CN107343882A - A kind of super large drugloading rate hydrogel patch and preparation method thereof - Google Patents

A kind of super large drugloading rate hydrogel patch and preparation method thereof Download PDF

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CN107343882A
CN107343882A CN201610294697.7A CN201610294697A CN107343882A CN 107343882 A CN107343882 A CN 107343882A CN 201610294697 A CN201610294697 A CN 201610294697A CN 107343882 A CN107343882 A CN 107343882A
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gel
drug containing
loss reducer
medicine
hydrogel patch
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吴震东
郝烈爱
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Shanxi sea Qingyuan Biological Technology Co. Ltd.
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Shanxi Hai Qing Medical Instrument Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

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Abstract

The present invention discloses a kind of super large drugloading rate hydrogel patch and preparation method thereof, is related to hydrogel patch field.Super large drugloading rate hydrogel patch, its raw material by mass percentage, including：Drug containing hydrophilic gel 35 45%, drug containing starch water-loss reducer gel 25 35%, medical herb slurry 15 25%, surfactant 0.03 0.06%, tartaric acid 0.2 0.25%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.1 0.2%, glycerine and Sodium Polyacrylate are pre-dissolved with 24:The mixture 7 12% of 1 ratio mixing.The invention further relates to the preparation method of above-mentioned hydrogel patch, obtained hydrogel patch drugloading rate reaches more than the 35% of patch gross mass, and its carrying medicament species is more, medicine pardon is strong, drugloading rate is big；The high-water performance of the hydrogel patch promotes keratoderma water to be multiplied, and is expanded into porous state, it is easier to which medicine penetrates, its good, long action time of drug release property.

Description

A kind of super large drugloading rate hydrogel patch and preparation method thereof
Technical field
The present invention relates to hydrogel patch field, especially a kind of super large drugloading rate hydrogel patch and preparation method thereof.
Background technology
Traditional ointment plaster can only typically load fat-soluble medicine composition mostly using rubber plaster as medium carrier, and medication has larger limitation, affect the treatment and the course for the treatment of, and Transdermal absorption effect is poor and easily produces allergic.Macromolecule hydrogel is the optimal carrier of medical tape preparation, and traditional plaster uses hydrogel matrix instead as carrier, not only good penetrability, and without allergic and stimulation, sticking more comfortable.But, because traditional plaster uses Chinese medicine preparation mostly, drugloading rate is very big, generally more than the 30% of gross mass, even more than 35%, and more than 20% of medicine capacity less than sole mass of load of hydrogel at present, therefore, its application is only confined to defervescence plaster used, adhesive bandage and wound dressing patch etc. not in medicated patches product, objectively limits extensive use of the hydrogel matrix as load medicine body.
The content of the invention
To solve the problems, such as that existing hydrogel load medicine capacity is small, the present invention provides a kind of super large drugloading rate hydrogel patch and preparation method thereof.
In order to solve the above technical problems, the technical solution adopted in the present invention is：
A kind of super large drugloading rate hydrogel patch, its raw material by mass percentage, including：Drug containing hydrophilic gel 35-45%, drug containing starch water-loss reducer gel 25-35%, medical herb slurry 15-25%, surfactant 0.03-0.06%, tartaric acid 0.2-0.25%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.1-0.2%, glycerine and Sodium Polyacrylate are pre-dissolved with 2-4:The mixture 7-12% of 1 ratio mixing；Wherein, drug containing hydrophilic gel includes hydrophilic gel 65-75%, medicine 20-30%, bleeding agent 4-6%；The hydrophilic gel is made up of following components：Carbomer 3-6%, gelatin 1-3%, pharmaceutical extraction thing 20-30%, deionized water 63-73%；Drug containing starch water-loss reducer gel includes：Starch water-loss reducer gel 75-85%, medicine 10-20%, bleeding agent 2-6%；The starch water-loss reducer gel is made up of following components：Carboxymethyl cellulose 5-15%, pectin 0.5-1%, pharmaceutical extraction thing 10-20%, deionized water 70-80%, 0.03-0.04% exciting agent；Medical herb slurry is pre-dissolved to be made up of following components：Pharmaceutical extraction thing 80-90%, three potassium sorbate 0.4-0.6%, dimethyl sulfoxide (DMSO) 3-5%, deionized water 6-15%.
