CN1613434A - Growth inducing stand for animal tissue - Google Patents
Growth inducing stand for animal tissue Download PDFInfo
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- CN1613434A CN1613434A CNA2003101034628A CN200310103462A CN1613434A CN 1613434 A CN1613434 A CN 1613434A CN A2003101034628 A CNA2003101034628 A CN A2003101034628A CN 200310103462 A CN200310103462 A CN 200310103462A CN 1613434 A CN1613434 A CN 1613434A
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Images
Abstract
A scaffold for inducing the growth of animal's tissue, especially for regenerating the damaged tubular organ is a hollow tube made of biocompatible material, which is composed of a supporting layer, a porous attaching layer made of degradable material for attaching tissue or cells to it, and a sealing layer made of degradable material.
Description
Technical field
The present invention relates to be transplanted to the intravital prosthese of animal, more particularly, the present invention relates to animal tissue's growth inducing support made from biological engineering material.Animal tissue of the present invention growth inducing support is specially adapted to the reconstruction of the damaged organ of tubulose.
Background technology
Clinically, because the pathological changes or the damage of some organ need to excise patient's part or all of organ sometimes.Some organ after part or all of excision because it is difficult to regeneration, perhaps its function can't be by compensation and by residual fraction or other organs on behalf of enforcement, therefore, tend to produce orthobiosis to the patient considerable influence.For example, some patient with esophageal carcinoma can cut part esophagus, and stomach is improved so that it coincide with residue esophagus epimere, thereby forms the thoracic cavity stomach, brings big painful to the patient.For these organs, if there is appropriate methods that it is repaired, farthest keep anatomical position structure between organ and required function, be very significant.
Clinically, the method for repair deficiency organ generally has three kinds of autotransplantation, heteroplastic transplantation and implanting tissue succedaneums.These three kinds of methods respectively have shortcoming.For example, autotransplantation does not have the danger of immunologic rejection, but under many circumstances, it is often very difficult to obtain suitable autologous tissue; Heteroplastic transplantation, the most scabrous is the immunologic rejection problem, mortality is higher, and the allosome organ origin is limited, is difficult to find suitable organ, in addition, even carried out successful transplanting, often also need additional lifelong immunosuppressant therapy, thereby make receptor that other diseases easily take place; Tissue substitute as silica gel, rustless steel, metal alloy etc., is not subjected to the restriction of donor source, application surface is the widest, but the deadly defect of most of tissue substitutes is poor with the tissue compatibility, can not permanent resident body in, cause infection easily, also need second operation sometimes.
In order to address the above problem, the tissue substitute that existing at present multiple employing biological engineering material is made has the favorable tissue compatibility, can replace impaired organ to exercise partial function to a certain extent.Wherein there is a class to be called as the tissue growth induction rack, or title cell growth support, except providing the mechanical support for impaired organ, also help the apposition growth of human normal tissue or cell, help promoting the reconstruction of the remaining organ of human body, thereby regenerate tissue or organ with specific modality and complete physiological function.
For example, United States Patent (USP) 6,241,774 disclose a kind of artificial esophagus, comprise a main passive pipe, and the meticulous fibrous collagen protein of one deck that is positioned at outer tube surface, wherein, can also contain b-FGF in the collagen layer.Chinese patent application 02145461.2 discloses a kind of tissue engineered esophageal, constitute by timbering material and seed cell and to contain epithelial layer and the double-deck tissue engineered esophageal of skin corium, wherein, the vascular endothelial cell in the skin corium is participated in the foundation of capillary network directly.Chinese patent application 02145460.4 discloses a kind of engineered trachea and preparation method thereof, by the engineered epithelial tissue of external structure, and with it plantation in tracheal replacement product medial surface, make engineered trachea.
But present tissue growth induction rack also exists some other defective.
Some tissue growth induction rack can not well solve the narrow problem of the tract that takes place in the organ process of reconstruction.For example, there is a sensitive period in the organ process of reconstruction, approximately occurs, lasting about three months, narrowly mainly occur in this period from newborn fibrous tissue.At this moment, newborn fibrous tissue is comparatively soft, and the reaction that stimulates to external world is comparatively fierce, if there is not effective support this moment, newborn fibrous tissue will be shunk gradually in default of constraint, thereby it is narrow that tract takes place.And the ratio that some tissue growth induction rack is degraded after implantation is very fast, does not just disintegrate when the organ reconstruction is also all finished, can not provide effective support for cambium, thereby cause the narrow of organ tract.
