A kind of mirror system of wearing of inducing rabbit myopia
Technical field
The utility model relates to zoopery apparatus, is specifically related to a kind of for inducing the headgear of the myopia animal models such as rabbit, cat, dog.
Background technology
The Research of Animal Model for Study of myopia has been established two kinds of experimental models, that is: ultrastructure in form deprivation myopia (formdeprivation myopia, FDM), refer to sewing up eyelid the myopia causing with translucent eyeglass or light tight headgear method affect the visual development of animal; Eyeglass inductivity myopia (lens induced myopia, LIM), or claim lens-induced myopia (defocus myopia), refer to force animal depending near or wear negative concave-sphere eyeglass and make the image focu of object in retina rear, thereby cause that axis oculi extends the myopia causing.Current research is clear and definite, and FDM and LIM are two kinds of myopia as different as chalk and cheese.
The near-sighted abductive approach that is usually used in laboratory animal has many kinds, comprise eyelid stitching, Goggle eyeglass method etc., but these methods all exists certain shortcoming.Eyelid is sewed up as there being the operation of wound property, the surface of a wound easily causes ocular infection, when coming off, suture needs again again to sew up, laboratory animal is more painful, and disturbs final myopia induction effect, sews up in addition as irreversibility, as carrying out optometry index checking, needs need cut off suture, after checking out, again sew up, and stitching itself may cause the compressing of cornea to affect the observation of the optometry indexs such as corneal curvature, so eyelid sewing method is eliminated just gradually.The normal employing stitching of Goggle eyeglass method (translucent eyeglass) fixes or adhesion method fixes eyeglass, although reduced the impact of the optometry indexs such as Corneal Curvature, but it equally also exists above-mentioned similar shortcoming in the middle of using, dismounting inconvenience causes the inconvenience of daily cleaning, administration and periodic measurement experimental index.Above-mentioned two kinds of methods are mainly used in the induction of FDM myopia animal model.Also have at the up cornea refractive surgery of animal corneal as PRK, set up LIM animal model, but it is higher that these class methods are set up model cost, be difficult for universal, for irreversibility operation, cannot set up convalescence model, can not observe convalescent change, postoperative conventional long-term use antibiotic and the hormone medicine eye droppings of needing is to avoid muddy generation under postoperative infection and corneal epithelium in addition, and the application of medicine may have interference to the result of experiment.
The bathomorphic modelling of induced animal is at present had nothing in common with each other, but be used for the meiofaunas such as mouse and cavy, be unsuitable for rabbit, cat, the medium-sized animal such as dog, the patent of invention that is 200910154157.9 as the patent No. discloses a kind of inducing tool of animal myopia model, it is mainly for carrying out ultrastructure in form deprivation myopia induction in mouse, the mouse bodily form is less, strength is limited, identical design is as being applied to rabbit, cat, the larger animals such as dog, substantially there is no practicality, because of the activity of these larger animals large, strength is also large, this eyeshade can be removed and caused Induction failure very easily.The eyeshade of its design need to be fixed on mouse head skin with suture, for there being the operation of wound property, has the possibility of the infection of causing, and in Induction Process, as animal activity causes eyeshade avulsion, not only causes the failure of induction but also causes suffering to animal.
The patent No. is 200410014098.2 patent of invention, discloses a kind of ultrastructure in form deprivation myopia animal model inducing tool, described instrument be by nontoxic, there is flexible rubber finger sleeve and make.What adopt due to it is that latex balloon covering method is induced near-sighted animal model, so in use easily drop, in order to be fixed in preferably the head of animal, need to be stretched tight to such an extent that can produce compared with hightension more like this, and this tension force can be to eyeball surface build-up of pressure, cause corneal curvature, the change of prescription and axis oculi, affects the accuracy of experimental result.If be applied in addition the larger animals such as rabbit, cat, dog, same existence very easily by animal's paw grabbed situation about falling, impact induction result.
