CN1289102C - Chinese-western medicine compound suppository for treating prostatic diseases - Google Patents
Chinese-western medicine compound suppository for treating prostatic diseases Download PDFInfo
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- CN1289102C CN1289102C CN 200410060523 CN200410060523A CN1289102C CN 1289102 C CN1289102 C CN 1289102C CN 200410060523 CN200410060523 CN 200410060523 CN 200410060523 A CN200410060523 A CN 200410060523A CN 1289102 C CN1289102 C CN 1289102C
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Abstract
The present invention relates to a Chinese-western medicine compound suppository, particularly to a Chinese-western medicine compound suppository for treating prostatic diseases. The compound suppository comprises ingredients of the following part by weight; 25 to 35 parts of metronidazole or 200 to 350 parts of tinidazole, 30 to 40 parts of chrysanthemum concrete, 15 to 35 parts of tween-80, 4 to 6 parts of indomethacin and 145 to 155 parts of suppository matrix. A preparation process comprises: melting the suppository matrix in water bath, cooling to room temperature, adding the chrysanthemum concrete, comminuted metronidazole or comminuted tinidazole, the indomethacin and the tween-80, blending, molding and packaging. The specification of the suppository is 1.5 g/granule. The Chinese-western medicine compound suppository for treating prostatic diseases of the present invention has the functions of clearing away heat, eliminating inflammation and removing pain. When clinically used for treating prostatitis, chronic prostatitis, etc., the compound suppository has the advantages of local application, outstanding curative effects, high safety, little toxic side effect, easy use, easy production, and easy acceptance by patients; the Chinese-western medicine compound suppository for treating prostatic diseases is promising and is favorable for popularization and application.
Description
One. technical field: the present invention relates to a kind of Chinese medicine and western medicine compound suppository, particularly relate to a kind of Chinese medicine and western medicine compound suppository for the treatment of prostatosis.
Two. background technology: prostatitis is commonly encountered diseases, a frequently-occurring disease clinically, and according to statistics, male prostatitis accounts for about 25% of hospital's urology department outpatient service, and the patient of about 70%-80% is simultaneously also with seminal vesiculitis in the prostatitis.In the 20-50 the young and the middle aged in year, sickness rate is up to 25%, and its clinical disease has: the one, and paruria; The 2nd, the physical distress discomfort; The 3rd, the neurasthenia is as weak, insomnia, seminal emission, premature ejaculation, erection difficulty etc.Anatomically, prostate such as chestnut size are positioned at bladder neck, hold the root of urethra, and its glandular tube and descending urethra meet at right angles, and prostatic fluid is constantly drained to urethra.When prostate is inflamed, be unfavorable for the drain of inflammatory liquid, also be beneficial to the interior antibacterial of urethra on the contrary and enter body of gland.Heavily about 20 grams of prostate account for three, four one thousandths of human body body weight, and after the patient took medicine, the medicine that enters body of gland caused this disease to be difficult to cure very little.And prostate and the seminal vesicle that closes on, bladder, urethra, rectum infect reciprocal causation, mutually and deposit.The local pathological process of chronic prostatitis is: body of gland hyperemia, edema, inflammation, the glandular tube resistance of becoming silted up, form focus and around fibrosis, disturbance of blood circulation, cause acinus parasecretion, Metabolic disorder at last.
