CN1293889C - Application of orostachys in medicine for curing intestinal tract disease and its drug - Google Patents
Application of orostachys in medicine for curing intestinal tract disease and its drug Download PDFInfo
- Publication number
- CN1293889C CN1293889C CN 03112118 CN03112118A CN1293889C CN 1293889 C CN1293889 C CN 1293889C CN 03112118 CN03112118 CN 03112118 CN 03112118 A CN03112118 A CN 03112118A CN 1293889 C CN1293889 C CN 1293889C
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- China
- Prior art keywords
- herba orostachyos
- water extract
- medicine
- extracting
- ethanol
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- Expired - Lifetime
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- 239000003814 drug Substances 0.000 title claims abstract description 31
- 201000010099 disease Diseases 0.000 title abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 15
- 210000001035 gastrointestinal tract Anatomy 0.000 title abstract description 12
- 229940079593 drug Drugs 0.000 title abstract description 7
- 241000304370 Orostachys Species 0.000 title abstract 7
- 238000002360 preparation method Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 55
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 44
- 239000007788 liquid Substances 0.000 claims description 13
- 238000001914 filtration Methods 0.000 claims description 10
- 239000002244 precipitate Substances 0.000 claims description 10
- 208000010643 digestive system disease Diseases 0.000 claims description 9
- 208000018685 gastrointestinal system disease Diseases 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000001556 precipitation Methods 0.000 claims description 7
- 229940125695 gastrointestinal agent Drugs 0.000 claims description 3
- 239000004083 gastrointestinal agent Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 238000000605 extraction Methods 0.000 abstract description 6
- 206010022714 Intestinal ulcer Diseases 0.000 abstract description 5
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 208000007107 Stomach Ulcer Diseases 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- 239000005720 sucrose Substances 0.000 description 6
- 239000002775 capsule Substances 0.000 description 5
- 239000002552 dosage form Substances 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 238000001035 drying Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- 241000220284 Crassulaceae Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides the new application of the traditional Chinese medicines of fimbriate orostachys herb and a medicine used in the new application, which belongs to the technical field of medicines. The fimbriate orostachys herb is used for preparing a medicine for treating intestinal tract disease and processed through effective component extraction to obtain the extract of the fimbriate orostachys herb for use, namely that the extract of the fimbriate orostachys herb is used as the medicine for treating the intestinal tract disease. The medicine prepared from the extract of the fimbriate orostachys herb for treating the intestinal tract disease has very obvious effect of treating gastrointestinal tract disease, such as gastric ulcers, intestinal ulcers, etc., and can be used as the medicine for treating the gastrointestinal tract disease. The medicine is prepared from the components of the traditional Chinese medicine solely and has the advantages of good curative effect, low medicinal application dose, no side effect, simple combination, simple and convenient preparation, easy operation and control and ensured production stability and product quality. In the present invention, a new way for the popularization and the application of the traditional Chinese medicinal materials of the fimbriate orostachys herb is developed.
Description
Technical field
The invention provides a kind of new purposes and drug application thereof of Chinese medicine Herba Orostachyos water extract, belong to medical technical field.
Background technology
As everyone knows, gastrointestinal tract such as gastric ulcer, duodenal ulcer class disease is a kind of clinically common frdquently encountered disease, and along with the quickening of modern life rhythm, people's psychentonia, mental workload increases, cause gastrointestinal tract class palindromia rates such as stomach, intestinal ulcer higher, directly have influence on human physical and mental health, quality of life.
Because its disease complexity of gastrointestinal tract class disease such as stomach, intestinal ulcer are used western medicines such as ranitidine, omeprazole, bismuth pectin at present clinically usually, short term effect is better, but exists the course of treatment long, occurs sense of discomfort and toxic and side effects after taking medicine; The Chinese medicine great majority of the treatment stomach that uses, intestinal class disease are compound preparation, and its curative effect is comparatively definite, but exist preparation process comparatively complicated, and quality controllability is relatively poor, has influence on Clinical Application.
Herba Orostachyos is the Crassulaceae plant, and nature and flavor acid, flat has hemostasis, holds back the effect of skin ulcer, once records in Pharmacopoeia of the People's Republic of China version in 1963 and version in 1977.Herba Orostachyos is not also applied at present widely.