Seepage can take place in some tissue growth induction rack, and the anastomotic stoma place that combines with the organ broken ends of fractured bone particularly usually can be because of stitching that can't be firm and seepage takes place.For example, trachea generation seepage usually can cause suffocates, and esophagus generation seepage can be with a part of content leaks in the thoracic cavity, possibility threat to life when serious.
Some tissue growth induction rack partly is made of degradable part and non-degradable, and still, the material of non-degradable part wherein and the compatibility of human body are bad, after the task of finishing the organ reconstruction, also need second operation that it is taken out.
The structure or the shape of some tissue growth induction rack are unreasonable, for example the surface is plane, be unfavorable for Normocellular adhering to and ramp, the organ reconstruction speed is slower, can't make the normal cell of human body participate in the organ reconstruction, can not carry out oriented growth by inducing cell according to predetermined initial configuration.
It is bad that the degradation time of the biological engineering material that some tissue growth induction rack is adopted is controlled, for example, degraded has not just taken place when the organ reconstruction is also finished, cause narrow or seepage, perhaps after the organ reconstruction is finished, still reside in for a long time in the human body and can't in time degrade, thereby cause adverse consequences such as inflammatory reaction.
Summary of the invention
In order to address the above problem, the invention provides a kind of novel animal tissue's growth inducing support, make by biocompatible materials, be hollow tubulose, its body portion comprises three-decker: supporting layer, adhesive layer and sealant, and wherein, sealant is made by degradation material, mainly play the seal isolation effect, be positioned at the inboard of adhesive layer; Adhesive layer is made by degradation material, is mainly the attachment that tissue or cell provide growth; Supporting layer mainly plays the mechanical support effect, is positioned at inboard, the outside of adhesive layer or is embedded in its inside.
Tissue growth induction rack of the present invention is specially adapted to the reconstruction of pipe, for example, and esophagus, trachea, intestinal, blood vessel, ureter, fallopian tube, bile duct etc.Can be according to factors such as animal organ's to be implanted shape, size, content, damaged situations, correspondingly adjust the parameter such as shape, size, material of tissue growth induction rack of the present invention.In a preferred embodiment of the invention, tissue growth induction rack of the present invention has one or more branches.
The surface area of the adhesive layer of tissue growth induction rack of the present invention is bigger, and the attachment of growth can be provided for cell, can be various structures, for example loose structure, filamentary structure etc.In a preferred embodiment of the invention, adhesive layer is cellular porous structure.Can scatter one or more penetrating or impermeable recessed districts in the described loose structure, to increase the surface area and the induced tissue three-dimensional growth of adhesive layer.
The end of tissue growth induction rack of the present invention can comprise the surgical stapling district, is used to provide with the identical of the organ broken ends of fractured bone be connected.The form fit ground of the surgical stapling of the present invention district and the organ broken ends of fractured bone is relatively good, has good intensity and toughness, and anti-stitching is difficult for taking place seepage, and can provide certain mechanical support for the organ in rebuilding.In addition, being connected between the diaphragm seal of internal layer and surgical stapling district is comparatively tight, can prevent the seepage of organ content effectively.The test of carrying out in the Canis familiaris L. body shows, the rare seepage of tissue growth induction rack of the present invention.
In a preferred embodiment of the invention, the surgical stapling district is made by seamless tube body or braiding structure, and its material can be a degradation material; Described surgical stapling district is marked with and is used for localized station location marker.Surgical stapling district and supporting layer can be integral formings, also can be to make respectively, link together then.
Tissue growth induction rack of the present invention has solved the narrow problem in the organ reconstruction preferably.The supporting layer of tissue growth induction rack of the present invention can be the metal rack with good biocompatibility, can be in rebuilding and rebuild that organ after finishing provides for a long time, effective mechanical support.In a preferred embodiment of the invention, described metal rack is made by titanium alloy, can be helix or grid webmaster shape.Supporting layer also can be made by degradation material, simultaneously characteristics such as the material of supporting layer, density, thickness, shape are carried out certain selection and design, make it just begin progressively to degrade after at least three months implanting, thereby make the organ in the reconstruction spend narrow sensitive period smoothly, degraded fully is unlikely to again that residence time is too of a specified duration in vivo after six months, 1 year or 2 years.In another preferred embodiment of the present invention, supporting layer is grid webmaster shape or helix, and its material is 3-hydroxybutyric acid and 3-hydroxycaproic acid copolymer.
