CN1320898C - Chinese medicinal preparation for skin stain removing and whitening - Google Patents
Chinese medicinal preparation for skin stain removing and whitening Download PDFInfo
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- CN1320898C CN1320898C CNB2005100244717A CN200510024471A CN1320898C CN 1320898 C CN1320898 C CN 1320898C CN B2005100244717 A CNB2005100244717 A CN B2005100244717A CN 200510024471 A CN200510024471 A CN 200510024471A CN 1320898 C CN1320898 C CN 1320898C
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Abstract
The present invention relates to a Chinese medicine preparation for removing the speckles on the skin and whitening the skin, which comprises active components prepared from Chinese medicinal materials of the following proportion by weight: 5 to 30 shares of ash bark, 5 to 30 shares of silkworm, 3 to 15 shares of mulberry leaf and 5 to 30 shares of buffalo horn. The medicinal materials are prepared into a drug for oral administration. The Chinese medicine preparation can also contain 0.5 to 1 share by weight of pearl protein powder so as to be prepared into a drug for external use. The Chinese medicine preparation has the advantages of fine curative effect, safety, mild drug property, and oral administration and/or external use for patients and normal people, and has an effective rate of 83% when used for treating the skin damage of patients with lupus erythematosus so as to achieve the purpose of complete regression or partial regression when the preparation is used for the treatment of erythema, rash, punctum, pigment and light sensitiveness. As for the facial beautification of the face of a normal person, facial rash, facial macule, facial stain, facial pigmentation, facial pruritus and photosensitive dermatitis can be eliminated by inunction treatment, and the preparation can smooth, clean, nourish and whiten the skin without toxic or side effect for long-term use.
Description
Technical field
The Chinese medicine preparation of the skin stain removing and whitening that the present invention relates to improve looks, main effect is to dispel facial colour spot, maculopapule and uvioresistant, and skin whitening.
Background technology
Skin pigment increases deeply, pigmented spots and various macule pimple are the common cosmetic problem of women's facial.Its reason is diversified, and as allergy, infection, chemical factors, sunlight, endocrine disturbance, medicine, disease, and factor such as heredity all can cause.
Systemic lupus erythematosus (sle) (SLE) is the serious and disease of refractory, and is the lifelong participation disease.The treatment difficulty is very big, requires very high.The present medical level of lupus erythematosus can only be accomplished to alleviate and alleviate fully, can not effect a radical cure.
The pathologic basis of SLE is cover warm nature vasculitis and inflammation of connective tissue.Skin lesion is the less important clinical manifestation of SLE, and the clam sickness rate has about 90% approximately, and is very general.Even after the SLE system damage used Chinese and western drugs treatment control to alleviate, many patients' skin lesion still existed, the pigmentation that has increases on the contrary deeply.And the acne that causes of prednisone isocortex hormone also can long-term existence, is difficult to eliminate.The aeg usually proposes to wish the facial problem of early settlement, otherwise is difficult to go out.Therefore, on the basis of treatment SLE system damage, also must treat skin lesion.
Skin treating commonly used at present is to adopt external to be coated with to put the external used medicine that contains hormone or anti-allergic agent on the skin, and its shortcoming is the easily recurrence of back of stopping using, and can produce the reaction of paying of drug resistance and facial local " becoming fat ".
The inventor is engaged in the tcm clinical practice research work of lupus erythematosus for a long time, in secular clinical practice process, has found some Chinese medicine medical material to have good elimination erythema, erythra, the effect of various pigmented spots.Not only eliminate pathologic macule, also can eliminate the pigmented spots and the various macule pimple of general normal women.And can make the original skin whitening of women.Life-time service does not have side reaction.
Summary of the invention
The invention provides a kind of Chinese medicine preparation of skin stain removing and whitening.This Chinese medicine preparation can be mixed with oral medicine or medicine for external use, and the Chinese medicine preparation that it is a kind of good effect, safety, the property of medicine is gentle can make skin eliminate macule and brighten.