The invention further relates to the preparation method of above-mentioned super large drugloading rate hydrogel patch, comprise the following steps：A, medicine is added into hydrophilic gel respectively, medicine and exciting agent are added in starch water-loss reducer gel, is stirred for the first time under normal temperature, two kinds of gels is fully carried medicine respectively；Bleeding agent is added into two kinds of gels respectively again, is stirred for the second time under normal temperature, respectively obtains drug containing hydrophilic gel, drug containing starch water-loss reducer gel；B, by drug containing hydrophilic gel, drug containing starch water-loss reducer gel and be pre-dissolved medical herb slurry be mixed in agitator, third time stir after, for the first time stand reaction；Surfactant, tartaric acid solution are successively added, reaction is stood second after stirring for the 4th time；Mixture, the Dihydroxyaluminium Aminoacetate solution crosslinking auxiliary agent of glycerine and Sodium Polyacrylate are added, after vacuumizing after the 5th stirring reaction certain time, blowing, coating, cutting at normal temperatures is packed.
Beneficial effects of the present invention：
The present invention uses two kinds of matrix, three kinds of main components altogether, first it is separately added into medicine, after each being acted on medicine, remix and further reacted, obtained hydrogel patch drugloading rate reaches more than the 35% of patch gross mass, not only possesses that the distinctive good moldability of common macromolecule hydrogel patch, tough elasticity are good, drug release property is good, it is comfortable to stick, easily take off noresidue, be non-stimulated, without allergy, and carrying medicament species is more, medicine pardon is strong, drugloading rate is big；The high-water performance of the hydrogel patch promotes keratoderma water to be multiplied, and is expanded into porous state, it is easier to which medicine penetrates, its good, long action time of drug release property.
Embodiment
With reference to specific embodiment, the invention will be further described.
The preparation method of super large drugloading rate hydrogel patch in embodiment, comprises the following steps：
A, medicine is added into hydrophilic gel respectively, medicine and exciting agent are added in starch water-loss reducer gel, is stirred for the first time under normal temperature, two kinds of gels is fully carried medicine respectively；Bleeding agent is added into two kinds of gels respectively again, is stirred for the second time under normal temperature, respectively obtains drug containing hydrophilic gel, drug containing starch water-loss reducer gel；
B, by drug containing hydrophilic gel, drug containing starch water-loss reducer gel and be pre-dissolved medical herb slurry be mixed in agitator, third time stir after, for the first time stand reaction；Surfactant, tartaric acid solution are successively added, reaction is stood second after stirring for the 4th time；Mixture, the Dihydroxyaluminium Aminoacetate solution crosslinking auxiliary agent of glycerine and Sodium Polyacrylate are added, after vacuumizing after the 5th stirring reaction certain time, blowing, coating, cutting at normal temperatures is packed.
In embodiment, hydrophilic gel, starch water-loss reducer gel and be pre-dissolved medical herb slurry preparation respective raw material need to be only mixed evenly.
In embodiment, Sodium Polyacrylate is commercially available prod, such as NP-800, NP-700 or NP-600.
Medicine and pharmaceutical extraction thing in the embodiment medicine according to needed for the selection of the therapeutic efficiency of specific hydrogel patch.
In embodiment, the bleeding agent is Laurocapram, borneol, methanol or dimethyl sulfoxide (DMSO) etc.；The surfactant is stearic acid, neopelex, anionic sldium lauryl sulfate or N- suberyl-N certain herbaceous plants with big flowers yl acetamides etc.；The exciting agent has hydration swelling, such as zinc oxide or alkali-activated carbonatite kaolinite stone flour, is commercially available prod.
