CN101385852B - Preparation method of bone collagen tablet - Google Patents
Preparation method of bone collagen tablet Download PDFInfo
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- CN101385852B CN101385852B CN2008102184979A CN200810218497A CN101385852B CN 101385852 B CN101385852 B CN 101385852B CN 2008102184979 A CN2008102184979 A CN 2008102184979A CN 200810218497 A CN200810218497 A CN 200810218497A CN 101385852 B CN101385852 B CN 101385852B
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- bone collagen
- ossein
- essence
- starch
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Abstract
The invention discloses a preparation method of ossein tablets the pelletization of which is divided into two steps. The method is characterized in that the pelletization of bonding agents proceeds by taking water as solvent firstly, and then the pelletization of bonding agents proceeds by taking hydrin as the solvent, then the particles obtained after the twice pelletization are mixed evenly and tableted; the method improves the proportion of the ossein in the tablets and enhances the curative effect of the ossein preparation, meanwhile, in the invention, essence is added in the ossein tablet, thus being capable of inhibiting the inherent scent of the ossein and improving the taste of the ossein tablet.
Description
Technical field
The present invention relates to a kind of preparation method of bone collagen tablet.
Background technology
Ossein has delaying osteoporosis, elimination arthralgia, treatment of arthritis disease, accelerating bone healing, maintenance skeleton toughness, prevents the effects such as loss of calcium.The preparation of traditional bone collagen tablet be by recipe quantity with the raw material mix homogeneously, and the raw material of mix homogeneously is made soft material, then with soft material granulation, drying, tabletting with pure water.Since ossein in water dissolubility less, therefore adopt the content of ossein in the ossein preparation that the traditional preparation process method makes lower, thereby can influence the curative effect of ossein preparation.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of preparation method of bone collagen tablet, this preparation method can improve the content of ossein in preparation, to strengthen the curative effect of ossein preparation.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of preparation method of bone collagen tablet, it is characterized in that its comprise the steps: (1), get the raw materials ready get ossein, dextrin, white sugar, lactose, ethanol (60%～80%) and an amount of starch, essence, magnesium stearate standby; (2) first preparation 8% starch slurry of first step granulation a. takes by weighing starch, food coloring and pure water by recipe quantity, gets a little pure water and starch, food coloring fully stirs, and purified water remainder is heated in the boiling back adding starch, stirs, and cools off standby; B. mix adjuvant, white sugar is crushed to fine powder, and lactose, a part of essence and a part of dextrin are crossed 80 mesh sieves, takes by weighing by recipe quantity and drops in the trough type mixing machine, fully mixes, and makes it even; C. make soft material, in trough type mixing machine, slowly add starch slurry while stirring, fully mix; D. granulate, soft material is put waved middle granulation, and cross 14 mesh sieves; E. dry, the granule that makes is placed baking oven, under 65 ± 5 ℃ temperature, make its bone dry; F. material all in one piece is crossed dried granule 12 mesh sieves, is weighed; (3), the second step granulation a. handles ossein, take by weighing ossein, remaining essence and dextrin by recipe quantity and cross 80 mesh sieves, put abundant mix homogeneously in the trough type mixing machine, slowly drop into 60%～80% ethanol behind the mix homogeneously while stirring, fully mix, cross 60 mesh sieves; B. the good granule of granulate drops in the multidirectional mixer in the first step being granulated, and drops into the magnesium stearate of above-mentioned bone collagen powder of handling well and recipe quantity again, fully mixes, and blanking, weighs; C. with the compound tabletting, promptly obtain bone collagen tablet.
The present invention can adopt food colorings commonly used such as amaranth.
The essence that the present invention adopts can be essence or the floral type or the cola type essence of fruit-like flavours such as strawberry essence, Fructus Citri Limoniae essence.
The monolithic Weight control of bone collagen tablet of the present invention is 0.3325---0.3675 gram.
