular anastomosis and its preparation method | |
EP1622596B1 (en) | Insoluble globin injectable implant | |
JP6782002B2 (en) | Method for manufacturing a microchannel structure having a capillary network-like microchannel | |
JP2011130995A (en) | Luminal structure and method for producing the luminal structure | |
CN1613434A (en) | Growth inducing stand for animal tissue | |
CN103263695B (en) | Method for preparing nerve conduit compounded by perfluorinated triethylamine emulsion and seed cells | |
CN115337452B (en) | Tissue engineering material and preparation method thereof | |
CN116942908B (en) | Absorbable biological isolation composite membrane material and preparation method thereof | |
CN101703808A (en) | Porous collagen/polylactic acid bracket | |
JP2007075271A (en) | Biologically absorbable material and producing method of the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |