CN1424095A - Analgestic plaster - Google Patents
Analgestic plaster Download PDFInfo
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- CN1424095A CN1424095A CN 02158929 CN02158929A CN1424095A CN 1424095 A CN1424095 A CN 1424095A CN 02158929 CN02158929 CN 02158929 CN 02158929 A CN02158929 A CN 02158929A CN 1424095 A CN1424095 A CN 1424095A
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Abstract
An exterior-applied Chinese medicine "Antalgesic ointment" for treating gonarthritis is prepared from 17 Chinese-medicinal materials including dahurian angelica root, clematis root, safflower, Chinese angelica root, liquorice root, etc through proportioning, drying, sterilizing, pulverizing by 30 meshes, and loading in bags. Its advantages are high curative effect, short course of treatment, low cost and less recurrence.
Description
Technical field the present invention is a field of pharmaceutical technology, relates to a kind of external Chinese medicine---ZHITONG GAO for the treatment of knee osteoarthritis.
The background technology knee osteoarthritis is common ailment of middle-aged and old, frequently-occurring disease.Main clinical manifestation is that the gonalgia is stiff, swelling and dysfunction.At present, the cause of disease to osteoarthritis is not clear and definite fully as yet both at home and abroad.Though Therapeutic Method is many but effect is all unsatisfactory, mainly contains naturopathy and oral drug therapy etc.Naturopathy needs the time longer, and the patient who has can not accept, and the oral drug therapy side effect is bigger, order. and curative effect is slow.The method of ZHITONG GAO treatment knee osteoarthritis is our accumulation of clinical experience for many years, with dispel the wind, collateral dredging, promoting blood circulation to remove blood stasis analgesic pure Chinese medicinal preparation.The traditional Chinese medical science is in the difference of methods such as determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, prescription, dosage form, processing technique, and curative effect is widely different.Chinese patent 99120466.2 is disclosed to be a kind of analgesic plaster for osteoarthritis, it is with RHIZONA GASTRODIAE, Radix Notoginseng, the system Cortex Eucommiae, Herba Epimedii, eupolyphaga, Radix Aconiti, Radix Aconiti Kusnezoffii, Scorpio, Scolopendra, Radix Polygoni Multiflori, Squama Manis, Hirudo, Olibanum (processed), Myrrha (processed), Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Semen Persicae, Radix Paeoniae Rubra, Caulis Spatholobi, Flos Carthami, Sanguis Draxonis, Radix Dipsaci, Herba Taxilli, Cortex Moutan, Rhizoma Curcumae Longae, the river Radix Achyranthis Bidentatae, Cortex Acanthopancis, Zaocys, Corium elephatis, Crinis Carbonisatus, Herba Ephedrae, Herba Asari, Radix Saposhnikoviae, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Rhizoma Arisaematis, Radix Et Rhizoma Rhei, Radix Puerariae, rice is honest, Borneolum Syntheticum, Chinese herbal medicine such as Semen Sinapis Albae are formed, and the pain that osteoarthritis is caused has the effect of treatment or relief of symptoms.Chinese patent 01131249.1 is disclosed to be a kind of pain-stopping ointment for bone, and it is a kind of medicine with functions such as blood circulation promoting and blood stasis dispelling, expelling wind and cold, Shujin bone strengthening, reducing swelling and alleviating pain.The pain-stopping ointment for bone of forming by natural Chinese medicinal herb such as Radix Angelicae Sinensis, Flos Carthami, Radix Notoginseng, Olibanum, Myrrha, Sanguis Draxonis, Herba speranskiae tuberculatae, Eupolyphaga Seu Steleophaga, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Carapax Trionycis, Ramulus Cinnamomi, Borneolum Syntheticums.
Summary of the invention the objective of the invention is to be more effective treatment knee osteoarthritis in order to overcome the shortcoming that above-mentioned naturopathy and oral drug therapy etc. exist, a kind of external Chinese medicine ZHITONG GAO of treatment knee osteoarthritis is provided.
