CN1296094C - Joint nutrient tablet - Google Patents
Joint nutrient tablet Download PDFInfo
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- CN1296094C CN1296094C CNB200510086270XA CN200510086270A CN1296094C CN 1296094 C CN1296094 C CN 1296094C CN B200510086270X A CNB200510086270X A CN B200510086270XA CN 200510086270 A CN200510086270 A CN 200510086270A CN 1296094 C CN1296094 C CN 1296094C
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Abstract
The present invention relates to a joint nutrient tablet which is prepared from major ingredients and auxiliary materials, wherein the major ingredients comprise: 100 to 700 mg of D-aminoglucose, 100 to 600 mg of composite bone collagen and 30 to 100 mg of vitamin C; the auxiliary materials comprise: 50 to 200 mg of xylitol, 10 to 200 mg of maltodextrin and 1 to 10 mg of magnesium stearate. The organic bond of the nutrients enables the present invention to mix various ingredients with different effects into the present invention, and the cooperation and synergistic effects of the ingredients enhance the vigor of the cartilage cells, increase lubrication of the joints, reduce trauma of the joints, promote nutritional rehabilitation of the damaged articular cartilages, promote normalization of joint metabolism and help regeneration of the degraded articular cartilages.
Description
Technical field:
The present invention relates to a kind of joint nutrient tablet that adopts D-glucosamine, compound ossein, vitamin C, xylitol, maltodextrin, magnesium stearate formulated to form.
Background technology:
At present, American National arthritis and skeletal muscle and dermatosis association (NIAMS) maintain the leading position for the research of osteoarthritis.NIAMS subsidizes the research worker of numerous domestic this disease is studied.Set up a particular study center now, be devoted to the research of osteoarthritis.Also has many scientists intracardiac work that goes in for the study in NIAMS multipurpose arthritis and skeletal muscle and dermatosis.Basis, clinical and laboratory research are carried out in these centers, and target is to disclose this sick cause of disease, improvement Therapeutic Method and prevention.Arthritis and skeletal muscle disease research personnel also study to the professional, to the patient and the public's education, projects such as epidemiology and health services.
For many years, scientist thinks that always osteoarthritis is exactly that a kind of the increase with the age joint " wear and tear and tear " sexually transmitted disease (STD) occurs and become.But in the past 10 years, studies show that except the age, to also have many other factorses in action.The achievement of research is, the keeping and destroying of cartilage in osteoarthritis is the same with bone destruction, is counted as a kind of successive reaction of disease or is cascade reaction.It is problem where to have occurred on earth that many research worker are just trying to find out in this cascade reaction.Understood where go wrong after, they also wish to find new prevention and treatment method.
Pain management and the method for improving function are often arranged in the osteoarthritis therapeutic scheme.Such scheme comprises exercise, rest and joint nursing, alleviating pain, controlling body weight, Drug therapy, surgical operation and Chinese traditional treatment.
Report is often arranged, nutritional support the treatment osteoarthritis in of great use.But,, therefore this class report is wanted careful attention because the concrete effect situation of the careful comment of research nutritional support is seldom arranged.Glucosamine has this nutrient very in a small amount in food, it also is the normal composition of cartilage.Scientific research about this nutrient Supporting Therapy shows that they have no impact to the state of an illness.Can but perhaps it can alleviate part patient's symptom, and the state-run additional and optional therapeutic community of NIH is carrying out a clinical trial, detect glucosamine and ease the pain, improve function when using separately.Patient is preferably in a part of just treating as a whole with this treatment under doctor's the guidance, just as exercise, rest, alleviating pain.
Based on above-mentioned result of study, propose treatment of arthritis in this product research exploitation and will possess and to build sweet smell and enclose, provide nutrition, improve joint lubrication, quicken comprehensive function such as joint repair.At present, be used for the treatment of on the market osteoarthritis medicine common analgesia chaste tree, NSAID (non-steroidal anti-inflammatory drug), local hormone injection and intra-articular injection hyaluronidase etc. are arranged, these medicines generally can only relief of symptoms, be difficult to thoroughly improve the function of joint and the state of an illness, and big multi-functional and effect is more single, or gentrify is lubricated etc.This product is then different, be by above nutraceutical combination, this product is had to be incorporated multiple different efficacies composition in the product, these compositions cooperatively interact, synergism, the vigor of raising chondrocyte increases the lubricated of joint, reduce joint injury, promote the nutritional rehabilitation of impaired articular cartilage.Can promote joint metabolism normalization, help the regeneration of degeneration articular cartilage.
Summary of the invention:
The objective of the invention is to develop a kind of joint nutrient tablet that adopts D-glucosamine, compound ossein, vitamin C, xylitol, maltodextrin, magnesium stearate formulated to form, by above nutraceutical combination, this product is had to be incorporated multiple different efficacies composition in the product, these compositions cooperatively interact, synergism, the vigor of raising chondrocyte increases the lubricated of joint, reduce joint injury, promote the nutritional rehabilitation of impaired articular cartilage.Can promote joint metabolism normalization, help the regeneration of degeneration articular cartilage.