Chinese medicine preparation of the present invention comprises the active ingredient that the Chinese medicine medical material of following row weight portion proportioning is prepared from:
Cortex Fraxini 5-30 part, Bombyx Batryticatus 5-30 part, Folium Mori 3-15 part and Cornu Bubali 5-30 part.Chinese medicine activity of drug ingredients composition and routine administration can be mixed with oral medicine with carrier, and pharmaceutical carrier can be dextrin, starch, sucrose and other common carrier.The dosage form of oral medicine is granule, mixture or capsule.
Chinese medicine preparation of the present invention also contains the Margarita albumen powder that weight portion is 0.5-1 part.
By Cortex Fraxini 5-30 part, Bombyx Batryticatus 5-30 part, the Margarita albumen powder that adds 0.5-1 part in the active ingredient that Folium Mori 3-15 part and Cornu Bubali 5-30 part Chinese medicine medical material are prepared from stirs evenly, and forms the Chinese medicine concentrated solution, contains among the every ml of Chinese medicine concentrated solution about Chinese medicine crude drug 4 grams.According to a conventional method Chinese medicine concentrated solution and mixed with excipients are mixed with the medicine for external use cream again.Contain Chinese medicine concentrated solution 2.5ml in medicine for external use cream 100g finished product, be equivalent to contain about Chinese medicine crude drug 10 grams, promptly its concentration (containing Chinese medicine crude drug amount) is about 10%.External-application cream is used for the part and embrocates.This cream has the fragrance of general natural very elegant smelling good, and any does not have unpleasant Chinese medicine abnormal smells from the patient.The slightly light ochre yellow of the color of cream is coated on the skin then and is colourless or pale slightly.
The Chinese medicine preparation of skin stain removing and whitening of the present invention can be operated routinely and be prepared into granule, close the oral medicine of making the capsule dosage form, or the medicine for external use cream, and its preparation method is as follows:
1, granule dosage form oral medicine
By each medical material component of above-mentioned prescription weighing, after the medical material mixing, decoct with water 3 times, remove medicinal residues, decocting liquid merges after-filtration, and it is 1.08g/cm that filtrate is concentrated to medicinal liquid density
3, add the ethanol postprecipitation, get supernatant, after recovery ethanol also concentrates, add the water stirring and left standstill 8 hours, get supernatant concentration and become half extractum.Add pharmaceutical carrier (dextrin or starch) and cane sugar powder again, heating makes the sugar fusion a little, mixes into the dough shape simultaneously thoroughly, cools, make graininess again, the granule of 20 order sizes is got in screening, and is dry again, temperature 60-80 ℃, 2-3 hour, oven dry back moisture content is 7%, with the finished product branch pouch of packing into, promptly gets the bagged granules agent.
2, mixture type oral medicine
By each medical material component of above-mentioned prescription weighing, after the medical material mixing, soaked 2-12 hour, boil, and keep boiling state 2 hours, extracting juice with little fire.Medicinal residues added water boil 2 hours again, and extracting juice merges twice medicine juice, concentrates, and getting concentration is 1: 1.Add antiseptic and stir evenly, mixture.
3, capsule formulation oral medicine
By each medical material component of above-mentioned prescription weighing, decoct with water secondary after the mixing, to filter, secondary filtrate merges, and being concentrated to medicinal liquid density is 1.08g/cm
3, add ethanol precipitation.Get supernatant, reclaim ethanol, add and left standstill 8 hours after water stirs, get supernatant, be condensed into half extractum, add pharmaceutical carrier (dextrin or starch) again and mix thoroughly, drying is pulverized, and adds the moderate lubrication agent, incapsulates after the granulation.
4, medicine for external use cream
By each medical material component of above-mentioned prescription weighing, decoct with water after the mixing, remove medicinal residues, fried liquid filters, and concentrates, and after the decolouring, Margarita albumen powder is added, and mixes thoroughly, forms the Chinese medicine concentrated solution, contains about the about 4g of Chinese medicine crude drug in every ml Chinese medicine concentrated solution.According to a conventional method Chinese medicine concentrated solution and routine are mixed with the medicine for external use cream with mixed with excipients again.
Chinese medicine preparation of the present invention has made it better curative effect because suitable cooperation produces good synergism.Introduce relevant main chemical compositions of each Chinese medicine medical material and main pharmacological below.
