CN112970666A - Simple and convenient animal myopia induction device and manufacturing method thereof - Google Patents
Simple and convenient animal myopia induction device and manufacturing method thereof Download PDFInfo
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- CN112970666A CN112970666A CN202110156065.5A CN202110156065A CN112970666A CN 112970666 A CN112970666 A CN 112970666A CN 202110156065 A CN202110156065 A CN 202110156065A CN 112970666 A CN112970666 A CN 112970666A
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- 230000006698 induction Effects 0.000 title claims abstract description 59
- 208000001491 myopia Diseases 0.000 title claims abstract description 44
- 230000004379 myopia Effects 0.000 title claims abstract description 44
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 40
- 241001465754 Metazoa Species 0.000 title claims abstract description 36
- 230000003044 adaptive effect Effects 0.000 claims abstract description 75
- 238000010146 3D printing Methods 0.000 claims abstract description 15
- 230000006978 adaptation Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 20
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- 239000003086 colorant Substances 0.000 claims description 9
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- 238000002360 preparation method Methods 0.000 claims description 5
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- 229920005989 resin Polymers 0.000 claims description 5
- 241000345998 Calamus manan Species 0.000 claims description 3
- 235000012950 rattan cane Nutrition 0.000 claims description 3
- 230000008901 benefit Effects 0.000 abstract description 8
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- 238000002474 experimental method Methods 0.000 abstract description 8
- 238000005516 engineering process Methods 0.000 abstract description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 29
- 210000001508 eye Anatomy 0.000 description 17
- 210000003128 head Anatomy 0.000 description 5
- 238000010171 animal model Methods 0.000 description 4
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
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- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Eye Examination Apparatus (AREA)
- Rehabilitation Tools (AREA)
Abstract
The invention relates to a simple and convenient animal myopia induction device, which comprises an adaptive lantern ring, an adaptive connecting rod and an adaptive carrier; the adaptive lantern ring is matched and fixed with an experimental object; the adaptive carrier is used for fixing the induction device, can cover the preset induction position of the experimental object, and is connected with the adaptive lantern ring and the adaptive carrier through a plurality of adaptive connecting rods, so that the stability and the high efficiency are realized; the adaptive lantern ring, the adaptive connecting rod and the adaptive carrier are manufactured by 3D printing, the manufacturing of the adaptive lantern ring, the adaptive connecting rod and the adaptive carrier is matched with the experimental object and the induction carrier, and the experimental object and the induction carrier are directly designed in a matching mode through a 3D printing technology, so that the adaptability and the stability of the device are effectively guaranteed, the rejection of the experimental object can be reduced, and the experiment progress is smoother; the advantages are that: the operation is simple, the wearing effect is stable, the interference is not easy to occur, the manufacture is simple and convenient, the adaptability is high, and the daily activities of the experimental subject cannot be limited.
Description
Technical Field
The invention relates to the field of animal model instruments, in particular to a simple and convenient animal myopia induction device.
Background
Myopia is a global hotspot problem, and is a big problem related to China and the future of nations. According to statistics, the myopia population of China in 2012 is about 4.5 hundred million, 6 hundred million in 2020, and the prevalence rate of teenagers in myopia is the top of the world. The prevalence rates of myopia of primary school students, junior middle school students and senior high school students in China are 34%, 71% and 93% respectively, wherein the proportion of high-level myopia of senior high school students is 20%, the myopia is greatly increased more than ten years ago, and the incidence trend is low-age with high-level. In the face of this severe situation, animal experiments are important experimental methods for studying myopia mechanisms, and it is difficult to make a myopia animal model, which is one of the obstacles to finding the mechanism.
Mouse models are commonly used for making myopia animal models, and the method for inducing myopia of mice is mainly FD. However, since the mouse has a small size and small eyes and is sexually active, it is difficult to design a tool which has a simple structure, is convenient to use, can continuously and stably obscure the visual input information of the mouse without causing great damage to the quality of life of the mouse, and is easy and convenient to maintain the mouse during deprivation. The existing induction tools mainly comprise the following parts:
firstly, suturing an eyelid; the basic operation method comprises the following steps: anesthetizing the mouse, and suturing an eyelid; the main advantages are that: the direct and classical methods are more acceptable to the reader, but have the disadvantages that: the eyeball is pressed, so that the intraocular pressure is increased, and the health condition of the eyeball is influenced; the cornea flattens, changing the true refractive power, so that the result measured in the first few days after suture removal tends to be hyperopic, before slowly becoming myopic; the mouse eyelid is small and fragile, and is easily scratched by the mouse, so that the FDM induction effect is influenced, and infection is easily caused. And for the reasons stated above, the induction tool has been phased out.
