CN1325517C - 抗丙型肝炎病毒抗体及其用途 - Google Patents

抗丙型肝炎病毒抗体及其用途 Download PDF

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Publication number
CN1325517C
CN1325517C CNB99808641XA CN99808641A CN1325517C CN 1325517 C CN1325517 C CN 1325517C CN B99808641X A CNB99808641X A CN B99808641XA CN 99808641 A CN99808641 A CN 99808641A CN 1325517 C CN1325517 C CN 1325517C
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China
Prior art keywords
antibody
antibodies
cells
hepatitis
hcv
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Expired - Fee Related
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CNB99808641XA
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English (en)
Chinese (zh)
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CN1309664A (zh
Inventor
C·赖特尔
F·哈伯泽策尔
A·富尔尼勒
C·特列波
C·德格朗热
G·安绍斯普
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Connex Gesellschaft zur Optimierung von Forschung und Entwicklung mbH
Institut National de la Sante et de la Recherche Medicale INSERM
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Connex Gesellschaft zur Optimierung von Forschung und Entwicklung mbH
Institut National de la Sante et de la Recherche Medicale INSERM
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Publication of CN1309664A publication Critical patent/CN1309664A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB99808641XA 1998-07-21 1999-07-20 抗丙型肝炎病毒抗体及其用途 Expired - Fee Related CN1325517C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98113595 1998-07-21
EP98113595.7 1998-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2007101063440A Division CN101088561A (zh) 1998-07-21 1999-07-20 抗丙型肝炎病毒抗体及其用途

Publications (2)

Publication Number Publication Date
CN1309664A CN1309664A (zh) 2001-08-22
CN1325517C true CN1325517C (zh) 2007-07-11

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Family Applications (2)

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CNB99808641XA Expired - Fee Related CN1325517C (zh) 1998-07-21 1999-07-20 抗丙型肝炎病毒抗体及其用途
CNA2007101063440A Pending CN101088561A (zh) 1998-07-21 1999-07-20 抗丙型肝炎病毒抗体及其用途

Family Applications After (1)

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CNA2007101063440A Pending CN101088561A (zh) 1998-07-21 1999-07-20 抗丙型肝炎病毒抗体及其用途

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US (3) US6951646B1 (enExample)
EP (1) EP1097172A1 (enExample)
JP (1) JP4593783B2 (enExample)
CN (2) CN1325517C (enExample)
AU (1) AU5285899A (enExample)
CA (1) CA2339045A1 (enExample)
WO (1) WO2000005266A1 (enExample)

