CN102872328A - Medicine for treating chronic pharyngitis and preparation method thereof - Google Patents
Medicine for treating chronic pharyngitis and preparation method thereof Download PDFInfo
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- CN102872328A CN102872328A CN2012104309551A CN201210430955A CN102872328A CN 102872328 A CN102872328 A CN 102872328A CN 2012104309551 A CN2012104309551 A CN 2012104309551A CN 201210430955 A CN201210430955 A CN 201210430955A CN 102872328 A CN102872328 A CN 102872328A
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- chronic pharyngitis
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- 239000003814 drug Substances 0.000 title claims abstract description 37
- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 229940079593 drug Drugs 0.000 title abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 238000002791 soaking Methods 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 239000000706 filtrate Substances 0.000 claims description 29
- 238000005303 weighing Methods 0.000 claims description 14
- 239000002893 slag Substances 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 10
- 241000133222 Lychnophora Species 0.000 claims description 6
- 235000021551 crystal sugar Nutrition 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 12
- 230000009471 action Effects 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000894007 species Species 0.000 abstract 2
- 241001571446 Scaphium scaphigerum Species 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229940126678 chinese medicines Drugs 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000037740 Coptis chinensis Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 240000002948 Ophiopogon intermedius Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241001412228 Scaphium lychnophorum Species 0.000 description 1
- 206010042209 Stress Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000009438 liyan Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
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Abstract
The invention discloses a medicine for treating chronic pharyngitis and a preparation method of the medicine, which belongs to the technical field of medicines. The medicine for treating chronic pharyngitis is prepared by soaking 8 to 12 parts of radix ophiopogonis, 5 to 8 parts of rhizoma coptidis and 10 to 15 parts of scaphium scaphigerum with white spirit, and then soaking with water and rock candy, and mixing the soak solution. The raw materials provided by the invention are few in species and easy to obtain and the raw material cost is low; due to the fact that the raw material medicine species are few, the pharmacologic action between the raw material medicines is relatively simple and clear and is free from toxic and side effects on the human body; the medicine provided by the invention is good in treatment effect on the chronic pharyngitis, the effective rate reaches up to 100%, and the cure rate reaches up to above 92%; and the chronic pharyngitis is healed after 5 to 10 days and unlikely to relapse, so that the taking course of treatment is relatively short.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of chronic pharyngitis and preparation method thereof.
Background technology
Owing to reasons such as living environment, life stresss, chronic pharyngitis becomes a kind of common chronic disease gradually, and sickness rate is more and more higher, and age of onset distributes also more and more wider.The chronic inflammatory disease of a kind of pharyngeal mucosa of chronic pharyngitis, its typical clinical symptoms is pharyngeal drying, itches, and foreign body sensation is arranged, and the phenomenons such as cough, nauseating retch are usually arranged, and when the body immunities such as flu reduced, these symptoms were particularly evident; Clinical examination usually has vasodilation, pachymucosa, pharyngeal congestion etc., affects people's work and life.
For the treatment of chronic pharyngitis, there is no at present definite effectively Therapeutic Method, generally adopt antibiotic to carry out anti-inflammatory treatment, relief of symptoms, but easily recurrence; A lot of Chinese patent medicine preparations are also arranged at present, such as Yanyan slice etc., these Chinese patent medicine preparations generally are comprised of several Chinese medicines even tens of kinds of Chinese medicines, and what have also comprises western medicine composition, and these Chinese medicine preparation are on the one hand owing to form more, raw material obtains difficult, cost is higher, because composition is more, toxic and side effects does not understand on the other hand, and these medicines need long-term taking, to potential health threat of existing of human body; Again, the curative effect of these Chinese medicine preparation is also imprecise.
Summary of the invention
Goal of the invention of the present invention is: for the problem of above-mentioned existence, provide that a kind of composition is simple, raw material is easy to get, determined curative effect, treat medicine and the preparation method of chronic pharyngitis safely and effectively.
