CN1307253C - Chitosan water-retaining gel adhesive substrate materials and method for preparing same - Google Patents
Chitosan water-retaining gel adhesive substrate materials and method for preparing same Download PDFInfo
- Publication number
- CN1307253C CN1307253C CNB2005100490389A CN200510049038A CN1307253C CN 1307253 C CN1307253 C CN 1307253C CN B2005100490389 A CNB2005100490389 A CN B2005100490389A CN 200510049038 A CN200510049038 A CN 200510049038A CN 1307253 C CN1307253 C CN 1307253C
- Authority
- CN
- China
- Prior art keywords
- solution
- chitosan
- polyvinyl alcohol
- polyvinylpyrrolidone
- natvosol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a chitosan water-retaining gel adhesive substrate material and a preparation method thereof. The chitosan water-retaining gel adhesive substrate material comprises the components of the following weight percentage content: 2.4 to 16 wt% of chitosan, 1.9 to 18 wt% of Na2HPO4*12H2O, 1.9 to 18 wt% of hydroxyethyl cellulose, 15 to 80 wt% of polyvinyl alcohol, 0.79 to 21 wt% of polyethyleneglycol, 0.54 to 56 wt% of glycerol, 0.44 to 35 wt% of tweenm 0.25 to 24 wt% of polyvinylpyrrolidone and 0.20 to 8.9 wt% of menthol. The preparation method comprises: the solution of the chitosan, ethanol and acetate, a polyvinyl alcohol solution containing Na2HPO4*12H2O, the hydroxyethyl cellulose and the polyvinylpyrrolidone, and a polyethyleneglycol solution containing the glycerol, the tween and the solution of the menthol and ethanol are mixed, and are coated, cut and separately packed. The material has the advantages of simple technology, good water-retaining performance, good medicine penetration performance, no skin anaphylactic reaction, low price, convenient use, etc.
Description
Technical field
The present invention relates to chitosan hydrogel adhibit agent host material and preparation method thereof.
Background technology
Patch is the important component part of China's traditional medicine, and the history in existing more than 2000 year has the incomparable advantage of other formulations, and is easy to use, sustainable administration, also interruption of the administration at any time.But traditional patch mainly with the rubber plaster as substrate material, this substrate material approaches greatly in appearance, its shortcoming is that active drug containing amount is little, airtight, the drug transdermal weak effect, easily stimulate irritated, can't alleviate the efficacy of a drug, viscosity can not be regulated and control, and generally, limited the development of patch dramatically only with the load fat-soluble medicine.Traditional gel adhesive, the matrix content height, water-retaining capacity is little.
Summary of the invention
The objective of the invention is for overcoming the problems referred to above that patch and conventional gel exist, and a kind of chitosan hydrogel adhibit agent host material and preparation method thereof is provided.
Chitosan hydrogel adhibit agent host material of the present invention, its component and weight percent content are:
Chitosan 2.4-16
Disodium hydrogen phosphate dodecahydrate 1.9-18
Natvosol 1.9-18
Polyvinyl alcohol 15-80
Polyoxyethylene glycol 0.79-21
Glycerine 0.54-56
Tween 0.44-35
Polyvinylpyrrolidone 0.25-24
Mentha camphor 0.20-8.9
The summation of said components equals 100%.
The preparation method of chitosan hydrogel adhibit agent host material may further comprise the steps:
1) preparation 0.5-1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 7-15% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 10-25% (m/v) in the pure water;
4) be 20% (m/v) mentha camphor ethanolic soln with the dehydrated alcohol compound concentration;
5) according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: (0.7-1.3), determine the use volume of polyvinyl alcohol solution, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: (1-5) determining the use volume of polyglycol solution, is chitosan according to weight percent: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: (0.8-1.2): (0.8-1.2): the weight of (0.1-2) determining disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: (0.1-2): (0.1-1): (0.25-1), glycerine, tween, mentha camphor ethanolic soln are joined in the polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Among the present invention, employed chitosan specification is: the range of viscosities that deacetylation 〉=85% chitosan is dissolved in 1% (v/v) acetic acid solution is: 400-600mPaS; Use the medium-viscosity Natvosol; The polyvinyl alcohol that uses there is not particular requirement, good with polyvinyl alcohol 124 results of use; Polyoxyethylene glycol can be a polyethylene glycol 6000, polyoxyethylene glycol 8000 or cetomacrogol 1000 0; Polyvinylpyrrolidone can adopt polyvinylpyrrolidone K30; Tween can be polysorbas20 or tween 80, and is good with the tween 80 result of use.