Preferably, in embodiment, the tartaric acid is concentration 1.3-1.5% tartaric acid solution, and the Dihydroxyaluminium Aminoacetate crosslinking agent is concentration 0.9-1.2% Dihydroxyaluminium Aminoacetate solution.
Embodiment 1
A kind of preparation method of super large drugloading rate hydrogel patch, comprises the following steps：
A, medicine is added into hydrophilic gel respectively, medicine and zinc oxide are added in starch water-loss reducer gel, is stirred for the first time under normal temperature, mixing speed is less than 40 turns/min, mixing time 20min, two kinds of gels is fully carried medicine respectively；Bleeding agent is added into two kinds of gels respectively again, is stirred for the second time under normal temperature, mixing speed is 80 turns/min, mixing time 8min, respectively obtains drug containing hydrophilic gel, drug containing starch water-loss reducer gel；Wherein,
Drug containing hydrophilic gel includes hydrophilic gel 65%, medicine 30%, Laurocapram 5%；The hydrophilic gel is made up of following components：Carbomer 3%, gelatin 2%, pharmaceutical extraction thing 25%, deionized water 70%；Drug containing starch water-loss reducer gel includes：Starch water-loss reducer gel 75%, medicine 20%, dimethyl sulfoxide (DMSO) 5%；The starch water-loss reducer gel is made up of following components：Carboxymethyl cellulose 5%, pectin 0.97%, pharmaceutical extraction thing 20%, deionized water 74%, zinc oxide 0.03%；
B, by drug containing hydrophilic gel, drug containing starch water-loss reducer gel and be pre-dissolved medical herb slurry be mixed in agitator, third time stirs, and mixing speed 40-80 turns/min, mixing time 20min, reaction is stood for the first time, reacts 8-12h under 18-20 DEG C of temperature conditionss；Surfactant, tartaric acid solution are successively added, is stirred for the 4th time, mixing speed 80-120 turns/min, mixing time 8min, stands reaction 3-5min second；Mixture, the Dihydroxyaluminium Aminoacetate solution crosslinking auxiliary agent of glycerine and Sodium Polyacrylate are added, the 5th stirring after vacuumizing, mixing speed 80-120 turns/min, after reacting 8min, blowing, coating at normal temperatures, cuts packaging；Wherein,
Drug containing hydrophilic gel 35%, drug containing starch water-loss reducer gel 35%, medical herb slurry 20%, anionic sldium lauryl sulfate 0.03%, tartaric acid 0.2%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.2%, glycerine and Sodium Polyacrylate are pre-dissolved with 2:The mixture 9.57% of 1 ratio mixing；Medical herb slurry is pre-dissolved to be made up of following components：Pharmaceutical extraction thing 80%, three potassium sorbates 0.4%, dimethyl sulfoxide (DMSO) 4.6%, deionized water 15%.
Embodiment 2
A kind of preparation method of super large drugloading rate hydrogel patch, comprises the following steps：
A, medicine is added into hydrophilic gel respectively, medicine and alkali-activated carbonatite kaolinite stone flour are added in starch water-loss reducer gel, is stirred for the first time under normal temperature, mixing speed is less than 40 turns/min, mixing time 20min, two kinds of gels is fully carried medicine respectively；Bleeding agent is added into two kinds of gels respectively again, is stirred for the second time under normal temperature, mixing speed is 80 turns/min, mixing time 8min, respectively obtains drug containing hydrophilic gel, drug containing starch water-loss reducer gel；Wherein,
Drug containing hydrophilic gel includes hydrophilic gel 70%, medicine 24%, dimethyl sulfoxide (DMSO) 6%；The hydrophilic gel is made up of following components：Carbomer 6%, gelatin 1%, pharmaceutical extraction thing 20%, deionized water 73%；Drug containing starch water-loss reducer gel includes：Starch water-loss reducer gel 85%, medicine 13%, borneol 2%；The starch water-loss reducer gel is made up of following components：Carboxymethyl cellulose 9.5%, pectin 0.46%, pharmaceutical extraction thing 10%, deionized water 80%, alkali-activated carbonatite kaolinite stone flour 0.04%；
