CN1324619A

CN1324619A - Health capsule of pure active chitosan and animal fiber

Info

Publication number: CN1324619A
Application number: CN00114574A
Authority: CN
Inventors: 龚平
Original assignee: Changxiang Biological Engineering Park Co Ltd Gedian Development Zone Hubei
Current assignee: Changxiang Biological Engineering Park Co Ltd Gedian Development Zone Hubei
Priority date: 2000-05-18
Filing date: 2000-05-18
Publication date: 2001-12-05

Abstract

The ultrapure high-activity chitosan animal fibre health-care capsule using crustacean as raw material is characterized by that it uses shrimp peel as raw material, adopts the processes of cleaning, drying, pulverizing into powder material, decalcification, defatting, decolouring, deacetylation, purification and hydrolysis, adding proteoglycan, xanthan gum and vanillin, mixing then, high-temp. sterilizing and filling to obtain the invented product with the functions of inhibiting cancer cell, reducing cholesterol and hypertension, invingorating liver function and preventing diabetes.

Description

Health capsule of pure active chitosan and animal fiber

Health capsule of pure active chitosan and animal fiber belongs to the health care preparation that contains organic active ingredient, is specifically related to arthropod, and as shell-fish the preparing technical field of the health product of raw material.

Not only can be used as a kind of novel nontoxic natural fruit and vegetable fresh-keeping agent with regard to chitosan known to the inventor is widely used in food industry, and the current research result shows that it is suppressing cancer, cholesterol reducing, hypertension, strengthen liver function, preventing and treating diabetes has certain effect.From pharmacology analysis as can be known: it can be decomposed by the intravital enzyme of people and absorb; Dissolve in acid solution, form the cation group of positively charged; Human body cell there is good affinity (can absorb and not repel), can makes cytoactiveization, immunologic function activation; Can improve the permeability of serum, improve microcirculation in human body, promptly keep the vigor of cell blood supply, oxygen supply, energize and nutritive quality; Can improve the sorptive force of serum albumin; Inducing cell is repaired injured cell; Have stronger adsorption function, remove rubbish in the body; But be the pure natural edible cellulose, antigenicity is extremely low, and is nontoxic, without any side effects, safety.Therefore, relevant expert and scholar think: it is the necessary the sixth-largest vital principle of human body (cellulose behind protein, sugar, fat, mineral, vitamin).Therefore, chitosan is a kind of edible animal cellulose with good medical health effect, and it causes that health care and nutrition educational circles extensively note, is that this ambit has one of exploitation Study on Value problem very much.As " chitosan film former The Characteristic Study ", Lin Baofeng, food and fermentation industries the 24th the 1st phase of volume, this article is at preserving fruit and vegetable utilizing, systematically study the film forming characteristic of chitosan." chitosan is to the influence of five kinds of alimentary toxicosis bacteria growings ", the microbiology circular, 1991 18 (6), this studies show that, chitosan has in various degree inhibitory action to five kinds of antibacterials such as escherichia coli, staphylococcus aureus, Salmonella typhimurium, Liszt's mononuclear cell propagation bacterium and yersinia enterocolitica." chitin/chitosan and Application in Food Industry (on) ", Lin Weizhong, article is introduced the preparation, character of chitin and chitosan and in Application in Food Industry.In order to verify the application's novelty, the applicant had once carried out preliminary retrieval to patent documentation, and the technological document that finds no is therewith mutually roughly the same filed an application to Patent Office of the People's Republic of China, also finds before this have this type of application to announce for Patent Office.On market, do not have this type of production marketing yet and used by the public.

Research the objective of the invention is: utilize aboundresources, nontoxic, free of contamination Crusta Penaeus seu Panulirus to be raw material, develop and a kind ofly suppress at cancerous cell, cholesterol reducing, hypertension are strengthened liver function and are prevented that from there is the medicine of medicinal health care function the diabetes and other diseases aspect.

The claimed technical scheme of the present invention is as follows: with the Crusta Penaeus seu Panulirus is raw material, and according to following production technology preparation: (1) is got Crusta Penaeus seu Panulirus and is raw material, cleans; (2) under 70 ℃ of temperature environments, dry, be ground into shrimp shell meal through pulverizer; (3) decalcification is handled, and joins in the shrimp shell meal with 10% hydrochloric acid (HCL) of 2 times of shrimp shell meal amounts, after 24 hours processing, washes filtering residue with water to neutral, after the drying, promptly gets the decalcification shrimp shell meal; (4) ungrease treatment in the decalcification shrimp shell meal, adds 8% the sodium hydroxide (NaOH) of 2 times of its amounts, stirs sucking filtration after 12 hours at normal temperatures, washes filtering residue with water to neutral, is the chitin crude product after the drying; (5) decolouring is handled, and in the chitin crude product, adds 0.5% potassium permanganate (KMnO ₄) solution soaking handles 1 hour after-filtration and remove bleaching liquid, rinse well, is the chitin product; (6) deacetylation is handled, and in the chitin product, adds 50% sodium hydroxide solution of 2 times of its amounts, is heated to 80 ℃, stirring reaction 2 hours, and filtering alkali liquor is washed to neutrality, and drying promptly gets the chitosan product.(7) purification hydrolysis is incorporated as the water that it measures 5 times in chitosan, add 1% chitinase, and pH:5.5-6.0 handled 8 hours under 45 ℃ environment, made its purification hydrolysis, and drying promptly gets the purifying water soluble chitosan; (9) allotment adds protein sugar in the purifying water soluble chitosan, xanthan gum and vanillin allocation processing, and, be health capsule of pure active chitosan and animal fiber through high temperature sterilize, fill.