Secondly, eye patch sticking; the basic operation method comprises the following steps: the eyeshade is stuck on the skin around the eyes of the mouse by strong adhesive; the main advantages are that: the operation is simple and convenient; the main disadvantages are as follows: the eyeshade of pasting is very easily grabbed by the mouse and falls off frequently of eyeshade greatly increased researcher's work load, reduced the efficiency of work, and the FD eye frequently sees the light moreover, can influence the induced efficiency of FDM.
Thirdly, sticking the necklace and the eyeshade; the basic operation method comprises the following steps: a hemispherical eye mask with a curvature radius of 8mm and an edge of lmm is pressed by a mold and is adhered to the skin around the eye. In order to prevent the eyeshade from being torn off by a mouse, a collar (made by cutting a thin plastic sheet into a circle at the edge and forming a round hole in the middle of the plastic sheet is sleeved on the neck of the mouse to prevent the eyeshade from being torn off by the mouse, and has the main advantages that the collar can prevent the eyeshade from being torn off by the mouse, the collar limits the movement of the mouse and prevents the water intake and ingestion behavior of the mouse, so that the free mobility of the experimental mouse is obviously reduced, the living quality is obviously reduced, the collar limit is SUd, the face washing action of the mouse needs to be manually replaced every day to wipe the dirt on the eyes, the workload of a researcher is increased, the working efficiency is influenced, the size of the central hole of the collar is difficult to grasp, the collar is too large (loose) to be pulled off by the mouse, the neck of the mouse is tightened (tight), the breathing is difficult and even suffocating is caused, and the neck becomes thick along with the growth of the mouse, the size and the tightness of the necklace need to be adjusted frequently, the daily maintenance is more complicated, and the elimination rate is higher.
Head. mounted glasses; the basic operation method comprises the following steps: a small piece of skin of the mouse head was cut away, exposing a square area of the skull, and the periosteum was scraped off. A special device was fixed to this area of the skull to cover the mouse at one eye. The device consists of five parts: the dental instrument comprises a metal covering sheet frame, a plastic covering sheet, a dental acrylic resin head seat, an acrylic resin square box and a balancing rod; the main advantage lies in can manually move the position of cover piece, can conveniently operate or measure the eye, is favorable to maintaining the health of eye. The main disadvantages are that: each mouse needs to be operated in advance, the operation is complicated, and the technical content requirement is high; the FD device is complex and difficult to popularize; the mice are subjected to considerable injury and pain.
In summary, there is a need for a simple and convenient animal myopia induction device and a manufacturing method thereof, which will not cause additional trauma to the subject, have stable wearing effect, are not easily interfered, are simple and convenient to manufacture, and have high adaptability.
Disclosure of Invention
The invention aims to provide a simple and convenient animal myopia induction device which does not cause additional trauma to an experimental subject, has a stable wearing effect, is not easy to interfere, is simple and convenient to manufacture and has high adaptability.
In order to achieve the purpose, the invention adopts the technical scheme that:
a simple and convenient animal myopia induction device comprises an adaptive lantern ring, an adaptive connecting rod and an adaptive carrier; the adaptation lantern ring with the adaptation carrier passes through the adaptation connecting rod links to each other, the adaptation carrier is equipped with induction device on it.
As a preferred technical scheme, the adaptive connecting rods are provided with a plurality of connecting rods.
As a preferred technical scheme, the adaptation lantern ring, the adaptation connecting rod and the adaptation carrier are adapted and manufactured by using 3D printing, an experimental object and an induction device.
As a preferable technical scheme, each group of the adaptive lantern ring, the adaptive connecting rod and the adaptive carrier has different color groups.
As a preferred embodiment, the subject includes, but is not limited to, a mouse, a rattan mouse; the inducing means include, but are not limited to, RGPs, resin lenses, translucent plastic sheets.
The invention also aims to provide a method for manufacturing the simple and convenient animal myopia induction device, which does not cause additional trauma to the experimental subject, has stable wearing effect, is not easy to interfere, is simple and convenient to manufacture and has high adaptability.