At present the Therapeutic Method for chronic prostatitis mainly contains following aspect: receive medicine in the anus 1.: as suppository of wild chrysanthemum flower, prostatitis bolt, HUAZHI SHUAN, anti-anti-inflammatory suppository for gynecopathy etc., in the morning with the evening defecation after, each is with one piece, 10-15 days is a course of treatment; 2. prostate direct drug injection: deferent duct direct injection and intubate injection, after injecting procaine and confirming that deferent duct is unimpeded, medicinal gentamycin or kanamycin, neomycin continuous use; Direct injection antibiotic method in also can prostate is as gentamycin, cephalosporin etc.; 3. kindheartedness hospital in Xi'an adopts ecphractic therapy: the purified especially instrument of main employing delays into anus subsides prostate drug treatment, and the acupuncture point administration is taken medicine etc.This method is effective, but operates loaded down with trivial detailsly, needs special instrument and medical treatment, costs an arm and a leg; 4. Shandong Medical University adopts radio-frequency (RF) therapy, adopt Israel to produce Theremex II type prostate radio-frequency therapeutic equipment, the F18 Foley catheter that the per urethra collar extension will have electrode inserts bladder, temperature is controlled at 42-43 ℃, time 60min, postoperative is taken antibacterials, and this method needs special instrument, is difficult to popularize; 5. Jiangsu Province's Huaiyin City institute of traditional Chinese medicine Andriatrics Dept. adopts the ultrasonic importing treatment of Chinese medicine prostate, also needs special instrument, the price height; 6. employing Chinese traditional treatment; 7. employing western medicine: commonly used have bactrim, erythromycin, kanamycin, streptomycin, rifampicin, norfloxacin, ofloxacin, minocycline etc., an oral administration.The commercially available anus medicine of receiving has certain curative effect, but the relapse rate height.
If medication is pursued antiphlogistic treatment merely not in conjunction with its pathology clinically, also only can be effective when this disease acute attack, can't resolve root problem.The main cause of this disease clinical practice antibiotic unsatisfactory curative effect is that medicine can not reach effective treatment concentration in prostata tissue and acinus, and owing to antibioticly abuse the increase that causes Resistant strain, cause low, the easily outbreak repeatedly of this sick cure rate, therefore delay is difficult.
Three. summary of the invention:
Purpose of the present invention: provide a kind of safe and reliable, determined curative effect, easy to use, toxic and side effects is little, the Chinese medicine and western medicine compound suppository of the treatment prostatosis that is easy to produce.
Technical scheme of the present invention:
A kind of Chinese medicine and western medicine compound suppository for the treatment of prostatosis, consumption represent that with weight portion wherein metronidazole is 25～35 parts, 30～40 parts of chrysanthemum concretes, 15～35 parts of tween 80s, 4～6 parts of indometacin, 145～155 parts in suppository base material.
Described chrysanthemum concrete is to use Flos Chrysanthemi Indici, or uses Flos Chrysanthemi, or uses Herba Tagetis Patulae, or is the extract of raw material with any or two kinds or three kinds or four kinds of Flos Chrysanthemi, and its proportioning is a chrysanthemum concrete: dry Flos Chrysanthemi=1: 2.
Described suppository base material is a semi-synthetic fatty acid glyceride, or is glycerin gelatine.
Described indometacin is an indomethacin.
The water-bath of suppository base material is melted, to be cooled to below 50 ℃ the time, add metronidazole, indometacin and the tween 80 of chrysanthemum concrete and porphyrize, mixing, irritate mould, solidify rear demoulding, packing.
Metronidazole among the present invention can replace with tinidazole.
Beneficial effect of the present invention:
1. all medicines are all that " contained kind is national essential drugs on the Chinese pharmacopoeia, makes the suppository type by galenic pharmacy research in the present invention prescription, local application, safety is big, and toxic and side effects is little, also reduced the side effect of oral administration, easy to use, be easy to produce.
2. through clinical trial: the Chinese medicine and western medicine compound suppository curative effect of treatment prostatosis of the present invention is better than matched group (Flos Chrysanthemi suppository), and curative effect is reliable, has reached every index of pre-provisioning request, illustrates that this clearly demarcated preparation is effective preparation of treatment chronic prostatosis.
