CN1159070C - Preparation of high molecular gel stick agent - Google Patents
Preparation of high molecular gel stick agent Download PDFInfo
- Publication number
- CN1159070C CN1159070C CNB011065885A CN01106588A CN1159070C CN 1159070 C CN1159070 C CN 1159070C CN B011065885 A CNB011065885 A CN B011065885A CN 01106588 A CN01106588 A CN 01106588A CN 1159070 C CN1159070 C CN 1159070C
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- CN
- China
- Prior art keywords
- gel
- agent
- high molecular
- pigment solution
- edible pigment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 238000002360 preparation method Methods 0.000 title claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 34
- 239000003814 drug Substances 0.000 claims abstract description 23
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 229920002472 Starch Polymers 0.000 claims abstract description 9
- 239000000049 pigment Substances 0.000 claims abstract description 9
- 239000008107 starch Substances 0.000 claims abstract description 9
- 235000019698 starch Nutrition 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 9
- 230000000149 penetrating effect Effects 0.000 claims abstract description 8
- 150000002978 peroxides Chemical class 0.000 claims abstract description 5
- 239000004568 cement Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 238000007664 blowing Methods 0.000 claims description 3
- 238000005520 cutting process Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 241000238876 Acari Species 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 12
- 239000000853 adhesive Substances 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract description 3
- 208000003455 anaphylaxis Diseases 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 239000003292 glue Substances 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 239000012190 activator Substances 0.000 abstract 2
- 230000035515 penetration Effects 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- 229920000715 Mucilage Polymers 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 229940044949 eucalyptus oil Drugs 0.000 abstract 1
- 239000010642 eucalyptus oil Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 25
- 239000004480 active ingredient Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000000017 hydrogel Substances 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 206010070834 Sensitisation Diseases 0.000 description 2
- 230000036783 anaphylactic response Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000010559 graft polymerization reaction Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Images
Abstract
The present invention relates to a method for preparing a high molecular gel sticking agent, which comprises: firstly, uniformly stirred gel mucilage with controlled temperature is added into starch class water keeping agent gel containing activators in three times in a stirring mode and then is uniformly mixed with edible pigment solution to react for two hours, and after the temperature is decreased, medicines and skin penetration promoting agents are added in sequence in a stirring mode; finally, the high molecular gel sticking agent is obtained through material discharge with heat preserved, coating, slitting and packaging. The high molecular gel sticking agent comprises hydrophilic gel glue, edible pigment solution, starch class water keeping agent gel, eucalyptus oil Chinese medicine penetration promoting agents, peroxide activators and extracted ingredients of natural medicines. The method of the present invention has the advantages of simple technology, favorable medicine penetrating properties of the product, no anaphylactic reaction between the product and skin, etc.
Description
Technical field
The present invention is a kind of method for making of high molecular gel stick agent.
Background technology
Patch is one of China's traditional medicine four big dosage forms, the history in existing more than 2000 year, and its clinical practice is just on the books, lasting over the past thousands of years in " 52 Bingfang " that be unearthed in the Mawangdui.But traditional patch adopts rubber plaster as host material mostly, the shortcoming of this substrate be airtight, be easy to generate sensitization.And generally can only load fat-soluble medicine composition, have significant limitation, can only contain medication amount on a small quantity, main is that its transdermal absorption factor is low, is difficult to reach ideal curative effect.Second filial generation PVC host material has improved air permeable effect, but is not solved for problems such as pharmaceutical pack capacity, Transdermal absorption at all.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned deficiency, a kind of method for making of high molecular gel stick agent is provided, this manufacture method is not only simple and practical, and the gel adhesive product that according to said method produces, but not only solved traditional patch substrate carrying medicament kind and reached problems such as transdermal absorption factor is low less, and overcome traditional rubber patch and the skin affinity is poor, zest is arranged, easily produce disadvantages such as too strong, the easy-to-draw pain skin of anaphylaxis and viscosity.This gel can be used as the host material of patch of new generation, for domestic other patch manufacturer model changes provide reliable guarantee.
The technical solution adopted for the present invention to solve the technical problems is: described gel adhesive, its weight percentages of components is respectively hydrophilic gel glue 78-90, edible pigment solution 0.1--0.3, starch based water-retaining agent gel 5--13, Oleum Eucalypti Chinese medicine penetrating agent 1--4, peroxide exciting agent 0.02--0.03, natural drug extraction component 3--5.The method of producing this gel adhesive is: the gel rubber cement that elder generation stirs evenly temperature control, under stirring condition, divide three minor ticks to add the starch based water-retaining agent gel that contains exciting agent; After 1 hour, add edible pigment solution, make it mixing, reaction two hours, again cooling; Then, under stirring condition, successively natural drug extract and Chinese medicine transdermal penetrating agent are added in the liquid after the cooling, stirred 1 hour; At last, after being incubated blowing, being coated with, cutting and pack, promptly get product.
Advantage of the present invention is: the one, and technology is simple, is convenient to operation.The 2nd, by the product that method provided by the invention is produced, not only active ingredient containing amount is big, can reach tens times of traditional patch, and fat-soluble, water solublity active ingredient all can contain, and has expanded the scope of application of patch greatly.The 3rd, this product has suction efficiently, slow release and water retention property, can be used as the host material of patch of new generation.The 4th, extremely similar because of the macromolecular scaffold of this product to skin texture, thereby can farthest solve the Transdermal absorption problem of active ingredient.The 5th, this product good biocompatibility, not sensitization, have no side effect, overcome traditional rubber patch and skin affinity poor, zest arranged, easily produce shortcomings such as too strong, the easy-to-draw pain skin of anaphylaxis and viscosity.
Description of drawings
Accompanying drawing is a technological process block diagram of the present invention.