Tissue growth induction rack of the present invention has good degradability and biocompatibility.After the organ reconstruction was finished, the various degradation materials that adopted can progressively be absorbed degraded by animal body, do not have residue; And the part that can not degrade is owing to have an excellent biological compatibility, therefore can be resident for a long time in animal body, need not to take out, thus the misery of having exempted second operation.
The process that tissue growth induction rack of the present invention can be rebuild according to organ, make various piece in steps, in a planned way degraded.The material of the various piece of tissue growth induction rack of the present invention, size, thickness, shape etc. are all passed through special design, can make it after finishing major function, more progressively degraded.For example, sealant mainly plays buffer action, prevents the content seepage, after organizing lumen to begin to take shape, the sealing function that is risen is finished, and can progressively degrade, and is beneficial to the formation of the tube chamber inner surface epithelium of new formation simultaneously, therefore, diaphragm seal is thinner usually, and degradation time relatively early; Therefore adhesive layer is a loose structure, and surface area is huge, and degraded is got up also than being easier to, can progressively degraded again after epithelial tissue forms; And supporting layer is therefore comparatively fine and close usually owing to the mechanical support that the long period will be provided for organ, and degradation time also will will progressively be degraded after spending narrow sensitive period substantially more usually again.
Description of drawings
Accompanying drawing is not necessarily proportional, and its purpose only is to explain the present invention better, so that the reader understanding should not be interpreted as limitation of the present invention with it.With the consideration that combines of accompanying drawing and the specific embodiment, the present invention may be better understood.
Fig. 1 shows a preferred embodiment of the present invention, and the tissue growth induction rack shown in the figure can be used for the reconstruction of animal esophagus;
Fig. 2 A shows another preferred embodiment of the present invention, and the tissue growth induction rack shown in the figure can be used for animal trachea or bronchial reconstruction, wherein, shows the tangent plane along the body length direction of tube wall in the circle in left side;
Fig. 2 B be in the circle of left side shown in the enlarged drawing of tangent plane.
The specific embodiment
The preferred embodiments of the present invention are described the present invention in order to explain in further detail below in conjunction with accompanying drawing.When these embodiment are described, known method, instrument, reagent and material etc. are not described in detail, a presumptuous guest usurps the role of the host to avoid, desalinated main contents of the present invention.
Embodiment 1 artificial esophagus
Fig. 1 shows a preferred embodiment of the present invention, and this tissue growth induction rack can be used for the reconstruction (hereinafter to be referred as " artificial esophagus ") of animal esophagus.
As shown in Figure 1, artificial esophagus of the present invention is hollow tubulose, comprises body portion and the surgical stapling district 104 that is positioned at two ends.Body portion is broadly divided into three-decker: supporting layer 102, adhesive layer 120 and sealant 140.Wherein, sealant 140 is positioned at the innermost layer, and its two ends are fixed in the surgical stapling district 104; In the middle of adhesive layer 120 was positioned at, supporting layer was positioned at outermost layer, also supporting layer can be placed the inboard of adhesive layer 120 or be embedded in the inside of adhesive layer 120.
The surgical stapling district
The major function in surgical stapling district comprises: as the bonding pad, be stitched together at when operation and animal organ's the broken ends of fractured bone, prevent seepage and come off; For tissue growth induction rack of the present invention provides to a certain degree mechanical support; The skeleton that adheres to is provided for sealant or adhesive layer etc.Therefore, the surgical stapling district should have certain intensity and toughness.
Supporting layer
Supporting layer 102 is positioned at the middle part of the artificial esophagus of the present invention, and its exterior contour roughly is consistent with the exterior contour of the artificial esophagus of the present invention; From direction, be grid webmaster shape perpendicular to tube wall.As shown in Figure 1, the two ends of supporting layer 102 link to each other with surgical stapling district 104.Supporting layer 102 is a grid uniform or that scatter, and its material is 3-hydroxybutyric acid and 3-hydroxycaproic acid copolymer (wherein containing the 12mol% caproic acid, weight average molecular weight 500,000).
Adopt injection moulding or heat pressing process to prepare supporting layer.By bonding surgical stapling district and supporting layer are linked together.