1, Cortex Fraxini
(1) main component: it is the Coumarins chemical compound that Cortex Fraxini contains fraxetin, and fraxetin is the general name of aseculin, Cortex Fraxini second poison etc.
(2) main pharmacology: fraxetin has antiallergic, anti-photosensitization, especially UV-induced erythema, erythra is had the obvious suppression effect.The effect of aesculetin is better than aseculin.That fraxetin also has is antibiotic, antiviral, anti-inflammatory effect.
(3) toxicity: the Compendium of Material Medica record is nontoxic.Cortex Fraxini decocting liquid oral administration and externally does not have toxicity.The LD of aseculin mouse gavaging
50(median lethal dose(LD 50)) is that the following nothing of 11.5g/kg: 3g/kg is dead.Illustrating that toxicity is very little, is very safe.External is safer.
(4) tradition record: bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica: " obey skin gloss for a long time.”
Cortex Fraxini traditional Chinese medical science tradition is treatment dysentery medicine.Being used for skin macule and photoallergic dermatitis is the long-term clinical practical experience of the inventor.External has no adverse reaction.
2, Bombyx Batryticatus
(1) main component: contain several amino acids, fatty acid, flood dragon corticosterone etc.
(2) main pharmacology: ecdysterone has sloughs off bad skin, bears the effect of bright and clean skin again.
(3) toxicity: the Compendium of Material Medica record is nontoxic.Taking orally does not have toxicity.External application does not have any untoward reaction.
(4) tradition record: Compendium of Material Medica record, Bombyx Batryticatus can be treated " black dim on the face " " it is good to make us complexion ".Bombyx Batryticatus is the medicine commonly used in noble women's cosmetics in ancient times.
Though tradition is used the record in ancient times is arranged, modern not report and exploitation still aspect beauty treatment.
3, Folium Mori
(1) main component: contain compositions such as ecdysterone, phytoestrogen and multivitamin, aminoacid, trace element.
(2) main pharmacology: ecdysterone and phytoestrogen can promote human body protein synthetic, stimulate the hypodermal cell division, produce new epidermis.
(3) toxicity: the Compendium of Material Medica record is nontoxic.The clinical toxicity that do not have for oral administration.External application does not have any untoward reaction.
(4) tradition record: Compendium of Material Medica record, washout treatment " facial varioliform exanthema " and " hair is not long ".
It is the medicine commonly used of treatment cold, fever that Folium Mori traditional Chinese medical science tradition is fried in shallow oil soup for oral administration.Though be used to improve looks ancient times on the books, tcm clinical practice does not have report.This is that the bright delicate inspiration of entire body is secular clinical practice experience to the inventor according to nibbling Folium Mori.
4, Cornu Bubali
(1) main component: contain sterols and several amino acids, protein.
(2) main pharmacology: for oral administration have an excretory effect of adrenocortical hormone in the body of promotion.
(3) toxicity: the Compendium of Material Medica record is nontoxic.Taking orally does not have toxicity.External application does not have any untoward reaction.
(4) tradition record: the Compendium of Material Medica record, exterior coating treatment " chancre, tinea corporis ".
The Chinese medicine preparation of skin stain removing and whitening of the present invention is at random got 100 examples to a large amount of cases through for many years clinical practice in outpatient service, adopt oral medicine and/or medicine for external use to treat, and curative effect is as follows:
One, clinical data
100 routine patients all clarify a diagnosis and are systemic lupus erythematosus (sle).Women's 97 examples wherein, male's 3 examples.Age 13～62, average 36.2 years old, ill the longest 27 years, the shortest 1 month.Average 4.6 years.
Two, facial and other clinical manifestations
100 routine patient's faces have erythema (comprising butterfly-like erythema, edematous erythema etc.), erythra, maculopapule person's 100 examples that differ in size, or have mottle, pigmentation person's 65 examples concurrently.Photaesthesia person's 85 examples.In addition, macule person's 72 examples are arranged on hand.
90 examples have the systematicness infringement among the 100 routine patients, and great majority are lupus nephritis, and arthritis, pericarditis, leukocyte, thrombocytopenia etc. are still arranged.Positive 100 examples of ANA, positive 26 examples of anti-Sm antibody, positive 95 examples of anti-dsDNA.(anti-Sm antibody can cause face red spot, and the anti-dsDNA antibody capable causes nephritis.Both are the labelling antibody of SLE, and one of them positive person can be diagnosed as SLE.)
