CN1306952C - Chinese traditional medicine for treating chronic pharyngolaryngitis and its preparing process - Google Patents
Chinese traditional medicine for treating chronic pharyngolaryngitis and its preparing process Download PDFInfo
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Abstract
The present invention relates to a Chinese traditional medicine for treating chronic laryngopharyngitis and method for making same. The chronic pharyngitis are inflammations of throat mucous membrane, mucous membrane beneath and lymphoid tissue, which aetiological agents are complicated and difficult to determine. The western medicine for treating the disease is principal local application antibiotic or antiinflammatory medicines, without remarkable curative effects and seeking both temporary and permanent solutions. According to the medicine composing prescription in accordance with the present invention, dried rehmannia root, radix scrophulariae and dendrobium are used for nourishing the haggis, the tummy and the kidney to open the source of mizutani. Since deficiency of Yin generates heat and deficiency of Qi generates wet, then the medicine exhibits effects such as yin-nourishing lung-heat clearing, phlegm resolving and sore-throat relieving, is used for treating throat painful swelling, chronic pharyngitis and laryngitis caused by deficiency of Yin and the like. The present invention possesses the advantages of precise composing prescription, remarkable curative effects, short period of treatment, fast effect, without toxic and side effects and safe clinical usage and the like.
Description
One, technical field:
The present invention relates to a kind of Chinese medicine for the treatment of chronic pharyngolaryngitis and preparation method thereof.Particularly for treatment chronic pharyngitis, laryngitis, the laryngopharynx swelling and pain that causes etc. has one group of Chinese medicine composition evident in efficacy, and specifically describing is raw material with Chinese herbal medicine, the pure Chinese medicinal preparation that forms through sophisticated equipment and its preparation process processed.
Two, background technology:
Chronic pharyngitis, laryngitis is a common clinical, frequently-occurring disease, relevant with environment, diet, living habit, Gong Ye sustainable development in addition, cause air environmental pollution, influence the human beings'health life deeply, therefore, the crowd who suffers from various laryngopharyngeal diseases continues to increase, sickness rate is wide, will cause medical circle and compatriots' attention.
Chronic pharyngitis, chronic laryngitis are common clinicals, are mainly in the adult, and it is longer to have the course of disease, generally all more than two months, and the symptom stubbornness, delay is difficult, and short term therapy is difficult to take effect.Give people particularly occupationals such as teacher, performer, announcer bring many inconvenience and misery with throat worker's daily life and work.Therefore it is significant that active research is prevented and treated above-mentioned disease.
Chronic pharyngitis is a pharyngeal mucosa, and mucosa reaches adenoid diffuse inflammation down.Its cause of disease complexity is difficult to determine.In short, it forms and manyly to show effect repeatedly or treat not thorough because of acute pharyngitis, the adjacent organs focus stimulates as sinusitis, tonsillitis, nasopharyngitis, tracheitis etc., tobacco and wine are excessive, dust and harmful gas stimulate, the occupational sounding is excessive, and with some systemic disease such as anemia, diabetes, constipation, heart disease, nephritis, liver cirrhosis are waited until and are caused that circulatory disturbance is relevant slightly at local end.Doctor trained in Western medicine mainly is the antibiotic or anti-inflammatory drug of topical application to the Therapeutic Method of primary disease, as: locally sprayed 2% iodine glycerol, 5% protargol liquid, 10% argyrol liquid, 2.4% copper sulfate solution, 1% zinc sulfate solution, gentamycin+dexamethasone atomizing sucks; Suck tabellae iodi gurgitis, it is rapids etc. that domiphen bromide buccal tablet, compound recipe borax solution contain.Above-mentioned Therapeutic Method curative effect is all not remarkable, and effect only can reach the effect of mitigation symptoms, and western medical treatment can not treating both the principal and secondary aspects of a disease.Therefore study determined curative effect, treating both the principal and secondary aspects of a disease, the dialectical seriation Chinese prescription preparation of controlling of executing has the important clinical meaning.