Each raw materials in part by weight of the present invention is: 40～70 parts of osseins, 50～80 parts in dextrin, 100～125 parts of white sugars, 40～70 parts of lactose, 8～12 parts of ethanol, an amount of starch, essence, magnesium stearate, wherein alcoholic acid weight concentration is 60～80%.
The invention has the beneficial effects as follows: the present invention elder generation water is cooked the granulation that solvent is made binding agent; reuse alcohol is done the granulation that solvent prepares ossein; with tabletting behind twice granulation mix homogeneously; because ossein dissolubility in alcohol is big than the dissolubility in the water; thereby improved the ratio of ossein in tablet, to strengthen the curative effect of ossein preparation, the present invention has simultaneously added essence in the ossein tablet; thereby can suppress the inherent abnormal smells from the patient of ossein, improve the taste of bone collagen tablet.
The present invention is further described below in conjunction with embodiment.
The specific embodiment
The method that the present invention prepares bone collagen tablet comprises the steps:
(1), get the raw materials ready get ossein 40～70kg, dextrin 50～80kg, white sugar 100～125kg, lactose 40～70kg, ethanol (weight concentration 60%～80%) 8～12kg, starch 14.4kg, strawberry essence 6.3kg, magnesium stearate 2.1kg are standby;
(2) first step is granulated
A. first preparation 8% starch slurry takes by weighing starch, amaranth and pure water by recipe quantity, gets a little pure water and starch, amaranth fully stirs, and purified water remainder is heated in the boiling back adding starch, stirs, and cools off standby;
B. mix adjuvant, white sugar is crushed to fine powder, and lactose, a part of strawberry essence and 20～30 parts of mistake 80 mesh sieves of dextrin take by weighing in the input trough type mixing machine by recipe quantity, fully mix 30 minutes, make it even;
C. make soft material, in trough type mixing machine, slowly add starch slurry while stirring, fully stirred mix homogeneously 30 minutes;
D. granulate, soft material is put waved middle granulation, and cross 14 mesh sieves;
E. dry, place the baking oven pallet to push in the baking oven granule that makes, close chamber door.Setting oven temperature is 65 ± 5 ℃, picks up counting when temperature arrives 65 ℃, amounts to dry about 4 hours (time can prolong as required, is as the criterion with bone dry).In exsiccant process, must per hour stir granule once, so that bone dry.After drying finishes, close the baking oven for heating device, open oven door, wait particle temperature to drop to blanking behind the room temperature;
F. material all in one piece is crossed dried granule 12 mesh sieves, is weighed;
(3), second step granulated
A. handle ossein, take by weighing ossein, remaining strawberry essence and remaining dextrin by recipe quantity and cross 80 mesh sieves, put in the trough type mixing machine and fully mixed 20 minutes, make it even, slowly drop into concentration behind the mix homogeneously while stirring and be 60%～80% ethanol 1.7L, fully mix, cross 60 mesh sieves;
B. always mix, the good granule of granulate dropped in the multidirectional mixer during the first step was granulated, and dropped into the magnesium stearate of above-mentioned bone collagen powder of handling well and recipe quantity again, fully mixed 30 minutes, blanking, weighed;
C. with the compound tabletting, the monolithic Weight control of bone collagen tablet is 0.3325---0.3675 gram, and heavy once every 15 minutes weighing sheets at least in the tabletting process, promptly obtain bone collagen tablet.