The technical solution used in the present invention is such: a kind of preparation method that is used for the treatment of the medicine of chronic pharyngitis may further comprise the steps:
(1) raw materials weighing: by weight, take by weighing following raw material,
Radix Ophiopogonis 8-12 part, Rhizoma Coptidis 5-8 part, Semen Sterculiae Lychnophorae 10-15 part;
(2) soaking in Chinese liquor: above-mentioned raw materials joined in 20-30 part Chinese liquor soaked 60-80 minute, and to keep temperature be 30-40 ℃ that the volumn concentration of ethanol is 45%-50% in the described Chinese liquor, filters after soaking, obtain just filtrate and just soak slag;
(3) water soaking: soak to step (2) gained first and to add crystal sugar 6-8 part, water 50-60 part in the slag, and to keep temperature be 65-80 ℃ that soaked 90-120 minute, filtration obtains filter liquor;
(4) merging filtrate: with the first filtrate of step (2) gained and step (3) gained filter liquor mix homogeneously, and get final product.
The present invention selects Radix Ophiopogonis, Rhizoma Coptidis and Semen Sterculiae Lychnophorae as base stock, and adopts suitable ratio and suitable preparation method, has made the medicine that is used for the treatment of chronic pharyngitis, wherein
Radix Ophiopogonis (O.japonicus(L. f.) Ker-Gawl.), usually have YIN nourishing and the production of body fluid promoting, the effect that lung moistening clears away heart-fire; Rhizoma Coptidis (Coptis chinensis Franch) has heat clearing and damp drying, the effect of eliminating fire and detoxication usually; Semen Sterculiae Lychnophorae (Sterculia lychnophora) has clearing heat and moistening lung usually, liyan jiedu, the effect of loosening bowel to relieve constipation.
The present inventor, by great many of experiments, by above-mentioned suitable immersion order, immersion solvent, soak time and soaking temperature, so that suitable composition is leached in the material medicine, mutually collaborative between the composition, can reach 100% to the treated effect of chronic pharyngitis.
As preferably: in the step (4), before the merging filtrate, first with the ethanol in the first filtrate, make the volumn concentration of ethanol in first filtrate be lower than 2%.Remove ethanol, can improve mouthfeel on the one hand, can improve curative effect on the other hand, retrieval ethanol is to pharyngeal stimulation.
As preferably: in the step (1), the raw material that takes by weighing is 10 parts of Radix Ophiopogonis, 6 parts of Rhizoma Coptidis, 12 parts of Semen Sterculiae Lychnophoraes.
As preferably: when soaking in the step (3), keeping temperature is 70 ℃.
The present invention also provides a kind of above-mentioned preparation method prepared medicine.The mixing filtrate of gained can directly be taken, and makes pharmaceutically common preparation after perhaps concentrating, such as tablet, granule etc.
In sum, owing to adopted technique scheme, the invention has the beneficial effects as follows: crude drug kind of the present invention is few and be easy to get, and cost of material is low; Because the crude drug kind is few, its pharmacological action each other is relatively simply distinct, to the almost non-toxic side effect of human body; The medicine that the present invention makes is good to the therapeutic effect of chronic pharyngitis, and effective percentage can reach 100%, and cure rate can reach more than 92%, and is difficult for recurrence, and it is relatively short to take the course for the treatment of, can cure in 5-10 days.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in detail.
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1
A kind of preparation method that is used for the treatment of the medicine of chronic pharyngitis may further comprise the steps:
(1) raw materials weighing: by weight, take by weighing following raw material,
8 parts of Radix Ophiopogonis, 5 parts of Rhizoma Coptidis, 10 parts of Semen Sterculiae Lychnophoraes;
(2) soaking in Chinese liquor: above-mentioned raw materials joined in 26 parts of Chinese liquor soaked 60 minutes, and to keep temperature be 40 ℃ that the volumn concentration of ethanol is 45% in the described Chinese liquor, filters after soaking, obtain just filtrate and just soak slag; Remove the ethanol in the first filtrate, make its ethanol content be lower than the 2%(volume);
(3) water soaking: soak to step (2) gained first and to add 8 parts in crystal sugar, 50 parts in water in the slag, and to keep temperature be 75 ℃ that soaked 90 minutes, filtration obtains filter liquor;
(4) merging filtrate: with the first filtrate of step (2) gained and step (3) gained filter liquor mix homogeneously, and get final product.
