CN101254215A - Preparing method of Chinese medicine catablasm base material - Google Patents
Preparing method of Chinese medicine catablasm base material Download PDFInfo
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- CN101254215A CN101254215A CNA2007100204189A CN200710020418A CN101254215A CN 101254215 A CN101254215 A CN 101254215A CN A2007100204189 A CNA2007100204189 A CN A2007100204189A CN 200710020418 A CN200710020418 A CN 200710020418A CN 101254215 A CN101254215 A CN 101254215A
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Abstract
The invention relates to a preparation method of matrix material for Chinese medicinal plaster, particularly to a preparation method of Chinese medicinal cataplasma matrix containing Chinese medicinal extracts. The method comprises the following steps of completely dissolving gelatin in 60 DEG C water, respectively adding sodium carboxymethyl cellulose, polyvinylpyrrolidone, gum arabic, Indian gum, triethanolamine and magnesium hydroxide into gelatin solution, and adding water for completely dissolving to obtain solution I; dispersing sodium polyacrylate, carbomer, polyvinyl alcohol, agar, gum tragacanth, colloidal silicon dioxide and sodium hydroxide in glycerol to obtain solution II; and mixing the solutions I and II to obtain cataplasma matrix. The inventive matrix has the advantages of good transdermal effect, good air permeability, no skin irritation, no anaphylaxis, comfortable application, good reusability, stable matrix properties, safe and environmentally friendly preparation process, good affinity with various drugs, and no reaction with principal drug.
Description
Technical field
The present invention relates to a kind of manufacturing of Chinese medicine plaster host material, specifically is a kind of manufacture method that adds the Chinese medicine patcher substrate of Chinese medical concrete.
Background technology
Traditional Chinese medicine plaster is adhesively fixed by patch in use and fixes on the human body skin, and it exists many defectives: can form the solid state of glue after 1, pasting on skin, tear disadvantages such as fine hair, pain, local redness, pruritus, pimple in the time of can bringing avulsion; 2, be subjected to the restriction of patch fiber ductility, when plaster is affixed on joint part, can produce senses of discomfort such as tearing involves; 3, the permeability of medicine is bad, affects the treatment; 4, macromole, plaster that water content is low easily produce anaphylaxis in use, influence its dependability.
Summary of the invention
It is strong that technical problem to be solved by this invention provides a kind of transdermal effect, good permeability, good with the affinity of various medicines, good with the affinity of skin, manufacturing process safety, environmental protection, non-stimulated to skin, anaphylaxis is little, paste with comfortable, can take off subsides repeatedly, and the manufacture method of the stable Chinese medicine patcher substrate of medium property.
Method of the present invention may further comprise the steps:
1, gets the raw materials ready.Be on the waiting list raw material according to following composition and weight portion: 0.8～3 part in gelatin, 4～21 parts of sodium carboxymethyl cellulose, 0.5～3 part of polyvinylpyrrolidone, 2～10 parts of arabic gums, 2～10 parts of gum ghatti, 1～6 part of triethanolamine, 0.2～1.5 part in magnesium hydroxide, 2～10 parts of sodium polyacrylate, 2～4 parts of carbomers, 30～50 parts of glycerol, 5～16 parts of polyvinyl alcohol, 0.2～2 part of agar, 0.5～3 part of tragacanth, 2～10 parts of micropowder silica gels, 20～80 parts in 1～3 part of sodium hydroxide and water;
2, preparation solution I: the gelatin in the raw material fully is dissolved in 60 ℃ of water, add sodium carboxymethyl cellulose, polyvinylpyrrolidone, arabic gum, gum ghatti, triethanolamine, magnesium hydroxide in the gelatin solution respectively again, add water and fully dissolve, leave standstill and promptly get solution I;
3, preparation solution II: the sodium polyacrylate in the raw material, carbomer, polyvinyl alcohol, agar, tragacanth, micropowder silica gel, sodium hydroxide are scattered in the glycerol, and stirring promptly gets solution II;
4, mixed solution I and solution II, and stir, catablasm base material promptly got.
Method of the present invention has adopted the material of water soluble polymer frame structure, uses it for the manufacturing of the external plaster agent of percutaneous dosing approach, compares with traditional plaster to have the following advantages:
(1) high-comfort---because moistening, adhesion can be adjusted the position by local at any time microcosmic after sticking, and the use that can not influence adhesion strength and paste once more.Can on skin, not form the solid state of glue, pull disadvantages such as fine hair, pain, part redness, pruritus, pimple when not having avulsion naturally.And the main cause that the traditional just plaster of the latter is hung back the patient.
(2) high ductibility---because the non-woven fabrics that uses of dosage form is the good kind of any direction extensibility, when sticking on the big positions such as joint of mobility, mastic can stretch with the stretching, extension of joint, skin fully.Uncomfortable sensation such as removed that the tearing of forcing at joint part involves.