The patent No. is 200620062570.4 utility model patent, a kind of animal myopia induction eyeshade is disclosed, but mainly for primates such as monkeys, it is designed to circular helmet sample design, structure is more complicated, need fixed screw, the hard accessories such as fixed band are fixed, two eyeglasses are positioned at the dead ahead of the helmet, be closely adjacent to each other, cassette tape is fixed on directly over head, prevent that the helmet from dropping downwards, therefore this design is suitable for binocular and is positioned at a dead ahead, head is positioned at directly over health, head shape connects rotund primate, be not suitable for being applied to binocular and be positioned at head both sides, head is positioned at health the place ahead, head shape approaches oblong, ear is positioned at the rabbit directly over head, cat, the laboratory animal such as dog.
Existing domestic multiplex myopia animal model has chicken, cavy, mouse and monkey.Eye structure and the people of chicken differ greatly, and eye has cartilaginous ring to exist.Though cavy and mouse better operate but its eyeball is less, excessively steep (the guinea pig eye bulb diameter 10mm of cornea, mouse Geng little Qie eye inner tissue's structure proportion and people differ larger), cannot observe the variation of some meticulous indexs of optometry as ACD, (eyeball is too small for crystal thickness, the too small detectability that exceeds instrument of variable quantity, be not easy to detect the difference value of induction front and back), and the tissue mass that can obtain while detecting the biochemical indicators such as protein is very little, need several laboratory animal to merge just and can detect, the accuracy of experiment reduces.With monkey, do the expense of testing larger, be difficult to carry out in general scientific research institution.
The diameter of lagophthalmos ball and cornea and the mankind are seemingly, if do myopic model with rabbit, can carry out the detection of the more accurate optometry indexs such as corneal topography, wave front aberration, and the tissue mass that lagophthalmos can provide is abundanter, being convenient to experiment detects, but not can be used at present inducing the bathomorphic mirror system of wearing of rabbit, cannot build effective rabbit myopia animal model.
Summary of the invention
For solving the deficiencies in the prior art, it is a kind of without wound, with low cost, convenient that the utility model provides, and induced animal myopia wears mirror system efficiently.
The mirror system of wearing described in the utility model comprises: truncated cone-shaped face shield, mirror holder, induction eyeglass, fixed band, buckle, wherein said truncated cone-shaped face shield front-back is provided with opening, truncated cone-shaped face shield middle part hollow, there are 2 holes the side of truncated cone-shaped face shield, after truncated cone-shaped face shield, be connected and fixed band, on fixed band, have buckle; Described mirror holder is round table-like, is fixed on truncated cone-shaped face shield, and communicates with 2 holes of truncated cone-shaped face shield side, and the side of mirror holder has air-vent, and the top of mirror holder is connected with induction eyeglass, and easily changes; The edge of described induction eyeglass has aperture, passes eyeglass aperture be connected with the top of mirror holder by fine rule, according to practical application, need to by taking out stitches, be easy to change different eyeglasses.
Above-mentioned truncated cone-shaped face shield the place ahead girth of wearing described in mirror system is 10-16cm, can be according to the front and back girth of laboratory animal head dummy size modification face shield to reach suitable adaptation, and the material of face shield is soft light and handy nylon material preferably; Hole on described truncated cone-shaped face shield side is for exposing the eye of laboratory animal, and the diameter of hole is 4-6cm.
Above-mentioned mirror holder of wearing described in mirror system is round table-like, and its base diameter is 5-7cm, and top diameter is 4-6cm, is highly 1.5-2.5cm, and the side of mirror holder has air-vent and forms water smoke to prevent lens surface; The material of described mirror holder is plastics, metal and silica gel etc., wherein preferred silica gel.
Concave lens, hyperopic lens, frosted glass eyeglass, translucent eyeglass or other similar specification shelters that the above-mentioned induction eyeglass of wearing described in mirror system is any number of degrees, its diameter is 4-6cm.
There has been the fixedly replaceable buckle of use at face shield described in the utility model rear, conveniently plucks and wears, and described buckle also can change adhesive tape into.For preventing that laboratory animal from grabbing face shield, the mirror system of wearing described in the utility model also comprises Elizabethan's necklace, and described its collar of Elizabethan's necklace is 19-27cm, and necklace height is 10-12cm.