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US7091324B2 (en) * 1998-11-05 2006-08-15 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes
AU2001232267A1 (en) * 2000-02-14 2001-08-20 Japan As Represented By Director General Of Agency Of National Institute Of Infectious Deseases Remedies for hepatitis c
IL137522A (en) * 2000-07-26 2007-06-17 Drk Blutspendediendst Baden Wu HCV human monoclonal antibody E2 glycoprotein antibody
EP1178116A1 (en) * 2000-08-03 2002-02-06 Hybrigenics S.A. Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
GB0021859D0 (en) * 2000-09-06 2000-10-18 Imp College Innovations Ltd Methods
GB0114629D0 (en) * 2001-06-15 2001-08-08 Pfizer Ltd Method
ITRM20020049A1 (it) 2002-01-30 2003-07-30 Biostrands S R L Frammenti fab di anticorpi monoclonali umani diretti contro la glicoproteina e2 di hcv e dotati di potere neutralizzante in vitro.
RU2353399C2 (ru) * 2003-01-17 2009-04-27 Этлон Медикал, Инк. Способ удаления вирусов из крови посредством лектин-аффинного гемодиализа
EP2336176B1 (en) 2003-04-01 2015-05-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies directed against hepatitis c virus e1e2 complex, and their epitopes
GB0309126D0 (en) * 2003-04-17 2003-05-28 Neutec Pharma Plc Clostridium difficile focussed antibodies
EP1765869B1 (en) * 2004-07-08 2015-05-20 JV Bio S.r.l Antigen binding proteins directed against scavenger receptor b1 that inhibit hcv replication
DE602006014720D1 (de) * 2005-10-07 2010-07-15 Proyecto Biomedicina Cima Sl Immunstimulatorische kombination zur vorbeugung und behandlung von hepatitis c
SG178712A1 (en) 2006-10-02 2012-03-29 Medarex Inc Human antibodies that bind cxcr4 and uses thereof
CN103172743B (zh) 2006-12-01 2015-04-08 梅达雷克斯有限责任公司 结合cd22的人抗体及其用途
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
US20100150950A1 (en) 2006-12-14 2010-06-17 Medarex, Inc. Human antibodies that bind cd70 and uses thereof
JP5642972B2 (ja) 2007-02-21 2014-12-17 ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ Ｃ型肝炎ウイルス（ｈｃｖ）に対するヒト抗体およびその使用
ITTO20080204A1 (it) 2008-03-17 2009-09-18 Pomona Biotechnologies Llc Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a
ITTO20080398A1 (it) 2008-05-27 2009-11-28 Pomona Biotechnologies Llc Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
EP3153524B1 (en) 2008-12-03 2025-04-23 Genmab A/S Antibody variants having modifications in the constant region
US20110033389A1 (en) * 2009-04-29 2011-02-10 Zhifeng Chen Modified antibodies for passive immunotherapy
CN102596996B (zh) * 2009-10-30 2014-06-18 东丽株式会社 对丙型肝炎病毒(hcv)具有感染抑制活性的抗体及其用途
BR112012029881A2 (pt) 2010-05-25 2019-09-24 Inserm (Institut National De La Santé De La Recherche Médicale) combinação de anticorpos anti-envelope e anticorpos anti-receptor para o tratamento e a presenção de infecção por hcv
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
CN103308697B (zh) * 2013-06-09 2014-11-26 卫生部北京医院 检测抗丙型肝炎病毒编码的非结构蛋白ns3和ns5的天然双特异性抗体的试剂盒
CN103472233A (zh) * 2013-06-21 2013-12-25 温州大学 丙型肝炎检测试剂盒及其应用
PT3031826T (pt) 2013-08-09 2019-01-18 Toray Industries Composição farmacêutica para o tratamento e/ou a prevenção do cancro
CN104974246A (zh) * 2014-04-01 2015-10-14 中国科学院上海巴斯德研究所 一种中和丙型肝炎病毒的全人单克隆抗体及其用途
GB201415714D0 (en) * 2014-09-05 2014-10-22 Medical Res Council Antibodies and antigen binding fragments thereof
CN105254756B (zh) * 2015-11-27 2018-09-07 武汉大学 一种针对丙型肝炎病毒包膜蛋白e2的单克隆抗体及应用
CN107286238B (zh) * 2017-08-07 2019-11-26 广州泰诺迪生物科技有限公司 抗hcv广谱中和抗体的制备、检测以及应用
MA52945A (fr) 2018-06-22 2021-04-28 Genmab As Procédé de production d'un mélange contrôlé d'au moins deux anticorps différents
AU2019310803B2 (en) 2018-07-25 2022-11-03 Innovent Biologics (Suzhou) Co., Ltd. Anti-TIGIT antibody and uses thereof
US12304946B2 (en) * 2018-12-19 2025-05-20 Humabs Biomed Sa Antibodies that neutralize hepatitis B virus and uses thereof
KR20210126559A (ko) 2018-12-20 2021-10-20 비르 바이오테크놀로지, 인코포레이티드 병용 hbv 요법
CN109762067B (zh) 2019-01-17 2020-02-28 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
US10570210B1 (en) 2019-03-04 2020-02-25 Beijing Mabworks Biotech Co.Ltd Antibodies binding CD40 and uses thereof
AU2021228061A1 (en) 2020-02-27 2022-10-13 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Antibodies binding IL4R and uses thereof
US20230272086A1 (en) 2020-05-12 2023-08-31 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. St2 antigen binding protein
EP4259658A4 (en) * 2020-12-10 2024-12-04 Wuxi Biologics Ireland Limited An antibody against p-cadherin and uses thereof
EP4438055A1 (en) 2021-11-25 2024-10-02 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Anti-siglec-15 antibody and use thereof
EP4495138A1 (en) 2022-03-18 2025-01-22 Beijing Mabworks Biotech Co., Ltd B7-h3-binding antibody and use thereof
CN118684767B (zh) * 2024-06-27 2025-02-18 山东省大健康精准医疗产业技术研究院 一种丙肝核心抗原单链抗体及其制备方法与应用

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WO1997040176A1 (en) * 1996-04-19 1997-10-30 Mats Axel Atterdag Persson Human monoclonal antibodies specific for hepatitis c virus (hcv) e2 antigen

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WO1997040176A1 (en) * 1996-04-19 1997-10-30 Mats Axel Atterdag Persson Human monoclonal antibodies specific for hepatitis c virus (hcv) e2 antigen

Also Published As

Publication number Publication date
JP4593783B2 (ja) 2010-12-08
WO2000005266A1 (en) 2000-02-03
AU5285899A (en) 2000-02-14
EP1097172A1 (en) 2001-05-09
CN101088561A (zh) 2007-12-19
JP2002521391A (ja) 2002-07-16
US7507408B2 (en) 2009-03-24
US20060153833A1 (en) 2006-07-13
CA2339045A1 (en) 2000-02-03
CN1309664A (zh) 2001-08-22
US20090104188A1 (en) 2009-04-23
US6951646B1 (en) 2005-10-04

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ASS Succession or assignment of patent right

Owner name: ZANMARBO UNITED CO., LTD.

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