CN1322881C - Immunological function intensifier pearl polysaccharide composition and its preparing method - Google Patents
Immunological function intensifier pearl polysaccharide composition and its preparing method Download PDFInfo
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- CN1322881C CN1322881C CNB2005100267418A CN200510026741A CN1322881C CN 1322881 C CN1322881 C CN 1322881C CN B2005100267418 A CNB2005100267418 A CN B2005100267418A CN 200510026741 A CN200510026741 A CN 200510026741A CN 1322881 C CN1322881 C CN 1322881C
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Abstract
The present invention relates to a pear polysaccharide composition of an immunological function intensifier, and a preparing method thereof. The composition is prepared from the following raw materials according to the proportion by weight: 5.0 to 10.0% of hydrotropic pearl powder, 60.0 to 70.0% of radix achyranthis bidentatae, 20.0 to 30.0% of milkvetch root and 10.0 to 20.0% of barbary wolfberry fruit. The preparation method comprises the processing steps of proportioning, soaking, filter pressing, drying, etc. The product of the present invention has strong effect on immunological function enhancement, the pearl powder contains a lot of ionic calcium which can regulate the production of immunologic cells and the secretion of immunoglobulin, the superimposed immunological function enhancement can be generated, and abilities of disease prevention and disease resistance can be strengthened by combining the plant polysaccharide with the hydrotropic pearl powder.
Description
Technical field
The present invention relates to a kind of health food or medicine, relate in particular to a kind of immunological function intensifier pearl polysaccharide composition and preparation method thereof with efficient immune function of human body potentiation.
Background technology
2003, Sars virus was wreaked havoc China and every country in Southeast Asia, though just obtained effective control through 1 year, this incident is given the caution of a profound grief of people.Sars virus have its occasionality and necessity.Its occasionality is that the Sars disease fails to lead to the commonly encountered diseases that becomes as the cold virus, and its necessity is the deterioration of environment for human survival, and the mutability probability of virus increases, and new virus will inevitably constantly produce, and it is human hard to guard against to make.Cause the immune function of human body decline exactly because the also anxious non-scienceization that becomes of the deterioration of living environment and people's dietary structure, nutrition are attached undue importance to one thing to the neglect of the other, the resistance of new virus is descended.Therefore, improving living environment is one, the more important thing is the immunity that strengthens human body self.
After eighties of last century found that polysaccharide (polysaccharide) can significantly strengthen the immunologic function of humans and animals, it is flourish that the increasing of polysaccharide exempts to study.Polysaccharide is nonspecific immunity regulator (human body can not synthesize), remarkable enhancing body's immunological function, thus reaching slow down aging, cancer-resisting, anti-chemicotherapy and protecting the liver is corrected the disease that abnormal liver function and control cause because of immunologic hypofunction.So the health care of polysaccharide and the attention that therapeutical effect quite is subjected to domestic and international medical science and pharmaceutical industry, and proposition " 21st century is polysaccharide century ".
Domestic the screening of polysaccharide and the research of function are attached great importance to, had data to show, the effect that has the polyoses extract of nearly 200 kind of plant medicines and fungus to have raise immunity.But very can become the few of curative, have only the listing of a few polysaccharide immune substance, price is very expensive, mainly is that the excessive absorbance of molecular weight of the pyrogen of product and antigenicity and polysaccharide is low.As most of Mycophyta polysaccharide, molecular weight surpasses 1,000,000 mostly, and belongs to proteoglycan mostly again, has pyrogen and antigenicity problem, has limited this saccharoidal range of application.Therefore screen that molecular weight is little, the vegetable polysaccharides of water solublity, absorbability height, no antigen and pyrogen, become the incidence of gazing at of domestic and international medical circle and Pharmaceutical circle.
The traditional Chinese medical science thinks that immunologic function and function are closely related, especially more close with the relation of spleen, kidney, lung.The spleen being concerned with nutrient QI and defensive QI is the foundation of acquired constitution, the source of vital function, has critical role in the adjusting of immunologic function.Modern medicine study also confirms that spleen is a lymphatic organ maximum in the body, can produce lymphocyte and antibody, and contain a large amount of macrophages, has important role in defence and removing function aspects." the kidney being the origin of congenital constitution ", the traditional Chinese medical science all belongs to kidney to the part defense function of body and all congenital factors, so some innate immunity defective diseases are all relevant with kidney.Modern medicine study also confirms, occurs immunologic hypofunction when suffering from a deficiency of the kidney.Because of immunologically competent cell all derives from versatile stem cell in the bone marrow, so kidney is given birth to generation and adjusting that the function of marrow comprises immunologically competent cell, and kidney-nourishing tcm drug has the effect that promotes that immunologically competent cell increases.Lung governing qi belongs to be defended, and lung qi plentifully then space between skin and muscles is solid close, and the power of lung qi is directly connected to the defense function of body.The effect of lung tool immunologic barrier, pulmonary alveolar macrophage has powerful phagocytosis.Liver principal solution poison, also relevant with immunologic function.