(3) high osmosis---this dosage form can guarantee contained drug at short notice rapid osmotic enter human body skin, and arrive local organization rapidly.What deserves to be mentioned is and since mastic in content of dispersion few, stick the back in local arthral fluid detected drug level much larger than blood Chinese medicine concentration.Illustrate that medicine is not after dependence is absorbed into blood, arrives performance drug effect in the articular cavity again; But passive epidermis, subcutaneous tissue and the articular cavity of penetrating into.
(4) high reliability---this dosage form seldom causes uncomfortable reactions such as allergy.Because ingredient is single, molecular weight is little, and compares reliability than macromole, plaster that water content is low and significantly improves.Clinical use PMS follow up survey for many years shows that reactions such as the allergy of this product only are 2.3%.
The specific embodiment
The embodiment of the invention may further comprise the steps:
1, gets the raw materials ready.Be on the waiting list gelatin 0.08g, sodium carboxymethyl cellulose 0.5g, polyvinylpyrrolidone 0.3g, arabic gum 0.8g, gum ghatti 0.4g, triethanolamine 0.1g, magnesium hydroxide 0.1g, water 8ml, sodium polyacrylate 0.25g, carbomer 0.2g, glycerol 5ml, polyvinyl alcohol 1.3g, agar 0.09g, tragacanth 0.3g, micropowder silica gel 0.2g, sodium hydroxide 0.25g;
2, preparation solution I.The gelatin of above-mentioned consumption fully is dissolved in 60 ℃ of water, sodium carboxymethyl cellulose, polyvinylpyrrolidone, arabic gum, gum ghatti, triethanolamine, magnesium hydroxide with above-mentioned consumption adds in the gelatin solution respectively again, add water and fully dissolve, leave standstill and promptly get solution I.
3, preparation solution II.Sodium polyacrylate, carbomer, polyvinyl alcohol, agar, tragacanth, micropowder silica gel, sodium hydroxide are scattered in the glycerol, and stirring promptly gets solution II.
4, mixed solution I and solution II, and stir, catablasm base material of the present invention promptly got.
Claims (1)
1. the manufacture method of a Chinese medicine patcher substrate is characterized in that: may further comprise the steps
A. get the raw materials ready, be on the waiting list raw material: 20～80 parts in 0.8～3 part in gelatin, 4～21 parts of sodium carboxymethyl cellulose, 0.5～3 part of polyvinylpyrrolidone, 2～10 parts of arabic gums, 2～10 parts of gum ghatti, 1～6 part of triethanolamine, 0.2～1.5 part in magnesium hydroxide, 2～10 parts of sodium polyacrylate, 2～4 parts of carbomers, 30～50 parts of glycerol, 5～16 parts of polyvinyl alcohol, 0.2～2 part of agar, 0.5～3 part of tragacanth, 2～10 parts of micropowder silica gels, 1～3 part of sodium hydroxide and water according to following composition and weight portion;
B. prepare solution I: the gelatin in the raw material fully is dissolved in 60 ℃ of water, add sodium carboxymethyl cellulose, polyvinylpyrrolidone, arabic gum, gum ghatti, triethanolamine, magnesium hydroxide in the gelatin solution respectively again, add water and fully dissolve, leave standstill and promptly get solution I;
C. prepare solution II: the sodium polyacrylate in the raw material, carbomer, polyvinyl alcohol, agar, tragacanth, micropowder silica gel, sodium hydroxide are scattered in the glycerol, and stirring promptly gets solution II;
D. mixed solution I and solution II, and stir.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100204189A CN101254215A (en) | 2007-02-26 | 2007-02-26 | Preparing method of Chinese medicine catablasm base material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100204189A CN101254215A (en) | 2007-02-26 | 2007-02-26 | Preparing method of Chinese medicine catablasm base material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101254215A true CN101254215A (en) | 2008-09-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100204189A Pending CN101254215A (en) | 2007-02-26 | 2007-02-26 | Preparing method of Chinese medicine catablasm base material |
Country Status (1)
| Country | Link |
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| CN (1) | CN101254215A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142561A (en) * | 2013-03-12 | 2013-06-12 | 桂林市中医医院 | Cataplasm basic material and preparation method thereof |
| CN103169688A (en) * | 2013-02-07 | 2013-06-26 | 江苏七○七天然制药有限公司 | Traditional Chinese medicine cataplasm matrix and preparation method |
-
2007
- 2007-02-26 CN CNA2007100204189A patent/CN101254215A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103169688A (en) * | 2013-02-07 | 2013-06-26 | 江苏七○七天然制药有限公司 | Traditional Chinese medicine cataplasm matrix and preparation method |
| CN103169688B (en) * | 2013-02-07 | 2014-10-29 | 江苏七○七天然制药有限公司 | Traditional Chinese medicine cataplasm matrix and preparation method |
| CN103142561A (en) * | 2013-03-12 | 2013-06-12 | 桂林市中医医院 | Cataplasm basic material and preparation method thereof |
| CN103142561B (en) * | 2013-03-12 | 2014-10-15 | 桂林市中医医院 | Cataplasm basic material and preparation method thereof |
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Open date: 20080903 |