B, by drug containing hydrophilic gel, drug containing starch water-loss reducer gel and be pre-dissolved medical herb slurry be mixed in agitator, third time stirs, and mixing speed 40-80 turns/min, mixing time 20min, reaction is stood for the first time, reacts 8-12h under 18-20 DEG C of temperature conditionss；Surfactant, tartaric acid solution are successively added, is stirred for the 4th time, mixing speed 80-120 turns/min, mixing time 8min, stands reaction 3-5min second；Mixture, the Dihydroxyaluminium Aminoacetate solution crosslinking auxiliary agent of glycerine and Sodium Polyacrylate are added, the 5th stirring after vacuumizing, mixing speed 80-120 turns/min, after reacting 8min, blowing, coating at normal temperatures, cuts packaging；Wherein,
Drug containing hydrophilic gel 45%, drug containing starch water-loss reducer gel 28%, medical herb slurry 15%, N- suberyl-N certain herbaceous plants with big flowers yl acetamide 0.05%, tartaric acid 0.25%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.1%, glycerine and Sodium Polyacrylate are pre-dissolved with 3：The mixture 11.6% of 1 ratio mixing；Medical herb slurry is pre-dissolved to be made up of following components：Pharmaceutical extraction thing 90%, three potassium sorbates 0.5%, dimethyl sulfoxide (DMSO) 3%, deionized water 6.5%.
Embodiment 3
A kind of preparation method of super large drugloading rate hydrogel patch, comprises the following steps：
A, medicine is added into hydrophilic gel respectively, medicine and alkali-activated carbonatite kaolinite stone flour are added in starch water-loss reducer gel, is stirred for the first time under normal temperature, mixing speed is less than 40 turns/min, mixing time 20min, two kinds of gels is fully carried medicine respectively；Bleeding agent is added into two kinds of gels respectively again, is stirred for the second time under normal temperature, mixing speed is 80 turns/min, mixing time 8min, respectively obtains drug containing hydrophilic gel, drug containing starch water-loss reducer gel；Wherein,
Drug containing hydrophilic gel includes hydrophilic gel 75%, medicine 20%, borneol 5%；The hydrophilic gel is made up of following components：Carbomer 4%, gelatin 3%, pharmaceutical extraction thing 30%, deionized water 63%；Drug containing starch water-loss reducer gel includes：Starch water-loss reducer gel 84%, medicine 10%, methanol 6%；The starch water-loss reducer gel is made up of following components：Carboxymethyl cellulose 15%, pectin 0.76%, pharmaceutical extraction thing 14.2%, deionized water 70%, alkali-activated carbonatite kaolinite stone flour 0.04%；
B, by drug containing hydrophilic gel, drug containing starch water-loss reducer gel and be pre-dissolved medical herb slurry be mixed in agitator, third time stirs, and mixing speed 40-80 turns/min, mixing time 20min, reaction is stood for the first time, reacts 8-12h under 18-20 DEG C of temperature conditionss；Surfactant, tartaric acid solution are successively added, is stirred for the 4th time, mixing speed 80-120 turns/min, mixing time 8min, stands reaction 3-5min second；Mixture, the Dihydroxyaluminium Aminoacetate solution crosslinking auxiliary agent of glycerine and Sodium Polyacrylate are added, the 5th stirring after vacuumizing, mixing speed 80-120 turns/min, after reacting 8min, blowing, coating at normal temperatures, cuts packaging；Wherein,
Drug containing hydrophilic gel 42%, drug containing starch water-loss reducer gel 25%, medical herb slurry 25%, neopelex 0.06%, tartaric acid 0.24%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.2%, glycerine and Sodium Polyacrylate are pre-dissolved with 4:The mixture 7.5% of 1 ratio mixing；Wherein, medical herb slurry is pre-dissolved to be made up of following components：Pharmaceutical extraction thing 84%, three potassium sorbates 0.6%, dimethyl sulfoxide (DMSO) 5%, deionized water 10.4%.
