CN1327844A - Chinese medicine for relieving fatigue and resisting oxygen lack and its preparing process - Google Patents
Chinese medicine for relieving fatigue and resisting oxygen lack and its preparing process Download PDFInfo
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- CN1327844A CN1327844A CN 01119825 CN01119825A CN1327844A CN 1327844 A CN1327844 A CN 1327844A CN 01119825 CN01119825 CN 01119825 CN 01119825 A CN01119825 A CN 01119825A CN 1327844 A CN1327844 A CN 1327844A
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- medicine
- resisting
- oxygen lack
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- folium ginkgo
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Abstract
A medicine for improving the resistance to fatigue and oxygen lack is prepared from ginseng, gingko leaf, schisandra fruit and ophiopogon root.
Description
The present invention relates to a kind of medicine, particularly relate to a kind of Chinese medicine and preparation method thereof with above-mentioned effect with resisting fatigue, resisting oxygen lack.
At present gingko leaf preparation is in pharmacy industry with health products trade is existing uses widely, and most of gingko leaf preparation is an one-component, and in the Folium Ginkgo extract general flavone content about 24%.Folium Ginkgo has good prospect in the treatment of numerous disease, it is still rare to develop the ginkgo leaf compound preparation with resisting fatigue, resisting oxygen lack.
The object of the invention be to provide a kind of evident in efficacy, have no side effect and Chinese medicine that Ginkgo total flavones content is high and preparation method thereof.
Technical solution of the present invention is achieved in that
Radix Ginseng 1-5 weight portion Folium Ginkgos 5-20 weight portions
Radix Ophiopogonis 2-8 weight portion Fructus Schisandrae Chinensis, 1-5 weight portions
With the above-mentioned raw materials medicine routinely technology make any acceptable drug clinically.The ginkgo leaf powder of material medicine can also be broken into coarse powder (crossing 20 mesh sieves), decoct three times with the aqueous solution that contains 1-2% antioxidant, each water consumption is 10-15 times, decocting time was respectively 1-2 hours, merge three times the decocting liquid medicinal liquid, by macroporous resin adsorption, adsorption column is with 50～90% alcohol desorptions, eluent reclaims ethanol, is condensed into thick paste; Radix Ginseng 1-5 weight portions, Radix Ophiopogonis 2-8, weight portion, Fructus Schisandrae Chinensis 1-5 weight portions were used decocting in water respectively three times, each water consumption is 6-12 times, and each extraction time is 1-2 hours, merges each decocting liquid, filter, filtrate is adsorbed with macroporous adsorptive resins, and with 60-90% ethanol elution, eluent returns ethanol, be concentrated into thick paste, merge with above-mentioned Folium Ginkgo concentrated solution, spray drying is made any clinical acceptable forms that contains suitable raw medicinal herbs 10g.
Antioxidant described in the inventive method can be sodium pyrosulfite, vitamin C or sodium sulfite; The antioxidant concentration of aqueous solution is 1-0.7%; The height of macroporous resin column and the ratio of diameter are 4-15.
Medicine of the present invention is through laboratory observation, takes experiment mice swimming with a load attached to the body time behind the medicine of the present invention, pole-climbing time and all significantly is longer than matched group (P＜0.01); Experiment mice serum urea nitrogen content and matched group descend more to some extent; Hepatic glycogen content is significantly higher than matched group; The blood lactic acid content significantly is lower than matched group; The serum superoxide dismutase is apparently higher than matched group.Experimental result shows that medicine of the present invention has the effect of resisting fatigue, resisting oxygen lack.
Medicine of the present invention detects through effective component and shows, Ginkgo total flavones content＞20mg in the unit formulation of suitable crude drug 10g, and the state-promulgated pharmacopoeia standard only is＞9.6mg.
Embodiment 1: Folium Ginkgo coarse powder 10kg, with the aqueous solution of 1-0.7% sodium pyrosulfite of 12 times of amounts, respectively heated and boiled, stir and extract three times, extraction time is 1 hour for the first time, being 1.5 hours for the second time, is 1.5 hours for the third time, removes medicinal residues, merge three times medicinal liquid, filter, filtrate is crossed macroporous adsorptive resins AB-8 (or WLD, D141), uses the triplication water washing, reuse 70% ethanol elution, eluent concentrates; Radix Ginseng 1kg, Radix Ophiopogonis, 2kg, Fructus Schisandrae Chinensis 1kg used decocting in water respectively three times, each water consumption is respectively 10,8,8 times, and each extraction time is 1 hour, merges each decocting liquid, filter, filtrate is adsorbed with macroporous adsorptive resins (the same), and with 70% ethanol elution, eluent returns ethanol, be concentrated into thick paste, merge with above-mentioned Folium Ginkgo concentrated solution, spray drying is made the capsule that contains suitable raw medicinal herbs 10g.Embodiment 2: Folium Ginkgo coarse powder 10kg, with 0.5% vitamin C water solution of 12 times of amounts, respectively heated and boiled, stir and extract three times, extraction time is 1 hour for the first time, being 1.5 hours for the second time, is 1.5 hours for the third time, removes medicinal residues, merge three times medicinal liquid, filter, filtrate is crossed macroporous adsorptive resins WLD or D141, uses the triplication water washing, reuse 75% ethanol elution, eluent concentrates; Radix Ginseng 1kg, Radix Ophiopogonis, 2kg, Fructus Schisandrae Chinensis 1kg used decocting in water respectively three times, and each water consumption is respectively 10,8,8 times, and each extraction time is 1 hour, merge each decocting liquid, filter, filtrate is adsorbed with macroporous adsorptive resins (the same), the ethanol elution with 75%, eluent returns ethanol, be concentrated into thick paste, merge spray granulation with above-mentioned Folium Ginkgo concentrated solution, packing, every bag is equivalent to crude drug 10g.