In order to achieve the purpose, the invention adopts the technical scheme that:
a method for manufacturing a simple animal myopia induction device comprises the following steps: manufacturing an adaptive carrier, wherein the adaptive carrier is matched and fixed with the induction device; manufacturing an adaptive lantern ring, wherein the adaptive lantern ring is matched and fixed with the neck of the experimental object; and manufacturing an adaptive connecting rod, and connecting the adaptive lantern ring with the adaptive carrier, wherein the induction device is positioned at a preset induction position.
As a preferable technical scheme, the manufacturing method is manufactured by applying a 3D printing technology.
As a preferred technical solution, the manufacturing of the adaptive carrier includes placing the induction device on a table, and manufacturing and placing the induction device around a circle along the periphery of the induction device, wherein the manufacturing of multiple sets of adaptive carriers can be performed simultaneously, and the adaptive carriers can be marked with different colors.
As a preferred technical solution, the manufacturing of the adapter collar comprises: anaesthetizing the subject; making the fitting collar around the neck of the subject; wherein, it can carry out the preparation of multiunit adaptation lantern ring simultaneously and it can adopt different colours to carry out the mark preparation.
As a preferred technical solution, the manufacturing of the adaptive connecting rod includes placing the adaptive carrier in front of the induction position of the experimental object, such as in front of the left eye and/or the right eye, and manufacturing the adaptive connecting rod for fixing.
The invention has the advantages that:
1. the adaptability is good, the conflict emotion of the experimental subject can be reduced, the daily activity of the experimental subject is not hindered, and the stable propulsion of the experiment is facilitated.
2. The structure is stable, and the damage to the induction device possibly caused by an experimental object can be effectively resisted.
3. The method is simple and convenient to operate, can be manufactured at any time and anywhere, can be quickly replaced along with the growth of animals, is convenient to adjust, has low operation threshold, and is beneficial to large-scale model construction.
4. The discrimination is high, the contrast requirements of different groups can be met through the combination of different colors, and the resolution is high.
Drawings
FIG. 1 is a perspective view of a simple and convenient animal myopia induction device of the present invention.
FIG. 2 is a schematic diagram of the combination of a simple and convenient animal myopia induction device and an experimental subject.
FIG. 3 is a flow chart of a method for manufacturing a simple and convenient animal myopia induction device.
FIG. 4 is a schematic diagram of the application of the simple animal myopia induction device.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.
The reference numerals and components referred to in the drawings are as follows:
1. adaptation lantern ring 2, adaptation connecting rod 3, adaptation carrier
4. Experimental subject 5 inducing device
Example 1
Referring to fig. 1 and 2, fig. 1 is a schematic perspective view of a simple and convenient animal myopia induction device of the present invention, and fig. 2 is a schematic view of the simple and convenient animal myopia induction device of the present invention in cooperation with an experimental subject; a simple and convenient animal myopia induction device comprises an adaptive lantern ring 1, an adaptive connecting rod 2 and an adaptive carrier 3; the adaptive lantern ring 1 is an annular structure which is matched and fixed with the neck of an experimental object 4 such as a mouse, a rattan and the like; the adaptive carrier 3 is used for fixing an inducing device 5, such as an RGP, a resin lens, a translucent plastic sheet and the like, so that the adaptive carrier 3 wrapping the inducing device 5 covers a preset inducing position of an experimental object 4, such as the front of the left eye or the right eye of a mouse, and then the adaptive connecting rod 2 is used for connecting the adaptive lantern ring 1 and the adaptive carrier 3, and the adaptive connecting rod 2 has a plurality of adaptive connecting rods, such as 3 adaptive connecting rods, 4 adaptive connecting rods and the like, in the embodiment, the adaptive lantern ring 1 and the adaptive carrier 3 are connected through the 3 adaptive connecting rods 2, so that the connection is more stable; it should be noted that the adaptive lantern ring 1, the adaptive connecting rod 2 and the adaptive carrier 3 are all manufactured by 3D printing, and it should be understood that the manufacturing of the adaptive lantern ring 1, the adaptive connecting rod 2 and the adaptive carrier 3 is identical to the experimental object 4 and the induction device 5, and the experimental object 4 and the induction device 5 are directly designed in a matching manner by the 3D printing technology, so that the adaptability and the stability of the device are effectively ensured, the rejection of the experimental object 4 can be reduced, and the experiment progress is more smooth.