3. that the Chinese medicine and western medicine compound suppository of treatment prostatosis of the present invention has is analgesic, antiinflammatory, analgesic activity, through the clinical treatment that is used for prostatitis, chronic prostatitis etc., and determined curative effect, patient is easy to accept.And with the patient that additive method is failed to respond to any medical treatment, with behind this suppository, symptom is obviously improved, and is a kind of Chinese medicine and western medicine compound suppository of up-and-coming treatment prostatosis, is worthy of popularization.
The clinical trial of medicine of the present invention:
Xinyang, Henan clinical pharmacy section of central hospital is during year October in July, 1997 to 1999, Chinese medicine and western medicine compound suppository treatment chronic prostatitis 156 examples with treatment prostatosis of the present invention, treat 46 examples with Flos Chrysanthemi suppository and do contrast, carry out clinical efficacy research, received satisfied curative effect.
A: clinical data: in the test case, age 21-56 year, course of disease March-12 year, married 136 examples.Cardinal symptom has perineum lower abdomen or waist and sacrum pain discomfort, and urgent micturition, frequent micturition be last dysurea eventually, and dripping urine is unclean, and urethra drips white, and sexual dysfunction or sterile, anus are examined prostatauxe, tenderness etc.All case prostatic fluid (EPS) microscopy: leukocyte＞10/HP before the treatment, pus cell+-+++, lecithin 0-+++/HP.The cotton examination of urethra secretions smear does not have gonococcus.56 routine EPS cultivate at random, and 24 examples have bacterial growth, are followed successively by staphylococcus epidermidis, escherichia coli, Bacillus proteus and Staphylococcus albus, the no bacterial growth of 32 examples.Clinical observation on the therapeutic effect, patient is divided into treatment group and matched group at random, and two groups are not had statistics difference (P＞0.05) in age, sex, the course of disease, confirm the effectiveness of medicine with this, require to observe case more than 50 examples.The warm water demibain, massage, the local Chinese medicine and western medicine etc. that uses that adopt present expert to recommend in the treatment.
B. Therapeutic Method:
After the patient is diagnosed as prostatitis, fill in 1 piece in anus after the demibain before sleeping evening each 1 sooner or later of every day, rise morning and fill in 1 piece in anus, be aided with massage of prostate 15 days 1 courses of treatment, 1 time weekly, water-bath every day is sat and is washed once, checks EPS simultaneously with observe the curative effect.Generally, can obviously prove effective 1-2 the course of treatment, on average uses 2.5 courses of treatment.
C. criterion of therapeutical effect
Cure: clinical symptom disappearance, EPS microscopy leukocyte＜10/HP, cell culture is turning out cloudy property all;
Produce effects: clinical symptom disappearance or be clearly better, EPS microscopy leukocyte＜10-15/HP, cell culture is turning out cloudy property all;
Invalid: symptom and EPS chemical examination do not have improvement, and cell culture is still positive;
D. observed result
Before this group patient, prostatauxe tenderness 141 examples, treatment back pain 72 examples that disappear account for 51%, and 54 examples that are clearly better account for 38.3%, and urethra drips white 65 examples, after treatment, cures 32 examples, accounts for 49.2%, and 20 examples that are clearly better account for 30.8%; Dysurea 52 examples, treatment back pain 38 examples that disappear account for 73.1%; Sexual dysfunction or sterile 34 examples, the treatment back 5 routine sexual dysfunction persons recover normally to account for 14.7%, and 18 examples that are clearly better account for 52.9%, specifically see the following form.