Chitosan hydrogel adhibit agent host material of the present invention, rely on electrostatic force, hydrophobic interaction and hydrogen bond action generation crosslinked with chitosan, disodium hydrogen phosphate dodecahydrate, Natvosol, with the polyvinyl alcohol is membrane-forming agent, glycerine, polyoxyethylene glycol are softening agent, tween is a thickening material, polyvinylpyrrolidone is tackifier, and the mentha camphor ethanolic soln is a Percutaneous absorption enhancer, works to improve the smell of gel simultaneously.Include a large amount of moisture in the gelling system, can make skin surface hydration, the effective ingredient in the matrix can successfully see through skin and enter in the body.Can add food dye and essence in the chitosan water-keeping gel simultaneously, to improve user's acceptability.
Preparation method of the present invention adopts the physical property crosslinking method to form gel, make whole gelling system form stable structure, can contain a large amount of moisture and medicine, comprise fat-soluble and water soluble drug, become not have in the glue process new material to generate simultaneously, make whole gelling system possess validity, security.Substrate material adopts the hydrophilic macromolecule material, with the skin good biocompatibility, possesses water retention property efficiently, not sensitization, have no side effect, can not draw pain skin yet.Therefore, this hydrogel can solve the deficiency of traditional patch, expands the range of application of patch.
Beneficial effect of the present invention is: 1. technology is simple, and is easy to operate; 2. the pharmaceutical pack capacity is big, and transdermal effect is good; 3. good water-retaining property, substrate material and skin good biocompatibility, sensitization does not have no side effect, and may command viscosity can not drawn pain skin.
Embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
The component of chitosan hydrogel adhibit agent host material and weight percent content are: chitosan 6.49, disodium hydrogen phosphate dodecahydrate 6.49, Natvosol 6.49, polyvinyl alcohol 43.29, polyoxyethylene glycol 6.49, glycerine 13.64, tween 11.70, polyvinylpyrrolidone 4.33, mentha camphor 1.08.
The raw material that adopts in this example: chitosan: deacetylation 90.1%, viscosity 430mPaS; Natvosol: the about 1500mPaS of viscosity (5% concentration in the aqueous solution); Polyvinyl alcohol 124; Polyoxyethylene glycol 8000; Tween 80; Polyvinylpyrrolidone K30, biochemical reagents; Disodium hydrogen phosphate dodecahydrate, analytical pure; Glycerine, analytical pure; Mentha camphor, pharmaceutical grade.
Its preparation method is as follows:
1) preparation 1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 10% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 20% (m/v) in the pure water;
4) with dehydrated alcohol preparation 20% (m/v) mentha camphor ethanolic soln;
5) get the 40ml chitosan solution, according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: 1, the volume that uses of determining polyvinyl alcohol solution is 40ml, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: 3, the volume that uses of determining polyglycol solution is 3ml, according to weight percent is chitosan: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: 1: 1: 0.67, determine that disodium hydrogen phosphate dodecahydrate is that 0.6 gram, Natvosol 0.6 restrain, polyvinylpyrrolidone is 0.4 gram;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: 0.67: 0.67: 0.33,1ml glycerine, 1ml tween, 0.5ml mentha camphor ethanolic soln are joined in the 3ml polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Embodiment 2:
The component of chitosan hydrogel adhibit agent host material and weight percent content are: chitosan 11.77, disodium hydrogen phosphate dodecahydrate 11.77, Natvosol 11.77, polyvinyl alcohol 43.93, polyoxyethylene glycol 1.37, glycerine 8.65, tween 7.41, polyvinylpyrrolidone 1.96, mentha camphor 1.37.
