CN103314873B - A kind of induce rabbit myopia wear mirror system and application thereof - Google Patents
A kind of induce rabbit myopia wear mirror system and application thereof Download PDFInfo
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- CN103314873B CN103314873B CN201310238070.6A CN201310238070A CN103314873B CN 103314873 B CN103314873 B CN 103314873B CN 201310238070 A CN201310238070 A CN 201310238070A CN 103314873 B CN103314873 B CN 103314873B
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Abstract
The invention discloses a kind of induce rabbit myopia wear mirror system and application thereof, described mirror system of wearing comprises: truncated cone-shaped face shield, mirror holder, induction eyeglass, fixed band and buckle.Induction eyeglass convenient disassembly of the present invention, can experimentally need to change different eyeglass.The present invention adopts the movable buckle of convenient disassembly, overcomes the drawback in the past dismantling inconvenience.Mirror system of wearing of the present invention also comprises Elizabethan's necklace, and it effectively can prevent laboratory animal infringement to experiment headgear in scratching process, ensures the success rate of experiment.The preferred nylon material of face shield of the present invention, plasticity is extremely strong, and face shield forms natural cover, prevents animal from stealing a glance at and disorderly sees.The present invention only wipes out the circumocular hair of laboratory animal, does not cause physiological damage to laboratory animal, ensures the survival rate of animal.Of the present inventionly wear mirror system, be applicable to rabbit, dog, the laboratory animal such as cat.
Description
Technical field
The present invention relates to zoopery apparatus, being specifically related to a kind of for inducing the headgear of the myopia animal models such as rabbit, cat, dog.
Background technology
The Research of Animal Model for Study of myopia establishes two kinds of experimental models, that is: ultrastructure in form deprivation myopia (formdeprivationmyopia, FDM), referring to sewing up eyelid, affecting the visual development of animal and the myopia that causes with translucent eyeglass or light tight headgear method; Eyeglass inductivity myopia (lensinducedmyopia, LIM), or claim lens-induced myopia (defocusmyopia), refer to force animal depending near or wear negative concave-sphere eyeglass and make the image focu of object in retina rear, thus cause axis oculi to extend the myopia caused.Current research specify that FDM and LIM is two kinds of myopia as different as chalk and cheese.
The near-sighted abductive approach being usually used in laboratory animal has many kinds, comprise eyelid suture, Goggle eyeglass method etc., but these methods all exists certain shortcoming.Eyelid suture is for there being the operation of wound property, the surface of a wound easily causes ocular infection, need again when suture comes off again to sew up, laboratory animal is more painful, and disturbs final near-sighted inducing effect, sews up as irreversibility in addition, suture need be cut off as needs carry out optometry index checking, again sew up after checking out, and stitching itself may cause the compressing of cornea to affect the observation of the optometry indexs such as corneal curvature, therefore eyelid suture method is eliminated just gradually.Goggle eyeglass method (translucent eyeglass) often adopts stitching to fix or adhesion method fixes eyeglass, although reduce the impact of the optometry indexs such as Corneal Curvature, but it equally also exists above-mentioned similar shortcoming in the middle of using, dismounting inconvenience causes the inconvenience of daily cleaning, administration and periodic measurement experimental index.Above-mentioned two kinds of methods are mainly used in the induction of FDM myopia animal model.Also have at the up cornea refractive surgery of animal corneal as PRK, set up LIM animal model, but this kind of method establishment model cost is higher, not easily popularize, for irreversibility operation, convalescence model cannot be set up, convalescent change can not be observed, the conventional Long-Time Service antibiotic of postoperative need and hormone medicine eye droppings occur with muddy under avoiding postoperative infection and corneal epithelium in addition, and the application of medicine may have interference to the result of experiment.