Three, Therapeutic Method
Behind the Chinese medicine and/or Western medicine medical material therapy system infringement significant effective such as 17-hydroxy-11-dehydrocorticosterone and immunosuppressant of orally for curing lupus sebaceus, emphasis is comparatively treated skin lesion.Adopt Chinese medicine preparation oral medicine of the present invention and/or medicine for external use to treat.Give patient's oral medicine mixture, every day three times, each 30ml (or oral medicine granule every day three times, each 1 bag (3.5g) or oral medicine capsule, every day three times, each four) use medicine for external use (speckle removing frost) to smear simultaneously, smear 2-3 time after washing one's face every day.When going out, smear the speckle removing frost after, and open an umbrella, avoid the direct irradiation of the sun long period summer.
Four, criterion of therapeutical effect
1, face red spot erythra, photosensitive whole eliminations are for alleviating fully.
What 2, part was eliminated is to take a turn for the better.
What 3, facial macule did not have improvement is invalid.
Five, therapeutic outcome
Observing time: 3-6 month.
In 100 examples fully alleviation person 72 examples are arranged, improvement person has 11 examples, the nonresponder has 17 examples.Total effective rate is 83%.Along with the continuous improvement of the ruthless skin ulcer whole body state of an illness, 17 invalid routine patients, through the longer time, about 2～3 years, the skin of face infringement can reach all effectively, not only various mottle full scale clearances, and also original skin is also more delicate.
Systemic lupus erythematosus (sle) is unusual one of refractory disease of not capturing as yet in the world.Even after the SLE system damage used Chinese and western drugs treatment control to alleviate, many patients' skin lesion still existed, the pigmentation that has increases on the contrary deeply.And the acne that causes of prednisone isocortex hormone also can long-term existence, is difficult to eliminate.After adopting Chinese medicine preparation oral medicine of the present invention and medicine for external use to use treatment simultaneously, face's erythema of large quantities of patients, erythra, mottle, pigment, photaesthesia reach and disappear fully or partly disappear.The patient who has is more pale than former skin.Effective percentage can reach 83%.
Chinese medicine preparation of the present invention also can be used for the beauty treatment of general normal person's face, can eliminate facial rash by embrocating treatment, macule, mottle pigmentation, pruritus and photoallergic dermatitis.Can take orally with external and carry out simultaneously also can smearing with medicine for external use separately, effect is splendid.And can make skin bright and clean moist, clear fair-skinned delicate.
For oral administration and a large amount of patient's long-term observation of external warp of Chinese medicine preparation of the present invention, no toxicity does not influence patients'blood cell and hepatic and renal function.Therefore, it is better that the present invention has provided a kind of curative effect, safety, and the property of medicine is gentle, can take orally for a long time and/or the Chinese medicine preparation of external patient and normal person are spendable.Oral medicine can be developed to Chinese patent medicine, and medicine for external use can be developed to cosmetics and skincare product, has the wide development prospect.
The specific embodiment
The preparation of embodiment 1 oral medicine bagged granules agent (having another name called the speckle removing granule)
Take by weighing 30 kilograms of medical material Cortex Fraxinis, 20 kilograms of Bombyx Batryticatus, 10 kilograms of 10 kilograms on Folium Mori and Cornu Bubalis add up to 70 kilograms, are put in and decoct with water three times in the pot, add for the first time 200 kilograms in water, decocted 2 hours, for the second time and respectively add 100 kilograms in water for the third time, each decocted 1 hour, three decocting liquids are merged after-filtration, and it is 1.08g/cm that filtrate is concentrated to medicinal liquid density
3, add 20 kilograms of ethanol postprecipitations, get supernatant, reclaim ethanol, add and left standstill 8 hours after water stirs, get supernatant concentration and become 12 kilograms of half extractum.Add 0.5 kilogram of 0.5 kilogram in dextrin and cane sugar powder then, heating makes the sugar fusion a little, mixes into the dough shape simultaneously thoroughly, cools, make graininess again, the granule of 20 order sizes is got in screening, and is dry again, 80 ℃ of temperature, 2 hours, oven dry back moisture content is 7%, gets 8 kilograms of finished products, is distributed into the bagged granules agent of 3.5 gram/bags.Every gram finished product is equivalent to the dosage of about 10 grams of crude drug.