Summary of the invention
Purpose of the present invention is exactly for a kind of immunological function intensifier pearl polysaccharide composition and preparation method thereof is provided.
Purpose of the present invention can be achieved through the following technical solutions:
A kind of immunological function intensifier pearl polysaccharide composition, it is characterized in that said composition adopts and comprises that the material of following component and weight ratio is a raw material: water soluble Margarita powder 5.0～10.0%, Radix Achyranthis Bidentatae 60.0～70.0%, the Radix Astragali 20.0～30.0%, Fructus Lycii 10.0～20.0%.
A kind of preparation method of immunological function intensifier pearl polysaccharide composition is characterized in that, this preparation method comprises following processing step:
(1). prepare burden by following component and weight ratio: water soluble Margarita powder 5.0～10.0%, Radix Achyranthis Bidentatae 60.0～70.0%, the Radix Astragali 20.0～30.0%, Fructus Lycii 10.0～20.0%; Radix Achyranthis Bidentatae, Radix Astragali decoction pieces are mixed with the Fructus Lycii section, and adding PH is about 2.0 about 3～4 times of amounts of deionized water, soaks 24 hours under the room temperature; Between soak period, stirred once every 1～2 hour, and adjust the pH value of soak at any time, it is remained on about PH2.0;
(2). medical material deckle board pressure filter filter pressing among the above-mentioned immersion, filtrate gets the primary water extract through 4000rpm centrifugal filtration, and adopting the KOH liquid water transfer extract pH value of 30% weight concentration is 6.5, the water soluble Margarita powder dry powder that adds above-mentioned proportion scale then stirs and makes it abundant dissolving;
(3). above-mentioned Margarita Chinese medicine extraction liquid, spray-dried, promptly get flaxen immunological function intensifier pearl polysaccharide composition product.
In the described step (1), the thickness of Radix Achyranthis Bidentatae, Radix Astragali decoction pieces is 2～5mm.
In the described step (1), adopt HCL to regulate the pH value of deionized water and soak.
Pearl polysaccharide composition product in the described step (3) can be made the multiple dosage form product that comprises water preparation, powder, tablet, buccal tablet, dissolved granule and filling capsule.
About immunologic function and the closely-related theory of function, the health food of homologous Margarita, Radix Achyranthis Bidentatae, the Radix Astragali, Fructus Lycii composition pearl polysaccharide is eaten in our drug of choice according to the traditional Chinese medical science.Modern medicine study proves that Margarita powder has the effect that bone strengthening is filled out marrow, suppressing the hyperactive liver and subsiding YANG, contains a large amount of calcium constituents in the Margarita powder, and the generation of immunocyte and the secretion of immune protein all are subjected to the adjusting of calcium, and long clothes Margarita powder immunologic function strengthens.The Radix Astragali is returned lung, spleen channel, and Radix Achyranthis Bidentatae and Fructus Lycii are returned liver, kidney channel, and a large amount of studies confirm that, they all have the effect of significant enhancing human body immunity function, and it is main increases that to exempt from composition be polysaccharide.Existing report points out that the polysaccharide molecular weight of the Radix Astragali and Fructus Lycii is dalton up to ten thousand.Soluble in water, absorbability is good.The polysaccharide molecular weight of Radix Achyranthis Bidentatae only is 1500 dalton, is connected to form by 8 glucoses and fructose exactly, is one of nature minimum molecular weight polysaccharide.Very easily water-soluble, the high absorption, belongs to non-proteoglycan at no antigen and pyrogen, and it is very strong to increase the effect of exempting from.And above-mentioned three kind of plant polysaccharide all have the effect of inducement interferon.
Vegetable polysaccharides mostly is water solublity greatly, except containing glucides such as polysaccharide, oligosaccharide, monosaccharide, disaccharidase, contains other water-soluble components simultaneously in its water extract.As the Radix Achyranthis Bidentatae water extract, except that containing about about 15% saccharide composition, also contain ecdyson, soap becomes and glycoside unit oleanolic acid.Oleanolic acid is a triterpenoid saponin, has the effect of the acute yellow cellulitis hepatitis of heart tonifying, antiinflammatory, diuresis and treatment.In like manner the Radix Astragali and Fructus Lycii give as the same, these active ingredients, we think and needn't remove and keep as health food.Needn't be made with extra care their polysaccharide.
For this reason, water soluble Margarita powder and Radix Achyranthis Bidentatae, the Radix Astragali, Fructus Lycii water extract being formed health food or medicine names and is " pearl polysaccharide ".
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment
Present embodiment adopts following raw material:
1. water soluble Margarita powder (mussel pearl): commercially available, No. the 0036th, hygienic food and health number [2001].
2. Radix Achyranthis Bidentatae: the dry root of looking for the plant Radix Achyranthis Bidentatae Achyfanths bidentata Blume of section.