The raw material that adopts in this example: chitosan: deacetylation 89%, viscosity 500mPaS; Natvosol: the about 1500mPaS of viscosity (5% concentration in the aqueous solution); Polyvinyl alcohol 124; Polyethylene glycol 6000; Polysorbas20; Polyvinylpyrrolidone K30, biochemical reagents; Disodium hydrogen phosphate dodecahydrate, analytical pure; Glycerine, analytical pure; Mentha camphor, pharmaceutical grade.
Its preparation method is as follows:
1) preparation 1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 8% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 10% (m/v) in the pure water;
4) with dehydrated alcohol preparation 20% (m/v) mentha camphor ethanolic soln;
5) get the 40ml chitosan solution, according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: 0.7, the volume that uses of determining polyvinyl alcohol solution is 28ml, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: 1, the volume that uses of determining polyglycol solution is 0.7ml, according to weight percent is chitosan: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: 1: 1: 0.17, determine that disodium hydrogen phosphate dodecahydrate is that 0.6 gram, Natvosol 0.6 restrain, polyvinylpyrrolidone is 0.1 gram;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: 1: 1: 1,0.35ml glycerine, 0.35ml tween, 0.35ml mentha camphor ethanolic soln are joined in the 0.7ml polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Embodiment 3:
The component of chitosan hydrogel adhibit agent host material and weight percent content are: chitosan 3.30, disodium hydrogen phosphate dodecahydrate 3.30, Natvosol 3.30, polyvinyl alcohol 34.34, polyoxyethylene glycol 7.15, glycerine 22.54, tween 19.32, polyvinylpyrrolidone 4.96, mentha camphor 1.79.
The raw material that adopts in this example: chitosan: deacetylation 91%, viscosity 560mPaS; Natvosol: the about 1500mPaS of viscosity (5% concentration in the aqueous solution); Polyvinyl alcohol 124; Cetomacrogol 1000 0; Tween 80; Polyvinylpyrrolidone K30, biochemical reagents; Disodium hydrogen phosphate dodecahydrate, analytical pure; Glycerine, analytical pure; Mentha camphor, pharmaceutical grade.
Its preparation method is as follows:
1) preparation 1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 12% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 20% (m/v) in the pure water;
4) with dehydrated alcohol preparation 20% (m/v) mentha camphor ethanolic soln;
5) get the 40ml chitosan solution, according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: 1.3, the volume that uses of determining polyvinyl alcohol solution is 52ml, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: 5, the volume that uses of determining polyglycol solution is 6.5ml, according to weight percent is chitosan: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: 1: 1: 1.5, determine that disodium hydrogen phosphate dodecahydrate is that 0.6 gram, Natvosol 0.6 restrain, polyvinylpyrrolidone is 0.9 gram;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: 1: 1: 0.5,3.25ml glycerine, 3.25ml tween, 1.63ml mentha camphor ethanolic soln are joined in the 6.5ml polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Embodiment 4:
The component of chitosan hydrogel adhibit agent host material and weight percent content are: chitosan 6.19, disodium hydrogen phosphate dodecahydrate 6.19, Natvosol 6.19, polyvinyl alcohol 32.98, polyoxyethylene glycol 4.12, glycerine 25.98, tween 11.13, polyvinylpyrrolidone 6.19, mentha camphor 1.03.
The raw material that adopts in this example: chitosan: deacetylation 90.1%, viscosity 430mPaS; Natvosol: the about 1500mPaS of viscosity (5% concentration in the aqueous solution); Polyvinyl alcohol 124; Polyoxyethylene glycol 8000; Polysorbas20; Polyvinylpyrrolidone K30, biochemical reagents; Disodium hydrogen phosphate dodecahydrate, analytical pure; Glycerine, analytical pure; Mentha camphor, pharmaceutical grade.