Embodiment 2
A kind of preparation method that is used for the treatment of the medicine of chronic pharyngitis may further comprise the steps:
(1) raw materials weighing: by weight, take by weighing following raw material,
10 parts of Radix Ophiopogonis, 6 parts of Rhizoma Coptidis, 12 parts of Semen Sterculiae Lychnophoraes;
(2) soaking in Chinese liquor: above-mentioned raw materials joined in 20 parts of Chinese liquor soaked 70 minutes, and to keep temperature be 30 ℃ that the volumn concentration of ethanol is 50% in the described Chinese liquor, filters after soaking, obtain just filtrate and just soak slag; Remove the ethanol in the first filtrate, make its ethanol content be lower than 2%;
(3) water soaking: soak to step (2) gained first and to add 6 parts in crystal sugar, 60 parts in water in the slag, and to keep temperature be 70 ℃ that soaked 120 minutes, filtration obtains filter liquor;
(4) merging filtrate: with the first filtrate of step (2) gained and step (3) gained filter liquor mix homogeneously, and get final product.
3 one kinds of preparation methoies that are used for the treatment of the medicine of chronic pharyngitis of embodiment may further comprise the steps:
(1) raw materials weighing: by weight, take by weighing following raw material,
12 parts of Radix Ophiopogonis, 8 parts of Rhizoma Coptidis, 15 parts of Semen Sterculiae Lychnophoraes;
(2) soaking in Chinese liquor: above-mentioned raw materials joined in 30 parts of Chinese liquor soaked 80 minutes, and to keep temperature be 36 ℃ that the volumn concentration of ethanol is 46% in the described Chinese liquor, filters after soaking, obtain just filtrate and just soak slag; Remove the ethanol in the first filtrate, make its ethanol content be lower than 2%;
(3) water soaking: soak to step (2) gained first and to add 7 parts in crystal sugar, 55 parts in water in the slag, and to keep temperature be 65 ℃ that soaked 100 minutes, filtration obtains filter liquor;
(4) merging filtrate: with the first filtrate of step (2) gained and step (3) gained filter liquor mix homogeneously, and get final product.
Embodiment 4
A kind of preparation method that is used for the treatment of the medicine of chronic pharyngitis may further comprise the steps:
(1) raw materials weighing: by weight, take by weighing following raw material,
9 parts of Radix Ophiopogonis, 7 parts of Rhizoma Coptidis, 12 parts of Semen Sterculiae Lychnophoraes;
(2) soaking in Chinese liquor: above-mentioned raw materials joined in 28 parts of Chinese liquor soaked 65 minutes, and to keep temperature be 32 ℃ that the volumn concentration of ethanol is 45%% in the described Chinese liquor, filters after soaking, obtain just filtrate and just soak slag; Remove the ethanol in the first filtrate, make its ethanol content be lower than 2%
(3) water soaking: soak to step (2) gained first and to add 6 parts in crystal sugar, 50 parts in water in the slag, and to keep temperature be 80 ℃ that soaked 110 minutes, filtration obtains filter liquor;
(4) merging filtrate: with the first filtrate of step (2) gained and step (3) gained filter liquor mix homogeneously, and get final product.
Embodiment 5
Compliance test result
Selecting pathological diagnosis is outpatient's 200 examples of chronic hypertrophic pharyngitis and chronic simple pharyngitis, be divided at random 4 groups, every group of 50 people, patient age is 20-50 year, age and sex random assortment, adopt respectively the medicine of embodiment 1-4 and the medicine of matched group to carry out administration, wherein matched group is that 201110082694.4 the disclosed prescription of Chinese patent is treated for adopting number of patent application
Administering mode is oral, and each 50ml's every day three times takes medicine a week altogether,
Criterion of therapeutical effect:
Effectively: patient's partial symptoms alleviates
Produce effects: all sx↓s of patient
Cure: all transference cures of patient
Table 1 therapeutic effect statistical table
As can be seen from Table 1, medicine of the present invention, for the treatment of chronic pharyngitis, effective percentage is more than 92%, and is evident in efficacy.