Three, summary of the invention:
The object of the present invention is to provide a kind of nourishing YIN and clearing away lung-heat that has, the sore-throat relieving that reduces phlegm is used for the treatment of deficiency of YIN lung-heat and the laryngopharynx swelling and pain that causes, Chinese medicine of chronic pharyngitis, laryngitis and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of Chinese medicine for the treatment of chronic pharyngolaryngitis, its special character is: the Chinese medicine of described treatment chronic pharyngolaryngitis is the medicament of being made by following materials of weight proportions:
Radix Scrophulariae 115-135 part Radix Rehmanniae 115-135 part 65-85 Radix Ophiopogonis part
Radix Scutellariae 40-60 part Cortex Moutan 65-85 part Radix Paeoniae Rubra 65-85 part
Bulbus Fritillariae Cirrhosae 65-85 part Rhizoma Alismatis 65-85 part Semen Coicis 65-85 part
Herba Dendrobii 65-85 part Bombyx Batryticatus 40-60 part Herba Menthae 20-30 part
Semen Sterculiae Lychnophorae 40-60 part Periostracum Cicadae 40-60 part Semen Oroxyli 40-60 part
Radix Glycyrrhizae 20-30 part
The Chinese medicine of above-mentioned treatment chronic pharyngolaryngitis is the medicament of being made by following materials of weight proportions:
75 parts of 125 portions of Radix Rehmanniae of Radix Scrophulariae 125 parts of Radix Ophiopogonis
75 parts of 75 parts of Radix Paeoniae Rubra of 50 parts of Cortex Moutans of Radix Scutellariae
75 parts of 75 parts of Semen Coiciss of 75 portions of Rhizoma Alismatis of Bulbus Fritillariae Cirrhosae
25 parts of 50 portions of Herba Menthaes of 75 parts of Bombyx Batryticatus of Herba Dendrobii
50 parts of 50 portions of Semen Oroxylis of 50 portions of Periostracum Cicadaes of Semen Sterculiae Lychnophorae
25 parts in Radix Glycyrrhizae
Above-mentioned medicament is the above a dosage form of any pharmaceutics.
Above-mentioned dosage form is pill, tablet, capsule.
Above-mentioned dosage form is that the processing step of preparation method of pill is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried respectively to jaundice with slow fire, and is standby;
(2), ten Six-element Chinese medicines all are ground into fine powder, cross the 100-120 mesh sieve, mix homogeneously, per 100 parts of fine powders and refined honey 35-50 part and an amount of purified water are mixed thoroughly, mix, stir, refine operation processes such as medicine, shaping, stranding ball, drying, screening ball, make pill.
Above-mentioned dosage form is that the processing step of preparation method of tablet is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add for the first time 10 times of amounts of boiling water, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfers PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, and filtered, precipitate adds the water of 6 times of amounts, transfer pH value 7.0-7.5 with (1mol/L) sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), remove Bulbus Fritillariae Cirrhosae, Cortex Moutan, all the other 13 flavor medical materials that Radix Scutellariae is outer, add for the first time 12 times of amounts of water, soaked 1 hour, heating decocted 2 hours, add for the second time 10 times of amounts of water, heating decocted 1 hour, merged decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, add ethanol and make pure content reach 60%, left standstill 12 hours, get supernatant, reclaim ethanol, add the Radix Scutellariae extracting solution in the above-mentioned steps (3) to there not being the alcohol flavor, being evaporated to temperature is 80 ℃, relative density is the extractum of 1.15-1.20, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder and adjuvant are granulated, and compacting in flakes, the bag film-coat, promptly.
Above-mentioned dosage form is that the processing step of capsular preparation method is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add for the first time 10 times of amounts of boiling water, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfers PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, and filtered, precipitate adds the water of 6 times of amounts, transfer pH value 7.0-7.5 with (1mol/L) sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), remove Bulbus Fritillariae Cirrhosae, Cortex Moutan, all the other 13 flavor medical materials that Radix Scutellariae is outer, add for the first time 12 times of amounts of water, soaked 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, adding ethanol makes pure content reach 60%, left standstill 12 hours, and got supernatant, reclaim ethanol to there not being the alcohol flavor, add the Radix Scutellariae extracting solution in the above-mentioned steps (3), being evaporated to temperature is 80 ℃, relative density is 1.15-1.20, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder mixing, granulate, oven dry incapsulates, promptly.
Above-mentioned dosage form is that the processing step of preparation method of granule is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add 10 times of amounts of boiling water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with the 1mol/L sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), remove Bulbus Fritillariae Cirrhosae, Cortex Moutan, all the other 13 flavor medical materials that Radix Scutellariae is outer, add for the first time 12 times of amounts of water, soaked 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, adding ethanol makes pure content reach 60%, left standstill 12 hours, and got supernatant, reclaim ethanol to there not being the alcohol flavor, add the Radix Scutellariae extracting solution in the above-mentioned steps (3), being evaporated to temperature is 80 ℃, relative density is 1.15-1.20, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder mixing;
(5) and then add 200 portions of sucrose, 100 parts of starch are granulated, promptly.
Above-mentioned dosage form is that the processing step of preparation of soft capsule method is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add 10 times of amounts of boiling water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with the 1mol/L sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), remove Bulbus Fritillariae Cirrhosae, Cortex Moutan, all the other 13 flavor medical materials that Radix Scutellariae is outer, add for the first time 12 times of amounts of water, soaked 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, adding ethanol makes pure content reach 60%, left standstill 12 hours, and got supernatant, reclaim ethanol to there not being the alcohol flavor, add the Radix Scutellariae extracting solution in the above-mentioned steps (3), being evaporated to temperature is 60 ℃, relative density is 1.38-1.40, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder mixing;
(5) and then add the suspension that salad oil is mixed into 45-50%, make soft capsule, promptly.