The utility model is by wear the above-mentioned mirror system of wearing to rabbit, and result shows by changing different induction eyeglasses, above-mentioned wear mirror system effectively induced animal set up lens-induced myopia animal model and ultrastructure in form deprivation myopia animal model.
Mirror described in the utility model is worn system and is had following beneficial effect:
It is 1) described in the utility model that to wear mirror system cost lower, non-invasive operation, and also mask designs of the present utility model is light and handy, there is no the hard objects such as screw, can need to make corresponding modification according to experiment;
2) described in the utility modelly wear the shape that mirror system is mainly applicable to head and be similar to the larger build laboratory animal such as oblong rabbit, cat, dog, can in myopia induction, measure multiple optometry index (laboratory animal such as large mouse, cavy because cornea eyeball is less, corneal curvature cross suddenly and cannot measure the optometry indexs such as corneal topography, wave front aberration);
3) the induction eyeglass of wearing mirror system described in the utility model has certain distance apart from cornea, and laboratory animal can normally blink, and less on the impact of eye normal physiological activity, the optometry indexs such as Corneal Curvature, aberration are without impact;
4) mirror system of wearing described in the utility model has disconnectable buckle conveniently to pluck and wear at any time, can facilitate the cleaning-nursing of eye between induction period, the collection of the application of eyedrops and experimental data;
5) number of degrees of wearing the induction eyeglass of mirror system described in the utility model can be changed at any time, the number of degrees and the characteristic of induction eyeglass are unrestricted, can need to be replaced by any time concave lens, hyperopic lens, frosted glass eyeglass, translucent eyeglass or other similar specification shelters of any number of degrees according to experiment;
6) mirror system of wearing described in the utility model, by changing different eyeglasses, can induce the different animal model of generation, if used, there is the eyeglass of the number of degrees can carry out lens-induced myopia induction, but can carry out ultrastructure in form deprivation myopia induction as eyeglass is changed to frosted glass or translucent eyeglass or other shelters;
7) the utility model has and prevents that the necklace that animal scratches eyeshade can not be interrupted to guarantee the induction effect of eyeshade, and this necklace can not affect feed and the drinking-water of rabbit.
Accompanying drawing explanation
Fig. 1 is the utility model embodiment face shield schematic diagram
Fig. 2 is the utility model embodiment Elizabethan necklace schematic diagram
Fig. 3 is the utility model embodiment application schematic diagram
Embodiment
Below in conjunction with Figure of description, the utility model is further explained, following examples are only for explaining the utility model, and can not be interpreted as restriction of the present utility model.
Embodiment 1
As shown in Figure 1, the mirror system of wearing described in the utility model comprises: truncated cone-shaped face shield 1, mirror holder 2, induction eyeglass 4, fixed band 7, buckle 8, wherein said truncated cone-shaped face shield front-back has opening 6 and 5, the girth of its middle open 6 is 10cm, truncated cone-shaped face shield middle part hollow, there are 2 holes the side of truncated cone-shaped face shield, and the diameter of hole is 4cm, after truncated cone-shaped face shield, be connected and fixed and be with 7, on fixed band, have buckle 8; The circular open 6 that truncated cone-shaped face shield front end arranges, breathes with diet laboratory animal very convenient, and to avoid affecting growing of laboratory animal, rear end is provided with a larger opening 5, so that face shield can be worn on animal head preferably.Described mirror holder 2 is round table-like, is fixed on truncated cone-shaped face shield 1, and communicates with 2 holes of truncated cone-shaped face shield side, mirror holder 2 its base diameters are 5cm, and top diameter is 4cm, and mirror holder 2 is highly 1.5cm, the side of mirror holder 2 has air-vent 3, and air-vent 3 prevents that eyeglass 4 surfaces from forming water smoke; The diameter of described induction eyeglass 4 is 4cm, and induction lens edge has aperture, passes eyeglass aperture be connected with the top of mirror holder 2 by fine rule, according to practical application, need to by taking out stitches, be easy to change different eyeglasses.The material of described truncated cone-shaped face shield is nylon material, and soft light and handy plasticity is extremely strong, and a mirror holder material is silica gel, and induction eyeglass is concave lens.The described mirror system of wearing also has Elizabethan's necklace 9, and its neck is trapped among 19-23cm, its necklace height 10.5cm.