The bathomorphic modelling of current induced animal is had nothing in common with each other, but be used for the meiofauna such as mouse and cavy, be unsuitable for rabbit, cat, the medium-sized animal such as dog, the patent of invention being 200910154157.9 as the patent No. discloses a kind of inducing tool of animal myopia model, it carries out ultrastructure in form deprivation myopia induction mainly in mouse, the mouse bodily form is less, limited strength, identical design is as being applied to rabbit, cat, the larger animals such as dog, substantially practicality is not had, because the activity of these larger animals is large, strength is also large, this eyeshade can be removed very easily and cause Induction failure.The eyeshade of its design needs to be fixed on mouse head skin with suture, for there being the operation of wound property, having the possibility causing infection, as animal activity causes eyeshade avulsion in Induction Process, not only causes the failure of induction but also cause suffering to animal.
The patent No. is the patent of invention of 200410014098.2, discloses a kind of ultrastructure in form deprivation myopia animal model inducing tool, described instrument be by nontoxic, there is flexible rubber finger sleeve make.What adopt due to it is that latex balloon covering method induces near-sighted animal model, so in use easily drop, in order to be fixed in the head of animal preferably, need to be stretched tight comparatively tightly can produce comparatively hightension like this, and this tension force can to eyeball surface build-up of pressure, cause corneal curvature, the change of prescription and axis oculi, affect the accuracy of experimental result.If be applied to the larger animals such as rabbit, cat, dog in addition, same existence is very easily grabbed situation about falling by animal's paw, impact induction result.
The patent No. is the utility model patent of 200620062570.4, disclose a kind of animal myopia induction eyeshade, but mainly for primates such as monkeys, it is designed to the design of circular helmet sample, structure is more complicated, need fixed screw, the hard accessories such as fixed band are fixed, two pieces of eyeglasses are positioned at the dead ahead of the helmet, be closely adjacent to each other, cassette tape is fixed on directly over head, prevent the helmet from dropping downwards, therefore this design is suitable for binocular and is positioned at a dead ahead, head is positioned at directly over health, head shape connects rotund primate, be not suitable for being applied to binocular and be positioned at head both sides, head is positioned at health front, head shape is close to oblong, ear is positioned at the rabbit directly over head, cat, the laboratory animal such as dog.
Existing domestic multiplex myopia animal model has chicken, cavy, mouse and monkey.Eye structure and the people of chicken differ greatly, and eye has cartilaginous ring to exist.Though cavy and mouse better operate but its eyeball is less, excessively steep (the guinea pig eye bulb diameter 10mm of cornea, mouse is less and eye inner tissue's structure proportion differs larger with people), the change of some meticulous indexs of optometry cannot be observed as ACD, (eyeball is too small for crystal thickness, the too small detectability exceeding instrument of variable quantity, be not easy to detect the difference value before and after induction), and the tissue mass that can obtain when detecting the biochemical indicators such as protein is very little, need several laboratory animal to carry out merging and just can detect, the accuracy of experiment reduces.Do the expense of testing with monkey comparatively large, be difficult to carry out in general scientific research institution.
The diameter of lagophthalmos ball and cornea and the mankind are seemingly, if do myopic model with rabbit, the detection of the more accurate optometry index such as corneal topography, wave front aberration can be carried out, and the tissue mass that lagophthalmos can provide is abundanter, be convenient to experiment detect, but not can be used at present induction rabbit is bathomorphic wearing mirror system, effective rabbit myopia animal model cannot be built.
Summary of the invention
For solving the deficiencies in the prior art, the invention provides a kind of without wound, with low cost, convenient, efficient induced animal myopia wear mirror system.
Mirror system of wearing of the present invention comprises: truncated cone-shaped face shield, mirror holder, induction eyeglass, fixed band, buckle, wherein said truncated cone-shaped face shield front-back is provided with opening, hollow in the middle part of truncated cone-shaped face shield, there are 2 holes the side of truncated cone-shaped face shield, be connected and fixed band after truncated cone-shaped face shield, fixed band has buckle; Described mirror holder is round table-like, is fixed on truncated cone-shaped face shield, and communicates with 2 holes of truncated cone-shaped face shield side, and the side of mirror holder has air-vent, and the top of mirror holder is connected with induction eyeglass, and easily changes; The edge of described induction eyeglass has aperture, is connected through eyeglass aperture by fine rule with the top of mirror holder, and the needs according to practical application are easy to change different eyeglasses by taking out stitches.