The present invention is with respect to prior art, and its advantage is as follows:
It is rigorous to have prescription, and the compatibility science is evident in efficacy, can bring into play curative effect of medication to a greater extent, takes effect obviously, and more the back is difficult for recurrence, the clinical characteristics that have no side effect safe in utilization.
Prescription of the present invention has changed ancient Chinese medicine decoction method from technology theory, and utilization modern pharmaceutical equipment is according to the existing characteristic of prescription, with rigorous its preparation process, by the process of preparing Chinese medicine to medical material, prescription is handled, take to pulverize, the part medicinal material extract is finally made and is convenient to control its quality standard detection with the existing processes technology, taking convenience, reliable in quality, pharmaceutical properties is stable, and is evident in efficacy, clinical use is reliable, the dependent oral preparation of Chinese traditional medicinal of no medicine.
Four, specific embodiment:
The objective of the invention is based on the traditional Chinese medical science " dialectical opinion is controlled " principle, in conjunction with clinical application custom and treatment basis, on the basis of clinical proved recipe, through studying for a long period of time, is to select medicament composing prescription of the present invention for use according to treatment with reference to modern medical theory and clinical experience.
Respectively the distinguish the flavor of property of medicine of medicine of prescription of the present invention is:
1, Radix Scrophulariae: be the dried root of goatweed Radix Scrophulariae.
Nature and flavor: bitter, sweet, salty, cold.Return lung, stomach, kidney channel.
Performance characteristics: this product bitter but sweet flavor is salty, the matter lubricant nature is trembled with fear, return lung stomach kidney, is the product of refrigerant moist dismission, can clearing away heat and cooling blood, and nourishing Yin, protecting battalion again can nourishing YIN to lower pathogenic fire, moisturizes laxation, also kind detoxicating and resolving stagnation of pathogens and treat toxic swelling tuberculosis.Be used for laryngopharynx swelling and pain, carbuncle sore tumefacting virus, scrofula sucutaneous nodule, YANG toxin syndrome necrosis, the constipation of deficiency of YIN dryness of the intestine.
2, Radix Rehmanniae: be the fresh or dried root of Scrophulariaceae Radix Rehmanniae.
Nature and flavor: sweet, bitter, cold.GUIXIN, liver, kidney channel.
Performance characteristics: clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis.Be applied to consumption of YIN caused by febrile disease, crimson tongue excessive thirst, haematemesis, epistaxis, laryngopharynx swelling and pain.
3, Radix Ophiopogonis: be the dried root of liliaceous plant dwarf lilyturf or Da Ye Radix Ophiopogonis.
Nature and flavor: sweet, little hardship, be slightly cold.Return lung, the heart, stomach warp.
Performance characteristics: the sweet profit hardship of this product is let out the heat clearing away that is slightly cold, for nourishing clear and rich product.Both kind lung moistening stomach reinforcing, YIN nourishing and the production of body fluid promoting, the relieving restlessness that can clear away heart-fire again, and double intestine moistening.
4, Radix Scutellariae: be cadre's root of labiate Radix Scutellariae.
Nature and flavor: bitter, cold.Return lung, gallbladder, stomach, large intestine channel.
Performance characteristics: this product bitter cold is let out dampness clearly, main lung and the large intestine, double stomach and the liver and gall of returning of returning.Effect is part of the body cavity above the diaphragm housing the heart and lungs lung and large intestine relatively, and the fire of kind lung heat clearing and large intestine except that last damp-heat in middle-JIAO, is doublely gone into blood system and removing heat from blood, heat clearing away etc.Be used for calentura excessive thirst, lung-heat cough with asthma, few positive cold and heat, pharyngalgia, conjunctival congestion, carbuncle.
5, Cortex Moutan: be the dry root bark of cohosh Paeonia suffruticosa.
Nature and flavor: bitter, hot, be slightly cold.GUIXIN, liver, kidney channel.
Performance characteristics: this product toil is slightly cold, and GUIXIN Liver and kidney warp is for letting out the diffusing product of row clearly, both kind clearing away heat and cooling blood, kind again blood circulation promoting and blood stasis dispelling, the reducing the asthenic fever of also holding concurrently, the saturating cloudy latent heat that divides.Removing heat from blood is arranged and do not stay the stasis of blood, invigorate blood circulation and the characteristics of motionless blood.
6, Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae or CHUANSHAO medicine.
Nature and flavor: bitter, be slightly cold.Return Liver Channel.
Performance characteristics: this product is bitter and be slightly cold, and specially goes into Liver Channel, for letting out the diffusing product of row clearly.Both kind clearing away liver-fire removes the hot and suffocating and removing heat from blood of blood system, kind again blood circulation promoting and blood stasis dispelling and pain relieving.
7, Bulbus Fritillariae Cirrhosae: be the liliaceous plant Bulbus Fritillariae Cirrhosae, dark violet Bulbus Fritillariae Uninbracteatae etc. descend bulb dryly.
Nature and flavor: sweet, bitter, be slightly cold.Return lung, heart channel.
