CN1297256C - 一种用于治疗冠心病的口服滴丸制剂及其制备方法 - Google Patents
一种用于治疗冠心病的口服滴丸制剂及其制备方法 Download PDFInfo
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- CN1297256C CN1297256C CNB2004100963320A CN200410096332A CN1297256C CN 1297256 C CN1297256 C CN 1297256C CN B2004100963320 A CNB2004100963320 A CN B2004100963320A CN 200410096332 A CN200410096332 A CN 200410096332A CN 1297256 C CN1297256 C CN 1297256C
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Abstract
Description
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇2000 | 50.0 | 65 | <30 | >10 | + |
聚乙二醇4000 | 50.0 | 74 | <30 | >10 | ++ |
聚乙二醇6000 | 50.0 | 81 | <30 | >10 | +++ |
聚乙二醇8000 | 50.0 | 82 | <30 | >10 | +++ |
聚乙二醇10000 | 50.0 | 84 | <30 | <10 | +++ |
聚乙二醇20000 | 50.0 | 86 | <30 | <10 | +++ |
硬脂酸聚烃氧40酯 | 50.0 | 75 | <30 | >10 | ++ |
倍他环糊精 | 50.0 | 73 | <30 | >10 | ++ |
泊洛沙姆 | 50.0 | 71 | <30 | >10 | ++ |
羧甲基淀粉钠 | 50.0 | 71 | <30 | >10 | ++ |
十二烷基硫酸钠 | 50.0 | 69 | <30 | >10 | ++ |
硬脂酸 | 50.0 | 57 | <30 | >10 | ++ |
硬脂酸钠 | 50.0 | 54 | <30 | >10 | +++ |
甘油明胶 | 50.0 | 56 | <30 | >10 | +++ |
虫胶 | 50.0 | 53 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇2000 | 25.0 | 81 | <30 | >10 | ++ |
聚乙二醇4000 | 25.0 | 84 | <30 | <10 | +++ |
聚乙二醇6000 | 25.0 | 92 | <30 | <10 | +++ |
聚乙二醇8000 | 25.0 | 90 | <30 | <10 | +++ |
聚乙二醇10000 | 25.0 | 91 | <30 | <10 | +++ |
聚乙二醇20000 | 25.0 | 92 | <30 | <10 | +++ |
硬脂酸聚烃氧40酯 | 25.0 | 84 | <30 | <10 | ++ |
倍他环糊精 | 25.0 | 82 | <30 | <10 | ++ |
泊洛沙姆 | 25.0 | 86 | <30 | <10 | +++ |
羧甲基淀粉钠 | 25.0 | 81 | <30 | >10 | ++ |
十二烷基硫酸钠 | 25.0 | 76 | <30 | >10 | ++ |
硬脂酸 | 25.0 | 74 | >30 | >10 | ++ |
硬脂酸钠 | 25.0 | 73 | >30 | >10 | +++ |
甘油明胶 | 25.0 | 70 | >30 | >10 | +++ |
虫胶 | 25.0 | 68 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
聚乙二醇2000 | 10.0 | 84 | <30 | >10 | ++ |
聚乙二醇4000 | 10.0 | 86 | <30 | <10 | +++ |
聚乙二醇6000 | 10.0 | 91 | <30 | <10 | +++ |
聚乙二醇8000 | 10.0 | 93 | <30 | <10 | +++ |
聚乙二醇10000 | 10.0 | 92 | <30 | <10 | +++ |
聚乙二醇20000 | 10.0 | 94 | <30 | <10 | +++ |
硬脂酸聚烃氧40酯 | 10.0 | 89 | <30 | <10 | ++ |
倍他环糊精 | 10.0 | 87 | <30 | <10 | ++ |
泊洛沙姆 | 10.0 | 90 | <30 | <10 | +++ |
羧甲基淀粉钠 | 10.0 | 82 | <30 | >10 | +++ |
十二烷基硫酸钠 | 10.0 | 81 | <30 | >10 | +++ |
硬脂酸 | 10.0 | 79 | >30 | >10 | +++ |
硬脂酸钠 | 10.0 | 81 | >30 | >10 | +++ |
甘油明胶 | 10.0 | 74 | >30 | >10 | +++ |
虫胶 | 10.0 | 75 | >30 | >10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 50 | 82 | <30 | >10 | ++ |
泊洛沙姆∶聚乙二醇=1∶1 | 50 | 81 | <30 | >10 | ++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 50 | 79 | <30 | <10 | ++ |
倍他环糊精∶聚乙二醇=1∶1 | 50 | 69 | <30 | >10 | + |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 25 | 87 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶1 | 25 | 89 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 25 | 86 | <30 | <10 | ++ |
倍他环糊精∶聚乙二醇=1∶1 | 25 | 84 | <30 | >10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶1 | 10 | 91 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶1 | 10 | 92 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶1 | 10 | 91 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶1 | 10 | 89 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 50 | 84 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 50 | 85 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 50 | 86 | <30 | <10 | ++ |
倍他环糊精∶聚乙二醇=1∶5 | 50 | 84 | <30 | >10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 25 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 25 | 91 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 25 | 89 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 25 | 88 | <30 | <10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶5 | 10 | 91 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶5 | 10 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶5 | 10 | 90 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶5 | 10 | 91 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 50 | 90 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 50 | 89 | <30 | <10 | ++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 50 | 88 | <30 | <10 | ++ |
倍他环糊精∶聚乙二醇=1∶10 | 50 | 89 | <30 | >10 | ++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 25 | 92 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 25 | 93 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 25 | 90 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 25 | 91 | <30 | <10 | +++ |
基质名称 | 有效成分(%) | 圆整率(%) | 溶散时限(分钟) | 丸重差异(%) | 硬度 |
硬脂酸聚烃氧40酯∶聚乙二醇=1∶10 | 10 | 90 | <30 | <10 | +++ |
泊洛沙姆∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
羧甲基淀粉钠∶聚乙二醇=1∶10 | 10 | 93 | <30 | <10 | +++ |
倍他环糊精∶聚乙二醇=1∶10 | 10 | 91 | <30 | <10 | +++ |
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CNB2004100963320A CN1297256C (zh) | 2004-11-30 | 2004-11-30 | 一种用于治疗冠心病的口服滴丸制剂及其制备方法 |
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CNB2004100963320A CN1297256C (zh) | 2004-11-30 | 2004-11-30 | 一种用于治疗冠心病的口服滴丸制剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN1634488A CN1634488A (zh) | 2005-07-06 |
CN1297256C true CN1297256C (zh) | 2007-01-31 |
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Country Status (1)
Country | Link |
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