CN1131074C - Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique - Google Patents
Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique Download PDFInfo
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- CN1131074C CN1131074C CN 01123976 CN01123976A CN1131074C CN 1131074 C CN1131074 C CN 1131074C CN 01123976 CN01123976 CN 01123976 CN 01123976 A CN01123976 A CN 01123976A CN 1131074 C CN1131074 C CN 1131074C
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Abstract
The present invention relates to a method for preparing quick-dissolving supports for a microtraumatic quick vascular anastomosis technique, which has the steps: firstly, preparing double-distilled water solution from dissolvable polymers; secondly, heating the solution, and adding physiological salt powder into the solution during fast mixing to form a viscous compound; finally, extruding or pulling the compound by a mould into a rod-shaped or hollow pipe which is similar to the blood vessel diameter of a human body so as to obtain a dissolvable support material. A vascular support prepared by the method of the present invention has nano-level porosity in structure, and the mechanical strength is enhanced after the vascular support is compounded with physiological salt crystals. When used, the vascular support has the characteristics of proper dissolving time, smooth surface, favorable elasticity, no injury to vascular intimal, no toxicity and no residue. In an adhesive operation, the dissolvable support can be used in blood vessels for auxiliary help to prevent blood vessels from bonding and narrowing; no liquid leaks from a fitting opening, and dissolvable support is high in fitting speed, simple in small vessel adhesion without special equipment and special experience. Thus, the present invention is especially suitable for base hospitals.
Description
Technical field:
The present invention relates to a kind of preparation method that is used for the instant bracket of microtraumatic quick vascular anastomosis technique,, simplify the operation, improve the identical speed of blood vessel, belong to technical field of biological materials to improve the identical quality of blood vessel.
Background technology:
The vascular anastomosis technology is the basic fundamental of surgery, it produces the development that has directly promoted whole surgery with development, traditional needlework vascular suture technology remains the vascular anastomosis technology that is most widely used at present, can obtain higher vascular anastomosis patency rate through screwing up discipline of long period, but the deficiency of its existence can not be ignored also: the doctor must could grasp this technology through strict professional skill training; Surgical condition requires high; Complicated operation; Difficulty is bigger; And it is time-consuming.The participation of needlework in sewing process be inevitably for the damage of blood vessel wall, and the damage of blood vessel wall is to cause the anastomotic stoma oozing of blood, anastomotic stricture, and there is certain identical mortality in thrombotic main cause so needlework are sewed up blood vessel.
Along with the further raising of surgical intervention level, the vascular anastomosis technology is had higher requirement.At first, under the condition that war wound and extensive disaster are hindered, produce a large amount of wounded in the short time, time this moment is deciding factor, under traditional this condition of vascular suture technology early stage repair blood vessel become impossible.Secondly, along with the thorough solution of immunologic rejection problem and organ origin problem, the novel vascular anastomosis can be applied in the organ transplantation process.The 3rd, blood vessel is a kind of in the numerous biological ducts of body, other body biological duct also comprises: deferent duct, fallopian tube, ureter, lymphatic vessel, biliary tract, urethra, intestinal, nasolacrimal duct or the like, coincideing of other biological pipeline also equally adopted the needlework sewing with blood vessel at present, it is also very similar that it sews up requirement, and method can further be applied in the kiss termination process of other biological duct of body so novel vascular of the present invention coincide.
People have successively invented multiple vascular anastomosis method, as: heat coagulable pipe method (method of laser welding, bipolar coagulation coincide method or the like), sleeve pipe or collar method and the apparatus method or the like of coincideing of coincideing of coincideing, because all there is the shortcoming of self in these methods, so do not obtain clinical practice always.The vascular anastomosis that adopts mainly is esters support, saccharide support, Polyethylene Glycol support with support at present, all there is weak point in all kinds of supports, as: meet water after-poppet intensity and obviously descend, can not play a supporting role in the overall process of coincideing, have potential cytology's toxicity, tunica intima is produced damage or the like.
Summary of the invention:
The objective of the invention is to propose a kind of preparation method that is used for the instant bracket of microtraumatic quick vascular anastomosis technique, a kind of quick to prepare, the easy used timbering material of vascular anastomosis method, solvable inner support is combined with adhesive technology, body biological duct kiss is connect method to be made improvements, coincide fast to be used for operating pipeline-like tissue, particularly the vascular anastomosis of microsurgery.
The preparation method of the instant bracket that is used for microtraumatic quick vascular anastomosis technique that the present invention proposes comprises following each step:
1, the resolvability polymer is configured to the DDW solution of 5%-30% concentration, this solution can solidify at 10～25 ℃, and the soluble polymeric thing can be a gelatin here, sodium alginate, but metabolism polymer such as aminopolysaccharide.
2. above-mentioned solution is heated to 50～90 ℃, adding accounts for solution quality than the physiology salt powder that is 3～25% under stirring fast, forms the thickness complex.The physiology salt here can be sodium hydrogen phosphate, sodium chloride etc.