Taking method: every day 3 times, each one bag, the boiled water impulsive motion, every day, dosage was equivalent to about 105 grams of crude drug.
The preparation of embodiment 2 oral medicine mixture (having another name called the speckle removing mixture)
Take by weighing 20 kilograms of medical material Cortex Fraxinis, 10 kilograms of Bombyx Batryticatus, 30 kilograms of 15 kilograms on Folium Mori and Cornu Bubalis add up to 75 kilograms.Add 300 kilograms in water after the mixing, soaked 6 hours, boil, and keep boiling state 2 hours with little fire, extracting juice, medicinal residues added water boil 2 hours again, and extracting juice merges twice medicine juice.Be condensed into 75 kilograms, its concentration is 1: 1.Add preservative sodium benzoate, addition is 1%, stir evenly, mixture, contain about 105 grams of crude drug in per 90 milliliters of mixture, divide the bottle of packing into.
Taking method: every day three times, each 30 milliliters, every day, dosage was equivalent to about 105 grams of crude drug.
The preparation of embodiment 3 oral medicine capsules (having another name called the speckle removing capsule)
Take by weighing 10 kilograms of medical material Cortex Fraxinis, 30 kilograms of Bombyx Batryticatus, 5 kilograms of 20 kilograms on Folium Mori and Cornu Bubalis add up to 65 kilograms, decoct with water secondary after the mixing, add 200 kg of water 2 hours for the first time, add 150 kg of water 1 hour for the second time, filter, secondary filtrate merges, and being concentrated to medicinal liquid density is 1.08g/cm
3, add 15 kilograms of ethanol precipitations.Get supernatant, reclaim ethanol, after adding water and stirring, left standstill 8 hours, get supernatant concentration and become 3.5 kilograms of half extractum.Add 0.2 kilogram in dextrin then, mix thoroughly, drying is pulverized, and adds an amount of magnesium stearate, and granulation incapsulates, and every capsules 0.5 gram contains about crude drug amount 8.8 grams
Taking method: every day three times, each four, every day, dosage was equivalent to about 105 grams of crude drug.
The preparation of embodiment 4 medicine for external use cream (having another name called the speckle removing frost)
Take by weighing Cortex Fraxini 60 grams, Bombyx Batryticatus 60 grams, Folium Mori 30 grams and Cornu Bubali 60 grams add up to 210 grams.Add 800 milliliters in water, with frying in shallow oil the soup into about 200ml, remove slag, filter, reconcentration becomes about 50ml, and decolouring adds 2 gram Margarita albumen powders, mixes thoroughly, promptly gets about 50 milliliters Chinese medicine concentrated solution, and the Chinese medicine concentrated solution contains about crude drug 4 grams for every milliliter, and is standby.
(1) gets emulsifying agent glyceryl monostearate 120 grams, sodium laurylsulfate 2 grams, stearic acid 240 grams, substrate lanoline 20 grams, white vaseline 100 grams, liquid Paraffin 300 grams, antiseptic ethyl hydroxybenzoate 1 gram, heating for dissolving together.
(2) humectant glycerol 200 gram of going bail in addition, stabilizing agent triethanolamine 6 grams, 50 milliliters of Chinese medicine concentrated solutions and distilled water 960 grams are mixed, are heated to 80 ℃.
(3) will (1) add in (2) and stir, treat cold after, add anti-allergic agent dyclonine 1g again, stir evenly, promptly make speckle removing frost 2000 grams, include about Chinese medicine crude drug 200 grams, promptly its concentration is 10%.
Be coated with usage: embrocate the part, every day 2-3 time.