Clinical symptoms is improved situation after using Chinese medicine and western medicine compound suppository of the present invention:
| Disease | The example number | Cure (%) | Produce effects (%) | Invalid (%) |
| The prostatauxe tenderness | 141 | 72(51) | 54(38.3) | 15(10.6) |
| Urethra drips white | 65 | 32(49.2) | 20(30.8) | 13(20.0) |
| Dysurea | 52 | 38(73) | 12(23.7) | 2(3.8) |
| Sexual dysfunction and sterile | 34 | 5(14.7) | 18(52.9) | 11(32.4) |
Use Chinese medicine and western medicine compound suppository of the present invention and Flos Chrysanthemi suppository obvious effective rate analytical table:
| Group | Produce effects number (%) | Produce effects number (%) not | The total number |
| Flos Chrysanthemi suppository | 28(60.87) | 18(39.13) | 46 |
| The Chinese medicine and western medicine compound suppository | 128(82.05) | 28(17.95) | 156 |
EPS microscopy leukocyte＜10/HP after the medication, turning out cloudy property of cell culture, clinical symptom disappearance 78 examples account for 52%; EPS microscopy leukocyte＜10-15/HP after the medication, turning out cloudy property of cell culture, the clinical symptom disappearance or the person of being clearly better 54 examples, account for 36%, symptom and EPS chemical examination do not have improvement, and still positive 18 examples of cell culture account for 12%, total effective rate 88% has been compared significant differences (P＜0.01) with matched group.
E. major side effects: patient only has minority local discomfort to occur during drug application, but can tolerate, and continues the medication transference cure, and the random inspection patient checks hepatic and renal function, and no abnormality seen changes.
F. discussion of results: the Chinese medicine and western medicine compound suppository curative effect of treatment prostatosis of the present invention is better than matched group (Flos Chrysanthemi suppository), and curative effect is reliable, has reached every index of pre-provisioning request, illustrates that this clearly demarcated preparation is effective preparation of treatment chronic prostatosis.
Model case:
1. Zhang, man, 22 years old, the peasant, urine end pain eventually appears in tired back before 1 month, and urine later and decadent stage of a school of thought white mucus is many January, perineum pain, PE: following abdominal pressure is painful, genitals pain, rectal touch: prostate surface imperfection, companion's tenderness, Rolandic fissure exists, EPS-Rt:WBC, ovum phosphorus body corpusculum ++, be diagnosed as chronic prostatitis.Give prostate suppository, bathe every night and wash the back and to play respectively 1 morning every day twice, continuous 15 days 1 courses of treatment, warm water demibain every day 1 time, massage of prostate, 1 time weekly.After 2 weeks, frequent micturition is alleviated, and dysurea alleviates, and urethra drips white disappearance.Add as stated above and used for 1 course of treatment, rectal touch: prostatauxe obviously alleviates, tenderness (), and EPS-Rt:WBC3-5/HP, ovum phosphorus body corpusculum ++ ++, EPS cultivates (-).Being diagnosed as chronic prostate cures.Suggestion: reuse prostate suppository, every day 1 time, each 1, totally 15 days, the warm water demibain, every day 1 time, totally 15 days, to deal with problems arising from an accident.
2. Lu, man, 38 years old, traffic police, uncomfortable 3 months of perineal position pain, once in a while urethra drip white, PE: tenderness on the lower abdomen pubis, anus is examined: prostatauxe, tenderness, Rolandic fissure exists, prostatic fluid routine examination: WBC, and ovum phosphorus body corpusculum ++, be diagnosed as chronic prostatitis.Give prostate suppository, bathe every night and wash the back and to play respectively 1 morning every day twice, continuous 15 days 1 courses of treatment, warm water demibain every day 1 time, massage of prostate, 1 time weekly.Return and examine, the perineal position pain relief, urethra drips white disappearance, and anus is examined: the prostate tenderness, EPS-Rt:WBC, ovum phosphorus body corpusculum +++, treat a course of treatment again with said method, anus is examined: prostate tenderness (-), EPS-Rt:WBC4-6/HP, ovum phosphorus body corpusculum ++ ++, be diagnosed as prostate and cure.Patient is enjoined in the back: reuse prostate suppository, and every day 1 time, each 1, totally 15 days, the warm water demibain, every day 1 time, totally 15 days, to deal with problems arising from an accident.