Through the return visit of half a year, adopt the patient of embodiment of the invention 1-3 treatment, only 5 people recurrence, relapse rate is low.
The above only is preferred embodiment of the present invention, not in order to limiting the present invention, all any modifications of doing within the spirit and principles in the present invention, is equal to and replaces and improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. preparation method that is used for the treatment of the medicine of chronic pharyngitis is characterized in that: may further comprise the steps:
(1) raw materials weighing: by weight, take by weighing following raw material,
Radix Ophiopogonis 8-12 part, Rhizoma Coptidis 5-8 part, Semen Sterculiae Lychnophorae 10-15 part;
(2) soaking in Chinese liquor: above-mentioned raw materials joined in 20-30 part Chinese liquor soaked 60-80 minute, and to keep temperature be 30-40 ℃ that the volumn concentration of ethanol is 45%-50% in the described Chinese liquor, filters after soaking, obtain just filtrate and just soak slag;
(3) water soaking: soak to step (2) gained first and to add crystal sugar 6-8 part, water 50-60 part in the slag, and to keep temperature be 65-80 ℃ that soaked 90-120 minute, filtration obtains filter liquor;
(4) merging filtrate: with the first filtrate of step (2) gained and step (3) gained filter liquor mix homogeneously, and get final product.
2. a kind of preparation method that is used for the treatment of the medicine of chronic pharyngitis as claimed in claim 1 is characterized in that: in the step (4), before the merging filtrate, first with the ethanol in the first filtrate, make the volumn concentration of ethanol in first filtrate be lower than 2%.
3. a kind of preparation method that is used for the treatment of the medicine of chronic pharyngitis as claimed in claim 1, it is characterized in that: in the step (1), the raw material that takes by weighing is 10 parts of Radix Ophiopogonis, 6 parts of Rhizoma Coptidis, 12 parts of Semen Sterculiae Lychnophoraes.
4. a kind of preparation method that is used for the treatment of the medicine of chronic pharyngitis as claimed in claim 1 is characterized in that: when soaking in the step (3), keeping temperature is 70 ℃.
5. the prepared medicine of the described preparation method of claim 1-4 any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210430955.1A CN102872328B (en) | 2012-11-02 | 2012-11-02 | Medicine for treating chronic pharyngitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210430955.1A CN102872328B (en) | 2012-11-02 | 2012-11-02 | Medicine for treating chronic pharyngitis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102872328A true CN102872328A (en) | 2013-01-16 |
| CN102872328B CN102872328B (en) | 2014-06-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210430955.1A Expired - Fee Related CN102872328B (en) | 2012-11-02 | 2012-11-02 | Medicine for treating chronic pharyngitis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998632A (en) * | 2016-07-22 | 2016-10-12 | 赵月 | Pharmaceutical composition for treating pharyngitis |
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2012
- 2012-11-02 CN CN201210430955.1A patent/CN102872328B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 黄存垣: "慢性咽炎的调养", 《老友》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998632A (en) * | 2016-07-22 | 2016-10-12 | 赵月 | Pharmaceutical composition for treating pharyngitis |
| CN106138695A (en) * | 2016-07-22 | 2016-11-23 | 赵月 | A kind of pharmaceutical composition for treating acute pharyngitis |
| CN106177413A (en) * | 2016-07-22 | 2016-12-07 | 赵月 | A kind of granule for treating pharyngitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102872328B (en) | 2014-06-11 |
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Free format text: CORRECT: INVENTOR; FROM: ZHAO YUE TO: YANG ZHUN Free format text: CORRECT: ADDRESS; FROM: 610066 CHENGDU, SICHUAN PROVINCE TO: 266011 QINGDAO, SHANDONG PROVINCE |
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