Technical scheme of the present invention:
By weight:
D-glucosamine 100～700mg
Compound ossein 100～600mg
Vitamin C 30～100mg
Xylitol 50～200mg
Maltodextrin 10～200mg
Magnesium stearate 1～10mg
Production technology:
For guaranteeing product quality, all operations all should carry out in clean and dry environment.
Select D-glucosamine, compound ossein, vitamin C, xylitol, maltodextrin, magnesium stearate for use, add material, mixing, adding binding agent, granulation, drying, granulate, tabletting, check, packing, finished product according to weight proportion, promptly make joint nutrient tablet.The joint nutrient tablet main component:
D-aminoacid glucose:
D-glucosamine (full name is a D-glucosamine): D-glucosamine is chitinous basic composition unit.Chitin is the natural animal diet nutrient that derives from the ocean, it extensively is present in the shell and shell of shrimp, Eriocheir sinensis, the medical circle in the U.S., Europe and the seventh-largest nutrient that nutrient research mechanism is called chitin the health after protein, fat, sugar, vitamin, mineral.Chitin degradable under acid condition is a D-glucosamine, and it is the important nutrient of human synovial health, and the aminoacid glucose is the key component that forms the connective tissue material of cartilage.It can stimulate the synthetic necessary important composition material of generation collagen, hyaluronic acid and mucopolysaccharide (GAG).When hyaluronic acid combined with GAG, collagen can be strengthened the cartilage robustness, produced the joint fluid of normal quantity.Glucosamine has following effect:
1) makes cartilage metabolism normalization, help to prevent chondroclasis;
2) attract and keep moisture in the joint here, make the cartilage can be dry, and therefore be easy to fracture;
3) produce joint fluid, the influence that the protection joint is not stressed and rubs.The joint fluid of normal quantity can increase the nutrition of cartilage;
4) make cartilage keep elasticity and toughness, when carrying out joint motions, can stretch and restore to the original state rapidly;
5) regulate the cartilage destruction enzyme, reduce the damage of existing cartilage;
6) reduce pain, strengthen body's natural and repair function, improve function of joint.
Compound ossein:
Compound ossein is the complex by the acid mucopolysaccharide of the pure natural that extracts in the qualified healthy animal cartilaginous tissue of national inspection and quarantine, collagen protein etc.The content of collagen protein 〉=60% wherein, the content of mucopolysaccharide 〉=26%.The content of proline, alanine, arginine, hydroxyproline is higher in the aminoacid of compound ossein is formed, and these aminoacid are the synthetic proteic very important ingredients of collagen of human body, have multiple important physical function and unique biological activity.The composition of mucopolysaccharide is then based on chondroitin sulfate, hyaluronic acid, keratan sulfate.
Collagen protein is the maximum protein of people's in-vivo content, accounts for the 25-33% of human body protein, is equivalent to 6% of body weight for humans, and it spreads all over each histoorgan of whole body, as skeleton, cartilage, ligament, skin, cornea, various inner membrance fascias or the like.Its major function is to keep the form and the structure of skin and histoorgan, also is the important source material material of repairing each damaged tissue.Collagen protein mainly is made up of glycine, proline and hydroxyproline etc., and it also extensively is present in the general protein food.
Collagen protein forms network-like arrangement in articular cartilage surface, and this shape has elastic characteristic, available buffer concussion and pressure.
Collagen protein can promote the metabolism of chondrocyte, and the nutrition of cartilage synovial membrane is provided, and increases the density and the intensity of bone, thereby plays the effect of defying age, promotion growth.Former albumen passes through the effect of a series of synthetic conversion competence exertion in vivo, and vitamin C helps it to finish this process.When hypovitaminosis C, collagen protein transforms limited, and its elasticity reduces, and occurs fracture easily.
Chondroitin sulfate and hyaluronic acid are mucopolysaccharides important in the articular cartilage.
1. chondroitin sulfate
Chondroitin sulfate is prevalent in the cartilage in joint, is the maximum mucopolysaccharide of content in the cartilage, accounts for 45%～75% of full formation; Can help cartilage to hold moisture, have lubricated and buffered effect, help softness and the obdurability of keeping the joint, promote the reparation of articular cartilage, be to form one of most important nutrient of chondrocyte.
2. hyaluronic acid
Hyaluronic acid has protection and removes function, can effectively remove inflammatory factor and harmful enzyme in the articular cavity, removes the factor that causes arthropathy, and the inflammation-inhibiting reaction takes place.