The artificial esophageal branches support of the present invention layer two ends seamless tube body is of a size of: external diameter 18-30mm, pipe range 6-20mm, wall thickness 0.2-1mm; Stage casing grid webmaster is of a size of: external diameter 18-30mm, and pipe range 60-160mm, wall thickness 0.2-1mm, the density of grid and size can be decided according to the actual requirements by those skilled in the art.
The major function of supporting layer is: for the organ in rebuilding provides mechanical support, keep the cavity body structure of organ defect section; For adhesive layer and sealant etc. provides mechanical support, and as the structural framework of tissue reconstruction.
Spending narrow sensitive period, after organ is rebuild and finished substantially, supporting layer will progressively be degraded.
Adhesive layer
The material of adhesive layer 120 is 3-hydroxybutyric acid and 3-hydroxycaproic acid copolymer (wherein containing the 12mol% caproic acid, weight average molecular weight 500,000).Adhesive layer thickness is 0.5mm to 2mm.
The aperture of micropore is the about 1000 μ m of about 50 μ m-, is preferably the about 500 μ m of about 100 μ m-, the about 300 μ m of more preferably about 150 μ m-.Porosity 〉=90%.Be the recessed district 122 of 0.5-1.5mm (being preferably 1mm) by 2-8 hole/centimetre (be preferably 6 holes/centimetre) diameter of evenly arranging on the body.
The main effect of adhesive layer is: help adhering to and growing of normal structure, cell, can make dissimilar cells keep the suitable way of contact, for cell provides spatial adhering to and growing environment, the beginning form of tissue apposition growth is changed, three-dimensional from the beginning apposition growth, thus the formation of lumen is organized in acceleration.
Sealant
In the present embodiment, adopt solution film casting prepared sealant 140.The thickness of sealant 140 is 0.01-0.1mm.
The preferred material of sealant 140 is 3-hydroxybutyric acid and 3-hydroxycaproic acid copolymer (wherein containing the 12mol% caproic acid, weight average molecular weight 500,000).
The main effect of sealant is: before forming from tissue beginning apposition growth to new tissue cavity's pipe, sealant mainly plays the seal isolation effect, prevents that the content of esophagus from leaking; New organize lumen to begin to take shape after, the sealing function that is risen is finished, sealant is degraded gradually and fragmentation is peeled off, the cambium lumen that exposes directly contacts with the esophagus broken ends of fractured bone, is beneficial to epithelium of esophagus and climbs fast to give birth to and cover cambium lumen inwall.
Finished product
Adopt to adopt hot pressing and technique for sticking, with surgical stapling district 104, supporting layer 102, adhesive layer 120 and sealant 140 in accordance with regulations size be combined into one.
The artificial esophagus of making is cleaned up with pure water, 60 ℃ of bakings of drying oven 8 hours, packing back ethylene oxide sterilizing promptly gets the artificial esophagus finished product.
In the artificial esophagus course of processing, should avoid technical process to pollute the releasing agent that uses in for example injection moulding course of processing etc. as far as possible.Therefore, the timely cleaning to workpiece is necessary after the per pass operation is finished.
Animal experiment
By surgical operation, artificial esophagus of the present invention is implanted in the body of Canis familiaris L., link together with the residual esophagus of Canis familiaris L..In 14 Canis familiaris L. bodies, test, find that esophageal reconstruction is respond well, and the ne-leakage phenomenon.After 7 days, begin to take shape the fibrosis tract; After 2 weeks, the reconstruction of esophagus tract initial stage is finished substantially.Sealant begins because of degraded comes off, disappears after 20 days, and basic degraded finishes after 40 days.Adhesive layer is one with cambium is long after 30 days, and begins degraded.The weight average molecular weight of the surplus material of supporting construction reduces to 280,000 after 150 days.
Embodiment 2 artificial tracheas
Fig. 2 A and Fig. 2 B show a preferred embodiment of the present invention, and this tissue growth induction rack can be used for the reconstruction (hereinafter to be referred as " artificial trachea ") of animal trachea.
Embodiment 2 and embodiment 1 are structurally closely similar, for example, include surgical stapling district, supporting layer, adhesive layer and sealant, and the function of three kinds of structures also is similar, do not repeat them here.To highlight both differences below.