The present invention is a kind of external Chinese medicine ZHITONG GAO of treatment knee osteoarthritis, content Description:
External Chinese medicine ZHITONG GAO of the present invention belongs to Chinese medicine preparation, it is characterized in that: the prescription of the ampoule ingredient of this medicine is: Cortex cercis chinensis 1000～5000g, the Radix Angelicae Dahuricae 400～800g, Radix Clematidis 300～600g, Flos Carthami 600～900g, Radix Stephaniae Tetrandrae 500～1000g, Rhizoma Arisaematis 300～600g, Radix Angelicae Sinensis 400～500g, Fructus Mume 400～700g, CHUANSHANLONG 600～900g, Herba Asari 400～800g, Radix Aconiti 300～600g, Cortex Phellodendri 500～900g, Rhizoma Atractylodis 300～800g, Radix Cynanchi Paniculati 500～1000g, Radix Aconiti Kusnezoffii 300～500g, Radix Et Rhizoma Rhei 400～700g, Radix Glycyrrhizae 400～4500g.
The preparation method of this Chinese medicine ZHITONG GAO is: the said medicine prescription is got it filled according to the percentage ratio of weight, dry sterilization, be crushed into the fine powder about granule 130 orders, packing 200g/ bag tempers into paste during use.
The present invention is that a kind of Chinese medicine of treatment knee osteoarthritis adopts plurality of Chinese to optimize prescription, has functions dispelling wind and clearing away cold, removing dampness, and the effect of dredging the meridian, regulating QI to relieve pain is made external preparation, easy to use, preparation technology is simple, with low cost.The present invention is a kind of Chinese medicine ZHITONG GAO of treatment knee osteoarthritis, and clinical trial is finished, and 2280 routine osteoarthritis patients have been carried out the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs clinical practice of traditional Chinese medical science typing, and wherein the course of disease is the longest 8 years, 4 the shortest weeks.Anemofrigid-damp arthralgia resistance type 1582 examples, QI and blood two empty type 315 examples, deficiency of both the liver and kidney type 279 example and bones and muscles injury type 104 examples.
Criterion of therapeutical effect: do efficacy evaluation according to " People's Republic of China's Chinese medicine industry standard one traditional Chinese medical science disease diagnosis criterion of therapeutical effect 94 years ".
Recovery from illness: a pain disappears; B knee joint mobility is normal; The swelling of c knee joint disappears; D erythrocyte sedimentation rate (ESR) recovery normal level (woman＜20mm/h, the man＜10mm/h).
Produce effects: idol has pain during the activity of a knee joint; B knee joint mobility (bending and stretching) recovers＞30% before the treatment; The swelling of c knee joint obviously alleviates (Zhou Jing descends 10% before the treatment) before the treatment; D erythrocyte sedimentation rate (ESR) is not higher than normal 10mm/h.
Effectively: the pain during activity of a knee joint; B knee joint mobility (bending and stretching) recovers＞20% before the treatment; The swelling of c knee joint obviously alleviates (Zhou Jing descends 5% before the treatment) before the treatment; D erythrocyte sedimentation rate (ESR) is not higher than normal 20mm/h.
Invalid: symptom and sign are with the preceding no change of treatment.
| Pattern of syndrome | The example number | Recovery from illness | Account for % | Produce effects | Account for % | Effectively | Account for % | Invalid | Account for % |
| The anemofrigid-damp arthralgia resistance type | 1582 | ?1270 | ?80.28 | ?138 | ?8.72 | ??159 | ?10.05 | ??15 | ?0.95 |
| QI and blood two empty types | 315 | ?201 | ?63.81 | ?93 | ?29.52 | ??12 | ?3.80 | ??9 | ?2.86 |
| The deficiency of both the liver and kidney type | 279 | ?152 | ?54.48 | ?121 | ?43.37 | ??2 | ?0.72 | ??5 | ?1.80 |
| The bones and muscles injury type | 104 | ?68 | ?65.39 | ?8 | ?7.70 | ??10 | ?9.62 | ??18 | ?17.31 |
| Add up to | 2280 | ?1691 | ?74.17 | ?360 | ?15.79 | ??183 | ?8.03 | ??47 | ?2.06 |
Through clinical treatment produce effects 2051 examples, obvious effective rate 89.96%; Total effective 2234 examples, total effective rate is 97.98%.What treatment time was the shortest is 15 days, and the longest 72 days, the efficacy consolidation incidence rate was lower, checks 1270 examples with examining after 4 months to 2 years, and 53 example recurrences are arranged, and the state of an illness is preceding light than treatment, and relapse rate is for checking 4.17% of case with examining.