The hydrogel patch of the present invention contains surfactant, high-effective penetrating accelerator, starch water-loss reducer gel, per-compound exciting agent and multi-medicament extraction component, natural drug extraction component needed for being added respectively in three components of aqueous gel, form multi-group medicinal gel rubber cement, when passing through control again, temperature control, rate controlling technology and technique, by each component fast lock water crosslinking, the target that multiplication loads dose is implemented as.
The matrix of hydrogel uses hydrophilic gel and starch water-loss reducer gel in embodiment, is soluble resin, by this large-scale linear polymeric material it is mixed with water after, add a certain amount of surfactant（Play peptizaiton）, pectin and gelatin（Play viscosifying action）Deng, and at certain temperature and pressure condition, graft polymerization reaction is carried out, form it into netted high-molecular gel system, i.e. the threedimensional solid network by being formed with hydrophilic macromolecule chain chemically or physically.The design and synthesis of super large drugloading rate hydrogel patch, the physical crosslinking method being led to using amphipathic nature block polymer or graft hydrophobic association, crystallization and hydrogen bond action.Macromolecule hydrogel water content of substrate is high, active ingredient inclusion quantity is big, connection is close, with contact human skin, a kind of sweat can be partially formed it is being difficult to the air-tight state of evaporation and diffusion, keratoderma water is set to increase to 50% by 5-15%, cuticula can be expanded into porous state through aquation, medicine is easier to penetrate, therefore the percutaneous rate of medicine can increase 4-5 times, promote the Transdermal absorption of ionic macromolecular drug, can be by a variety of different classes of drug loadings to gel carrier, all kinds of percutaneous administration patch products are made in grafting.Hydrogel itself is nontoxic, will not cause the mutation and harmful structure reaction of human body cell, and has good biology or histocompatbility, or allergic phenomena non-stimulated to skin.
Embodiments of the invention are explained in detail above; but the present invention is not limited to above-described embodiment; in those of ordinary skill in the art's possessed knowledge, various change can also be made obtaining on the premise of present inventive concept is not departed from, also should be regarded as protection scope of the present invention.

Claims (9)

  1. A kind of 1. super large drugloading rate hydrogel patch, it is characterised in that：Its raw material by mass percentage, including：Drug containing hydrophilic gel 35-45%, drug containing starch water-loss reducer gel 25-35%, medical herb slurry 15-25%, surfactant 0.03-0.06%, tartaric acid 0.2-0.25%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.1-0.2%, glycerine and Sodium Polyacrylate are pre-dissolved with 2-4:The mixture 7-12% of 1 ratio mixing；Wherein,
    Drug containing hydrophilic gel includes hydrophilic gel 65-75%, medicine 20-30%, bleeding agent 4-6%；The hydrophilic gel is made up of following components：Carbomer 3-6%, gelatin 1-3%, pharmaceutical extraction thing 20-30%, deionized water 63-73%；
    Drug containing starch water-loss reducer gel includes：Starch water-loss reducer gel 75-85%, medicine 10-20%, bleeding agent 2-6%；The starch water-loss reducer gel is made up of following components：Carboxymethyl cellulose 5-15%, pectin 0.5-1%, pharmaceutical extraction thing 10-20%, deionized water 70-80%, exciting agent 0.03-0.04%；
    Medical herb slurry is pre-dissolved to be made up of following components：Pharmaceutical extraction thing 80-90%, three potassium sorbate 0.4-0.6%, dimethyl sulfoxide (DMSO) 3-5%, deionized water 6-15%.
  2. 2. super large drugloading rate hydrogel patch as claimed in claim 1, it is characterised in that：The bleeding agent is Laurocapram, borneol, methanol or dimethyl sulfoxide (DMSO)；The surfactant is stearic acid, neopelex, anionic sldium lauryl sulfate or N- suberyl-N certain herbaceous plants with big flowers yl acetamides；The exciting agent is zinc oxide or alkali-activated carbonatite kaolinite stone flour.