Embodiment 2
As shown in Figure 1, the mirror system of wearing described in the utility model comprises: truncated cone-shaped face shield 1, mirror holder 2, induction eyeglass 4, fixed band 7, buckle 8, wherein said truncated cone-shaped face shield front-back has opening 6 and 5, the girth of its middle open 6 is 12cm, truncated cone-shaped face shield middle part hollow, there are 2 holes the side of truncated cone-shaped face shield, and the diameter of hole is 5.3cm, after truncated cone-shaped face shield, be connected and fixed and be with 7, on fixed band, have buckle 8; The circular open 6 that truncated cone-shaped face shield front end arranges, breathes with diet laboratory animal very convenient, and to avoid affecting growing of laboratory animal, rear end is provided with a larger opening 5, so that face shield can be worn on animal head preferably.Described mirror holder 2 is round table-like, is fixed on truncated cone-shaped face shield 1, and coaxial with 2 holes of truncated cone-shaped face shield side, mirror holder 2 its base diameters are 6cm, and top diameter is 4.5cm, and mirror holder 2 is highly 1.9cm, the side of mirror holder 2 has air-vent 3, and air-vent 3 prevents that eyeglass 4 surfaces from forming water smoke; The diameter of described induction eyeglass 4 is 4.5cm, and induction lens edge has aperture, passes eyeglass aperture be connected with the top of mirror holder 2 by fine rule, according to practical application, need to by taking out stitches, be easy to change different eyeglasses.The material of described truncated cone-shaped face shield is nylon material, and soft light and handy plasticity is extremely strong, and a mirror holder material is silica gel, and induction eyeglass is concave lens.The described mirror system of wearing also has Elizabethan's necklace 9, and its neck is trapped among 19-23cm, its necklace height 10.5cm.
Embodiment 3
As shown in Figure 1, the mirror system of wearing described in the utility model comprises: truncated cone-shaped face shield 1, mirror holder 2, induction eyeglass 4, fixed band 7, buckle 8, wherein said truncated cone-shaped face shield front-back has opening 6 and 5, the girth of its middle open 6 is 16cm, truncated cone-shaped face shield middle part hollow, there are 2 holes the side of truncated cone-shaped face shield, and the diameter of hole is 6cm, after truncated cone-shaped face shield, be connected and fixed and be with 7, on fixed band, have buckle 8; The circular open 6 that truncated cone-shaped face shield front end arranges, breathes with diet laboratory animal very convenient, and to avoid affecting growing of laboratory animal, rear end is provided with a larger opening 5, so that face shield can be worn on animal head preferably.Described mirror holder 2 is round table-like, is fixed on truncated cone-shaped face shield 1, and communicates with 2 holes of truncated cone-shaped face shield side, mirror holder 2 its base diameters are 7cm, and top diameter is 6cm, and mirror holder 2 is highly 2.5cm, the side of mirror holder 2 has air-vent 3, and air-vent 3 prevents that eyeglass 4 surfaces from forming water smoke; The diameter of described induction eyeglass 4 is 6cm, and induction lens edge has aperture, passes eyeglass aperture be connected with the top of mirror holder 2 by fine rule, according to practical application, need to by taking out stitches, be easy to change different eyeglasses.The material of described truncated cone-shaped face shield is nylon material, and soft light and handy plasticity is extremely strong, and a mirror holder material is plastics, and induction eyeglass is concave lens.The described mirror system of wearing also has Elizabethan's necklace 9, and neck is trapped among the necklace height 12cm of 22-27cm.
Object at the necklace 9 described in embodiment 1-3 is to wear in laboratory animal neck place, plays the protective effect to face shield, reduces the destruction of laboratory animal to face shield, guarantees experiment success rate.