3. under 0～20 ℃, utilize mould to extrude or be drawn into the bar-shaped or hollow pipe suitable above-mentioned complex, be trimmed to length 5～20mm, be the solubility timbering material with the human vas diameter.
In actual production, use, can be with above-mentioned timbering material pre-freeze 8～24 hours under-10～-80 ℃ low temperature, then in lyophilizing on the freezer dryer more than 24 hours.Demarcate size, the quality of support, ethylene oxide or cobalt-60 sterilization packagings, stored refrigerated is standby.When using in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone.Outside blood vessel that the broken ends of fractured bone is bonding with adhesive of medical, open vascular clamp, support melts rapidly in blood, and anastomotic stoma is led to blood.
Novel vascular stent with method of the present invention preparation structurally has micron-sized porous, and mechanical strength increases behind compound physiology salt crystal, and it is suitable to have dissolution time in the use, smooth surface, good springiness, arterial intima not, the characteristics of nontoxic residue-free.The present invention assists solubility inner support in the above-mentioned blood vessel when bonding, anti-hemostatic tube bonding is narrow, and there is not the seepage phenomenon in anastomotic stoma, and the speed of coincideing is fast, and little blood vessel is bonding simple, does not need special installation and special experience thereof, is specially adapted to basic hospital.The present invention can substitute traditional sewing method in being applied to vascular anastomosis, be a kind of fast, easy vascular anastomosis method will improve the success rate of vascular anastomosis greatly.
The specific embodiment:
The raw material sources that use among the present invention are: gelatin, Beijing chemical reagents corporation, chemical pure.Sodium alginate is that produce in Lianyun Harbour, and chitosan is the Qingdao product.Physiology salt is analytical pure, and water uses distilled water.
Embodiment 1:
With gelatin in 90 ℃ of solution that are configured to 20% (mass ratio), this solution can solidify at 20 degrees centigrade.
2. heat this solution to 80 ℃, stir fast and add 10% sodium hydrogen phosphate down, stirs be incubated after 10 minutes standby
3. under 10 ℃ external environment, utilize proper mold to extrude or be drawn into the bar-shaped of suitable thickness or hollow pipe support fused complex, be trimmed to length 5～20mm
4. timbering material is in-40 ℃ of following pre-freezes 12 hours, lyophilizing 24 hours on freezer dryer then
5. demarcate size, the quality of support, cobalt-60 sterilization packaging, 4 ℃ of preservations are standby
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with adhesive of medical, open vascular clamp, support melts rapidly in blood, and anastomotic stoma is led to blood.
Embodiment 2:
1. with the solution of gelatin in 90 ℃ of configurations 20% (mass ratio), this solution can solidify at 20 degrees centigrade.
2. heat this solution, stir fast the sodium hydrogen phosphate that adds 20% quality down, stirs be incubated after 10 minutes standby
3. under 10 ℃ external environment, the bar-shaped of suitable thickness or hollow pipe support are extruded or be drawn into to fused complex, be trimmed to length 5～20mm
4. timbering material is in-20 ℃ of following pre-freezes 12 hours, lyophilizing 30 hours on freezer dryer then
5. demarcate size, the quality of support, cobalt-60 sterilization packaging, 4 ℃ of preservations are standby
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with adhesive of medical, open vascular clamp, support melts rapidly in blood, and anastomotic stoma is led to blood.
Embodiment 3:
1. with the solution of gelatin in 90 ℃ of configurations 20% (mass ratio), this solution can solidify at 20 degrees centigrade.
2. heat this solution, stir fast the sodium chloride that adds 20% quality down, stirs be incubated after 10 minutes standby
3. under 0 ℃ of environment, the bar-shaped of suitable thickness or hollow pipe support are extruded or be drawn into to fused complex, be trimmed to length 5～20mm
4. timbering material is in-40 ℃ of following pre-freezes 24 hours, lyophilizing 30 hours on freezer dryer then
5. demarcate size, the quality of support, cobalt-60 sterilization packaging, 4 ℃ of preservations are standby
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with adhesive of medical, open vascular clamp, support melts rapidly in blood, and anastomotic stoma is led to blood
Embodiment 4:
1. with the solution of gelatin in 90 ℃ of configurations 30% (mass ratio), this solution can solidify at 17 ℃.
2. heat this solution, with the powder of the sodium chloride of the porphyrize of adding 20% quality under the quick stirring
3. under 0 ℃ of environment, the bar-shaped of suitable thickness or hollow pipe support are extruded or be drawn into to fused complex, be trimmed to length 5～20mm
4. in-40 ℃ of following pre-freezes 12 hours, lyophilizing 30 hours on freezer dryer then
5. demarcate size, the quality of support, cobalt-60 sterilization packaging, 4 ℃ of preservations are standby
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with the medical grade cyanoacrylate binding agent, open vascular clamp, support melts rapidly in blood, and anastomotic stoma is led to blood.
Embodiment 5:
With sodium alginate in 90 ℃ the configuration 20% (mass ratio) solution, can solidify at 20 ℃.