The above-mentioned truncated cone-shaped face shield front girth worn described in mirror system is 10-16cm, can the front and back girth of experimentally animal head type size modification face shield to reach suitable adaptation, the nylon material that the material of face shield is preferably soft light and handy; Hole on described truncated cone-shaped face shield side is for exposing the eye of laboratory animal, and the diameter of hole is 4-6cm.
Above-mentioned mirror holder of wearing described in mirror system is round table-like, and its base diameter is 5-7cm, and top diameter is 4-6cm, is highly 1.5-2.5cm, and the side of mirror holder has air-vent and forms water smoke to prevent lens surface; The material of described mirror holder is plastics, metal and silica gel etc., wherein preferred silica gel.
The above-mentioned induction eyeglass worn described in mirror system is the concave lens of any number of degrees, hyperopic lens, frosted glass eyeglass, translucent eyeglass or other similar specification shelters, and its diameter is 4-6cm.
There has been fixing replaceable buckle at face shield rear of the present invention, conveniently plucks and wears, and described buckle also can change adhesive tape into.For preventing laboratory animal from being grabbed by face shield, mirror system of wearing of the present invention also comprises Elizabethan's necklace, and described its collar of Elizabethan's necklace is 19-27cm, and necklace height is 10-12cm.
The present invention above-mentioned wears mirror system by wearing to rabbit, and result display is by changing different induction eyeglasses, and above-mentioned mirror system of wearing effectively can set up lens-induced myopia animal model and ultrastructure in form deprivation myopia animal model by induced animal.
Mirror of the present invention is worn system and is had following beneficial effect:
1) of the present invention to wear mirror system cost lower, non-invasive operation, and mask designs of the present invention is light and handy, does not have the hard objects such as screw, can experimentally need to make corresponding amendment;
2) of the present inventionly wear the shape that mirror system is mainly applicable to head and be similar to the larger build laboratory animal such as oblong rabbit, cat, dog, multiple optometry index (laboratory animal such as large mouse, cavy because cornea eyeball is less, corneal curvature cross and suddenly cannot measure the optometry such as corneal topography, wave front aberration index) can be measured while myopia induction;
3) the induction eyeglass distance cornea wearing mirror system of the present invention has certain distance, and laboratory animal can normal blink, and less on the impact of eye normal physiological activity, the optometry such as Corneal Curvature, aberration index is without impact;
4) mirror system of wearing of the present invention has convenient the plucking at any time of disconnectable buckle to wear, and can facilitate the collection of the cleaning-nursing of eye between induction period, the application of eyedrops and experimental data;
5) number of degrees wearing the induction eyeglass of mirror system of the present invention can be changed at any time, the induction number of degrees of eyeglass and characteristic unrestricted, experimentally can need to be replaced by any time the concave lens of any number of degrees, hyperopic lens, frosted glass eyeglass, translucent eyeglass or other similar specification shelters;
6) of the present inventionly mirror system is worn, by changing the animal model that different eyeglasses can induce generation different, if using has the eyeglass of the number of degrees to carry out lens-induced myopia induction, but ultrastructure in form deprivation myopia induction can be carried out as eyeglass is changed to frosted glass or translucent eyeglass or other shelters;
7) the present invention has and prevents animal from scratching the necklace of eyeshade to ensure that the inducing effect of eyeshade can not be interrupted, and this necklace can not affect feed and the drinking-water of rabbit.
Accompanying drawing explanation
Fig. 1 is embodiment of the present invention face shield schematic diagram
Fig. 2 is embodiment of the present invention Elizabethan necklace schematic diagram
Fig. 3 is embodiment of the present invention application schematic diagram
Embodiment
Be further explained the present invention below in conjunction with Figure of description, following examples only for explaining the present invention, and can not be interpreted as limitation of the present invention.