D-glucosamine is the basic substance of synthetic mucopolysaccharide, is the main component of articular cartilage, and with advancing age, the intravital D-glucosamine of people, collagen content all can reduce gradually.After collagen protein or mucopolysaccharide content reduced, it is lax that mucopolysaccharide is connected with the net of collagen protein, makes articular cartilage easy deformation and increase the weight of to wear and tear the initiation arthropathy when stressed.The loss of collagen protein and mucopolysaccharide and synthetic deficiency are the main causes that causes the articular cartilage pathological changes, therefore will keep the lubricated and flexible motion in joint, should in time replenish the healthy needed various nutrients of articular cartilage.
When articular cartilage nutrient source is not enough, will cause mucopolysaccharide and collagen protein synthesis minimizing in the body, pathological changes will appear in cartilage, as osteoarthritis.
Technological merit of the present invention:
The joint nutrient tablet that the present invention adopts formulated such as D-glucosamine, compound ossein, vitamin C, xylitol, maltodextrin, magnesium stearate to form, by above nutraceutical combination, this product is had to be incorporated multiple different efficacies composition in the product, these compositions cooperatively interact, the performance synergism.
So joint nutrient tablet is being adjusted function of human body, for joint and cartilage supply nutrition, can promote joint metabolism normalization, help the regeneration of degeneration articular cartilage, its effect mainly contains following two aspects:
1) improves joint lubrication
Joint nutrient tablet can impel knuckle synovia to generate in a large number, for joint tissue provides prescribing adequate nutrition, keeps the lubricated of cartilage surface, and then effectively alleviates the pain that the bone friction produces, and makes joint motion nimbly and freely.D-glucosamine is many more in the cartilage, and newborn mucopolysaccharide is just many more, and absorbent lubricating fluid is also many more, just is of value to articular cartilage health more.
2) repair cartilaginous tissue
By the synthetic mucopolysaccharide of D-glucosamine.It can promote the chondrocyte normal metabolic joint nutrient tablet, and constantly repair the articular cartilage that has been worn with collagen protein, promote the regeneration of degeneration articular cartilage, thereby the elasticity and the motility that recover articular cartilage delay the process of joint disease.
The specific embodiment:
Embodiment 1
The present invention is a joint nutrient tablet, it is characterized in that it is the product made from the raw material of following weight ratio.
Prescription:
By weight
D-glucosamine 100mg
Compound ossein 600mg
Vitamin C 100mg
Xylitol 170mg
Maltodextrin 20mg
Magnesium stearate 10mg
Add material, mixing, adding binding agent, granulation, drying, granulate, tabletting, check, packing, finished product according to weight proportion, promptly make joint nutrient tablet.
Embodiment 2
The present invention is a joint nutrient tablet, it is characterized in that it is the product made from the raw material of following weight ratio.
Prescription:
By weight
D-glucosamine 400mg
Compound ossein 300mg
Vitamin C 60mg
Xylitol 100mg
Maltodextrin 134mg
Magnesium stearate 6mg
Technology according to embodiment 1 is made tablet.
Embodiment 3
The present invention is a joint nutrient tablet, it is characterized in that it is the product made from the raw material of following weight ratio.
Prescription:
By weight
D-glucosamine 700mg
Compound ossein 100mg
Vitamin C 30mg
Xylitol 50mg
Maltodextrin 117mg
Magnesium stearate 3mg
Technology according to embodiment 1 is made tablet.
Claims (1)
1. joint nutrient tablet, it is characterized in that: it is the product made from the raw material of following weight ratio,
Prescription:
By weight:
D-glucosamine 100～700mg
Compound ossein 100～600mg
Vitamin C 30～100mg
Xylitol 50～200mg
Maltodextrin 10～200mg
Magnesium stearate 1～10mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200510086270XA CN1296094C (en) | 2005-08-22 | 2005-08-22 | Joint nutrient tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200510086270XA CN1296094C (en) | 2005-08-22 | 2005-08-22 | Joint nutrient tablet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1733297A CN1733297A (en) | 2006-02-15 |
| CN1296094C true CN1296094C (en) | 2007-01-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200510086270XA Expired - Fee Related CN1296094C (en) | 2005-08-22 | 2005-08-22 | Joint nutrient tablet |
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| CN (1) | CN1296094C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101385852B (en) * | 2008-10-17 | 2011-03-30 | 关伟 | Preparation method of bone collagen tablet |
| CN103704684A (en) * | 2012-09-29 | 2014-04-09 | 邱多福 | Bone health product |
| CN109043518A (en) * | 2016-02-15 | 2018-12-21 | 北京东方兴企食品工业技术有限公司 | A kind of functional nutrient food improving bone and joint diseases symptom |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1364464A (en) * | 2002-01-29 | 2002-08-21 | 郑刚 | Aminoglucose hydrochloride medicinal composition |
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- 2005-08-22 CN CNB200510086270XA patent/CN1296094C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1364464A (en) * | 2002-01-29 | 2002-08-21 | 郑刚 | Aminoglucose hydrochloride medicinal composition |
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| Publication number | Publication date |
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| CN1733297A (en) | 2006-02-15 |
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Granted publication date: 20070124 Termination date: 20160822 |