Performance characteristics: this product is cool in nature and sweet, is clear and rich product, can removing heat from the lung and dissipating phlegm, again can nourishing the lung to arrest cough, and be the dryness of the lung, the many usefulness of cough due to consumptive disease also have the merit of heat clearing away eliminating stagnation.
8, Rhizoma Alismatis: be the dry tuber of Alismataceae plant Rhizoma Alismatis.
Nature and flavor: sweet, light, cold.Return kidney, urinary bladder channel.
Performance characteristics: this product is sweet light cold in nature, returns kidney and urinary bladder channel, and it is wet promptly to be apt to ooze diuretic, and the heat that can let out kidney and bladder again clearly is so be apt to control the inferior the card that Jiao is damp and hot and edema is held concurrently heat.
9, Semen Coicis (stir-fry): be the dry mature kernal of grass Semen Coicis.
Nature and flavor: sweet, light, be slightly cold.Return spleen, stomach, lung meridian.
Performance characteristics: sweet light being slightly cold of this product, give birth to oozing sharp heat clearing away, the eliminating impediment evacuation of pus of holding concurrently, water the wet hot person that holds concurrently should throw.
10, Herba Dendrobii: be the fresh or dry stem of orchid dendrobium loddigesii Rolfe and Dendrobium nobile etc.
Nature and flavor: sweet, be slightly cold.Return stomach, kidney channel.
Performance characteristics: the sweet cold of this product, go into the kind nourishing stomach-YIN of stomach, born fluid, go into the kind nourishing kidney-yin of kidney, clearind deficient heat.In addition, can also make eye bright, strong waist.
11, Bombyx Batryticatus (parched with bran): for the larva of Bombycidae animal silkworm before not weaving silk, because of infecting the muscardine lethal rigid polypide that falls ill.
Nature and flavor: salty, hot, flat.
Performance characteristics: flat the holding concurrently of Bombyx Batryticatus can be reduced phlegm, and twitches with treating the liver wind or the hot infantile convulsion of expectorant and is advisable, again can wind-expelling pain-stopping, and detoxicating and resolving stagnation of pathogens, it is swollen to control headache, pharyngalgia, rubella, furuncle, diseases such as erysipelas.
12, Herba Menthae: be the stem and leaf of labiate Herba Menthae.
Nature and flavor: hot, cool.Return lung, Liver Channel.
Performance characteristics: the cold of this product suffering, fragrant odour, the light weight come-up, catharsis is sharp clearly, goes into the both kind diffusing part of the body cavity above the diaphragm housing the heart and lungs wind heat of lung liver and the clear sharp head and throat, and dermexanthesis is malicious and soothing the liver thoroughly again.
13, Semen Sterculiae Lychnophorae: be the dry mature seed of Sterculiaceae plant Semen Sterculiae Lychnophorae.
Nature and flavor: sweet, cold.
Performance characteristics: clear lung qi dispersing gas, bowel relieving relieving constipation.Be used for the lung-heat celostomia, phlegm-heat cough etc.
14, Periostracum Cicadae: be the shell after the emergence of cicada Cryptotympana atrata Fabr..
Nature and flavor: sweet, cold.Return lung, Liver Channel.
Performance characteristics: the sweet cold light weight of this product, evacuate clear saturating spasmolytic, merit is at lung liver two warps.And in the expelling wind to relieve convulsion and the sound producing that makes eye bright.Be mainly used in anemopyretic cold, epidemic febrile disease is from the beginning of, hoarseness pharyngalgia.
15, Semen Oroxyli: be the dry mature seed of Bignoniaceae plant Semen Oroxyli.
Nature and flavor: bitter, sweet, cool.Return lung, liver, stomach warp.
Performance characteristics: have removing heat from the lung and relieving sorethroat, the merit of dispersing the stagnated liver-QI for regulating the stomach is used for the cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach etc.
16, Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume.
Nature and flavor: sweet, flat.GUIXIN, lung, spleen, stomach warp.
Performance characteristics: the flat sweet in the mouth of this moral character, can the QI invigorating invigorating middle warmer, again can relieving spasm to stop pain, relax the property of medicine, can also lung moistening eliminate the phlegm and relieving cough and asthma detoxifcation.
According to the dialectical mechanism of tcm clinical practice summary, lung governing qi and root be in kidney, kidney master water, and the lung being the upper source of fluids, since asthenia, impairment of both QI and YIN, impairment caused by overstrain lung kidney, deficiency of body fluid, hyperactivity of deficient fire causes yang-energy low, and the anti-rising tune door of YIN diseasei vocal cores relaxes vertical closure can not.