Embodiment 5 treatment cases
One 35 years old female patients, nineteen ninety-five is suffered from arthralgia, facial butterfly-like erythema, photaesthesia, both hands are abound with erythra and maculopapule, and pericardial effusion is arranged, leukopenia, the ANA positive, the anti-Sm antibody positive etc.Diagnosis: systemic lupus erythematosus (sle).Through the Chinese and western drugs combined treatment, the sick mixture of Chinese medicine preparation numbness (being provided by the Shanghai Chinese Medicine Hospital) of taking prednisone and treatment lupus erythematosus is about half a year, pericardial effusion, and leukopenia, arthralgia is all eliminated.Lupus erythematosus is controlled, but the face red spot erythra is not moved back.Prednisone is decrement and inactive gradually.Continue to take the sick mixture of numbness, add Chinese medicine preparation oral medicine speckle removing mixture of the present invention, every day three times, each 30ml.And external Chinese medicine preparation external of the present invention speckle removing frost, every day 2-3 time.Half a year, rear face macule and mottle pigment were all eliminated.Skin on one's body is more delicate than originally.Existing lupus erythematosus is alleviated fully, resumes work already.At present also in after treatment, prevention of recurrence.Long-term Orally taken and externally, skin of face is bright and clean delicate, the non-pigment calmness.
Embodiment 6 treatment cases
One 32 years old female patients, calendar year 2001 is checked and finds the little swollen property erythema of frostbite of face sample because arthralgia is gone to a doctor, maculopapule, assorted have pigmented spots, photaesthesia, it is facial as Beijing opera performer paint face, is difficult to go out.Thrombocytopenia, the ANA positive, anti-dsDNA is weak positive, is diagnosed as systemic lupus erythematosus (sle).The state of an illness is lighter, takes the sick mixture of numbness, adds and takes Chinese medicine preparation oral medicine speckle removing mixture of the present invention, and every day three times, each 30ml puts wiping on the skin with preparation medicine for external use speckle removing frost of the present invention simultaneously, and every day 2-3 time is with treatment lupus erythematosus and face red spot.Do not use any Western medicine, after half a year treatment, be clearly better, after 1 year on the basis that lupus erythematosus is alleviated fully, erythema, erythra disappears fully.Photaesthesia also takes an evident turn for the better, and pigmented spots disappear fully after 2 years, and skin originally also seems pale than before.Treatment now make up a prescription for a long time to consolidate curative effect.
Embodiment 7 treatment cases
One 11 years old female patients, heating in 2000, arthralgia, facial butterfly-like erythema, and maculopapule is arranged, and there is the sunlight face aglow slightly, present the photaesthesia state, the both hands biped also has many maculopapules and edematous erythema.The ANA positive, the anti-Sm antibody positive etc.Be diagnosed as systemic lupus erythematosus (sle).After certain hospital was with prednisone and oxychloroquine treatment, heating, arthralgia were eliminated, and erythema facial, brothers also make moderate progress, but still obviously exist.Since take hormone, moon face, and there is a large amount of acnes at facial chest back.The hospitalization that comes, Western medicine prednisone continue to obey every day 30mg (6), and oxychloroquine is obeyed 300mg (3) every day.Take sick mixture of numbness and Chinese medicine preparation oral medicine speckle removing granule of the present invention again orally, every day three times, each bag (3.5g), the speckle removing of external simultaneously frost, put on the skin 2-3 every day, and Western medicine is kept commercial weight, through treatment half a year, erythema facial, brothers subtract light gradually, and scope is dwindled.Prednisone and oxychloroquine begin decrement.Through treatment in a year, prednisone is reduced to obeyed 15mg every day, and oxychloroquine is stopped using, and face red spot obviously subtracts light, but pigmentation is still obvious.Through treatment in 2 years, face red spot was eliminated fully.Light sunlight has not influenced flushing.Photaesthesia takes an evident turn for the better, and pigmentation and acne are eliminated substantially.Prednisone is reduced to obeys 5mg every day.Now still outpatient service continues treatment to consolidate curative effect.
Embodiment 8 treatment cases
One 22 years old female patients, sunlight one irradiation in annual spring and summer sky is then flush red all over, even whole body is aglow, and gargalesthesia is arranged.Can't out on tours.Be diagnosed as photoallergic dermatitis.Once used hormone therapy, effective during use, still like this after stopping using.Calendar year 2001 rises through using Chinese medicine preparation medicine for external use speckle removing frost of the present invention, every day 2-3 time, and a Chinese medicine preparation speckle removing cutter of the present invention for oral administration simultaneously, every day three times, behind each bag (3.5g), photoallergic dermatitis alleviates year by year, and spring and summer sky solar radiation can not cause flush red all over again after 2 years.Can out on tours and swimming.