The specific embodiment
Embodiment 1
Go to a doctor in Tanggangzi Hospital year October in January calendar year 2001～2002, anemofrigid-damp arthralgia resistance type knee osteoarthritis patient 1582 examples, the prescription of seance amount medication is: Cortex cercis chinensis 3000g, Radix Angelicae Dahuricae 600g, Radix Clematidis 500g, Flos Carthami 800g, Radix Stephaniae Tetrandrae 800g, Rhizoma Arisaematis 400g, Radix Angelicae Sinensis 500g, Fructus Mume 400g, CHUANSHANLONG 700g, Herba Asari 400g, Radix Aconiti 400g, Cortex Phellodendri 500g, Rhizoma Atractylodis 500g, Radix Cynanchi Paniculati 500g, Radix Aconiti Kusnezoffii 400g, Radix Et Rhizoma Rhei 400g, Radix Glycyrrhizae 400g.The said medicine prescription is got it filled according to the percentage ratio of weight, dry sterilization, be crushed into the fine powder about granule 130 orders, packing 200g, water reconciles into paste, and spreading on the affected part after heating with hot water bag, the lid layer soft plastic cloth covers two layers of towel again, increase temperature with hot water bag, applied 2 hours every day.Make medicine act on body by skin by heating power, functions dispelling wind and clearing away cold, removing dampness, dredging the meridian, regulating QI to relieve pain reach the purpose of curing the disease.Reach 99.05% through the treatment total effective rate.
Embodiment 2
Go to a doctor in Tanggangzi Hospital in January, 2000～June, QI and blood two empty type knee osteoarthritis patient 315 examples, Cortex cercis chinensis 4000g, Radix Angelicae Dahuricae 800g, Radix Clematidis 600g, Flos Carthami 900g, Radix Stephaniae Tetrandrae 700g, Rhizoma Arisaematis 400g, Radix Angelicae Sinensis 400g, Fructus Mume 600g, CHUANSHANLONG 700g, Herba Asari 800g, Radix Aconiti 500g, Cortex Phellodendri 700g, Rhizoma Atractylodis 500g, Radix Cynanchi Paniculati 800g, Radix Aconiti Kusnezoffii 400g, Radix Et Rhizoma Rhei 600g, Radix Glycyrrhizae 4500g.The said medicine prescription is got it filled according to the percentage ratio of weight, dry sterilization, be crushed into the fine powder about granule 130 orders, packing 200g, water reconciles into paste, and spreading on the affected part after heating with hot water bag, the lid layer soft plastic cloth covers two layers of towel again, increase temperature with hot water bag, applied 2 hours every day.Make medicine act on body by skin by heating power, functions dispelling wind and clearing away cold, removing dampness, dredging the meridian, regulating QI to relieve pain reach the purpose of curing the disease.Reach 97.14% through the treatment total effective rate.
Embodiment 3
Go to a doctor in Tanggangzi Hospital in July, 2000～December, deficiency of both the liver and kidney type knee osteoarthritis patient 279 examples, Cortex cercis chinensis 5000g, Radix Angelicae Dahuricae 400g, Radix Clematidis 600g, Flos Carthami 900g, Radix Stephaniae Tetrandrae 1000g, Rhizoma Arisaematis 600g, Radix Angelicae Sinensis 400g, Fructus Mume 700g, CHUANSHANLONG 900g, Herba Asari 400g, Radix Aconiti 600g, Cortex Phellodendri 900g, Rhizoma Atractylodis 800g, Radix Cynanchi Paniculati 1000g, Radix Aconiti Kusnezoffii 500g, Radix Et Rhizoma Rhei 400g, Radix Glycyrrhizae 800g.The said medicine prescription is got it filled according to the percentage ratio of weight, dry sterilization, be crushed into the fine powder about granule 130 orders, packing 200g, water reconciles into paste, and spreading on the affected part after heating with hot water bag, the lid layer soft plastic cloth covers two layers of towel again, increase temperature with hot water bag, applied 2 hours every day.Make medicine act on body by skin by heating power, functions dispelling wind and clearing away cold, removing dampness, dredging the meridian, regulating QI to relieve pain reach the purpose of curing the disease.Reach 99.20% through the treatment total effective rate.