Nourish the lung stomach with the Radix Rehmanniae, Radix Scrophulariae, Herba Dendrobii in the medicament composing prescription of the present invention, take into account its kidney, with the source of boiled water paddy, heat formation from yin deficiency, the deficiency of vital energy is given birth to wet, being aided with Bulbus Fritillariae Cirrhosae, Semen Sterculiae Lychnophorae, Semen Coicis expelling wind and dampness reduces phlegm, assistant makes with Herba Menthae, Semen Oroxyli tying-in sore-throat relieving with the Cortex Moutan removing heat from blood and promoting blood circulation, and all medicines are shared to be intended to moisten sore throat relieving, take the usefulness of " prevention of diseae, disease is preapred for an unfavorable turn of events " at ordinary times.Full side 16 flavor Chinese herbal medicine have nourishing YIN and clearing away lung-heat, and sore-throat relieving reduces phlegm.The laryngopharynx swelling and pain that is used for deficiency of YIN lung-heat and causes, chronic pharyngitis, laryngitis.
Prescription of the present invention is made up of 16 flavor Chinese herbal medicine compositions, adopts advanced Chinese medicine process equipment, with rigorous technology manufacture technique, makes and is convenient to control its quality standard detection, the pure oral preparation of Chinese traditional medicinal of the convenient transportation that is easy to carry.
The present invention is through Xian Medical Univ's pharmacology, and the pharmacodynamics toxicological experiment proves; That this medical instrument has is antibacterial, antiinflammatory, analgesic activity, and facilitating digestion is arranged, and promotes the pharmacological action of intestinal propulsion effect.Prove that by anxious, slow toxicity test this medicine is to liver, kidney and histopathological examination all do not have obviously change, and its LD50 does not find any toxic reaction greater than 168/kg in the long term toxicity test in the gastric infusion rat acute toxicity in one to two week.
In sum, principle-method-recipe-medicines of the present invention had both met the understanding of the traditional Chinese medical science to chronic pharyngitis, laryngitis, have simultaneously practical experience characteristic and clinical trial basis again, also has the basic research of modern Chinese medicine pharmacological evaluation, its prescription is rational, it is leading that this invention research reaches domestic similar drug research science and technology, filled up domestic research throat disease and selected a blank in the serial Chinese medicine preparation for use in treatment.
In order further to show the clinical efficacy of chronic pharyngitis of the present invention, laryngitis, enumerate some clinical datas and case below.
The present invention, through Xi-an City Central Hospital, No. 4 Hospital of Xi-an City, among the clinical 298 routine patients of unit such as Xi'an red meeting hospital, the present invention is to chronic pharyngitis, and the cure rate of laryngitis is 24.2%, obvious effective rate is 34.6%, and effective percentage is 30.9%, and total effective rate is 89.7%.
Illustrate that clinical efficacy of the present invention is remarkable, can recover voice after one to two cycle medication and reach the healing therapeutic effect.
Model case:
1, Ran Shuzhen, the woman, 32 years old, the Xi'an Railway Bureau Passenger Dept., the announcer suffers from chronic laryngitis, every morning, celostomia was easily tired, dry pharynx, and bilateral vocal cords canescence, it is coarse that mucosa is slightly, portion's dysraphism between Wood-scoop, clothes " the present invention " are after 10 days, and the self-induction effect is obvious, uses the acoustic compliance profit, and the larynx picture is the same.
2, Wang Hemin, man, 31 years old, masonry dam river, Baoji people's commune, the peasant, surplus the bimester of celostomia, easily tired with sound, to cry out sometimes, the bilateral vocal cords are bois de rose, the edge pachymucosa, still smooth, glottis is the elongated crack, clothes " the present invention " 15 days, sounding recovers normally substantially, and vocal cords are canescence, smooth mucosal, the glottis closure is good.
Embodiment 1:
Radix Scrophulariae 115g Radix Rehmanniae 115g 65g Radix Ophiopogonis Radix Scutellariae 40g
Cortex Moutan 65g Radix Paeoniae Rubra 65g Bulbus Fritillariae Cirrhosae 65g Rhizoma Alismatis 65g
Semen Coicis (stir-fry) 65g Herba Dendrobii 65g Bombyx Batryticatus (parched with bran) 40g Herba Menthae 20g
Semen Sterculiae Lychnophorae 40g Periostracum Cicadae 40g Semen Oroxyli 40g Radix Glycyrrhizae 20g
Produce its preparation process following steps of pill:
With above ten Six-elements: handle and all be ground into fine powder by concocting prescription, cross 100 mesh sieves, mix homogeneously, every 100g fine powder and refined honey 35-50g and an amount of purified water are mixed thoroughly, mix, close and stick together, refine medicine, shaping, stranding ball, adopt microwave far infrared drying equipment, and temperature is controlled at 60-80 ℃ of drying, the exsiccant pill of institute is by operation processes such as standard net sieve balls, make the pill that is up to the standards, claim to such an extent that per 10 heavy 1 restrain the finished product of promptly every bottled 36 grams or 360 dresses.