Because artificial trachea of the present invention both can be used for trachea, also can be used for bronchus, therefore, artificial trachea of the present invention can be branchiess tubulose, also can tell one or more branches on the main pipe, shown in Fig. 2 A.Sealant 240 is positioned at the body innermost layer, is fixed on the adhesive layer 220.Surgical stapling district 204 is positioned at several ends of body.Recessed district 222 evenly or unevenly is distributed in the adhesive layer 220; The body region of supporting layer is a metal rack 202, is made by the biocompatibility preferred metal, is preferably titanium alloy.Titanium alloy has superior biocompatibility, physical property and processability, is specially adapted to tissue growth induction rack of the present invention.Metal rack 202 is helix (comprising single-screw, Double helix or many spirals) or grid webmaster shape.After tracheal reconstruction is finished, metal rack 202 will forever be kept somewhere in vivo to keep the trachea tract open.
Other ins and outs please refer to embodiment 1.
The degradation material that the artificial esophagus various piece of the present invention is adopted comprises surgical stapling district, supporting layer, adhesive layer and sealant etc., can be following three class degradation materials:
The first kind: degradable poly-(beta-hydroxy alkanoic acid ester) and poly--(ω-hydroxyalkanoate), the i.e. homopolymer of three kinds of structures shown in the structural formula I-III or copolymer or their blend;
Wherein, R
1Be H or C
1-2Alkyl, n are 1 or 2;
Wherein, R
2Be C
3-19Alkyl or C
3-19Alkenyl;
Wherein, R
3Be H, C
1-19Alkyl or C
1-19Alkenyl, m are 1 or 2;
Second class: degradable poly-(Alpha-hydroxy alkanoic acid ester) and poly--(ω-hydroxyalkanoate), the i.e. homopolymer of two kinds of structures shown in the structural formula IV-V or copolymer or their blend;
Wherein, R is H or CH
3
Wherein, n=5;
The 3rd class: degradable poly alkylene dicarboxylic acids ester, the i.e. homopolymer of structure or copolymer shown in the structural formula VI or their blend.
Wherein, m=2, n=2 or m=4, n=2 or (m=4, n=2) and (m=4, n=4) copolymerization;
Wherein, comprise following particular compound and blend thereof: 3-hydroxybutyric acid and 3-hydroxycaproic acid copolymer, poly-3-hydroxybutyric acid, poly (l-lactic acid) (PLLA), poly-DL-lactic acid (PDLLA), copolymerization (L-lactic acid/DL-lactic acid) (PLLA-co-PDLLA), polyglycolic acid (PGA), copolymerization (lactic acid/glycolic) bipolymer (PLGA), copolymerization (lactic acid/caprolactone) bipolymer (PLC), polycaprolactone (PCL), copolymerization (glycolic/lactic acid/caprolactone) terpolymer (PLGC), polycaprolactone/polyether block copolymer (PCE), polycaprolactone/polyethers/polylactic acid terpolymer (PCEL), polylactic acid/polyether bipolymer (PLE).
Wherein, more preferably 3-hydroxybutyric acid and 3-hydroxycaproic acid copolymer.Compare with other degradation materials, this material has more superior biocompatibility, physical property and processability, is specially adapted to tissue growth induction rack of the present invention.
The surgical stapling district can be made of seamless tube body, also can be braiding structure or other structures.Adopt the advantage of braiding structure to be that the adaptation that can provide higher sews up the intensity that requires, simultaneously more pliable and tougher, degradation speed can make things convenient for adjustment by the variation of braided material and technological parameter.
Supporting layer can have various structures, shape and size, can be decided according to the actual requirements by those skilled in the art.For example, supporting layer can be plane, reinforcement, perhaps the combination of the two.The described plane grid that can be uniform or scatter, open curved surface, tubulose, closed surface, perhaps their combination in any.Described reinforcement can be grid, ring-type, helical form, perhaps their combination in any.
Can be used for the surgical stapling district is also comprised with the technology that supporting layer links together: integrated growth, hot pressing, welding, connector are connected etc.
Can be used for the technology that adhesive layer and supporting layer link together is also comprised: ultra-sonic welded technology, heat merges, bonding etc.
Can be used for the technology that surgical stapling district, supporting layer, adhesive layer and sealant link together is also comprised: ultra-sonic welded technology etc.
The technology that can be used to prepare sealant also comprises: hot calender or hot blow are moulded membrane process.