According to technique scheme, can draw out the health capsule of pure active chitosan and animal fiber technological process of production figure shown in Figure of description, making according to the technology of this figure is a typical embodiment.

In the production preparation process, the applicant has quoted national standard as working specifications such as the technical parameter of this enterprise product, the method for inspection, inspection rule, packing, sign, transportation, storages.

The specification requirement of product:

Color and luster: sepia

Flavour: mouthfeel is simple and elegant, tasty and refreshing, a little astringent taste is arranged

Abnormal smells from the patient: soft fragrance

Chitosan: (to take off the acetyl epidemic disease) 〉=85%

PH value: 5.5 ± 0.5

Arsenic: (mg/kg)≤0.3

Plumbous: (mg/kg)≤0.5

Total plate count: (cfu/g)≤100

Coliform: (MPN/100g)≤6

Mycete: (cfu/g)≤10

Yeast: (cfu/g)≤10

Pathogenic bacterium: must not detect (duodenum 12 road pathogenic bacterium and pathogenic coccus)

This product was once done toxicity test, utilized this oral liquid that the Kunming mouse of two kinds of sexes is irritated stomach, and once irritating stomach concentration is 20ml/Kg.bw, observes a week, does not find obvious poisoning symptom, did not also have dead.Press the acute toxicity grading criteria regulation, this is tried thing and is belonged to nontoxic level class material.The result is all negative for three mutagenicity tests (PCEMNR micronucleus test, mouse sperm deformity test, Salmonella reversion test).

This product was also made function assessment and is commented and check, and its result proves that institute's sample survey has the blood lipid regulation effect.

The hygiology examining report is the result show, institute's test data all meets specification requirement.

Compare with background technology, the present invention has following beneficial effect: the first, have preferably curative effect And health care. To modern civilization diseases, as cardiovascular and cerebrovascular diseases, high blood pressure, diabetes, gastrointestinal disease, The illnesss such as cancer have good curative effect. The second, needed raw material can extract from the shells such as shrimp, crab, the past this A little resources are not familiar with by people, cause waste and to the pollution of environment, and enforcement of the present invention makes and uselessly becomes precious, subtracts Lacked the pollution to environment. Estimate that this product has wide market prospects, and investment risk is little, is that competition is arranged The healthcare products of power.

Claims

A kind of health capsule of pure active chitosan and animal fiber is characterized in that with the Crusta Penaeus seu Panulirus being raw material, prepares according to following production technology:

(1) getting Crusta Penaeus seu Panulirus is raw material, cleans;

(2) under 70 ℃ of temperature environments, dry, be ground into shrimp shell meal through pulverizer;

(3) decalcification is handled, and joins in the shrimp shell meal with 10% hydrochloric acid (HCL) of 2 times of shrimp shell meal amounts, after 24 hours processing, washes filtering residue with water to neutral, after the drying, promptly gets the decalcification shrimp shell meal;

(4) ungrease treatment in the decalcification shrimp shell meal, adds 2 times of its amount 8% sodium hydroxide (NaOH), stirs sucking filtration after 12 hours at normal temperatures, washes filtering residue with water to neutral, is the chitin crude product after the drying;

(5) decolouring is handled, and in the chitin crude product, adds 0.5% potassium permanganate (KMnO ₄) solution soaking handles 1 hour after-filtration and remove bleaching liquid, rinse well, is the chitin product;

(6) deacetylation is handled, and in the chitin product, adds 50% sodium hydroxide solution of 2 times of its amounts, is heated to 80 ℃, stirring reaction 2 hours, and filtering alkali liquor is washed to neutrality, and drying promptly gets the chitosan product;

(7) purification hydrolysis is incorporated as the water that it measures 5 times in chitosan, add 1% chitinase, and pH:5.5-6.0 handled 8 hours under 45 ℃ environment, made its purification hydrolysis, and drying promptly gets the purifying water soluble chitosan;

(8) allotment adds protein sugar in the purifying water soluble chitosan, xanthan gum and vanillin allocation processing, and, be health capsule of pure active chitosan and animal fiber through high temperature sterilize, fill.