Embodiment 2:
Radix Scrophulariae 250g Radix Rehmanniae 250g 150g Radix Ophiopogonis Radix Scutellariae 100g
Radix Paeoniae Rubra 150g Cortex Moutan 150g Rhizoma Alismatis 150g Bulbus Fritillariae Cirrhosae 150g
Herba Dendrobii 150g Semen Sterculiae Lychnophorae 100g Herba Menthae 50g Semen Coicis (stir-fry) 150g
Radix Glycyrrhizae 50g Semen Oroxyli 100g Periostracum Cicadae 100g Bombyx Batryticatus (parched with bran) 100g
Produce capsular its preparation process following steps:
More than ten Six-elements, get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 order fine powder, and is standby; Radix Scutellariae decocts with water three times, adds 10 times of amounts of boiling water for the first time, decocts 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 1.05-1.10 (80 ℃) that filtrate decompression is concentrated into relative density, adds the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with (1mol/L) sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use; All the other 13 flavors add 12 times of amounts of water for the first time, soak 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 1.00-1.05 (60 ℃) that filtrate decompression is concentrated into relative density, be cooled to 40 ℃, add ethanol and make pure content reach 60%, left standstill 12 hours, get supernatant, reclaim ethanol to there not being the alcohol flavor, add above-mentioned Radix Scutellariae extracting solution, being evaporated to relative density is 1.15-1.20 (80 ℃), spray drying, gained medicated powder and Bulbus Fritillariae Cirrhosae and Cortex Moutan fine powder mixing, granulate, oven dry incapsulates, make 1000 altogether, promptly.
Embodiment 3:
Radix Scrophulariae 135g Radix Rehmanniae 135g 85g Radix Ophiopogonis Radix Scutellariae 60g
Cortex Moutan 85g Radix Paeoniae Rubra 85g Bulbus Fritillariae Uninbracteatae 85g Rhizoma Alismatis 85g
Semen Coicis (stir-fry) 85g Herba Dendrobii 85g Bombyx Batryticatus (parched with bran) 60g Herba Menthae 30g
Semen Sterculiae Lychnophorae 60g Periostracum Cicadae 60g Semen Oroxyli 60g Radix Glycyrrhizae 30g
Produce its preparation process following steps of tablet:
More than ten Six-elements, get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 order fine powder, and is standby; Radix Scutellariae decocts with water three times, adds 10 times of amounts of boiling water for the first time, decocts 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 1.05-1.10 (80 ℃) that filtrate decompression is concentrated into relative density, adds the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with (1mol/L) sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use; All the other 13 flavors add 12 times of amounts of water for the first time, soak 1 hour, heating decocted 2 hours, add for the second time 10 times of amounts of water, heating decocted 1 hour, merged decocting liquid twice, filter, it is 1.00-1.05 (60 ℃) that filtrate decompression is concentrated into relative density, is cooled to 40 ℃, adds ethanol and makes pure content reach 60%, left standstill 12 hours, get supernatant, reclaim ethanol, add above-mentioned Radix Scutellariae extracting solution to there not being the alcohol flavor, being evaporated to relative density is the extractum of 1.15-1.20 (80 ℃), spray drying, gained medicated powder and Bulbus Fritillariae Cirrhosae and Cortex Moutan fine powder and adjuvant commonly used are granulated, and compacting is in flakes, the bag film-coat, promptly.
Embodiment 4:
Radix Scrophulariae 250g Radix Rehmanniae 250g 150g Radix Ophiopogonis Radix Scutellariae 100g
Radix Paeoniae Rubra 150g Cortex Moutan 150g Rhizoma Alismatis 150g Bulbus Fritillariae Cirrhosae 150g
The fat big 100g Herba Menthae 50g Semen Coicis of Herba Dendrobii 150g (stir-fry) 150g
Radix Glycyrrhizae 50g Semen Oroxyli 100g Periostracum Cicadae 100g Bombyx Batryticatus (parched with bran) 100g
The production dosage form is that the processing step of preparation method of granule is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add 10 times of amounts of boiling water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with the 1mol/L sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), remove Bulbus Fritillariae Cirrhosae, Cortex Moutan, all the other 13 flavor medical materials that Radix Scutellariae is outer, add for the first time 12 times of amounts of water, soaked 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, adding ethanol makes pure content reach 60%, left standstill 12 hours, and got supernatant, reclaim ethanol to there not being the alcohol flavor, add the Radix Scutellariae extracting solution in the above-mentioned steps (3), being evaporated to temperature is 80 ℃, relative density is 1.15-1.20, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder mixing;
(5) and then add 400g sucrose, 200g starch is granulated, promptly.