Embodiment 1
As shown in Figure 1, mirror system of wearing of the present invention comprises: truncated cone-shaped face shield 1, mirror holder 2, induction eyeglass 4, fixed band 7, buckle 8, wherein said truncated cone-shaped face shield front-back has opening 6 and 5, the girth of its middle open 6 is 10cm, hollow in the middle part of truncated cone-shaped face shield, there are 2 holes the side of truncated cone-shaped face shield, and the diameter of hole is 4cm, be connected and fixed band 7 after truncated cone-shaped face shield, fixed band have buckle 8; The circular open 6 that truncated cone-shaped face shield front end is arranged, makes laboratory animal breathe with diet very convenient, and to avoid affecting growing of laboratory animal, rear end is provided with a comparatively big uncork 5, can wear preferably on animal head to make face shield.Described mirror holder 2 is round table-like, is fixed on truncated cone-shaped face shield 1, and communicates with 2 holes of truncated cone-shaped face shield side, its base diameter of mirror holder 2 is 5cm, and top diameter is 4cm, and mirror holder 2 is highly 1.5cm, the side of mirror holder 2 has air-vent 3, and air-vent 3 prevents eyeglass 4 surface from forming water smoke; The diameter of described induction eyeglass 4 is 4cm, and induction lens edge has aperture, is connected through eyeglass aperture by fine rule with the top of mirror holder 2, and the needs according to practical application are easy to change different eyeglasses by taking out stitches.The material of described truncated cone-shaped face shield is nylon material, and soft light and handy plasticity is extremely strong, and mirror holder material is silica gel, and induction eyeglass is concave lens.Described mirror system of wearing also has Elizabethan's necklace 9, and its neck is trapped among 19-23cm, its necklace height 10.5cm.
Embodiment 2
As shown in Figure 1, mirror system of wearing of the present invention comprises: truncated cone-shaped face shield 1, mirror holder 2, induction eyeglass 4, fixed band 7, buckle 8, wherein said truncated cone-shaped face shield front-back has opening 6 and 5, the girth of its middle open 6 is 12cm, hollow in the middle part of truncated cone-shaped face shield, there are 2 holes the side of truncated cone-shaped face shield, and the diameter of hole is 5.3cm, be connected and fixed band 7 after truncated cone-shaped face shield, fixed band have buckle 8; The circular open 6 that truncated cone-shaped face shield front end is arranged, makes laboratory animal breathe with diet very convenient, and to avoid affecting growing of laboratory animal, rear end is provided with a comparatively big uncork 5, can wear preferably on animal head to make face shield.Described mirror holder 2 is round table-like, is fixed on truncated cone-shaped face shield 1, and coaxial with 2 holes of truncated cone-shaped face shield side, its base diameter of mirror holder 2 is 6cm, and top diameter is 4.5cm, and mirror holder 2 is highly 1.9cm, the side of mirror holder 2 has air-vent 3, and air-vent 3 prevents eyeglass 4 surface from forming water smoke; The diameter of described induction eyeglass 4 is 4.5cm, and induction lens edge has aperture, is connected through eyeglass aperture by fine rule with the top of mirror holder 2, and the needs according to practical application are easy to change different eyeglasses by taking out stitches.The material of described truncated cone-shaped face shield is nylon material, and soft light and handy plasticity is extremely strong, and mirror holder material is silica gel, and induction eyeglass is concave lens.Described mirror system of wearing also has Elizabethan's necklace 9, and its neck is trapped among 19-23cm, its necklace height 10.5cm.