Summary of the invention
Technical problem to be solved by this invention is: a kind of new purposes of Herba Orostachyos water extract is provided, and with the medicine of Herba Orostachyos water extract preparation treatment gastroenteropathy, good effect has no side effect, and one-component is formed simply, prepare easyly, and operation is controlled easily.
The new purposes of Herba Orostachyos water extract of the present invention is with the application of Herba Orostachyos water extract as preparation treatment gastrointestinal agent.
The optimal way of using is the extraction of Herba Orostachyos being carried out effective ingredient, obtains the Herba Orostachyos water extract and uses.
The extracting mode of Herba Orostachyos water extract is as follows:
The Herba Orostachyos extracting in water concentrates extracting liquid filtering, behind precipitate with ethanol, again through centrifugal go to precipitate clear liquor, reconcentration gets extractum, becomes the Herba Orostachyos water extract.The technological parameter of operation is as follows respectively:
Herba Orostachyos extracting in water 2～3 times, each 50～80 minutes; Extracting liquid filtering is merged, and it is 1.1～1.2 that filtrate is concentrated into proportion; The ethanol more than 95% below 30 ℃ concentrated solution being added 1.2～2 times of weight leaves standstill 20～28 hours precipitate with ethanol after stirring evenly; Alcohol deposit fluid makes clear liquor through the centrifugal precipitation of going again, and reconcentration to extractum proportion is 1.2～1.3, becomes the Herba Orostachyos water extract.
With the Herba Orostachyos water extract can be directly as the medicine of treatment gastroenteropathy, one-component is formed simply, prepare easyly, operation is controlled easily.
By adjuvant, can make various pharmaceutical dosage forms with the Herba Orostachyos extract, go up said dosage form as agent such as tablet, granule, oral liquids, usually, the Herba Orostachyos extract adds adjuvants such as sucrose, Pulvis Talci, makes capsule through filling, contains Herba Orostachyos extractum in every capsules and is equivalent to former medicine 6 grams; The Herba Orostachyos extract adds adjuvants such as dextrin, sucrose, makes granule through granulation, drying; The Herba Orostachyos extract adds adjuvants such as steviosin, makes oral solutions through the fill sterilization; The Herba Orostachyos extract adds adjuvants such as starch, sucrose or emblem crystalline cellulose element, makes tablet through granulation, drying, tabletting or coating.
Treatment of diseases for stomach should be selected dosage forms such as tablet, granule, oral liquid for use, directly acts on stomach sufferer place after taking.And for the intestinal illness, the then suitable dosage forms such as capsule, enteric coatel tablets of using are not earlier dissolved under one's belt, dissolve behind the arrival intestinal to play a role.
Other NM preparation requires to require to get final product according to the routine operation of pharmaceutical industry, is not repeated.
With the resulting medicine of preparation technology of the present invention, when being used for the treatment of gastrointestinal tract class diseases such as stomach, intestinal ulcer, its usage and consumption are example with the capsule, and oral every day three times, each 5, take 40 minutes ante cibum.Other dosage form is oral, and each clothes are equivalent to former medicine 30 grams, and every day three times, take 30 minutes ante cibum.Be 15 days a course of treatment.
Clinical trial of the present invention is as follows:
1, administrated method: oral capsule or granule, adult every day 3 times, each 2, take 30 minutes ante cibum, and 15 days is a course of treatment.
2, therapeutic effect: therapeutic effect is with clinical symptom disappearance.Its medication therapeutic effect gathers and sees the following form 1.
Table 1: medication treatment back effect summary sheet
As seen from Table 1, with the gastroenteropathy medicine of Herba Orostachyos water extract preparation of the present invention, aspect gastrointestinal tract class diseases such as treatment stomach, intestinal ulcer, its effective percentage is very significant, can be used as the drug use of treatment gastrointestinal tract class disease.
The present invention is with the medicine of the treatment gastroenteropathy of Herba Orostachyos water extract preparation, single Chinese medicinal components, and good effect, dosage is little, has no side effect, and forms simply, prepare easyly, and operation control easily can guarantee steady production, the assurance product quality.