Embodiment 5:
Radix Scrophulariae 250g Radix Rehmanniae 250g 150g Radix Ophiopogonis Radix Scutellariae 100g
Radix Paeoniae Rubra 150g Cortex Moutan 150g Rhizoma Alismatis 150g Bulbus Fritillariae Cirrhosae 150g
Herba Dendrobii 150g Semen Sterculiae Lychnophorae 100g Herba Menthae 50g Semen Coicis (stir-fry) 150g
Radix Glycyrrhizae 50g Semen Oroxyli 100g Periostracum Cicadae 100g Bombyx Batryticatus (parched with bran) 100g
The production dosage form is that the processing step of preparation of soft capsule method is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add 10 times of amounts of boiling water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with the 1mol/L sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), remove Bulbus Fritillariae Cirrhosae, Cortex Moutan, all the other 13 flavor medical materials that Radix Scutellariae is outer, add for the first time 12 times of amounts of water, soaked 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, adding ethanol makes pure content reach 60%, left standstill 12 hours, and got supernatant, reclaim ethanol to there not being the alcohol flavor, add the Radix Scutellariae extracting solution in the above-mentioned steps (3), being evaporated to temperature is 60 ℃, relative density is 1.38-1.40, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder mixing;
(5) and then add the suspension that salad oil is mixed into 45-50%, make soft capsule, promptly.
Claims (8)
1, a kind of Chinese medicine for the treatment of chronic pharyngolaryngitis is characterized in that: the contained active ingredient of described Chinese medicine is to be made by the Chinese crude drug of following weight proportion:
Radix Scrophulariae 115-135 part Radix Rehmanniae 115-135 part 65-85 Radix Ophiopogonis part
Radix Scutellariae 40-60 part Cortex Moutan 65-85 part Radix Paeoniae Rubra 65-85 part
Bulbus Fritillariae Cirrhosae 65-85 part Rhizoma Alismatis 65-85 part Semen Coicis 65-85 part
Herba Dendrobii 65-85 part Bombyx Batryticatus 40-60 part Herba Menthae 20-30 part
Semen Sterculiae Lychnophorae 40-60 part Periostracum Cicadae 40-60 part Semen Oroxyli 40-60 part
Radix Glycyrrhizae 20-30 part.
2, a kind of Chinese medicine for the treatment of chronic pharyngolaryngitis according to claim 1, it is characterized in that: the contained active ingredient of described Chinese medicine is to be made by the Chinese crude drug of following weight proportion:
75 parts of 125 portions of Radix Rehmanniae of Radix Scrophulariae 125 parts of Radix Ophiopogonis
75 parts of 75 parts of Radix Paeoniae Rubra of 50 parts of Cortex Moutans of Radix Scutellariae
75 parts of 75 parts of Semen Coiciss of 75 portions of Rhizoma Alismatis of Bulbus Fritillariae Cirrhosae
25 parts of 50 portions of Herba Menthaes of 75 parts of Bombyx Batryticatus of Herba Dendrobii
50 parts of 50 portions of Semen Oroxylis of 50 portions of Periostracum Cicadaes of Semen Sterculiae Lychnophorae
25 parts in Radix Glycyrrhizae.
3, Chinese medicine according to claim 1 and 2 is characterized in that: the dosage form of described Chinese medicine is pill, tablet, capsule, granule or soft capsule.
4, Chinese medicine according to claim 3 is characterized in that: wherein the preparation method step of pill is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried respectively to jaundice with slow fire, and is standby;
(2), ten Six-element Chinese medicines all are ground into fine powder, cross the 100-120 mesh sieve, mix homogeneously, medicine, shaping, stranding ball, drying, screening ball are mixed, stir, refined to per 100 parts of fine powders and refined honey 35-50 part and an amount of purified water, makes pill.
5, Chinese medicine according to claim 3 is characterized in that: wherein the preparation method step of tablet is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add 10 times of amounts of boiling water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with the 1mol/L sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), with Radix Scrophulariae, Radix Rehmanniae, Radix Ophiopogonis, Radix Paeoniae Rubra, Rhizoma Alismatis, Semen Coicis, Herba Dendrobii, Bombyx Batryticatus, Herba Menthae, Semen Sterculiae Lychnophorae, Periostracum Cicadae, Semen Oroxyli, Radix Glycyrrhizae 13 flavor medical materials add 12 times of amounts of water for the first time, soak 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, add ethanol and make pure content reach 60%, left standstill 12 hours, get supernatant, reclaim ethanol, add the Radix Scutellariae extracting solution in the above-mentioned steps (3) to there not being the alcohol flavor, being evaporated to temperature is 80 ℃, relative density is the extractum of 1.15-1.20, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder and adjuvant are granulated, and compacting in flakes, the bag film-coat, promptly.
6, Chinese medicine according to claim 3 is characterized in that: wherein the preparation method step of capsule is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add 10 times of amounts of boiling water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with the 1mol/L sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), with Radix Scrophulariae, Radix Rehmanniae, Radix Ophiopogonis, Radix Paeoniae Rubra, Rhizoma Alismatis, Semen Coicis, Herba Dendrobii, Bombyx Batryticatus, Herba Menthae, Semen Sterculiae Lychnophorae, Periostracum Cicadae, Semen Oroxyli, Radix Glycyrrhizae 13 flavor medical materials add 12 times of amounts of water for the first time, soak 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, add ethanol and make pure content reach 60%, left standstill 12 hours, get supernatant, reclaim ethanol, add the Radix Scutellariae extracting solution in the above-mentioned steps (3) to there not being the alcohol flavor, being evaporated to temperature is 80 ℃, relative density is 1.15-1.20, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder mixing, granulate, oven dry incapsulates, promptly.