It should be noted that: the invention has the advantages of simple and convenient use, no wound, reversibility, low cost and high success rate, can be made of materials with different colors, can be used for distinguishing and marking among groups, and is greatly convenient for experiment execution and experiment data processing; the simple and convenient animal myopia induction device does not cause compression on eyeballs, improves the conflict emotion of the experimental object 4, has good stability, and does not fear the struggle and scratch of the experimental object 4; the invention has simple structure, does not influence the daily activities of the experimental object 4, does not need invasive fixation and has no risk of infection.
Example 2
Referring to FIG. 3, FIG. 3 is a flow chart of a method for manufacturing a simple and convenient animal myopia induction device according to the present invention; a method for manufacturing a simple animal myopia induction device at least comprises the following steps S100-S104:
step S100: manufacturing an adaptive carrier 3, wherein the adaptive carrier 3 is adaptive and fixed with an induction device 5;
in some preferred embodiments, the manufacturing is performed by using 3D printing technology, the inducing device 5, such as a resin lens, is placed on a table, and is manufactured and placed around a circle along the periphery of the inducing device 5, during the process of setting, the manufacturing of the adapting carrier 3 required by other groups can be performed, and each group can be distinguished by using materials with different colors;
step S102: manufacturing an adaptive lantern ring 1, wherein the adaptive lantern ring 1 is matched and fixed with the neck of an experimental object 4;
in some preferred embodiments, the fabrication is performed using 3D printing techniques, including the steps of:
step S1022: anaesthetizing the subject 4; limiting the movement ability of the experimental object 4 and preventing the movement of the experimental object 4 from interfering with the forming of the adapting lantern ring 1;
step S1024: making the adaptor collar 1 around the neck of the subject 4; the 3D printing technology is utilized to directly carry out customized customization according to the size of the experimental object 4, so that extremely high adaptability is ensured, and the experimental object can be marked by adopting different colors;
step S104: manufacturing an adaptive connecting rod 2, and connecting the adaptive lantern ring 1 with the adaptive carrier 3, wherein the inducing device 5 is at a preset inducing position;
will adaptation carrier 3 places before its induction position of subject 4, for example before left eye andor right eye to the preparation adaptation connecting rod 2 is fixed, for make its connection more stable, can construct a certain amount of adaptation connecting rod 2 according to actual need.
It should be noted that: the simple and convenient animal myopia induction device is a personalized mouse head carrier, can quickly and effectively manufacture a myopia model head cover by using a portable 3D printing technology, quickly adheres all lenses (including RGP, resin lenses or semitransparent plastic sheets), has low price, can be manufactured at any time and any place without customization, can be quickly replaced along with the growth of animals, and is convenient to adjust and simple and convenient to operate; it should also be understood that the present invention utilizes rapid prototyping of 3D printing to perform the relevant operations, and as the technology is iteratively updated, it is within the scope of the present invention to utilize other instant prototyping to complete the simple and convenient animal myopia induction device of the present invention.
Example 3
Referring to fig. 4, fig. 4 is a schematic view of an application of the simple and convenient animal myopia induction device of the present invention; the embodiment specifically describes the simple and convenient animal myopia induction device provided by the invention:
the required materials are as follows: 3D printing pen, 3D printing PLA consumable, scissors and semitransparent plastic sheet
The simple animal myopia induction device is manufactured in the following mode:
1. inserting a printing pen into the USB interface, putting printing consumables into the USB interface, and preheating for 30 seconds;
2. the translucent plastic sheet is placed on the table top, the printing pen is opened and the carrier 3 is fitted around the circumference. (more than one time), 1 time for 5-10 seconds;
3. anesthetizing the mice for 5 minutes;
4. manufacturing a grouping collar, namely an adapting collar 1 by using consumables with different colors; 1 for 10-20 seconds;
5. placing the semitransparent plastic sheet in front of eyes of a mouse, and manufacturing three fixed ties, namely an adaptive connecting rod 2 and 1 tie by using a printing pen for 5-10 seconds;
in conclusion, the simple animal myopia induction device has the advantages that the forming time does not include the anesthesia time, only about 1 minute is needed for manufacturing an animal model, the efficiency and the safety are high, the cost is low, the discrimination is high, the operation threshold is low, and the stable promotion of the experiment is facilitated.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.
Claims (10)
1. A simple and convenient animal myopia induction device is characterized by comprising an adaptive lantern ring, an adaptive connecting rod and an adaptive carrier; the adaptation lantern ring with the adaptation carrier passes through the adaptation connecting rod links to each other, the adaptation carrier is equipped with induction device on it.