The present invention has opened up a new channel for applying of Herba Orostachyos Chinese crude drug.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment.
Embodiment 1
The present invention is used for preparation treatment gastroenteropathy medicine to the Herba Orostachyos water extract, and Herba Orostachyos is carried out the extraction of effective ingredient, obtains the Herba Orostachyos water extract and uses.
The extracting mode of Herba Orostachyos water extract is:
Herba Orostachyos extracting in water 3 times, each 1 hour, extracting liquid filtering is merged, it is 1.15 that filtrate is concentrated into proportion, at 25 ℃ concentrated solution is added 96% ethanol of 1.5 times of weight, leaves standstill 24 hours precipitate with ethanol after stirring evenly; Alcohol deposit fluid makes clear liquor through the centrifugal precipitation of going again, and reconcentration to extractum proportion is 1.25, becomes the Herba Orostachyos water extract.
The Herba Orostachyos water extract is added starch, sucrose adjuvant, make tablet through tabletting.
Embodiment 2
The present invention is used for preparation treatment gastroenteropathy medicine to the Herba Orostachyos water extract, and Herba Orostachyos is carried out the extraction of effective ingredient, obtains the Herba Orostachyos water extract and uses.
The extracting mode of Herba Orostachyos water extract is:
Herba Orostachyos extracting in water 2 times, each 70 minutes, extracting liquid filtering is merged, it is 1.12 that filtrate is concentrated into proportion, at 25 ℃ concentrated solution is added 97% ethanol of 1.5 times of weight, leaves standstill 25 hours precipitate with ethanol after stirring evenly; Alcohol deposit fluid makes clear liquor through the centrifugal precipitation of going again, and reconcentration to extractum proportion is 1.22, becomes the Herba Orostachyos water extract.
The Herba Orostachyos water extract is added adjuvants such as sucrose, Pulvis Talci, make capsule through filling.
Embodiment 3
The present invention is used for preparation treatment gastroenteropathy medicine to the Herba Orostachyos water extract, and Herba Orostachyos is carried out the extraction of effective ingredient, obtains the Herba Orostachyos water extract and uses.
The extracting mode of Herba Orostachyos water extract is:
Herba Orostachyos extracting in water 3 times, each 55 minutes, extracting liquid filtering is merged, it is 1.16 that filtrate is concentrated into proportion, at 28 ℃ concentrated solution is added 95% ethanol of 1.8 times of weight, leaves standstill 26 hours precipitate with ethanol after stirring evenly; Alcohol deposit fluid makes clear liquor through the centrifugal precipitation of going again, and reconcentration to extractum proportion is 1.27, becomes the Herba Orostachyos water extract.
The Herba Orostachyos water extract is added adjuvants such as dextrin, sucrose, make granule through granulation, drying.
Embodiment 4
The present invention is used for preparation treatment gastroenteropathy medicine to the Herba Orostachyos water extract, and Herba Orostachyos is carried out the extraction of effective ingredient, obtains the Herba Orostachyos water extract and uses.
The extracting mode of Herba Orostachyos water extract is:
Herba Orostachyos extracting in water 3 times, each 65 minutes, extracting liquid filtering is merged, it is 1.13 that filtrate is concentrated into proportion, at 22 ℃ concentrated solution is added 98% ethanol of 1.3 times of weight, leaves standstill 24 hours precipitate with ethanol after stirring evenly; Alcohol deposit fluid makes clear liquor through the centrifugal precipitation of going again, and reconcentration to extractum proportion is 1.3, becomes the Herba Orostachyos water extract.
The Herba Orostachyos water extract is added adjuvants such as Flos Chrysanthemi, make oral liquid through the fill sterilization.
Claims (4)
1, the Herba Orostachyos water extract is as the application of preparation treatment gastrointestinal agent, and wherein the extracting mode of Herba Orostachyos water extract is: the Herba Orostachyos extracting in water concentrates extracting liquid filtering, behind precipitate with ethanol, again through centrifugal go to precipitate clear liquor, reconcentration gets extractum, becomes the Herba Orostachyos water extract.