  3. 3. super large drugloading rate hydrogel patch as claimed in claim 1, it is characterised in that：The tartaric acid is concentration 1.3-1.5% tartaric acid solution, and the Dihydroxyaluminium Aminoacetate crosslinking agent is concentration 0.9-1.2% Dihydroxyaluminium Aminoacetate solution.
  4. 4. super large drugloading rate hydrogel patch as claimed in claim 2, it is characterised in that：Its raw material by mass percentage, including：Drug containing hydrophilic gel 35%, drug containing starch water-loss reducer gel 35%, medical herb slurry 20%, anionic sldium lauryl sulfate 0.03%, tartaric acid 0.2%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.2%, glycerine and Sodium Polyacrylate are pre-dissolved with 2:The mixture 9.57% of 1 ratio mixing；Wherein,
    Drug containing hydrophilic gel includes hydrophilic gel 65%, medicine 30%, Laurocapram 5%；The hydrophilic gel is made up of following components：Carbomer 3%, gelatin 2%, pharmaceutical extraction thing 25%, deionized water 70%；
    Drug containing starch water-loss reducer gel includes：Starch water-loss reducer gel 75%, medicine 20%, dimethyl sulfoxide (DMSO) 5%；The starch water-loss reducer gel is made up of following components：Carboxymethyl cellulose 5%, pectin 0.97%, pharmaceutical extraction thing 20%, deionized water 74%, zinc oxide 0.03%；
    Medical herb slurry is pre-dissolved to be made up of following components：Pharmaceutical extraction thing 80%, three potassium sorbates 0.4%, dimethyl sulfoxide (DMSO) 4.6%, deionized water 15%.
  5. 5. super large drugloading rate hydrogel patch as claimed in claim 2, it is characterised in that：Its raw material by mass percentage, including：Drug containing hydrophilic gel 45%, drug containing starch water-loss reducer gel 28%, medical herb slurry 15%, N- suberyl-N certain herbaceous plants with big flowers yl acetamide 0.05%, tartaric acid 0.25%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.1%, glycerine and Sodium Polyacrylate are pre-dissolved with 3:The mixture 11.6% of 1 ratio mixing；Wherein,
    Drug containing hydrophilic gel includes hydrophilic gel 70%, medicine 24%, dimethyl sulfoxide (DMSO) 6%；The hydrophilic gel is made up of following components：Carbomer 6%, gelatin 1%, pharmaceutical extraction thing 20%, deionized water 73%；
    Drug containing starch water-loss reducer gel includes：Starch water-loss reducer gel 85%, medicine 13%, borneol 2%；The starch water-loss reducer gel is made up of following components：Carboxymethyl cellulose 9.5%, pectin 0.46%, pharmaceutical extraction thing 10%, deionized water 80%, alkali-activated carbonatite kaolinite stone flour 0.04%；
    Medical herb slurry is pre-dissolved to be made up of following components：Pharmaceutical extraction thing 90%, three potassium sorbates 0.5%, dimethyl sulfoxide (DMSO) 3%, deionized water 6.5%.
  6. 6. super large drugloading rate hydrogel patch as claimed in claim 2, it is characterised in that：Its raw material by mass percentage, including：Drug containing hydrophilic gel 42%, drug containing starch water-loss reducer gel 25%, medical herb slurry 25%, neopelex 0.06%, tartaric acid 0.24%, Dihydroxyaluminium Aminoacetate crosslinking agent 0.2%, glycerine and Sodium Polyacrylate are pre-dissolved with 4:The mixture 7.5% of 1 ratio mixing；Wherein,
    Drug containing hydrophilic gel includes hydrophilic gel 75%, medicine 20%, borneol 5%；The hydrophilic gel is made up of following components：Carbomer 4%, gelatin 3%, pharmaceutical extraction thing 30%, deionized water 63%；
    Drug containing starch water-loss reducer gel includes：Starch water-loss reducer gel 84%, medicine 10%, methanol 6%；The starch water-loss reducer gel is made up of following components：Carboxymethyl cellulose 15%, pectin 0.76%, pharmaceutical extraction thing 14.2%, deionized water 70%, alkali-activated carbonatite kaolinite stone flour 0.04%；
    Medical herb slurry is pre-dissolved to be made up of following components：Pharmaceutical extraction thing 84%, three potassium sorbates 0.6%, dimethyl sulfoxide (DMSO) 5%, deionized water 10.4%.