Sealant can be made of thin film, and its thickness can be decided according to the practical situation of animal body to be implanted by those skilled in the art; It also can be other structure.Sealant is usually located at the innermost layer of tissue growth induction rack of the present invention, also can be positioned at the intermediate layer sometimes.Its two ends can be fixed on the inner surface in surgical stapling district; Except the fixed area at two ends, can fix between all the other zones of sealant and the adhesive layer, can not fix yet.Technology such as can adopt integrated growth, ultra-sonic welded, heat to merge in the time of fixedly or bonding.The various routine techniquess that can adopt those skilled in the art to be familiar with carry out certain clean to the surface of sealant, with pollutant such as removing oils and fatss, for example handle with lipase.
In the tissue growth induction rack of the present invention, can also contain the medicine that promotes the cell growth, somatomedin for example perhaps prevents the medicine of hyperplasia, for example paclitaxel.
Related herein list of references comprises patent document, scientific paper, publication etc., all by reference its full content is included in herein.
It should be noted that, related various technical matters or operation among the present invention, include but not limited to: injection moulding or heat pressing process, dissolved salt pore method, solution film casting, hot calender or hot blow are moulded membrane process, integral forming, welding, connector connects, ultra-sonic welded, node is tied up technology, heat merges technology, ethylene oxide sterilizing etc., be the ordinary skill in the art, if do not specify in the text, then those of ordinary skill in the art can be with reference to the various common tool books before the present patent application day, scientific and technical literature or relevant description, handbooks etc. are implemented.
More than listed preferred embodiment be for explaining and illustrative purposes, should not being understood that to limit the scope of the present invention.Though the present invention is described in conjunction with above-mentioned preferred embodiment, the present invention also can be implemented in other mode, and is not limited to disclosed content.
Should be appreciated that under situation without departing from the spirit and scope of the present invention those of ordinary skill in the art can make various changes and improvements to it in form and details, and these all are considered to fall into protection scope of the present invention.
Claims (18)
1. animal tissue's growth inducing support is made by biocompatible materials, is hollow tubulose, and its body portion comprises three-decker: supporting layer, adhesive layer and sealant, wherein:
Described adhesive layer is made by degradation material, is mainly the attachment that tissue or cell provide growth;
Described sealant is made by degradation material, mainly plays the seal isolation effect, is positioned at the inboard of described adhesive layer;
Described supporting layer mainly plays the mechanical support effect, is positioned at inboard, the outside of described adhesive layer or is embedded in its inside.
2. animal tissue as claimed in claim 1 growth inducing support is characterized in that described adhesive layer is a loose structure.
3. animal tissue as claimed in claim 2 growth inducing support is characterized in that the aperture of described loose structure is between 50-1000 μ m.
4. animal tissue as claimed in claim 3 growth inducing support is characterized in that the aperture of described loose structure is between 100-500 μ m.
5. animal tissue as claimed in claim 4 growth inducing support is characterized in that the aperture of described loose structure is between 150-300 μ m.
6. animal tissue as claimed in claim 1 growth inducing support is characterized in that the end of described body also comprises the surgical stapling district.
7. animal tissue as claimed in claim 6 growth inducing support is characterized in that described surgical stapling district is made of seamless tube body or braiding structure.
8. animal tissue as claimed in claim 7 growth inducing support is characterized in that the material in described surgical stapling district is a degradation material.
9. animal tissue as claimed in claim 6 growth inducing support is characterized in that described surgical stapling district and supporting layer are integral formings.
10. animal tissue as claimed in claim 6 growth inducing support is characterized in that described surgical stapling district and supporting layer are made, and then the two are linked together.
11. as the described animal tissue of one of claim 1-10 growth inducing support, it is characterized in that, also comprise one or more penetrating or impermeable recessed districts in the described adhesive layer.
12. as the described animal tissue of one of claim 1-10 growth inducing support, it is characterized in that described degradation material is a kind of or its blend in the following material: 3-hydroxybutyric acid and 3-hydroxycaproic acid copolymer, poly-3-hydroxybutyric acid, poly (l-lactic acid), poly-DL-lactic acid, copolymerization (L-lactic acid/DL-lactic acid), polyglycolic acid, copolymerization (lactic acid/glycolic) bipolymer, copolymerization (lactic acid/caprolactone) bipolymer, polycaprolactone, copolymerization (glycolic/lactic acid/caprolactone) terpolymer, polycaprolactone/polyether block copolymer, polycaprolactone/polyethers/polylactic acid terpolymer, the polylactic acid/polyether bipolymer.
