CN1321492A

CN1321492A - Medicine for curing necrosis of femoral head

Info

Publication number: CN1321492A
Application number: CN 01110595
Authority: CN
Inventors: 阎胜海
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-04-16
Filing date: 2001-04-16
Publication date: 2001-11-14
Anticipated expiration: 2021-04-16
Also published as: CN1133448C

Abstract

The present invention relates to a Chinese medicine for curing necrosis of femoral head with obvious therapeutic effect. Said Chinese medicine is made up by using 16 Chinese medicinal materials of ginseng, astragalus root, atractylodes root, poria, alisma tuber, Chinese angelica root and others, according to a certain proportion.

Description

A kind of medicine for the treatment of osteonecrosis of femoral head

The present invention relates to a kind of Chinese medicine, particularly relate to a kind of Chinese medicine for the treatment of femur head necrosis.

Ischemic necrosis of femoral head has had the history in more than 100 year since finding first in 1888.In recent years.Along with the rising of sickness rate, also be growing more intense about the discussion of the cause of disease and treatment aspect.Its pathogenic factor, the relatively unified in recent years fat embolism theory that surely belongs to.The traditional Chinese medical science is thought, blockage of meridian, and qi and blood stagnation, deficiency of the liver and kindey, the expectorant stasis of blood is stopped up, and kidney is main bone etc. not.In treatment, also be that means are different; But final curative effect is all undesirable.Hormonal and alcoholic-toxic ischemic necrosis of femoral head, modern medicine think that the cause of disease is a blood capillary fat embolism in the femoral head, blocks due to the blood supply.Zoopery proves that rabbit can cause lipid metabolic disorder after drinking in filling, and hyperlipemia and fatty liver also can cause femoral head adipose cell in marrow hypertrophy, the osteocyte steatosis.A large amount of hormones that use can make the femoral head capillary density reduce after 4 weeks, and the microcirculation exchange area reduces.Find that in light microscopic and electron microscopic observation osseous tissue various kinds of cell generation fatty becomes, the dissolving of osteocyte film is downright bad phenomenon, also can see fat in the endotheliocyte slurry and drip, and sees fat embolism in the blood vessel in the femoral head.Though the traditional Chinese medical science does not have detailed record to this, according to taking sign such as the central obesity that is showed behind the hormone, limbs are stranded heavy, white and greasy fur, and analyses such as relaxed and soft pulse or stringy and rolling pulse meet phlegm resistance, the pathogenesis of damp and hot contamination.Wet is YIN pathogen, and its property becomes down, and deep viscous easily is detained the joint, blocks mechanism of qi, so " element asks lunar sun bright opinion " said: " hinder in wet person, be subjected to it earlier down ".Wine helps damp and hot, need not dispute on.The wine extremely hot in nature, and body is same as water, is typical damp and hot product." book on Chinese herbal medicine spreads out and discusses addendum " said: " heating in wet ".Long-term excessive consumption of alcohol forms the card of damp invasion of lower energizer easily.Clear leaf sky scholar says: " wet plain Sheng the in the drinker ".The traditional Chinese medical science is thought " spleen preferring dryness to dampness ", " all damp-edema are full, all belong to spleen ", " the spleen being the source of producing phlegm ".The effect of amcinonide and ethanol has damaged the function of spleen, makes the strong fortune imbalance of spleen, the catharsis function of related liver is impaired, and depression and stagnation of QI causes the turbid fat of phlegm-damp, retardance meridians, the body fluid QI and blood can not normally be failed cloth, and limbs lose and moisten fosterly, and cause ischemic necrosis of femoral head.The clear and definite cause of disease is treated targetedly, the task of top priority of real genus.

The object of the invention is to provide a kind of nontoxic pair of effect of femur head necrosis, Chinese medicine evident in efficacy for the treatment of.

The present invention seeks to be achieved through the following technical solutions;

Choose crude drug: (by weight)

Radix Ginseng 5-15 Radix Astragali 5-15

Rhizoma Atractylodis 10-20 Poria 10-20,

Rhizoma Alismatis 15-30 Radix Angelicae Sinensis 10-20

Semen Coicis 15-30 Radix Notoginseng 5-10

Arisaema Cum Bile 5-10 Bulbus Fritillariae Cirrhosae 5-10

Radix Stephaniae Tetrandrae 5-15 Radix Paeoniae Alba 15-30

Radix Glycyrrhizae 5-10 Semen Cassiae 5-15

Cortex Phellodendri 15-30 Radix Scutellariae 15-30

The above-mentioned raw materials medicine is made any clinical acceptable forms according to common process, as capsule, tablet, electuary, granule etc.

The medicine of the present invention fat capsule of living that disappears is intended to remove the fat embolism of blood vessel in the femoral head and even eliminates the root that produces fat embolism.The Radix Astragali, Radix Ginseng, Rhizoma Atractylodis in the side, invigorating the spleen and benefiting QI dampness.Rhizoma Alismatis, Poria, Semen Coicis, Radix Stephaniae Tetrandrae, Semen Cassiae, promoting diuresis with drugs of tasteless flavour.According to pharmacological research, said medicine all has remarkable effect for reducing fat, and can also improve the lipid metabolism of liver and lipotropic effect is arranged, wherein Semen Coicis, Radix Stephaniae Tetrandrae, merit is at the dampness removing eliminating impediment, the Shujin emergency.Radix Angelicae Sinensis, Radix Notoginseng, Hirudo, nourishing blood and promoting blood circulation.Arisaema Cum Bile, Bulbus Fritillariae Cirrhosae, eleminating phlegm and freeing channels.The Radix Paeoniae Alba, Radix Glycyrrhizae, yin nourishing is in case the dampness removing impairment of YIN.Cortex Phellodendri, Radix Scutellariae, the heat clearing away bath is wet, with system ginseng, stilbene warm nature, damp proof and heat seal, glued one-tenth expectorant.Full side plays clearing away heat-damp and promoting diuresis altogether, and the clearing away phlegm fat of dispelling makes blood flow smooth and easy, and ischemic necrosis of femoral head is because of must the blood rehabilitation.The fat that disappears is lived capsule through 136 routine clinical observations confirmations, and total effective rate reaches 98%.