Prove according to pharmacological research: Cortex cercis chinensis has promoting blood circulation to restore menstrual flow, subduing swelling and detoxicating, controls bones and muscles pain, anemofrigid-damp arthralgia, apathy; Radix Stephaniae Tetrandrae, Radix Clematidis, Radix Cynanchi Paniculati have blood circulation promoting and blood stasis dispelling, pain relieving, expelling wind and removing dampness effect; Flos Carthami, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis have the active effect of promoting blood circulation to restore menstrual flow.The present invention is the comprehensive prescription of the rule of treatment with blood circulation promoting and blood stasis dispelling, dredging the meridian.By eliminating muscle spasm, improve local blood circulation and histotrophic nutrition, ease the pain, increase range of motion.
Claims (2)
1, a kind of Chinese medicine for outer use for the treatment of knee osteoarthritis is characterized in that: the ampoule medicament composing prescription of the external Chinese medicine of treatment knee osteoarthritis is: Cortex cercis chinensis 1000～5000g, Radix Angelicae Dahuricae 400～800g, Radix Clematidis 300～600g, Flos Carthami 600～900g, Radix Stephaniae Tetrandrae 500～1000g, Rhizoma Arisaematis 300～600g, Radix Angelicae Sinensis 400～500g, Fructus Mume 400～700g, CHUANSHANLONG 600～900g, Herba Asari 400～800g, Radix Aconiti 300～600g, Cortex Phellodendri 500～900g, Rhizoma Atractylodis 300～800g, Radix Cynanchi Paniculati 500～1000g, Radix Aconiti Kusnezoffii 300～500g, Radix Et Rhizoma Rhei 400～700g, Radix Glycyrrhizae 400～4500g.
2, a kind of external Chinese medicine of treatment knee osteoarthritis according to claim 1, it is characterized in that its preparation method follows these steps to make: the said medicine prescription is got it filled according to the percentage ratio of weight, dry sterilization, be ground into the fine powder about granule 130 orders, packing 200g/ bag tempers into paste during use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021589291A CN1181879C (en) | 2002-12-27 | 2002-12-27 | Analgestic plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021589291A CN1181879C (en) | 2002-12-27 | 2002-12-27 | Analgestic plaster |
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| CN1424095A true CN1424095A (en) | 2003-06-18 |
| CN1181879C CN1181879C (en) | 2004-12-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021589291A Expired - Fee Related CN1181879C (en) | 2002-12-27 | 2002-12-27 | Analgestic plaster |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288238A (en) * | 2015-11-19 | 2016-02-03 | 山东明仁福瑞达制药股份有限公司 | Preparation method of blood-activating and stasis-resolving traditional Chinese medicine composition containing 22 components and paste thereof |
| CN107184720A (en) * | 2017-05-26 | 2017-09-22 | 广州智润生物制药科技有限公司 | It is a kind of to treat patch of gonitis and preparation method thereof |
| CN114699363A (en) * | 2022-06-08 | 2022-07-05 | 江西中医药大学附属医院 | Traditional Chinese medicine wax mud for osteoarthritis and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316229B (en) * | 2013-07-04 | 2014-04-02 | 虞攀峰 | Medicine for treating knee osteoarthropathy |
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2002
- 2002-12-27 CN CNB021589291A patent/CN1181879C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288238A (en) * | 2015-11-19 | 2016-02-03 | 山东明仁福瑞达制药股份有限公司 | Preparation method of blood-activating and stasis-resolving traditional Chinese medicine composition containing 22 components and paste thereof |
| CN107184720A (en) * | 2017-05-26 | 2017-09-22 | 广州智润生物制药科技有限公司 | It is a kind of to treat patch of gonitis and preparation method thereof |
| CN114699363A (en) * | 2022-06-08 | 2022-07-05 | 江西中医药大学附属医院 | Traditional Chinese medicine wax mud for osteoarthritis and preparation method thereof |
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| Publication number | Publication date |
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| CN1181879C (en) | 2004-12-29 |
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