Its preparation method is as follows:
1) preparation 1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 8% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 20% (m/v) in the pure water;
4) with dehydrated alcohol preparation 20% (m/v) mentha camphor ethanolic soln;
5) get the 40ml chitosan solution, according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: 1, the volume that uses of determining polyvinyl alcohol solution is 40ml, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: 2, the volume that uses of determining polyglycol solution is 2ml, according to weight percent is chitosan: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: 1: 1: 1, determine that disodium hydrogen phosphate dodecahydrate is that 0.6 gram, Natvosol 0.6 restrain, polyvinylpyrrolidone is 0.6 gram;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: 2: 1: 0.5,2ml glycerine, 1ml tween, 0.5ml mentha camphor ethanolic soln are joined in the 2ml polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
Claims (4)
1. chitosan hydrogel adhibit agent host material is characterized in that its component and weight percent content are:
Chitosan 2.4-16
Disodium hydrogen phosphate dodecahydrate 1.9-18
Natvosol 1.9-18
Polyvinyl alcohol 15-80
Polyoxyethylene glycol 0.79-21
Glycerine 0.54-56
Tween 0.44-35
Polyvinylpyrrolidone 0.25-24
Mentha camphor 0.20-8.9
The summation of said components equals 100%.
2. the preparation method of chitosan hydrogel adhibit agent host material according to claim 1 is characterized in that may further comprise the steps:
1) preparation 0.5-1.0% (v/v) ethanol 0.5% (v/v) acetic acid aqueous solution system, with this solution system dissolving chitosan, compound concentration is the chitosan solution of 1.5% (m/v);
2) polyvinyl alcohol is dissolved in compound concentration is the polyvinyl alcohol solution of 7-15% (m/v) in the hot pure water, it is standby to be cooled to room temperature;
3) polyoxyethylene glycol is dissolved in is mixed with the polyglycol solution that concentration is 10-25% (m/v) in the pure water;
4) be 20% (m/v) mentha camphor ethanolic soln with the dehydrated alcohol compound concentration;
5) according to chitosan solution and polyvinyl alcohol solution with volume ratio 1: (0.7-1.3), determine the use volume of polyvinyl alcohol solution, according to polyvinyl alcohol solution and polyglycol solution volume ratio is 40: (1-5) determining the use volume of polyglycol solution, is chitosan according to weight percent: disodium hydrogen phosphate dodecahydrate: Natvosol: polyvinylpyrrolidone=1: (0.8-1.2): (0.8-1.2): the weight of (0.1-2) determining disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone;
6) above-mentioned disodium hydrogen phosphate dodecahydrate, Natvosol, polyvinylpyrrolidone are joined in the polyvinyl alcohol solution, mix;
7) press polyglycol solution, glycerine, tween, mentha camphor ethanolic soln with following volume ratio 2: (0.1-2): (0.1-1): (0.25-1), glycerine, tween, mentha camphor ethanolic soln are joined in the polyglycol solution and go, mix;
8) mixing solutions with step 7) joins in the mixing solutions of step 6), mixes;
9) mixing solutions with step 8) joins in the step 1) chitosan solution, mixes, and coating is cut, and packing gets final product.
3. the preparation method of chitosan hydrogel adhibit agent host material according to claim 2, it is characterized in that employed chitosan is: the range of viscosities that deacetylation 〉=85% chitosan is dissolved in 1% (v/v) acetic acid solution is: 400-600mPaS.
4. the preparation method of chitosan hydrogel adhibit agent host material according to claim 2 is characterized in that said polyoxyethylene glycol is a polyethylene glycol 6000, polyoxyethylene glycol 8000 or cetomacrogol 1000 0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100490389A CN1307253C (en) | 2005-02-03 | 2005-02-03 | Chitosan water-retaining gel adhesive substrate materials and method for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100490389A CN1307253C (en) | 2005-02-03 | 2005-02-03 | Chitosan water-retaining gel adhesive substrate materials and method for preparing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1663999A CN1663999A (en) | 2005-09-07 |
| CN1307253C true CN1307253C (en) | 2007-03-28 |
Family
ID=35035323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100490389A Expired - Fee Related CN1307253C (en) | 2005-02-03 | 2005-02-03 | Chitosan water-retaining gel adhesive substrate materials and method for preparing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1307253C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101525541B (en) * | 2008-03-04 | 2010-10-06 | 钟维安 | Soil stabilizing and curing agent |