The clinical observation on the therapeutic effect of experimental example medicine of the present invention

1, clinical data

1.1 physical data

This group patient 136 examples, wherein male 124 examples, women 12 examples, the oldest 66 years old, minimum 23 years old, 41 years old mean age.The course of disease is the longest 13 years, the shortest two weeks.Wherein there are 3 examples to do one-sided bone grafting, 2 routine single hips and do that rack supports, 6 examples were done interventional therapy, 2 examples were done the boring decompression.All among the patient, hormone medication history person 83 examples are arranged, long-term alcoholic 65 examples, bad the dead of bilateral 133 examples, one-sided downright bad 3 examples.All patients all take the blood-activating and stasis-removing treatment and curative effect does not show for a long time, and wherein an example is taken 6 years blood-activating and stasis-removing oral administration and externallies continuously.At the ill initial stage, the X-ray sheet shows that the femoral head capsule sexually revises, the femoral head complete form, and the X-ray sheet shows that the femoral head cauliflower form changes after 6 years, the joint space is smudgy.

1.2 Clinical symptoms

All the patient all has hipbone pain, and dysfunction is walked lamely, and the patient who did operation mostly is goose walk.

2, Therapeutic Method

Adopt from intending the fat capsule alive that disappears, by the administration course of treatment, two months is a course of treatment, three times on the one, one time ten (quite crude drug 5g), and warm water delivery service, clothes amcinonide and blood-activating and stasis-removing are prohibited in the period in a medicine alleviating alcohol addiction.

3, curative effect determinate standard

3.1 clinical cure: pain, limping, dysfunction disappear, and the X line is taken the photograph sheet, CT scan shows that femoral head sequestrum district subsides, and osteonecrosis and bone regeneration hardening phenomenon disappear substantially.

3.2 produce effects: pain, limping, dysfunction disappear, and the X line is taken the photograph sheet, CT scan shows that femoral head becomes big or flat, but osteonecrosis and bone regeneration hardening phenomenon have improvement.

3.3 invalid: pain, limping, dysfunction do not have improvement substantially, and the X line is taken the photograph sheet, CT scan is shown femur head necrosis and bone regeneration hardening phenomenon, and femoral head sequestrum district subsides not have and changes.

4, therapeutic outcome

Clinical cure 112 examples, produce effects 17 examples, invalid 7 examples, total effective rate 98%.It is all effective in one month generally to take medicine, and small number of patients took effect in 15 days, 38 examples of fully recovering the course of treatment of taking medicine, and 56 examples of fully recovering 3 courses of treatment of taking medicine, all the other are all cured in two courses of treatment.Wherein there are 2 examples to take ten days therapy discontinued.

Embodiment:

Choose crude drug according to following prescription:

Radix Ginseng 100g Radix Astragali 100g

Rhizoma Atractylodis 150g Poria 150g

Rhizoma Alismatis 200g Radix Angelicae Sinensis 150g

Semen Coicis 200g Radix Notoginseng 50g

Arisaema Cum Bile 50g Bulbus Fritillariae Cirrhosae 50g

Radix Stephaniae Tetrandrae 100g Radix Paeoniae Alba 200g

Radix Glycyrrhizae 50g Semen Cassiae 100g

Cortex Phellodendri 200g Radix Scutellariae 200g

Prescription medicine is cleaned with clear water, be placed on the screen cloth and drain the water, in oven dry, dry rearmounted crusher for crushing then, cross 100 mesh sieves, pour in No. 0 capsule promptly.

Claims

1, a kind of Chinese medicine for the treatment of femur head necrosis is characterized in that this medicine made by following bulk drugs:

Radix Ginseng 5-15 Radix Astragali 5-15

Rhizoma Atractylodis 10-20 Poria 10-20,

Rhizoma Alismatis 15-30 Radix Angelicae Sinensis 10-20

Semen Coicis 15-30 Radix Notoginseng 5-10

Arisaema Cum Bile 5-10 Bulbus Fritillariae Cirrhosae 5-10

Radix Stephaniae Tetrandrae 5-15 Radix Paeoniae Alba 15-30

Radix Glycyrrhizae 5-10 Semen Cassiae 5-15

Cortex Phellodendri 15-30 Radix Scutellariae 15-30

2, Chinese medicine as claimed in claim 1 is characterized in that this medicine made by following bulk drugs:

Radix Ginseng 10 Radixs Astragali 10

Rhizoma Atractylodis 15 Poria 15

Rhizoma Alismatis 20 Radix Angelicae Sinensis 15

Semen Coicis 20 Radix Notoginseng 5

Arisaema Cum Bile 5 Bulbus Fritillariae Cirrhosae 5

Radix Stephaniae Tetrandrae 10 Radix Paeoniae Albas 20

Radix Glycyrrhizae 5 Semen Cassiaes 10

Cortex Phellodendri 20 Radix Scutellariaes 20