CN102872328B - Medicine for treating chronic pharyngitis and preparation method thereof - Google Patents
Medicine for treating chronic pharyngitis and preparation method thereof Download PDFInfo
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- CN102872328B CN102872328B CN201210430955.1A CN201210430955A CN102872328B CN 102872328 B CN102872328 B CN 102872328B CN 201210430955 A CN201210430955 A CN 201210430955A CN 102872328 B CN102872328 B CN 102872328B
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- 239000003814 drug Substances 0.000 title claims abstract description 37
- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 229940079593 drug Drugs 0.000 title abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 238000002791 soaking Methods 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 239000000706 filtrate Substances 0.000 claims description 29
- 239000002893 slag Substances 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 10
- 241000133222 Lychnophora Species 0.000 claims description 6
- 235000021551 crystal sugar Nutrition 0.000 claims description 6
- 239000012467 final product Substances 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 238000007654 immersion Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 11
- 230000009471 action Effects 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000894007 species Species 0.000 abstract 2
- 241001571446 Scaphium scaphigerum Species 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229940126678 chinese medicines Drugs 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000037740 Coptis chinensis Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 240000002948 Ophiopogon intermedius Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241001412228 Scaphium lychnophorum Species 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000009438 liyan Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
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Abstract
The invention discloses a medicine for treating chronic pharyngitis and a preparation method of the medicine, which belongs to the technical field of medicines. The medicine for treating chronic pharyngitis is prepared by soaking 8 to 12 parts of radix ophiopogonis, 5 to 8 parts of rhizoma coptidis and 10 to 15 parts of scaphium scaphigerum with white spirit, and then soaking with water and rock candy, and mixing the soak solution. The raw materials provided by the invention are few in species and easy to obtain and the raw material cost is low; due to the fact that the raw material medicine species are few, the pharmacologic action between the raw material medicines is relatively simple and clear and is free from toxic and side effects on the human body; the medicine provided by the invention is good in treatment effect on the chronic pharyngitis, the effective rate reaches up to 100%, and the cure rate reaches up to above 92%; and the chronic pharyngitis is healed after 5 to 10 days and unlikely to relapse, so that the taking course of treatment is relatively short.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of chronic pharyngitis and preparation method thereof.
Background technology
Due to the reason such as living environment, life stress, chronic pharyngitis becomes a kind of common chronic disease gradually, and sickness rate is more and more higher, and age of onset distributes also more and more wider.Chronic pharyngitis is a kind of chronic inflammatory disease of pharyngeal mucosa, and its typical clinical symptoms is to be pharyngeally dried, to itch, and has foreign body sensation, usually has cough, phenomenons such as retchs of feeling sick, and when reduction such as body immunity such as flu grade, these symptoms are particularly evident; Clinical examination usually has vasodilation, pachymucosa, pharyngeal congestion etc., affects people's work and life.
For the treatment of chronic pharyngitis, there is no at present definite effectively Therapeutic Method, generally adopt antibiotic to carry out anti-inflammatory treatment, relief of symptoms, but easily recurrence; Also there are at present a lot of Chinese patent medicine preparations, such as Yanyan slice etc., these Chinese patent medicine preparations generally by several Chinese medicines even tens of kinds of Chinese medicines form, what have also comprises western medicine composition, these Chinese medicine preparation are on the one hand because composition is more, raw material obtains difficult, cost is higher, and on the other hand because composition is more, toxic and side effects does not understand, and these medicines need long-term taking, to the potential health threat of existing of human body; Again, the curative effect of these Chinese medicine preparation is also imprecise.
Summary of the invention
Goal of the invention of the present invention is: for the problem of above-mentioned existence, provide that a kind of composition is simple, raw material is easy to get, determined curative effect, the medicine for the treatment of safely and effectively chronic pharyngitis and preparation method.
The technical solution used in the present invention is such: a kind of preparation method of the medicine that is used for the treatment of chronic pharyngitis, comprises the following steps: (1) raw materials weighing: by weight, take following raw material,
Radix Ophiopogonis 8-12 part, Rhizoma Coptidis 5-8 part, Semen Sterculiae Lychnophorae 10-15 part;
(2) soaking in Chinese liquor: above-mentioned raw materials is joined in 20-30 part Chinese liquor and soaks 60-80 minute, and to keep temperature be 30-40 DEG C, in described Chinese liquor, the volumn concentration of ethanol is 45%-50%, filters after soaking, and obtains just filtrate and just soaks slag;
(3) water soaking: soak and add crystal sugar 6-8 part, water 50-60 part in slag to step (2) gained first, and to keep temperature be 65-80 DEG C, soak 90-120 minute, filter, obtain filter liquor;
(4) merging filtrate: first step (2) gained filtrate is mixed homogeneously with step (3) gained filter liquor, to obtain final product.