Claims (5)
1. the preparation method of a bone collagen tablet is characterized in that it comprises the steps: (1), gets 40～70 parts of osseins, 50～80 parts in dextrin, 100～125 parts of white sugars, 40～70 parts of lactose, 8～12 parts of ethanol and an amount of starch, essence, magnesium stearate be standby; (2) first preparation 8% starch slurry of first step granulation a. takes by weighing starch, food coloring and pure water by recipe quantity, gets a little pure water and starch, food coloring fully stirs, and purified water remainder is heated in the boiling back adding starch, stirs, and cools off standby; B. mix adjuvant, white sugar is crushed to fine powder, and lactose, a part of essence and a part of dextrin are crossed 80 mesh sieves, takes by weighing by recipe quantity and drops in the trough type mixing machine, fully mixes, and makes it even; C. make soft material, in trough type mixing machine, slowly add starch slurry while stirring, fully mix; D. granulate, soft material is put waved middle granulation, and cross 14 mesh sieves; E. dry, the granule that makes is placed baking oven, under 65 ± 5 ℃ temperature, make its bone dry; F. material all in one piece is crossed dried granule 12 mesh sieves, is weighed; (3), the second step granulation a. handles ossein, take by weighing ossein, remaining essence and dextrin by recipe quantity and cross 80 mesh sieves, put abundant mix homogeneously in the trough type mixing machine, slowly drop into 60%～80% ethanol behind the mix homogeneously while stirring, fully mix, cross 60 mesh sieves; B. the good granule of granulate drops in the multidirectional mixer in the first step being granulated, and drops into the magnesium stearate of above-mentioned bone collagen powder of handling well and recipe quantity again, fully mixes, and blanking, weighs; C. with the compound tabletting, promptly obtain bone collagen tablet.
2. the preparation method of a kind of bone collagen tablet according to claim 1 is characterized in that described food coloring is amaranth.
3. the preparation method of a kind of bone collagen tablet according to claim 1 is characterized in that described essence is strawberry essence.
4. the preparation method of a kind of bone collagen tablet according to claim 1, the monolithic weight that it is characterized in that bone collagen tablet is 0.3325---0.3675 gram.
5. the preparation method of a kind of bone collagen tablet according to claim 1 is characterized in that described alcoholic acid weight concentration is 60%～80%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102184979A CN101385852B (en) | 2008-10-17 | 2008-10-17 | Preparation method of bone collagen tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102184979A CN101385852B (en) | 2008-10-17 | 2008-10-17 | Preparation method of bone collagen tablet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101385852A CN101385852A (en) | 2009-03-18 |
| CN101385852B true CN101385852B (en) | 2011-03-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008102184979A Expired - Fee Related CN101385852B (en) | 2008-10-17 | 2008-10-17 | Preparation method of bone collagen tablet |
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| Country | Link |
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| CN (1) | CN101385852B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111067107A (en) * | 2018-10-19 | 2020-04-28 | 佛山市肽硒其生物科技有限公司 | Ossein tablet and processing method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334302A (en) * | 2001-04-08 | 2002-02-06 | 内蒙古草原兴发股份有限公司 | Process for preparing bone collagen |
| CN1733297A (en) * | 2005-08-22 | 2006-02-15 | 北京东方兴企食品工业技术有限公司 | Joint nutrient tablet |
| CN1903360A (en) * | 2006-08-18 | 2007-01-31 | 孙天民 | Calcium-tablet for preventing osteoporosis |
-
2008
- 2008-10-17 CN CN2008102184979A patent/CN101385852B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334302A (en) * | 2001-04-08 | 2002-02-06 | 内蒙古草原兴发股份有限公司 | Process for preparing bone collagen |
| CN1733297A (en) * | 2005-08-22 | 2006-02-15 | 北京东方兴企食品工业技术有限公司 | Joint nutrient tablet |
| CN1903360A (en) * | 2006-08-18 | 2007-01-31 | 孙天民 | Calcium-tablet for preventing osteoporosis |
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| Publication number | Publication date |
|---|---|
| CN101385852A (en) | 2009-03-18 |
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| C14 | Grant of patent or utility model | ||
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| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20090318 Assignee: Guangzhou Saijian Bio-tech Co., Ltd. Assignor: Guan Wei Contract record no.: 2013440000317 Denomination of invention: Preparation method of bone collagen tablet Granted publication date: 20110330 License type: Exclusive License Record date: 20130620 |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110330 Termination date: 20181017 |