Embodiment 3
As shown in Figure 1, mirror system of wearing of the present invention comprises: truncated cone-shaped face shield 1, mirror holder 2, induction eyeglass 4, fixed band 7, buckle 8, wherein said truncated cone-shaped face shield front-back has opening 6 and 5, the girth of its middle open 6 is 16cm, hollow in the middle part of truncated cone-shaped face shield, there are 2 holes the side of truncated cone-shaped face shield, and the diameter of hole is 6cm, be connected and fixed band 7 after truncated cone-shaped face shield, fixed band have buckle 8; The circular open 6 that truncated cone-shaped face shield front end is arranged, makes laboratory animal breathe with diet very convenient, and to avoid affecting growing of laboratory animal, rear end is provided with a comparatively big uncork 5, can wear preferably on animal head to make face shield.Described mirror holder 2 is round table-like, is fixed on truncated cone-shaped face shield 1, and communicates with 2 holes of truncated cone-shaped face shield side, its base diameter of mirror holder 2 is 7cm, and top diameter is 6cm, and mirror holder 2 is highly 2.5cm, the side of mirror holder 2 has air-vent 3, and air-vent 3 prevents eyeglass 4 surface from forming water smoke; The diameter of described induction eyeglass 4 is 6cm, and induction lens edge has aperture, is connected through eyeglass aperture by fine rule with the top of mirror holder 2, and the needs according to practical application are easy to change different eyeglasses by taking out stitches.The material of described truncated cone-shaped face shield is nylon material, and soft light and handy plasticity is extremely strong, and a mirror holder material is plastics, and induction eyeglass is concave lens.Described mirror system of wearing also has Elizabethan's necklace 9, and neck is trapped among the necklace height 12cm of 22-27cm.
The object of the necklace 9 described in embodiment 1-3 wears in laboratory animal neck place, plays the protective effect to face shield, reduces laboratory animal to the destruction of face shield, ensure experiment success rate.
Embodiment 4 wears the application of mirror system in the induction of lens-induced myopia model
Choose rabbit 6 in 3 week age, Random assignment, experimental group and each 3 of control group, experimental group: experimental group rabbit is worn and of the present inventionly wears mirror system, each mouth is mutually corresponding, and after finally movable buckle being buckled in rabbit ears, induction eyeglass is-4D resin lens, afterwards Elizabethan's necklace is set on rabbit neck, effectively prevents animal to the destruction of wearing mirror system.Experimental rabbit wears the design sketch wearing mirror system of the present invention as shown in Figure 3.3 rabbit do not deal with control group.
Experimental group rabbit is worn and wears mirror system after 28 days, carries out diopter detection, VCD detects and axiallength detects.Result display experimental group diopter is to near-sighted future development, vitreous chamber and axiallength extend, detect data with control group and there is obvious difference, and there is statistical significance, experimental group 3 rabbit are all successfully induced lens-induced myopia, illustrate of the present inventionly to wear the foundation that mirror system can be used in lens-induced myopia animal model.
Embodiment 5 wears the application of mirror system in Form Deprived Myopia induction
Choose rabbit 6 in 3 week age, Random assignment, experimental group and each 3 of control group, experimental group: experimental group rabbit is worn and of the present inventionly wears mirror system, each mouth is mutually corresponding, and after finally movable buckle being buckled in rabbit ears, induction eyeglass is frosted glass, afterwards Elizabethan's necklace is set on rabbit neck, effectively prevents animal to the destruction of wearing mirror system.Experimental rabbit wears the design sketch wearing mirror system of the present invention as shown in Figure 3.3 rabbit do not deal with control group.
Experimental group rabbit is worn and wears mirror system after 35 days, carries out diopter detection, VCD detects and axiallength detects.Result display experimental group and control group detect data and have obvious difference, and there is statistical significance, experimental group 3 rabbit are all successfully induced ultrastructure in form deprivation myopia, illustrate of the present inventionly to wear the foundation that mirror system can be used in ultrastructure in form deprivation myopia animal model.
Claims (9)
1. wear mirror system for one kind, comprise: truncated cone-shaped face shield, mirror holder, induction eyeglass, fixed band, buckle, wherein said truncated cone-shaped face shield front-back is provided with opening, hollow in the middle part of truncated cone-shaped face shield, there are 2 holes the side of truncated cone-shaped face shield, be connected and fixed band after truncated cone-shaped face shield, fixed band has buckle; Described mirror holder is round table-like, is fixed on truncated cone-shaped face shield, and communicates with 2 holes of truncated cone-shaped face shield side, and the side of mirror holder has air-vent, and the edge of described induction eyeglass has aperture, is connected through eyeglass aperture by fine rule with the top of mirror holder.