  7. 7. a kind of preparation method of super large drugloading rate hydrogel patch as described in any one of claim 1-6 claim, comprises the following steps：
    A, medicine is added into hydrophilic gel respectively, medicine and exciting agent are added in starch water-loss reducer gel, is stirred for the first time under normal temperature, two kinds of gels is fully carried medicine respectively；Bleeding agent is added into two kinds of gels respectively again, is stirred for the second time under normal temperature, respectively obtains drug containing hydrophilic gel, drug containing starch water-loss reducer gel；
    B, by drug containing hydrophilic gel, drug containing starch water-loss reducer gel and be pre-dissolved medical herb slurry be mixed in agitator, third time stir after, for the first time stand reaction；Surfactant, tartaric acid solution are successively added, reaction is stood second after stirring for the 4th time；Mixture, the Dihydroxyaluminium Aminoacetate solution crosslinking auxiliary agent of glycerine and Sodium Polyacrylate are added, after vacuumizing after the 5th stirring reaction certain time, blowing, coating, cutting at normal temperatures is packed.
  8. 8. the preparation method of super large drugloading rate hydrogel patch as claimed in claim 7, it is characterised in that：In step a, the speed of stirring is less than 40 turns/min, mixing time 20min for the first time；The speed of second of stirring is 80 turns/min, mixing time 8min；In step b, the speed 40-80 of third time stirring turns/min, mixing time 20min；The speed 80-120 of 4th stirring turns/min, mixing time 8min；The speed 80-120 of 5th stirring turns/min.
  9. 9. the preparation method of super large drugloading rate hydrogel patch as claimed in claim 8, it is characterised in that：Reaction is stood for the first time reacts 8-12h under 18-20 DEG C of temperature conditionss, second of standing reaction 3-5min；5th stirring reaction 8min.
CN201610294697.7A 2016-05-06 2016-05-06 A kind of super large drugloading rate hydrogel patch and preparation method thereof Pending CN107343882A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111773209A (en) * 2020-06-16 2020-10-16 浙江中医药大学 Application of psoralen in preparation of medicine for preventing or treating cochlear hair cell injury

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314189A (en) * 2001-03-30 2001-09-26 王海波 Preparation of high molecular gel stick agent
WO2006082596A2 (en) * 2005-01-19 2006-08-10 Kamalinder Kaur Singh Neem oil contraceptive formulations
CN102210773A (en) * 2011-05-31 2011-10-12 南京中医药大学 Chinese medicinal cataplasm for treating infantile pneumonia, preparation method thereof and application thereof
CN105125648A (en) * 2015-10-08 2015-12-09 青岛云天生物技术有限公司 Traditional Chinese medicine gel paste preparation for treating qi-blood deficiency decubitus in clinical nursing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314189A (en) * 2001-03-30 2001-09-26 王海波 Preparation of high molecular gel stick agent
WO2006082596A2 (en) * 2005-01-19 2006-08-10 Kamalinder Kaur Singh Neem oil contraceptive formulations
CN102210773A (en) * 2011-05-31 2011-10-12 南京中医药大学 Chinese medicinal cataplasm for treating infantile pneumonia, preparation method thereof and application thereof
CN105125648A (en) * 2015-10-08 2015-12-09 青岛云天生物技术有限公司 Traditional Chinese medicine gel paste preparation for treating qi-blood deficiency decubitus in clinical nursing

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111773209A (en) * 2020-06-16 2020-10-16 浙江中医药大学 Application of psoralen in preparation of medicine for preventing or treating cochlear hair cell injury
CN111773209B (en) * 2020-06-16 2022-06-17 浙江中医药大学 Application of psoralen in preparation of medicine for preventing or treating cochlear hair cell injury

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