Embodiment 9 treatment cases
One 32 years old female patients, the big light crineous pigmentation of lamellar of face in puerperal, and begin to get fat.5 or six years, often use various cosmetics and skincare product, can not eliminate pigment.Rose in 2002 through wiping Chinese medicine preparation speckle removing frost of the present invention after half a year, facial pigmentation subtracts light gradually, and up to elimination, skin of face is more antenatal more delicate.Do not obey any medicine in the therapeutic process.
Embodiment 10 treatment cases
One 42 years old female patients, face often has pigmented spots and erythra, itches slightly, and is 3 or four years, obvious gradually.Often use some cosmetics, skin care item, the commentaries on classics of not getting better.Rose in 2003 through smearing Chinese medicine preparation speckle removing frost of the present invention after 1 year, pigmented spots and erythra subtract light gradually, disappear.
Embodiment 11 treatment cases
One 27 years old female patients, face often has acne, assorted maculopapule is arranged in this year, have an itch, more than 10 jin of weight increase, through smearing speckle removing frost every day 2-3 time and this Chinese medicine preparation speckle removing mixture for oral administration, every day three times is at every turn behind the 30ml.About about 3 months, face was clear substantially, and acne, maculopapule disappear substantially.
Claims (4)
1, a kind of Chinese medicine preparation of skin stain removing and whitening is characterized in that comprising the active ingredient that the Chinese medicine medical material of following row weight portion proportioning is prepared from:
Cortex Fraxini 5-30 part, Bombyx Batryticatus 5-30 part, Folium Mori 3-15 part and Cornu Bubali 5-30 part.
2, the Chinese medicine preparation of skin stain removing and whitening as claimed in claim 1 is characterized in that also including the Margarita albumen powder that weight portion is 0.5-1 part, and mixing becomes the Chinese medicine concentrated solution, contains Chinese medicine crude drug 4 grams in every milliliter of the Chinese medicine concentrated solution.
3, the Chinese medicine preparation of skin stain removing and whitening as claimed in claim 1 is characterized in that described Chinese medicine preparation is mixed with the oral medicine of granule, mixture or capsule.
4, the Chinese medicine preparation of skin stain removing and whitening as claimed in claim 2 is characterized in that described Chinese medicine preparation is mixed with the medicine for external use cream, contains 2.5ml Chinese medicine concentrated solution in per 100 gram cream.
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| CNB2005100244717A CN1320898C (en) | 2005-03-18 | 2005-03-18 | Chinese medicinal preparation for skin stain removing and whitening |
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| CNB2005100244717A CN1320898C (en) | 2005-03-18 | 2005-03-18 | Chinese medicinal preparation for skin stain removing and whitening |
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| CN1320898C true CN1320898C (en) | 2007-06-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813684A (en) * | 2012-07-27 | 2012-12-12 | 上海市中医医院 | Traditional Chinese medicine composition for skin de-speckling and whitening and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1406605A (en) * | 2001-08-30 | 2003-04-02 | 王清纯 | Oral liquid for quick action treating acne and preparation thereof |
| CN1555782A (en) * | 2003-12-30 | 2004-12-22 | 钚 田 | Spot eliminating face washing liquid |
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- 2005-03-18 CN CNB2005100244717A patent/CN1320898C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1406605A (en) * | 2001-08-30 | 2003-04-02 | 王清纯 | Oral liquid for quick action treating acne and preparation thereof |
| CN1555782A (en) * | 2003-12-30 | 2004-12-22 | 钚 田 | Spot eliminating face washing liquid |
Non-Patent Citations (1)
| Title |
|---|
| 系统性红斑狼疮辨证治疗体会 谢孔缓 蒋旭华，四川中医，第18卷第1期 2000 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813684A (en) * | 2012-07-27 | 2012-12-12 | 上海市中医医院 | Traditional Chinese medicine composition for skin de-speckling and whitening and application thereof |
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| CN1686247A (en) | 2005-10-26 |
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