The present invention selects Radix Ophiopogonis, Rhizoma Coptidis and Semen Sterculiae Lychnophorae as base stock, and adopts suitable ratio and suitable preparation method, has made the medicine that is used for the treatment of chronic pharyngitis, wherein
Radix Ophiopogonis (O.japonicus(L. f.) Ker-Gawl.), conventionally there is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire; Rhizoma Coptidis (Coptis chinensis Franch), has heat clearing and damp drying, effect of eliminating fire and detoxication conventionally; Semen Sterculiae Lychnophorae (Sterculia lychnophora), has clearing heat and moistening lung conventionally, liyan jiedu, effect of loosening bowel to relieve constipation.
Present inventor, by great many of experiments, by above-mentioned suitable immersion order, immersion solvent, soak time and soaking temperature, composition suitable in material medicine is leached, mutually collaborative between composition, can reach 100% to the treated effect of chronic pharyngitis.
As preferably: in step (4), before merging filtrate, first by the ethanol in first filtrate, make the volumn concentration of ethanol in first filtrate lower than 2%.Remove ethanol, can improve mouthfeel on the one hand, can improve on the other hand curative effect, retrieval ethanol is to pharyngeal stimulation.
As preferably: in step (1), the raw material taking is 10 parts of Radix Ophiopogonis, 6 parts of Rhizoma Coptidis, 12 parts of Semen Sterculiae Lychnophoraes.
As preferably: while immersion in step (3), keeping temperature is 70 DEG C.
The present invention also provides a kind of above-mentioned preparation method prepared medicine.The mixing filtrate of gained, can directly take, or makes pharmaceutically common preparation after concentrated, such as tablet, granule etc.
In sum, owing to having adopted technique scheme, the invention has the beneficial effects as follows: crude drug kind of the present invention is few and be easy to get, cost of material is low; Because crude drug kind is few, its pharmacological action is each other relatively simply distinct, to the almost non-toxic side effect of human body; The medicine that the present invention makes is good to the therapeutic effect of chronic pharyngitis, and effective percentage can reach 100%, and cure rate can reach more than 92%, and is difficult for recurrence, takes the course for the treatment of relatively short, within 5-10 days, can cure.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in detail.
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1
A preparation method that is used for the treatment of the medicine of chronic pharyngitis, comprises the following steps:
(1) raw materials weighing: by weight, take following raw material,
8 parts of Radix Ophiopogonis, 5 parts of Rhizoma Coptidis, 10 parts of Semen Sterculiae Lychnophoraes;
(2) soaking in Chinese liquor: above-mentioned raw materials is joined in 26 parts of Chinese liquor and soaks 60 minutes, and to keep temperature be 40 DEG C, in described Chinese liquor, the volumn concentration of ethanol is 45%, filters after soaking, and obtains just filtrate and just soaks slag; Remove the ethanol in first filtrate, make its ethanol content lower than 2%(volume);
(3) water soaking: soak and add 8 parts, crystal sugar, 50 parts, water in slag to step (2) gained first, and to keep temperature be 75 DEG C, soak 90 minutes, filter, obtain filter liquor;
(4) merging filtrate: first step (2) gained filtrate is mixed homogeneously with step (3) gained filter liquor, to obtain final product.
Embodiment 2
A preparation method that is used for the treatment of the medicine of chronic pharyngitis, comprises the following steps:
(1) raw materials weighing: by weight, take following raw material,
10 parts of Radix Ophiopogonis, 6 parts of Rhizoma Coptidis, 12 parts of Semen Sterculiae Lychnophoraes;
(2) soaking in Chinese liquor: above-mentioned raw materials is joined in 20 parts of Chinese liquor and soaks 70 minutes, and to keep temperature be 30 DEG C, in described Chinese liquor, the volumn concentration of ethanol is 50%, filters after soaking, and obtains just filtrate and just soaks slag; Remove the ethanol in first filtrate, make its ethanol content lower than 2%;
(3) water soaking: soak and add 6 parts, crystal sugar, 60 parts, water in slag to step (2) gained first, and to keep temperature be 70 DEG C, soak 120 minutes, filter, obtain filter liquor;
(4) merging filtrate: first step (2) gained filtrate is mixed homogeneously with step (3) gained filter liquor, to obtain final product.
3 one kinds of embodiment are used for the treatment of the preparation method of the medicine of chronic pharyngitis, comprise the following steps:
(1) raw materials weighing: by weight, take following raw material,
12 parts of Radix Ophiopogonis, 8 parts of Rhizoma Coptidis, 15 parts of Semen Sterculiae Lychnophoraes;
(2) soaking in Chinese liquor: above-mentioned raw materials is joined in 30 parts of Chinese liquor and soaks 80 minutes, and to keep temperature be 36 DEG C, in described Chinese liquor, the volumn concentration of ethanol is 46%, filters after soaking, and obtains just filtrate and just soaks slag; Remove the ethanol in first filtrate, make its ethanol content lower than 2%;
(3) water soaking: soak and add 7 parts, crystal sugar, 55 parts, water in slag to step (2) gained first, and to keep temperature be 65 DEG C, soak 100 minutes, filter, obtain filter liquor;
(4) merging filtrate: first step (2) gained filtrate is mixed homogeneously with step (3) gained filter liquor, to obtain final product.
