CN1284297A - Food additive for diabetic - Google Patents
Food additive for diabetic Download PDFInfo
- Publication number
- CN1284297A CN1284297A CN00111268A CN00111268A CN1284297A CN 1284297 A CN1284297 A CN 1284297A CN 00111268 A CN00111268 A CN 00111268A CN 00111268 A CN00111268 A CN 00111268A CN 1284297 A CN1284297 A CN 1284297A
- Authority
- CN
- China
- Prior art keywords
- zinc
- sea
- brown
- diabetic
- chromium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The food additive includes cellulose, chromium compound and zinc compound and features its composition comprising chromium element 0.00001-0.01 wt% and zinc element 0.001-0.5 wt% except water soluble cellulose. It provides diabetic with water soluble cellulose and trace elements chromium and zinc, has definite treatment effect and is easy to be added into various food, delicious and acceptable for diabetics.
Description
The invention belongs to food additives, particularly relate to the additive of a kind of cereal flour that can be used for treating diabetes.
Diabetes are a kind of lifelong property, disable seriously, the mankind are threatened greatly, are subjected to the extreme disease of paying close attention in the whole world, and its incidence of disease is about 2%-3% in China, and the whole world on average is about 1%.Dietary therapy is the Primary Care and the main methods of treatment of diabetes at present, and a large amount of for many years zooperies and clinical research prove that cellulose and some trace element have substantial connection with the generation and the development of diabetes and chronic complicating diseases thereof in the meals.Therefore, dietary structure, reasonable supplement cellulose and the trace element that changes the diabetes patient is the important component part of diabetic diet treatment, also is the domestic and international research focus.At present, have some dieletic foodstuff additives both at home and abroad, as Chinese invention patent " functional food additive material for diabetes " (patent No. is 93117201.2), Chinese invention patent ublic specification of application " compound method of diabetic rehabilitation biscuit " etc., but they have following shortcoming; That (1) replenishes is micro-single, and curative effect is limited; (2) food form dullness does not meet people's eating habit, as the various food forms that only have instant noodles, biscuit, preserved material can not arbitrarily become the individual to like with various flour hybrid process; (3) uncertain therapeutic efficacy is cut; (4) cost an arm and a leg: existing add as the agent price highly, cause patient to be difficult to prolonged application.As the pyridine acid chrome of commercially available homemade high chromium yeast (trade name " sugared safe capsule ") and import trade name " No. one, Tang An ") and etc. all be to give the diabetes patient to replenish Organic Chromium; Because above Organic Chromium can only be as an auxiliary or health medicine a lot of a little less than distance equates other hypoglycemic of price, fat-reducing medicament aspect hypoglycemic, the effect for reducing fat, therefore only the patient of numbers of poles minority takes Organic Chromium.Because diabetes are a kind of lifelong diseases, additive also is applied in the feed throughout one's life every day, this will consider patient's long-term ability to bear, promptly require examples of such additives necessary cheap, this to so underdeveloped, the most of people of China to the medical expense holding capacity a little less than, country be even more important.Otherwise, both made the treatment measure that curative effect is good again, security is high more also lack using value and social benefit.
The objective of the invention is to provides a kind of comprehensive supplementing water cellulose of solubleness and trace element for diabetic, determined curative effect, safe and harmless, can be flexible be processed into various food forms, mouthfeel is good, cheap, the food additive that can bear for a long time and be easy to accept for general diabetes patient's economic capability.
The food additives of developing among the present invention comprise the compound of cellulose, chromium and the compound of zinc.Said cellulose is a water-soluble cellulose, and said chromium is the elemental chromium in the trivalent inorganic chromium compound; Said zinc is the element zinc in the zinc compound.
Food additives of the present invention are made by following component: (weight %)
Elemental chromium 0.00001-0.01
Element zinc 0.001-0.5
Surplus is a cellulose except that the zinc compound weight of trivalent inorganic chromium compound that contains above elemental chromium and element zinc.
Preferred (weight %) proportioning of preparation food additives of the present invention is:
Elemental chromium 0.0007-0.005
Element zinc 0.01-0.2
Surplus is water-soluble cellulose (except that trivalent inorganic chromium compound and a zinc compound weight).
The best of food additives of the present invention (weight %) proportioning is:
Elemental chromium 0.001
Element zinc 0.06
Surplus is water-soluble cellulose (except that trivalent inorganic chromium compound and a zinc compound weight).