2. The simple animal myopia induction device of claim 1, wherein the adapter rod includes a plurality of rods.
3. The simple and convenient animal myopia induction device of claim 1, wherein the adaptation lantern ring, the adaptation connecting rod and the adaptation carrier are adapted to the experimental subject and the induction device by 3D printing.
4. The simple animal myopia induction device of claim 1, wherein each set of said adapter collar, adapter connector rod, and adapter carrier has a different color grouping.
5. A simple animal myopia induction device according to claim 3, wherein the subject includes but is not limited to a mouse, a rattan mouse; the inducing means include, but are not limited to, RGPs, resin lenses, translucent plastic sheets.
6. A method for manufacturing a simple animal myopia induction device is characterized by comprising the following steps:
manufacturing an adaptive carrier, wherein the adaptive carrier is matched and fixed with the induction device;
manufacturing an adaptive lantern ring, wherein the adaptive lantern ring is matched and fixed with the neck of the experimental object;
manufacturing an adaptive connecting rod, and connecting the adaptive lantern ring with the adaptive carrier, wherein the induction device is positioned at a preset induction position;
the method for manufacturing the simple and convenient animal myopia induction device is used for manufacturing the simple and convenient animal myopia induction device of any one of claims 1 to 5.
7. The method of claim 5, wherein the device is manufactured by 3D printing.
8. The method of claim 6 wherein the adapting carrier is formed by placing the inducing device on a table and forming and placing the inducing device around a circle around the circumference of the inducing device, wherein the adapting carrier is formed in a plurality of sets simultaneously and is marked with different colors.
9. The method of claim 6 wherein the step of forming an adapter collar comprises:
anaesthetizing the subject;
making the fitting collar around the neck of the subject;
wherein, it can carry out the preparation of multiunit adaptation lantern ring simultaneously and it can adopt different colours to carry out the mark preparation.
10. The method of claim 6, wherein the step of forming the adapter rod comprises placing the adapter carrier in front of the inducing position of the subject, such as the left eye or the right eye, and forming the adapter rod for fixation.
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| CN202110156065.5A CN112970666B (en) | 2021-02-04 | 2021-02-04 | Simple and convenient animal myopia induction device and manufacturing method thereof |
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| CN202110156065.5A CN112970666B (en) | 2021-02-04 | 2021-02-04 | Simple and convenient animal myopia induction device and manufacturing method thereof |
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| CN112970666B CN112970666B (en) | 2023-02-03 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114568343A (en) * | 2022-03-11 | 2022-06-03 | 成都合拓创展生物科技有限公司 | Headwear for preparing eye disease model, application of headwear and preparation method of eye disease model |
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| CN103314873A (en) * | 2013-06-17 | 2013-09-25 | 西安交通大学医学院第一附属医院 | Glasses wearing system for inducing rabbit myopia and application thereof |
| US20140303013A1 (en) * | 2011-03-15 | 2014-10-09 | University Of Utah Research Foundation | Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof |
| US20190209291A1 (en) * | 2014-12-27 | 2019-07-11 | Jitander Dudee | Accommodating intraocular lens assembly |
| US20200150457A1 (en) * | 2017-03-06 | 2020-05-14 | Tsubota Laboratory, Inc. | Mouse myopia-induced model and endoplasmic reticulum stress suppressant for preventing and suppressing myopia |
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2021
- 2021-02-04 CN CN202110156065.5A patent/CN112970666B/en active Active
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| US20060031951A1 (en) * | 2004-01-23 | 2006-02-09 | Klimanskaya Irina V | Improved modalities for the treatment of degenerative diseases of the retina |
| CN101703421A (en) * | 2009-11-06 | 2010-05-12 | 温州医学院眼视光研究院 | Inducing tool of animal myopia model |
| US20140303013A1 (en) * | 2011-03-15 | 2014-10-09 | University Of Utah Research Foundation | Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof |
| CN103314873A (en) * | 2013-06-17 | 2013-09-25 | 西安交通大学医学院第一附属医院 | Glasses wearing system for inducing rabbit myopia and application thereof |
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| CN114568343A (en) * | 2022-03-11 | 2022-06-03 | 成都合拓创展生物科技有限公司 | Headwear for preparing eye disease model, application of headwear and preparation method of eye disease model |
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