| CN101926833B (en) * | 2010-08-06 | 2012-01-04 | 云南白药集团无锡药业有限公司 | Hydrogel patch and preparation method thereof |
| CN105030659A (en) * | 2015-06-16 | 2015-11-11 | 贵州大学 | Gel for body surface wound and preparation method of gel |
| CN106474529B (en) * | 2015-08-28 | 2019-05-28 | 贵州扬生医用器材有限公司 | A kind of hemostasis adhesive of the body containing amino acid lipids and preparation method thereof |
| CN108113963A (en) * | 2017-12-28 | 2018-06-05 | 仙居优亿医疗器械有限公司 | A kind of Dispoable medical hydrogel eye plaster and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1098931B1 (en) * | 1998-07-17 | 2002-10-09 | Kemestrie Inc. | Polyionic hydrogels based on xanthan and chitosan for stabilising and controlled release of vitamins |
| CN1389503A (en) * | 2002-07-15 | 2003-01-08 | 浙江大学 | In-situ compounding process of synthesizing nano composite chitosan/hydroxyapatite material |
| CN1422668A (en) * | 2001-11-29 | 2003-06-11 | 浙江大学 | Medical micro porouse chitoglycan asymmetric film and preparation method thereof |
| JP2004217933A (en) * | 2003-01-09 | 2004-08-05 | Jakwang Co Ltd | Water-soluble natural film and its manufacturing method |
-
2005
- 2005-02-03 CN CNB2005100490389A patent/CN1307253C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1098931B1 (en) * | 1998-07-17 | 2002-10-09 | Kemestrie Inc. | Polyionic hydrogels based on xanthan and chitosan for stabilising and controlled release of vitamins |
| CN1422668A (en) * | 2001-11-29 | 2003-06-11 | 浙江大学 | Medical micro porouse chitoglycan asymmetric film and preparation method thereof |
| CN1389503A (en) * | 2002-07-15 | 2003-01-08 | 浙江大学 | In-situ compounding process of synthesizing nano composite chitosan/hydroxyapatite material |
| JP2004217933A (en) * | 2003-01-09 | 2004-08-05 | Jakwang Co Ltd | Water-soluble natural film and its manufacturing method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1663999A (en) | 2005-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20220339096A1 (en) | Compositions and Methods For the Delivery of Agents | |
| CN101885853B (en) | Cured cross-linked glutinous rice flour hydrogel, preparation method and application thereof | |
| CN101889958B (en) | Freeze-dried composition | |
| CN1307253C (en) | Chitosan water-retaining gel adhesive substrate materials and method for preparing same | |
| KR20080014461A (en) | Cosmetic transdermal patch | |
| TW201034693A (en) | Gel sheet for cosmetic patching | |
| EP2237772A2 (en) | Method and multilayered device for controlled topical delivery of therapeutic agents to the skin | |
| KR20070008676A (en) | Crosslinkable pressure-sensitive adhesive for the skin | |
| US11801373B1 (en) | Insoluble transdermal microneedle patch, and preparation method therefor and application thereof | |
| CN115531293A (en) | Micro-emulsified high-viscosity stable gel plaster matrix and preparation method thereof | |
| CN103126975B (en) | Preparation method of hydrogel patch substrate with gradient drug concentration | |
| CN100469367C (en) | Transdermal preparations comprising eperisone, tolperisone or salts thereof | |
| CN107049930B (en) | Wound healing promoting gel and preparation method thereof | |
| CN101229146B (en) | Chitosan and polyvinyl alcohol compound cataplasm matrix and preparing method thereof | |
| CN1883450A (en) | A hydrophilic gel plaster substrate | |
| WO2010115426A1 (en) | Skin care compositions for the delivery of agents | |
| CN102258469B (en) | Oxybutynine ethosomal composition and preparation method thereof | |
| CN105534880B (en) | A kind of PVA/TA- β-CD composite hydrogels and its matrix and preparation method | |
| CN1552308A (en) | Nano spectrum endermatic medicinal paste and its preparation | |
| CN1159070C (en) | Preparation of high molecular gel stick agent | |
| CN115006337B (en) | Double-layer hydrophilic gel patch for repairing skin wound surface and preparation method thereof | |
| CN109498698A (en) | A kind of skin gel application production method of the anti-onychomycosis of targeting | |
| CN103893394A (en) | Ethosome gel film-coating agent with multiple wound repair effects and preparation method of ethosome gel film-coating agent | |
| JPS63160661A (en) | Surgical composition | |
| CN101254215A (en) | Preparing method of Chinese medicine catablasm base material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070328 Termination date: 20130203 |