3. for certain, the man, 40 years old, the cadre, the back of drinking before February occurs back cloudy weigh down bloated, frequent micturition, urethra is bled, PE: tenderness on the lower abdomen pubis, anus is examined: prostate touches, tenderness, and enlargement is obvious, the Rolandic fissure existence is smooth; WBC, ovum phosphorus body corpusculum ++, be diagnosed as chronic prostatitis and seminal vesiculitis.Give prostate suppository, bathe every night and wash the back and to play respectively 1 morning every day twice, continuous 15 days 1 courses of treatment, warm water demibain every day 1 time, massage of prostate, 1 time weekly.Andrenobazon sheet 5mg, t.i.d., p.o., hold a consultation after the course of treatment: tenderness and prostate touch on the lower abdomen pubis, tenderness obviously alleviates, EPS-Rt:WBC, ovum phosphorus body corpusculum +++, EPS cultivates asepsis growth.Prostatitis treating is the same, and the vitamin K sheet is used in hemostasis, and 2, oral, every day 3 times.Medicine uses up the back and returns and to examine, frequent micturition, return cloudy uncomfortable, the urethra disappearance of bleeding.Pubis, prostate tenderness (-), prostate is enlargement slightly, smooth surface.EPS-Rt:WBC3-5/HP, ovum phosphorus body corpusculum ++ ++, be diagnosed as prostate and cure.Patient is enjoined in the back: reuse prostate suppository, every day 1 time, each 1, totally 15 days, the warm water demibain, 15 days, was drunk totally less at every day 1 time.
4. Chu, the man, 34 years old, urgent micturition, frequent micturition companion dysurea appearred in the cadre before January, and urethra drips whitely once in a while, drinks well, smoking.PE: hypogastric region is pressed painful, and anus is examined: prostatauxe, and tenderness, Rolandic fissure exists, and the prostate microscopy: pus cell increases, and lecithin reduces, and is diagnosed as chronic prostatitis.Give prostate suppository, every day twice, bathe every night and wash the back and play each 1 morning, continuous 15 days 1 courses of treatment, warm water demibain every day 1 time, massage of prostate, 1 time weekly, after the course of treatment, frequent micturition disappears substantially, urethra drips white disappearance, and pain is obviously alleviated, and anus is examined: the prostate tenderness is not obvious, EPS-Rt:WBC, ovum phosphorus body corpusculum +++, again 1 course of treatment of administration, usage is the same.Return and examine the result: perineal position pain disappears, and anus is examined: the prostate tenderness disappears, EPS-Rt:WBC4-6/HP, and ovum phosphorus body corpusculum ++ ++, be diagnosed as prostate and cure.Patient is enjoined in the back: reuse prostate suppository, and every day 1 time, each 1, totally 15 days, the warm water demibain, every day 1 time, totally 15 days, to consolidate curative effect.
Pharmacological action: the chrysanthemum concrete among the present invention has analgesic, antiinflammatory, resisting pathogenic microbes and analgesic effect, experimental hyperpyrexia rabbit is had refrigeration function, and nervus centralis is had sedation; Injection can make capillary resistance increase to mouse peritoneal, and vascular permeability suppresses, and antiinflammatory action is arranged; 9 kinds of dermatophytess such as external staphylococcus aureus, Hemolytic streptococcus, dysentery bacterium, escherichia coli, Bacillus proteus, Bacillus typhi, vibrio cholera, bacillus pyocyaneus and trichophyton there is inhibitory action.Indometacin has antiinflammatory, analgesic, analgesic activity, and is wherein the strongest with antiinflammatory action, and clinical experiment shows stronger more than 80 times than Phenylbutazone, and its refrigeration function effect is fast and remarkable.Metronidazole and tinidazole have greater activity to protozoon and anaerobe, and Bacteroidess such as bacteroides fragilis, Fusobacterium, dyspepsiacoccus, peptostreptococcus, Wei Rong Coccus and Jia Dena bacterium etc. are had antibacterial activity.Therefore, the Chinese medicine and western medicine compound suppository of treatment prostatosis of the present invention has analgesic, antiinflammatory, analgesic activity.