2. according to claim 1ly wear mirror system, it is characterized in that, its front girth of described truncated cone-shaped face shield is 10-16cm, and the hole on described truncated cone-shaped face shield side is for exposing the eye of laboratory animal, and the diameter of hole is 4-6cm.
3. according to claim 1ly wear mirror system, it is characterized in that, described its base diameter of mirror holder is 5-7cm, and top diameter is 4-6cm, is highly 1.5-2.5cm.
4. according to claim 1ly wear mirror system, it is characterized in that, described induction eyeglass is the concave lens of any number of degrees, hyperopic lens, frosted glass eyeglass, translucent eyeglass, and the diameter of induction eyeglass is 4-6cm.
5. according to claim 1ly wear mirror system, it is characterized in that, described mirror system of wearing also comprises Elizabethan's necklace.
6. according to claim 5ly wear mirror system, it is characterized in that, described its collar of Elizabethan's necklace is 19-27cm, and necklace height is 10-12cm.
7. wear mirror system described in claim 1-6 any one, it is characterized in that, the preferred nylon material of material of described truncated cone-shaped face shield; The material of described mirror holder is plastics, metal or silica gel.
8. in claim 1-7 described in any one, wear mirror system in the application of setting up lens-induced myopia animal model.
9. in claim 1-7 described in any one, wear mirror system in the application of setting up ultrastructure in form deprivation myopia animal model.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103598143A (en) * | 2013-11-18 | 2014-02-26 | 浙江大学 | Mouse myopia model, and inducing device and inducing method thereof |
| CN203986282U (en) * | 2014-07-07 | 2014-12-10 | 四川大学华西医院 | Rhesus monkey head pipe-planting protective cap |
| FR3104902B1 (en) * | 2019-12-20 | 2021-12-03 | Paris Sciences Lettres Quartier Latin | Device for linking a laboratory animal to at least one experimental system, and a method for attaching such a device. |
| CN112970666B (en) * | 2021-02-04 | 2023-02-03 | 复旦大学附属眼耳鼻喉科医院 | Simple and convenient animal myopia induction device and manufacturing method thereof |
| CN113133431A (en) * | 2021-02-25 | 2021-07-20 | 中南大学 | Establishment method, model and application of chronic ocular hypertension combined long-axis animal model |
| CN114568343B (en) * | 2022-03-11 | 2023-04-07 | 成都合拓创展生物科技有限公司 | Headwear for preparing eye disease model and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6178552B1 (en) * | 1997-04-15 | 2001-01-30 | Steven Robinson | Welding helmet |
| US5868104A (en) * | 1998-03-12 | 1999-02-09 | Ramirez; Yolanda | Pet sunglasses system |
| US6311645B1 (en) * | 2001-05-03 | 2001-11-06 | Joseph S. Brown | Animal training method and apparatus |
| DE20209155U1 (en) * | 2002-06-13 | 2003-10-23 | Dr. Eugen Beck GmbH & Co., 59302 Oelde | Spectacles, in particular stunned drilling glasses |
| CN1296017C (en) * | 2004-02-16 | 2007-01-24 | 温州医学院眼视光研究院 | Tool for shape sensing deprivating of shortsightedness animal model |
| CN2919855Y (en) * | 2006-07-17 | 2007-07-11 | 叶繁华 | Glasses for dogs |
| CN200994333Y (en) * | 2006-08-04 | 2007-12-26 | 中山大学中山眼科中心 | Eyemasks for animals |
| CN201098256Y (en) * | 2007-08-23 | 2008-08-13 | 刘征元 | Welding protective mask |
| CN101703421B (en) * | 2009-11-06 | 2011-03-23 | 温州医学院眼视光研究院 | Inducing tool of animal myopia model |
| CN203407331U (en) * | 2013-06-17 | 2014-01-29 | 西安交通大学医学院第一附属医院 | Glasses wearing system for inducing rabbit to be myopic |
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