Said water-soluble cellulose comprises one or more in brown (sea) phycocolloid and derivative, other polysaccharide or natural plant gum class, the semisynthetic fibre element etc.Wherein brown (sea) phycocolloid and derivative thereof comprise brown (sea) phycocolloid, brown (sea) mosanom, brown (sea) potassium alginate, brown (sea) ammonium alginate, brown (sea) calcium alginate, brown (sea) propylene glycol alginate, brown (sea) alginic acid triethanolamine, brown (sea) alginic acid dibutyl amine, agar and carragheen etc.; Other polysaccharide or natural plant gum class, as Glucomannan, mannosan, araboxylan, tamarind seed polysaccharide glue, glucan, pectin, natural gum, edible gelatin, Arabic gum, sesbania gum, xanthans, bean gum and guanidine glue; Semisynthetic fibre is plain as sodium cellulosate, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethylcellulose, methylethylcellulose.
The compound of said trivalent inorganic chromium can be selected one or more from chromium trichloride, chrome green, chromic nitrate, chromic acetate and nicotinic acid chromium.
Said zinc compound can be selected one or more from zinc sulfate, zinc acetate, zinc chloride, zinc lactate, orotic acid-arginine zinc, zinc citrate, zinc gluconate, licorzinc, amino-acid zinc and zinc albuminate.
A large amount of for many years zooperies and clinical research prove that the generation of the minimizing of cellulose and trace element chromium and zinc and diabetes and chronic complicating diseases thereof and development have substantial connection in the meals.Therefore, change diabetes patient's dietary structure, reasonable supplement cellulose, chromium and zinc are the important component parts of diabetic diet treatment.Water-soluble cellulose has defecating feces excretion tangible reduction diabetes blood glucose and blood fat and slight; Obviously, treatment of diabetes water intaking cellulose of solubleness is got water insoluble cellulosic for well,, also can reduce it GI side effect because this promptly can give full play to the effect of curing the disease of plant cellulose.And chromium can reduce blood sugar, blood fat and the auspicious sclerosis of artery congee that lacks the chromium diabetes.Zinc can improve glycometabolism and the islet function that lacks the zinc patient.
The using method of food additives of the present invention is: additive through after fully soaking dissolving, with a certain proportion of flour mixed together, is made into food again, also can directly takes in meal.
For showing progressive of the present invention, reinforcement powder and smart powder (calling common flour in the following text) that this additive and wheat system flour (commercially available smart powder) are mixed compare:
1, animal experiment
1. carbohydrate tolerance test: test shows to 20 normal mouses and diabetic mice bread meal, area under phase blood sugar and the blood glucose curve when strengthening powder and can obviously reduce after the meal each.
2. to the influence of cholesterol and liver fat: 24 normal mouse test-meals are shown, strengthen powder and can obviously reduce serum cholesterol and liver tg.
3. to the influence of ordinary circumstance: 30 diabetic mices are fed showed in 28 days, strengthen that powder can make it water uptake and the urine amount obviously reduces, body weight obviously increases, being full of animal spirits.
2, clinical observation
1. bread meal carbohydrate tolerance test: 50 routine diabetics are done the bread meal carbohydrate tolerance test show, strengthen that powder can obviously reduce after the meal 30,60,120, and area under the blood sugar of phase and the total blood glucose curve 180 minutes the time.
2. long-term hypoglycemic observation: after 70 routine diabetics are used and are strengthened powder, its fasting blood-glucose (FBG), 2 hours after the meal blood sugar (P
2hBG) and the glycosylated hemoglobin (HbAIC) that reflects nearly 2-3 monthly average blood sugar level behind this additive of clothes, obvious decline is all arranged before than treatment 1 month, 2 months the time, and it is more more remarkable than 1 month to obey this additive 2 months continuously.Wherein the mean change of 1 month and 2 months indexs is: body weight descends 0.80%, 10.76% respectively, and fasting blood-glucose descends 4.1%, 22.62%, and blood sugar descended 20.04%, 32.32% in two hours after the meal, and glycosylated hemoglobin descends 26.22%, 33.02%.
3. improve the observation of dyslipidemia: after 30 routine diabetics are used the reinforcement powder; cholesterol (TC), triglycerides (TG) and the apolipoprotein B (APOB) of reflection atherosclerosis risk factor all have obvious decline; and the aPoA (APOA) of the reflection artery sclerosis protection factor obviously raises, and is more obvious when above-mentioned blood fat changes in the time of 2 months than 1 month.Wherein the mean change of 1 month and 2 months indexs is: cholesterol descends 3.96%, 17.76% respectively, triglycerides descends 10.02%, 32.72% respectively, aPoA raises 1.23%, 1.43% respectively, and apolipoprotein B descends 10.02%, 28.75% respectively.
4. to the influence of serum insulin: use and strengthen before and after the powder, the insulin secretion level does not have significant change.