2. heat this solution, with the powder of the sodium hydrogen phosphate of the porphyrize of adding 20% quality under the quick stirring
3. under 0 ℃ of environment, the bar-shaped of suitable thickness extruded or be drawn into to fused complex
4. in-20 ℃ of following pre-freezes 12 hours, lyophilizing 30 hours on freezer dryer then
5. demarcate size, the quality of support, cobalt-60 sterilization packaging, 4 ℃ of preservations are standby
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with the medical grade cyanoacrylate binding agent, open vascular clamp, support melts rapidly in blood, and anastomotic stoma is led to blood.
Embodiment 6:
1. (1: 1wt/wt) in the solution of 90 ℃ of configurations 20% (mass ratio), this solution can solidify at 20 ℃ with chitosan and gelatin.
2. heat this solution, with the powder of the sodium hydrogen phosphate of the porphyrize of adding 10% quality under the quick stirring
3. under 0 ℃ of environment, the bar-shaped of suitable thickness extruded or be drawn into to fused complex
4. in-20 ℃ of following pre-freezes 12 hours, lyophilizing 24 hours on freezer dryer then
5. demarcate size, the quality of support, cobalt-60 sterilization packaging, 4 ℃ of preservations are standby
6. in the operation, get the support that is fit to diameter, put into and treat anastomosis of blood vessel, the involutory broken ends of fractured bone
7. outside blood vessel that the broken ends of fractured bone is bonding with the medical grade cyanoacrylate binding agent, open vascular clamp, support melts rapidly in blood, and anastomotic stoma is led to blood.
Claims (1)
1, a kind of preparation method that is used for the instant bracket of microtraumatic quick vascular anastomosis technique is characterized in that this method comprises following each step:
(1), the resolvability polymer is configured to the DDW solution of 5%-30% concentration, this solution can solidify at 10～25 ℃, and soluble polymeric thing wherein is any in gelatin, sodium alginate or the aminopolysaccharide;
(2), above-mentioned solution is heated to 50～90 ℃, stir fast to add down and account for solution quality than the physiology salt powder that is 3～25%, formation thickness complex, physiology salt wherein is sodium hydrogen phosphate or sodium chloride;
(3) under 0～20 ℃, utilize mould to extrude or be drawn into the bar-shaped or hollow pipe suitable above-mentioned complex with the human vas diameter, be trimmed to length 5～20mm, be the solubility timbering material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01123976 CN1131074C (en) | 2001-08-10 | 2001-08-10 | Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01123976 CN1131074C (en) | 2001-08-10 | 2001-08-10 | Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique |
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| Publication Number | Publication Date |
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| CN1328853A CN1328853A (en) | 2002-01-02 |
| CN1131074C true CN1131074C (en) | 2003-12-17 |
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| CN 01123976 Expired - Fee Related CN1131074C (en) | 2001-08-10 | 2001-08-10 | Preparation method for quick-dissolving support for microtraumatic quick vascular anastomosis technique |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101077424B (en) * | 2006-05-25 | 2011-04-06 | 范恒华 | Blood vessel bonding anastomosis sealant and kit |
| CN104096271A (en) * | 2007-01-19 | 2014-10-15 | 万能医药公司 | Biodegradable endoprostheses and methods for their fabrication |
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| US8814930B2 (en) | 2007-01-19 | 2014-08-26 | Elixir Medical Corporation | Biodegradable endoprosthesis and methods for their fabrication |
| US20130150943A1 (en) | 2007-01-19 | 2013-06-13 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
| DE102007024256A1 (en) * | 2007-05-16 | 2008-11-20 | Gelita Ag | vascular stent |
| CN101732111A (en) * | 2008-11-27 | 2010-06-16 | 梁向党 | Method for preparing T-shaped instant stent for end-to-side adhesion of biological duct |
| US9730819B2 (en) | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9259339B1 (en) | 2014-08-15 | 2016-02-16 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9480588B2 (en) | 2014-08-15 | 2016-11-01 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US9855156B2 (en) | 2014-08-15 | 2018-01-02 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| WO2017200956A1 (en) | 2016-05-16 | 2017-11-23 | Elixir Medical Corporation | Uncaging stent |
| US11622872B2 (en) | 2016-05-16 | 2023-04-11 | Elixir Medical Corporation | Uncaging stent |
-
2001
- 2001-08-10 CN CN 01123976 patent/CN1131074C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101077424B (en) * | 2006-05-25 | 2011-04-06 | 范恒华 | Blood vessel bonding anastomosis sealant and kit |
| CN104096271A (en) * | 2007-01-19 | 2014-10-15 | 万能医药公司 | Biodegradable endoprostheses and methods for their fabrication |
| CN104096271B (en) * | 2007-01-19 | 2015-12-30 | 万能医药公司 | Biodegradable endoprostheses and manufacture method thereof |
| CN105616044A (en) * | 2007-01-19 | 2016-06-01 | 万能医药公司 | Biodegradable endoprostheses and methods for their fabrication |
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| Publication number | Publication date |
|---|---|
| CN1328853A (en) | 2002-01-02 |
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