13. animal tissue as claimed in claim 12 growth inducing support is characterized in that, described degradation material is 3-hydroxybutyric acid and 3-hydroxycaproic acid copolymer.
14., it is characterized in that described supporting layer is a metal rack as the described animal tissue of one of claim 1-10 growth inducing support.
15. animal tissue as claimed in claim 14 growth inducing support is characterized in that described metal is a titanium alloy.
16. animal tissue as claimed in claim 14 growth inducing support is characterized in that, on the body of described animal tissue growth inducing support, can also tell one or more branches.
17. animal tissue as claimed in claim 14 growth inducing support is characterized in that, described metal rack is helix or grid webmaster shape.
18., it is characterized in that described surgical stapling district is marked with and is used for localized station location marker as the described animal tissue of one of claim 6-10 growth inducing support.
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| CNB2003101034628A CN100536799C (en) | 2003-11-03 | 2003-11-03 | Growth inducing stand for animal tissue |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104207807A (en) * | 2014-09-04 | 2014-12-17 | 中国人民解放军兰州军区兰州总医院 | Absorbable cranioplasty patching three-dimensional poly-L-lactide lactic acid mesh |
| CN104225678A (en) * | 2014-09-30 | 2014-12-24 | 广西中医药大学 | Medicinal titanium metal material and preparation method thereof |
| CN106604694A (en) * | 2014-07-07 | 2017-04-26 | 库克医学技术有限责任公司 | Migration-resistant gastrointestinal barrier with adhesive portion |
| CN106963515A (en) * | 2017-02-24 | 2017-07-21 | 上海长海医院 | A kind of aorta tectorial membrane stent |
| CN107095728A (en) * | 2017-05-19 | 2017-08-29 | 东莞颠覆产品设计有限公司 | Carried stent in tube chamber |
| CN107115165A (en) * | 2017-05-11 | 2017-09-01 | 常州大学 | A kind of technology of preparing of reinforcement silicone airway stent |
| CN108601646A (en) * | 2015-11-12 | 2018-09-28 | 博奥司时代有限责任公司 | Systems and methods for producing gastrointestinal tract tissue |
| CN110192932A (en) * | 2019-06-06 | 2019-09-03 | 苏州晶俊新材料科技有限公司 | A kind of degradable intestinal stent for the protection of rectum previous anastomotic |
| CN111803713A (en) * | 2020-05-29 | 2020-10-23 | 广州新诚生物科技有限公司 | Woven film, woven bag and weaving method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106604694A (en) * | 2014-07-07 | 2017-04-26 | 库克医学技术有限责任公司 | Migration-resistant gastrointestinal barrier with adhesive portion |
| CN104207807A (en) * | 2014-09-04 | 2014-12-17 | 中国人民解放军兰州军区兰州总医院 | Absorbable cranioplasty patching three-dimensional poly-L-lactide lactic acid mesh |
| CN104225678A (en) * | 2014-09-30 | 2014-12-24 | 广西中医药大学 | Medicinal titanium metal material and preparation method thereof |
| CN104225678B (en) * | 2014-09-30 | 2016-05-11 | 广西中医药大学 | A kind of medical titanium metal material and preparation method thereof |
| CN108601646A (en) * | 2015-11-12 | 2018-09-28 | 博奥司时代有限责任公司 | Systems and methods for producing gastrointestinal tract tissue |
| CN108601646B (en) * | 2015-11-12 | 2021-10-12 | 博奥司时代有限责任公司 | Systems and methods for producing gastrointestinal tract tissue |
| CN106963515A (en) * | 2017-02-24 | 2017-07-21 | 上海长海医院 | A kind of aorta tectorial membrane stent |
| CN106963515B (en) * | 2017-02-24 | 2018-12-18 | 上海长海医院 | A kind of aorta tectorial membrane stent |
| CN107115165A (en) * | 2017-05-11 | 2017-09-01 | 常州大学 | A kind of technology of preparing of reinforcement silicone airway stent |
| CN107095728A (en) * | 2017-05-19 | 2017-08-29 | 东莞颠覆产品设计有限公司 | Carried stent in tube chamber |
| CN110192932A (en) * | 2019-06-06 | 2019-09-03 | 苏州晶俊新材料科技有限公司 | A kind of degradable intestinal stent for the protection of rectum previous anastomotic |
| CN111803713A (en) * | 2020-05-29 | 2020-10-23 | 广州新诚生物科技有限公司 | Woven film, woven bag and weaving method |
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