7, Chinese medicine according to claim 3 is characterized in that: wherein the preparation method step of granule is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add 10 times of amounts of boiling water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with the 1mol/L sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), with Radix Scrophulariae, Radix Rehmanniae, Radix Ophiopogonis, Radix Paeoniae Rubra, Rhizoma Alismatis, Semen Coicis, Herba Dendrobii, Bombyx Batryticatus, Herba Menthae, Semen Sterculiae Lychnophorae, Periostracum Cicadae, Semen Oroxyli, Radix Glycyrrhizae 13 flavor medical materials add 12 times of amounts of water for the first time, soak 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, adding ethanol makes pure content reach 60%, left standstill 12 hours, and got supernatant, reclaim ethanol to there not being the alcohol flavor, add the Radix Scutellariae extracting solution in the above-mentioned steps (3), being evaporated to temperature is 80 ℃, relative density is 1.15-1.20, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder mixing;
(5) and then add 200 portions of sucrose, 100 parts of starch are granulated, promptly.
8, Chinese medicine according to claim 3 is characterized in that: wherein the preparation method step of soft capsule is as follows:
(1), with the Bombyx Batryticatus parched with bran, Semen Coicis is fried to jaundice with slow fire, and is standby;
(2), get Bulbus Fritillariae Cirrhosae, Cortex Moutan is ground into 100-120 purpose fine powder, and is standby;
(3), Radix Scutellariae is decocted with water three times, add 10 times of amounts of boiling water for the first time, decocted 2 hours, second and third time adds 8 times of amounts of water respectively, decocts 1 hour, merges three times decocting liquid, filter, it is 80 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.05-1.10, add the dilute hydrochloric acid test solution in the time of 80 ℃, transfer PH1.0-2.0, be incubated after 1 hour, left standstill 24 hours, filter, precipitate adds the water of 6 times of amounts, transfers pH value 7.0-7.5 with the 1mol/L sodium hydroxide solution, stirring is fully dissolved it, filters filtrate for later use;
(4), with Radix Scrophulariae, Radix Rehmanniae, Radix Ophiopogonis, Radix Paeoniae Rubra, Rhizoma Alismatis, Semen Coicis, Herba Dendrobii, Bombyx Batryticatus, Herba Menthae, Semen Sterculiae Lychnophorae, Periostracum Cicadae, Semen Oroxyli, Radix Glycyrrhizae 13 flavor medical materials add 12 times of amounts of water for the first time, soak 1 hour, heating decocted 2 hours, added 10 times of amounts of water for the second time, and heating decocted 1 hour, merge decocting liquid twice, filter, it is 60 ℃ that filtrate decompression is concentrated into temperature, when relative density is 1.00-1.05, be cooled to 40 ℃, adding ethanol makes pure content reach 60%, left standstill 12 hours, and got supernatant, reclaim ethanol to there not being the alcohol flavor, add the Radix Scutellariae extracting solution in the above-mentioned steps (3), being evaporated to temperature is 60 ℃, relative density is 1.38-1.40, spray drying, the Bulbus Fritillariae Cirrhosae of gained medicated powder and step (2) preparation, Cortex Moutan fine powder mixing;
(5) and then add the suspension that salad oil is mixed into 45-50%, make soft capsule, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100382464A CN1306952C (en) | 2003-05-21 | 2004-05-18 | Chinese traditional medicine for treating chronic pharyngolaryngitis and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03108055 CN1453017A (en) | 2003-05-21 | 2003-05-21 | Chinese medicine for treating chronic laryngopharyngitis and its prepn |
| CN03108055.3 | 2003-05-21 | ||
| CNB2004100382464A CN1306952C (en) | 2003-05-21 | 2004-05-18 | Chinese traditional medicine for treating chronic pharyngolaryngitis and its preparing process |
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| CN1306952C true CN1306952C (en) | 2007-03-28 |
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| CN1318059C (en) * | 2005-09-22 | 2007-05-30 | 太阳石（唐山）药业有限公司 | Chinese medicinal formulation for treating infant lung and stomach exuberance heat |
| CN103585472A (en) * | 2013-10-23 | 2014-02-19 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine for treating chronic hypertrophic pharyngitis |
| CN104984165A (en) * | 2015-07-16 | 2015-10-21 | 韦春翠 | Chronic pharyngolaryngitis lozenge and preparing method of chronic pharyngolaryngitis lozenge |
| CN110507777A (en) * | 2019-09-23 | 2019-11-29 | 江西轩豪中药饮片有限公司 | A kind of Chinese patent drug preparation method for treating chronic bronchitis |
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2004
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Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部药品标准中药成方制剂 中华人民共和国卫生部药典委员会，183.184，中华人民共和国卫生部药典委员会 1998 * |
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