2, the purposes of Herba Orostachyos water extract according to claim 1, the extracting mode that it is characterized in that the Herba Orostachyos water extract is: Herba Orostachyos extracting in water 2～3 times, extracting liquid filtering is merged, it is 1.1～1.2 that filtrate is concentrated into proportion, ethanol below 30 ℃ concentrated solution being added more than 95% leaves standstill precipitate with ethanol after stirring evenly, alcohol deposit fluid again through centrifugal go to precipitate clear liquor, reconcentration to extractum proportion is 1.2～1.3, becomes the Herba Orostachyos water extract.
3, the purposes of Herba Orostachyos water extract according to claim 2 is characterized in that the extracting mode of Herba Orostachyos water extract is: Herba Orostachyos extracting in water 2～3 times, each 50～80 minutes; Extracting liquid filtering is merged, and it is 1.1～1.2 that filtrate is concentrated into proportion; The ethanol more than 95% below 30 ℃ concentrated solution being added 1.2～2 times of weight leaves standstill 20～28 hours precipitate with ethanol after stirring evenly; Alcohol deposit fluid makes clear liquor through the centrifugal precipitation of going again, and reconcentration to extractum proportion is 1.2～1.3, becomes the Herba Orostachyos water extract.
4, a kind of medicine for the treatment of gastroenteropathy is characterized in that active component is the Herba Orostachyos water extract, and wherein the Herba Orostachyos water extract is made by following extracting mode:
Herba Orostachyos extracting in water 2～3 times, each 50～80 minutes; Extracting liquid filtering is merged, and it is 1.1～1.2 that filtrate is concentrated into proportion; The ethanol more than 95% below 30 ℃ concentrated solution being added 1.2～2 times of weight leaves standstill 20～28 hours precipitate with ethanol after stirring evenly; Alcohol deposit fluid makes clear liquor through the centrifugal precipitation of going again, and reconcentration to extractum proportion is 1.2～1.3, becomes the Herba Orostachyos water extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03112118 CN1293889C (en) | 2003-04-03 | 2003-04-03 | Application of orostachys in medicine for curing intestinal tract disease and its drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03112118 CN1293889C (en) | 2003-04-03 | 2003-04-03 | Application of orostachys in medicine for curing intestinal tract disease and its drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1444973A CN1444973A (en) | 2003-10-01 |
| CN1293889C true CN1293889C (en) | 2007-01-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03112118 Expired - Lifetime CN1293889C (en) | 2003-04-03 | 2003-04-03 | Application of orostachys in medicine for curing intestinal tract disease and its drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1293889C (en) |
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2003
- 2003-04-03 CN CN 03112118 patent/CN1293889C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1444973A (en) | 2003-10-01 |
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Owner name: RUIYANG PHARMACY CO., LTD. Free format text: FORMER NAME OR ADDRESS: SHANGDONG RUIYANG PHARMACEUTICAL CO., LTD. |
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Address after: No. 6 Erlang mountain road, Yiyuan County, Zibo, Shandong Patentee after: REYOUNG PHARMACEUTICAL Co.,Ltd. Address before: No. 6 Erlang mountain road, Yiyuan County, Zibo, Shandong Patentee before: SHANDONG REYOUNG PHARMACEUTICA |
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Denomination of invention: Application of orostachys in medicine for curing intestinal tract disease and its drug Effective date of registration: 20161027 Granted publication date: 20070110 Pledgee: Agricultural Bank of China Limited by Share Ltd. Yiyuan county subbranch Pledgor: REYOUNG PHARMACEUTICAL Co.,Ltd. Registration number: 2016990000912 |
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Address after: 256100 No. 6 Erlang Road, Yiyuan County, Zibo, Shandong Patentee after: Ruiyang Pharmaceutical Co.,Ltd. Address before: 256100 No. 6 Erlang Road, Yiyuan County, Zibo, Shandong Patentee before: REYOUNG PHARMACEUTICAL Co.,Ltd. |
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| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20201228 Granted publication date: 20070110 Pledgee: Agricultural Bank of China Limited by Share Ltd. Yiyuan county subbranch Pledgor: REYOUNG PHARMACEUTICAL Co.,Ltd. Registration number: 2016990000912 |
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