CN1296017C - Tool for shape sensing deprivating of shortsightedness animal model - Google Patents
Tool for shape sensing deprivating of shortsightedness animal model Download PDFInfo
- Publication number
- CN1296017C CN1296017C CN 200410014098 CN200410014098A CN1296017C CN 1296017 C CN1296017 C CN 1296017C CN 200410014098 CN200410014098 CN 200410014098 CN 200410014098 A CN200410014098 A CN 200410014098A CN 1296017 C CN1296017 C CN 1296017C
- Authority
- CN
- China
- Prior art keywords
- animal model
- tool
- form deprivation
- headgear
- deprivating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000010171 animal model Methods 0.000 title claims abstract description 14
- 208000001491 myopia Diseases 0.000 title claims abstract description 13
- 230000004379 myopia Effects 0.000 title abstract description 6
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 3
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 3
- 210000005069 ears Anatomy 0.000 claims description 4
- 101001010782 Drosophila melanogaster Fez family zinc finger protein erm Proteins 0.000 claims description 3
- 229920001971 elastomer Polymers 0.000 claims description 2
- 239000013013 elastic material Substances 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 241000700199 Cavia porcellus Species 0.000 description 8
- 210000000744 eyelid Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 210000001508 eye Anatomy 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 3
- 210000003786 sclera Anatomy 0.000 description 3
- 210000003128 head Anatomy 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Landscapes
- Toys (AREA)
- Instructional Devices (AREA)
Abstract
The present invention relates to a tool for carrying out form deprivation to an animal model in near-sightedness investigation. In the tool for carrying out form deprivation to an animal model, mouth piston holes (1) with matched sizes are arranged on a position corresponding to a mouth and a nose, and a retaining cap of a reference port (2) is arranged on a reference hole and is made of a nontoxic elastic material. Compared with the prior art, the tool has the advantages of convenient use, no wound, reversibility, low cost and high success ratio.
Description
Technical field:
The present invention relates to a kind of instrument that in myopia research, animal model is carried out form deprivation.
Background technology:
In myopia research, for understanding bathomorphic genesis mechanism, all be experiment method by animal model, generally select for use chicken, tree mouse, monkey, Cavia porcellus etc. as model.But in the experiment of existing near-sighted animal model, form deprivation method commonly used is that monocular suture of eyelid is sewed up, but there is following shortcoming in the method that eyelid is sewed up: 1, eyelid is sewed up easily and is broken away from, and as form deprivation, as long as find that suture comes off, this animal just need exclude.General suture success rate after 8 weeks has only about 20%.On experimental design and animal consumption, need to improve greatly like this, increase difficulty for experiment; 2, suture method interrupted suture commonly used, whether therefore also very difficult sometimes assurance reaches the full form feel is peeled off, thereby influences experimental result; 3, eyelid is sewed up, and is traumatic method, and suture infects easily, and the compressing cornea also can produce other pathologic damage and influence corneal curvature, and these all might influence experimental result; 4, it is reversible that eyelid is sewed up right and wrong, and this comprises two kinds of possibilities, and the one, after suture was removed, because sew up for a long time, therefore eyelid adhesion sometimes can't observe the near-sighted recovery situation of animal model; The 2nd, in experimentation, dosing eyes and inconvenience thereof because in case after removing suture, because eyelid damage just can't go stitching again, so often causes testing and can't carry out, also can't be observed effect of drugs.
Goal of the invention:
The objective of the invention is to for overcoming the deficiencies in the prior art, a kind of wound easy to use, no, reversible, cost is low, success rate is high near-sighted animal model visual deprivation instrument are provided.
For achieving the above object, the technical solution used in the present invention is: near-sighted animal model form deprivation instrument offers the headgear of contrast mouthful for offer match trepanning, contrast eye place of size at corresponding mouth and nose place, and described headgear is made by nontoxic, rubber-like rubber finger sleeve.
As the further setting of the present invention, headgear also offers trepanning at corresponding ears place.