Embodiment 4
A preparation method that is used for the treatment of the medicine of chronic pharyngitis, comprises the following steps:
(1) raw materials weighing: by weight, take following raw material,
9 parts of Radix Ophiopogonis, 7 parts of Rhizoma Coptidis, 12 parts of Semen Sterculiae Lychnophoraes;
(2) soaking in Chinese liquor: above-mentioned raw materials is joined in 28 parts of Chinese liquor and soaks 65 minutes, and to keep temperature be 32 DEG C, in described Chinese liquor, the volumn concentration of ethanol is 45%%, filters after soaking, and obtains just filtrate and just soaks slag; Remove the ethanol in first filtrate, make its ethanol content lower than 2%
(3) water soaking: soak and add 6 parts, crystal sugar, 50 parts, water in slag to step (2) gained first, and to keep temperature be 80 DEG C, soak 110 minutes, filter, obtain filter liquor;
(4) merging filtrate: first step (2) gained filtrate is mixed homogeneously with step (3) gained filter liquor, to obtain final product.
Embodiment 5
Compliance test result
Selecting pathological diagnosis is outpatient's 200 examples of chronic hypertrophic pharyngitis and chronic simple pharyngitis, be divided at random 4 groups, every group of 50 people, patient age is 20-50 year, age and sex random assortment, adopt respectively the medicine of embodiment 1-4 and the medicine of matched group to carry out administration, wherein matched group is to adopt the disclosed formula of Chinese patent that number of patent application is 201110082694.4 to treat
Administering mode is oral, and each 50ml, every day three times, takes medicine one week altogether,
Criterion of therapeutical effect:
Effective: patient's partial symptoms alleviates
Effective: all symptoms of patient alleviate
Cure: all transference cures of patient
Table 1 therapeutic effect statistical table
As can be seen from Table 1, medicine of the present invention, for the treatment of chronic pharyngitis, effective percentage is more than 92%, evident in efficacy.
Through the return visit of half a year, adopt the patient of embodiment of the present invention 1-3 treatment, only 5 people's recurrences, relapse rate is low.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (5)
1. a preparation method that is used for the treatment of the medicine of chronic pharyngitis, is characterized in that: comprise the following steps:
(1) raw materials weighing: by weight, take following raw material,
Radix Ophiopogonis 8-12 part, Rhizoma Coptidis 5-8 part, Semen Sterculiae Lychnophorae 10-15 part;
(2) soaking in Chinese liquor: above-mentioned raw materials is joined in 20-30 part Chinese liquor and soaks 60-80 minute, and to keep temperature be 30-40 DEG C, in described Chinese liquor, the volumn concentration of ethanol is 45%-50%, filters after soaking, and obtains just filtrate and just soaks slag;
(3) water soaking: soak and add crystal sugar 6-8 part, water 50-60 part in slag to step (2) gained first, and to keep temperature be 65-80 DEG C, soak 90-120 minute, filter, obtain filter liquor;
(4) merging filtrate: first step (2) gained filtrate is mixed homogeneously with step (3) gained filter liquor, to obtain final product.
2. the preparation method of a kind of medicine that is used for the treatment of chronic pharyngitis as claimed in claim 1, is characterized in that: in step (4), before merging filtrate, first by the ethanol in first filtrate, make the volumn concentration of ethanol in first filtrate lower than 2%.
3. the preparation method of a kind of medicine that is used for the treatment of chronic pharyngitis as claimed in claim 1, is characterized in that: in step (1), the raw material taking is 10 parts of Radix Ophiopogonis, 6 parts of Rhizoma Coptidis, 12 parts of Semen Sterculiae Lychnophoraes.
4. the preparation method of a kind of medicine that is used for the treatment of chronic pharyngitis as claimed in claim 1, is characterized in that: while immersion in step (3), keeping temperature is 70 DEG C.
5. the prepared medicine of preparation method described in claim 1-4 any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210430955.1A CN102872328B (en) | 2012-11-02 | 2012-11-02 | Medicine for treating chronic pharyngitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210430955.1A CN102872328B (en) | 2012-11-02 | 2012-11-02 | Medicine for treating chronic pharyngitis and preparation method thereof |
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| CN102872328A CN102872328A (en) | 2013-01-16 |
| CN102872328B true CN102872328B (en) | 2014-06-11 |
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| CN105998632A (en) * | 2016-07-22 | 2016-10-12 | 赵月 | Pharmaceutical composition for treating pharyngitis |
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Non-Patent Citations (2)
| Title |
|---|
| 慢性咽炎的调养;黄存垣;《老友》;20021231(第4期);正文部分右栏第1-5段 * |
| 黄存垣.慢性咽炎的调养.《老友》.2002,(第4期),正文部分. |
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