3. the Radix Astragali: the dry root of leguminous plant Mongolia astragalus Astragalus membranaceus (Fisch) Bge.Var.mongholicus (Fisch) Bge..
4. Fructus Lycii: plant of Solanaceae Lycium barbarum L. Lycium barbarus L, dry mature fruit.
A kind of preparation method of immunological function intensifier pearl polysaccharide composition, this method comprises following technology:
Prepare burden by following component and weight ratio: water soluble Margarita powder 2g, Radix Achyranthis Bidentatae decoction pieces 19g, Radix Astragali decoction pieces 6g, Fructus Lycii section 3g; With Radix Achyranthis Bidentatae, the Radix Astragali, Fructus Lycii decoction pieces or section, be submerged to medical material surface (about 3～4 times of amounts) with the deionized water of PH2.0 (HCL accent), soaked at ambient temperature 24 hours.Between soak period, stirred once every 1～2 hour, to increase the leaching of the hydrotrope in the medical material.And the pH value to 2.0 of water is soaked in adjustment at any time.If medical material imbibition and surfacing then should add the PH2.0 deionized water again with submergence medical material face.Soak and finish, with the filter pressing of deckle board pressure filter, filtrate gets clear and bright water extract again through 4000rpm centrifugal filtration.Repeatedly mensuration shows, the about 3.0g of water extract dry weight, and yield is about 10%.Polyoses content about 80.0～85.0% in the dried water extract.It is 6.5 that medical material water extract is transferred pH value with the KOH liquid of 30% weight concentration, adds the water soluble Margarita powder of above-mentioned dosage, stirs and makes abundant dissolving.Spray-dried, promptly get the about 5.0g of faint yellow pearl polysaccharide dry powder doses.Wherein contain the about 300mg of ion state calcium amount, contain the total polysaccharides amount and be about 2.4g.
Claims (5)
1, a kind of immunological function intensifier pearl polysaccharide composition is characterized in that, the weight that makes raw materials of effective components consists of: water soluble Margarita powder 5.0～10.0%, Radix Achyranthis Bidentatae 60.0～70.0%, the Radix Astragali 20.0～30.0%, Fructus Lycii 10.0～20.0%.
2, a kind of preparation method of immunological function intensifier pearl polysaccharide composition is characterized in that, this preparation method comprises following processing step:
(1). prepare burden by following component and weight ratio: water soluble Margarita powder 5.0～10.0%, Radix Achyranthis Bidentatae 60.0～70.0%, the Radix Astragali 20.0～30.0%, Fructus Lycii 10.0～20.0%; Radix Achyranthis Bidentatae, Radix Astragali decoction pieces are mixed with the Fructus Lycii section, and adding PH is about 2.0 about 3～4 times of amounts of deionized water, soaks 24 hours under the room temperature; Between soak period, stirred once every 1～2 hour, and adjust the pH value of soak at any time, it is remained on about PH2.0;
(2). medical material deckle board pressure filter filter pressing among the above-mentioned immersion, filtrate gets the primary water extract through 4000rpm centrifugal filtration, and adopting the KOH liquid water transfer extract pH value of 30% weight concentration is 6.5, the water soluble Margarita powder dry powder that adds above-mentioned proportion scale then stirs and makes it abundant dissolving;
(3). above-mentioned Margarita Chinese medicine extraction liquid, spray-dried, promptly get faint yellow immunologic function potentiator pearl polysaccharide composition product one by one.
3, the preparation method of a kind of immunological function intensifier pearl polysaccharide composition according to claim 2 is characterized in that, in the described step (1), the thickness of Radix Achyranthis Bidentatae, Radix Astragali decoction pieces is 2～5mm.
4, the preparation method of a kind of immunological function intensifier pearl polysaccharide composition according to claim 2 is characterized in that, in the described step (1), adopts HCL to regulate the pH value of deionized water and soak.
5, the preparation method of a kind of immunological function intensifier pearl polysaccharide composition according to claim 2, it is characterized in that the pearl polysaccharide composition product in the described step (3) can be made the multiple dosage form product that comprises water preparation, powder, tablet, buccal tablet, dissolved granule and filling capsule.
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| CNB2005100267418A CN1322881C (en) | 2005-06-15 | 2005-06-15 | Immunological function intensifier pearl polysaccharide composition and its preparing method |
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| CN1709346A CN1709346A (en) | 2005-12-21 |
| CN1322881C true CN1322881C (en) | 2007-06-27 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1457824A (en) * | 2002-05-13 | 2003-11-26 | 曲秀勤 | Chinese medicinal pill for reinforcing kidney and strengthening yang, warming and recuperating Qi and blood, and improving crganism immunity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1457824A (en) * | 2002-05-13 | 2003-11-26 | 曲秀勤 | Chinese medicinal pill for reinforcing kidney and strengthening yang, warming and recuperating Qi and blood, and improving crganism immunity |
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