Compared with prior art, the present invention has following advantage: 1, the eyeshield made of headgear, because it is ball is flexible, fixing easily, convenient.General success rate after 8 weeks can arrive more than 90%; 2, the headgear method is owing to use opaque balloon, can guarantee therefore that full form is felt to peel off, and can not influence experimental result; 3, the eyeshield made of balloon does not have traumaticly, can not influence experimental result; 4, the eyeshield made of balloon can put easily and take off, can administration in the experimentation, and also can be designed to remove form deprivation and make and recover animal and all can; 5, used balloon is a latex material, and the glove that use during with operation are the same, and therefore, these materials do not possess toxicity.
With specific embodiment this utility model is further described with reference to the accompanying drawings below.
Description of drawings:
Fig. 1 is a specific embodiment of the invention sketch map;
Fig. 2 uses sketch map for the embodiment of the invention;
The specific embodiment: as shown in Figure 1, described headgear can be selected market milk glue balloon for use, with the Cavia porcellus is that example is selected latex balloon for use 6～No. 8 according to the size of selected Cavia porcellus, offer circular muzzle hole 1 and contrast mouth 2 respectively at corresponding mouth and nose and a position that contrasts eye, in order to be fixed on the head of Cavia porcellus better, also can offer ear muff hole 3 in the position of corresponding ears, above-mentioned muzzle hole 1, contrast mouthful 2 gill trepannings 3 can be decided according to the nose shape of Cavia porcellus.
During use, headgear is enclosed within the Cavia porcellus head, ears and mouth and nose stretch out from the muzzle hole 1 of correspondence and ear muff hole 3 respectively, and a contrast eye exposes from contrast mouthful 2 holes.We adopt the Cavia porcellus in birth 3～4 weeks of back as animal pattern, adopt 6～No. 8 balloon to make headgear, form animal form deprivation model.A glance is deprived, a glance contrast.When depriving the 2nd week of back, 4 weeks, 6 weeks, 8 weeks, adopt skiametry to measure its refractive diopter, the super axiallength of measuring of A, the sclera dry weight is the amount of back utmost point portion sclera relatively.Find bereft a glance, axis oculi prolongs, and dioptric is myopia, and the sclera dry weight reduces, and and normal control and do not deprive eye relatively, have statistical significance.Therefore, Cavia porcellus can be used as the animal model of myopia, and balloon is made deprives the effective ways that can be used as form deprivation.
Claims (2)
1, a kind of near-sighted animal model form deprivation instrument, it is characterized in that: described form deprivation instrument offers the headgear of contrast mouthful (2) for offer match muzzle hole (1), contrast eye place of size at corresponding mouth and nose place, and described headgear is made by opaque, nontoxic, rubber-like rubber finger sleeve.
2, near-sighted animal model form deprivation instrument according to claim 1, it is characterized in that: described headgear also offers ear muff hole (3) at corresponding ears place, plays fixation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410014098 CN1296017C (en) | 2004-02-16 | 2004-02-16 | Tool for shape sensing deprivating of shortsightedness animal model |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410014098 CN1296017C (en) | 2004-02-16 | 2004-02-16 | Tool for shape sensing deprivating of shortsightedness animal model |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1559357A CN1559357A (en) | 2005-01-05 |
| CN1296017C true CN1296017C (en) | 2007-01-24 |
Family
ID=34440193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410014098 Expired - Lifetime CN1296017C (en) | 2004-02-16 | 2004-02-16 | Tool for shape sensing deprivating of shortsightedness animal model |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1296017C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703421B (en) * | 2009-11-06 | 2011-03-23 | 温州医学院眼视光研究院 | Inducing tool of animal myopia model |
| CN103314873B (en) * | 2013-06-17 | 2015-12-30 | 西安交通大学医学院第一附属医院 | A kind of induce rabbit myopia wear mirror system and application thereof |
| CN110123264A (en) * | 2019-05-24 | 2019-08-16 | 山东中医药大学 | A kind of adjustable cavy glasses based on 3D scanning and printing |
| CN113412792B (en) * | 2021-07-12 | 2022-02-25 | 温州眼视光国际创新中心 | Myopia animal model construction instrument |
-
2004
- 2004-02-16 CN CN 200410014098 patent/CN1296017C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1559357A (en) | 2005-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070124 |
|
| CX01 | Expiry of patent term |