The specific embodiment
The invention will be further described below in conjunction with embodiment and accompanying drawing.
Embodiment:
Technological process provided by the invention is as shown in drawings: the gel rubber cement that 80 ℃ of temperature controls are stirred evenly earlier, and under the stirring condition of 80 commentariess on classics/min, divides three times and add the starch based water-retaining agent gel that contains exciting agent, the interval is 20 minutes at every turn.Add the edible pigment solution mixing after 1 hour.Reacted two hours, and cooled the temperature to 70 ℃, the mixing speed of agitator is 80 commentaries on classics/min, successively adds natural drug extract and Chinese medicine transdermal penetrating agent.Stirred 1 hour, and after being incubated blowing, being coated with, cutting and pack, promptly got product.
The gel adhesive of producing according to the method described above, its component and weight percent are such as shown in the subordinate list, comprise: hydrophilic gel rubber cement 78--90, edible pigment solution 0.1--0.3, starch based water-retaining agent gel 5--13, Oleum Eucalypti Chinese medicine penetrating agent 1--4, peroxide exciting agent 0.02--0.03, natural drug extraction component 3--5.
Four kinds of schemes are arranged in the subordinate list, and result of use is all good.
In the said components, the hydrophilic macromolecule gel belongs to the drug carrier material in the medical macromolecular materials, and strictness should belong to functional high molecule material in fact.Can be widely used in excipient substance or controlled release, slow release, targeting vector.
With hydrophilic polymer (as PVA) or natural gum class (as pectin) is that the preparation that framework material is made is called the aquogel type skeleton preparation, this material is attached to skin surface generation hydration and generates gel, because the barrier effect of gel, the rate of release of control active substance, select the material of different performance and the ratio between the active substance consumption etc., the rate of release of scalable preparation.The material that can prepare hydrogel is a lot, and the skeleton of polyvinyl alcohol hydrogel type is through moistening formation hydrogel layer, make the active substance stripping, gel layer continues aquation, and skeleton expands, gel layer thickens, and has delayed the release of active ingredient, and active ingredient at this moment can discharge by the hydrogel layer diffusion.
Above-mentioned gel adhesive, the major ingredient of its substrate is a polyvinyl alcohol, with this large-scale linear polymeric material mixed with water after, add certain amount of dispersant, the viscosifier and the agent etc. that balances each other, and under certain temperature and pressure condition, carry out graft polymerization reaction, make it form netted high-molecular gel system, this gel rubber system water content height, active ingredient containing amount is big, connect closely, can combine closely with skin, make keratodermatitis become gel state under water function, the active ingredient of being contained in the gel-type vehicle can see through skin absorbs smoothly and enter human body.And can with multiple different classes of drug loading to this kind carrier, carry out transdermal administration.
Subordinate list
Claims (2)
1. high molecular gel stick agent, contain Oleum Eucalypti Chinese medicine penetrating agent, starch based water-retaining agent gel, it is characterized in that described patch also comprises the hydrophilic gel rubber cement, edible pigment solution, peroxide exciting agent and natural drug extraction component, the percentage by weight of each component is respectively: hydrophilic gel rubber cement 78～90, edible pigment solution 0.1～0.3, starch based water-retaining agent gel 5～13, Oleum Eucalypti Chinese medicine penetrating agent 1～4, peroxide exciting agent 0.02～0.03, natural drug extraction component 3～5
The preparation method of above-mentioned patch is: 80 ℃ the gel rubber cement that elder generation stirs evenly temperature control, and under the agitator stirring condition of 80 commentaries on classics/min, divide three minor ticks to add the starch based water-retaining agent gel that contains exciting agent, be 20 minutes each blanking time; After 1 hour, add edible pigment solution, make it mixing, reaction two hours, again cooling; Then, under stirring condition, successively natural drug extract and Chinese medicine transdermal penetrating agent are added in the liquid after the cooling, stirred 1 hour; At last, after being incubated blowing, being coated with, cutting and pack, promptly get product.
2. high molecular gel stick agent according to claim 2 is characterized in that the liquid after the described cooling, and its temperature is 70 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011065885A CN1159070C (en) | 2001-03-30 | 2001-03-30 | Preparation of high molecular gel stick agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011065885A CN1159070C (en) | 2001-03-30 | 2001-03-30 | Preparation of high molecular gel stick agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1314189A CN1314189A (en) | 2001-09-26 |
| CN1159070C true CN1159070C (en) | 2004-07-28 |
Family
ID=4655581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011065885A Expired - Lifetime CN1159070C (en) | 2001-03-30 | 2001-03-30 | Preparation of high molecular gel stick agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1159070C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294899C (en) * | 2004-01-20 | 2007-01-17 | 北京金维元医药技术开发公司 | Black soya bean oil contained compound gelling agent |
| US7811503B2 (en) * | 2007-04-18 | 2010-10-12 | Coopervision International Holding Company, Lp | Devices, assemblies, and methods for extracting extractable materials from polymerized biomedical devices |
| CN101947322B (en) * | 2010-09-03 | 2012-07-04 | 南方医科大学 | Gel patch matrix and preparation method and application thereof |
| CN107343882A (en) * | 2016-05-06 | 2017-11-14 | 山西海清医疗器械有限公司 | A kind of super large drugloading rate hydrogel patch and preparation method thereof |
-
2001
- 2001-03-30 CN CNB011065885A patent/CN1159070C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1314189A (en) | 2001-09-26 |
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Address after: 519020 Guangdong province Zhuhai Sanzao Science Park Airport Road No. 697 Patentee after: ZHUHAI GUOJIA NEW MATERIAL CO., LTD. Address before: 519020 Guangdong province Zhuhai Sanzao Science Park Airport Road No. 697 Patentee before: Zhuhai State-kai Polymer and New Materials Co., Ltd. |
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