Four: the specific embodiment:
Embodiment one: consumption is represented with weight portion, 25 parts of metronidazoles, 30 parts of chrysanthemum concretes, 15 parts of tween 80s, 4 parts of indometacin, 145 parts in suppository base material.The water-bath of suppository base material is melted, condenses to room temperature, add metronidazole, indometacin and the tween 80 of chrysanthemum concrete and porphyrize, mixing, irritate mould, solidify rear demoulding, packing, the suppository specification is the 1.5g/ grain.
Embodiment two: consumption is represented with weight portion, 35 parts of metronidazoles, 40 parts of chrysanthemum concretes, 35 parts of tween 80s, 6 parts of indometacin, 155 parts in suppository base material.Its production method does not repeat at this with embodiment one.
Embodiment three: consumption is represented with weight portion, 30 parts of metronidazoles, 35 parts of chrysanthemum concretes, 20 parts of tween 80s, 5 parts of indometacin, 150 parts in suppository base material.Its production method does not repeat at this with embodiment one.
Embodiment four: consumption is represented with weight portion, 30 parts of metronidazoles, 30 parts of chrysanthemum concretes, 35 parts of tween 80s, 4 parts of indometacin, 155 parts in suppository base material.Its production method does not repeat at this with embodiment one.
Embodiment five: consumption is represented with weight portion, 32 parts of metronidazoles, 34 parts of chrysanthemum concretes, 19 parts of tween 80s, 4.5 parts of indometacin, 149 parts in suppository base material.Its production method does not repeat at this with embodiment one.
Embodiment six: consumption is represented with weight portion, 28 parts of metronidazoles, 37 parts of chrysanthemum concretes, 32 parts of tween 80s, 5.5 parts of indometacin, 151 parts in suppository base material.Its production method does not repeat at this with embodiment one.
Claims (5)
1. Chinese medicine and western medicine compound suppository for the treatment of prostatosis, consumption is represented with weight portion, it is characterized in that: wherein metronidazole is 25～35 parts, 30～40 parts of chrysanthemum concretes, 15～35 parts of tween 80s, 4～6 parts of indometacin, 145～155 parts in suppository base material.
2. the Chinese medicine and western medicine compound suppository of treatment prostatosis according to claim 1, it is characterized in that: described chrysanthemum concrete is to use Flos Chrysanthemi Indici, or use Flos Chrysanthemi, or use Herba Tagetis Patulae, or be the extract of raw material with any or two kinds or three kinds or four kinds of Flos Chrysanthemi, its proportioning is a chrysanthemum concrete: dry Flos Chrysanthemi=1: 2.
3. the Chinese medicine and western medicine compound suppository of treatment prostatosis according to claim 1 is characterized in that: described suppository base material is a semi-synthetic fatty acid glyceride, or is glycerin gelatine.
4. the Chinese medicine and western medicine compound suppository of treatment prostatosis according to claim 1 is characterized in that: described indometacin is an indomethacin.
5. according to the Chinese medicine and western medicine compound suppository of each described treatment prostatosis of claim 1～4, it is characterized in that: the water-bath of suppository base material is melted, to be cooled to below 50 ℃ the time, the metronidazole, indometacin and the tween 80 that add chrysanthemum concrete and porphyrize, mixing, irritate mould, solidify rear demoulding, packing.
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| CN 200410060523 CN1289102C (en) | 2004-09-17 | 2004-09-17 | Chinese-western medicine compound suppository for treating prostatic diseases |
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| CN 200410060523 CN1289102C (en) | 2004-09-17 | 2004-09-17 | Chinese-western medicine compound suppository for treating prostatic diseases |
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| CN1289102C true CN1289102C (en) | 2006-12-13 |
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