Claims (7)
1, a kind of medicine with resisting fatigue, resisting oxygen lack is characterized in that this medicine made by following bulk drugs:
Radix Ginseng 1-5 Folium Ginkgos 5-20
Radix Ophiopogonis 2-8 Fructus Schisandrae Chinensis 1-5
2, medicine as claimed in claim 1 is characterized in that this medicine is by descending bulk drugs to make:
Radix Ginseng 1 Folium Ginkgo 10
Radix Ophiopogonis 4 Fructus Schisandrae Chinensis 2
3, a kind of preparation method with medicine of resisting fatigue, resisting oxygen lack, it is characterized in that this method is: Folium Ginkgo coarse powder 5-20 weight portions, with the aqueous solution of 1-2% antioxidant of 10-15 times of amounts, respectively heated and boiled, stir and extract three times, each extraction time is 1-2 hours, remove medicinal residues, merge three times medicinal liquid, filter, filtrate is crossed macroporous adsorptive resins, use the triplication water washing, reuse 60-90% ethanol elution, eluent concentrates; Radix Ginseng 1-5 weight portions, Radix Ophiopogonis 2-8, weight portion, Fructus Schisandrae Chinensis 1-5 weight portions were used decocting in water respectively three times, each water consumption is 6-12 times, and each extraction time is 1-2 hours, merges each decocting liquid, filter, filtrate is adsorbed with macroporous adsorptive resins, and with 60-90% ethanol elution, eluent returns ethanol, be concentrated into thick paste, merge with above-mentioned Folium Ginkgo concentrated solution, spray drying is made any clinical acceptable forms that contains suitable raw medicinal herbs 10g.
4, a kind of preparation method as claimed in claim 3 with medicine of resisting fatigue, resisting oxygen lack, it is characterized in that this method is: Folium Ginkgo coarse powder 10kg, aqueous solution with 1-0.7% antioxidant of 12 times of amounts, heated and boiled, stirring are extracted three times respectively, extraction time is 1 hour for the first time, it is 1.5 hours for the second time, be 1.5 hours for the third time, remove medicinal residues, merge three times medicinal liquid, filter, filtrate is crossed macroporous adsorptive resins AB-8, use the triplication water washing, reuse 70% ethanol elution, eluent concentrates; Radix Ginseng 1kg, Radix Ophiopogonis, 2kg, Fructus Schisandrae Chinensis 1kg used decocting in water respectively three times, each water consumption is respectively 10,8,8 times, and each extraction time is 1 hour, merges each decocting liquid, filter, filtrate is adsorbed AB-8 with macroporous adsorptive resins, and with 70% ethanol elution, eluent returns ethanol, be concentrated into thick paste, merge with above-mentioned Folium Ginkgo concentrated solution, spray drying is made the capsule that contains suitable raw medicinal herbs 10g.
5, as claim 3 or 4 described a kind of preparation methoies: it is characterized in that the antioxidant in this method can be sodium pyrosulfite, vitamin C or sodium sulfite with medicine of resisting fatigue, resisting oxygen lack; The antioxidant concentration of aqueous solution is 0.5%.
6, as claim 3 or 4 described a kind of preparation methoies: it is characterized in that the height of the macroporous resin column in this method and the ratio of diameter are 4-15 with medicine of resisting fatigue, resisting oxygen lack.
7, a kind of preparation method as claimed in claim 6: it is characterized in that the height of the macroporous resin column in this method and the ratio of diameter are 4 with medicine of resisting fatigue, resisting oxygen lack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011198257A CN1136004C (en) | 2001-06-29 | 2001-06-29 | Chinese medicine for relieving fatigue and resisting oxygen lack and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011198257A CN1136004C (en) | 2001-06-29 | 2001-06-29 | Chinese medicine for relieving fatigue and resisting oxygen lack and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1327844A true CN1327844A (en) | 2001-12-26 |
| CN1136004C CN1136004C (en) | 2004-01-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011198257A Expired - Fee Related CN1136004C (en) | 2001-06-29 | 2001-06-29 | Chinese medicine for relieving fatigue and resisting oxygen lack and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1136004C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412843A (en) * | 2015-12-30 | 2016-03-23 | 南京中医药大学 | Traditional Chinese medicine composition capable of enhancing memory and relieving depression, preparation method and applications thereof |
| CN105748895A (en) * | 2014-12-19 | 2016-07-13 | 烟台宝备生物技术有限公司 | Drug or health food with anti-fatigue effect |
-
2001
- 2001-06-29 CN CNB011198257A patent/CN1136004C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748895A (en) * | 2014-12-19 | 2016-07-13 | 烟台宝备生物技术有限公司 | Drug or health food with anti-fatigue effect |
| CN105412843A (en) * | 2015-12-30 | 2016-03-23 | 南京中医药大学 | Traditional Chinese medicine composition capable of enhancing memory and relieving depression, preparation method and applications thereof |
| CN105412843B (en) * | 2015-12-30 | 2019-07-16 | 南京中医药大学 | Remember with enhancing, improves the Chinese medicine composition and the preparation method and application thereof of depressive emotion effect |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1136004C (en) | 2004-01-28 |
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Assignee: Sichuan Kechuang Medicine Group Co., Ltd. Assignor: Xinshiji Science and Technology Co., Ltd., Chengdu Contract record no.: 2010510000020 Denomination of invention: Chinese medicine for relieving fatigue and resisting oxygen lack and its preparing process Granted publication date: 20040128 License type: Exclusive License Open date: 20011226 Record date: 20100512 |
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