5. to the influence of diabetic symptom: 70 routine diabetics are used strengthen treated powders and showed in 2 months, the relevant symptom of diabetes all has obviously as hungry or many foods, many drinks or diuresis, weak, constipation and alleviates, and its remission rate is respectively 94%, 89%, 74%, 76%.
6. to the observation of additive toxic and side effect: 70 routine diabetics are used strengthen treated powders and showed that the incidence of the symptom of digestive tract relevant with additive was lower than 10% in 2 months, generally slight, can die away.Its routine blood test, hepatic and renal function do not have obvious change.
3, clinical expansion is observed
Application through example surplus 400 being reached 3 years shows, this additive has obvious reduction blood sugar, improve dyslipidemia and improve the effect of diabetic symptom.
Additive of the present invention has following characteristics through clinical observation:
Further specify the present invention with several examples more below.Example 1, example 1: so-and-so, 64 years old, diabetes B (obesity), fasting blood-glucose 7.88mmol/L, patient finds end antidiabetic drug after the diabetes, only use steamed bun and pancake treatment that additive of the present invention makes, fasting blood-glucose is reduced to normally, is 5.69-6.1mmol/L, the 6kg that loses weight, muscle power obviously strengthens.
Example 2, so-and-so, 57 years old, diabetes B, obviously fat (height 164cm, body weight 71.5kg), former clothes antidiabetic drug poor effect, fasting blood-glucose 11.1mmol/L, 2 hours after the meal blood sugar 15.6mmol/L, cholesterol 8.37mmol/L.Under the constant situation of former clothes antidiabetic drug, add with this additive treatment 3 months, its fasting blood-glucose is normal, and blood sugar dropped to 5.8mmol/L in 2 hours after the meal, and courage drops to 6.88mmol/L because of alcohol, body weight decline 5.5kg, symptom obviously alleviates.
Above zoopery, clinical testing and apply to observe and prove that fully the present invention has following advantage:
(1) can significantly reduce diabetic blood sugar, improve dyslipidemia and fat-reducing, do not cause the hyperinsulinemia that sulfonylureas drugs for diabetes and insulin produce again, thereby help avoiding, the generation and the development of minimizing or delaying complications of diabetes.(2) can obviously improve symptoms such as the hunger of diabetic, many foods, many drinks, and defecating feces excretion is arranged.(3) be difficult for taking place hypoglycemia, safety non-toxic, side effect is little, better tolerance.(4) easy to use, not influencing the northern China people is the eating habit of staple food with flour, can arbitrarily be processed into the various food forms that the individual likes.(5) cheap, inorganic chromium only needed the RMB red cent in two months, was about 1/39000 of Organic Chromium price, and patient has long-term ability to bear.(6) sufficient raw, additive is easy to long preservation, never degenerates.(7) mouthfeel is better.(8) also edible of ND normal person helps allaying one's hunger, lose weight, preventing the generation of obesity and diabetes.(9) be suitable for family's processing, also be suitable for the food that food-processing industry large-scale production is used for the diabetes patient.In a word, this additive diabetic diet of being difficult to grasp and comply with for complicated and patient is treated provides a kind of novelty, effective, safe, economic new method.Additive of the present invention has extremely strong using value and DEVELOPMENT PROSPECT, will benefit numerous diabetes patients, produces obvious social and economic benefit.
Further specify the present invention by the following examples, but do not limit the present invention in any way.
Embodiment 1:
Additive formulations: carragheen 10 grams, chromium trichloride (CrCl
33H
2O) 420 micrograms, zinc lactate are 30 milligrams.
During use, above-mentioned additive is soaked in water spends the night, add amount of water again with 150 gram faces and mix, be processed into cake, baking forms.
Embodiment 2:
Additive formulations: Glucomannan 15 grams, chrome green 600 micrograms, 70 milligrams of zinc gluconates.
During use, with above-mentioned additive soaked overnight.When beginning to have meal and food take jointly.
Embodiment 3:
Additive formulations: 15 milligrams of agar 5 grams, chromic acetate 400 micrograms, zinc acetate.
During use, above-mentioned additive with soaking in advance more than 8 hours, is mixed above-mentioned additive with 80 gram flour and suitable moisture, be processed into noodles.
Embodiment 4:
Additive formulations: 200 milligrams of sodium carboxymethylcellulose 5 grams, nicotinic acid chromium 800 micrograms, licorzinc.
During use, above-mentioned additive is soaked in water spends the night, and millet face 50 restrains and suitable moisture hybrid process becomes thin pancake with above-mentioned additive and flour 100 grams.
Embodiment 5:
Additive formulations: sodium alginate 10 grams, hydrated chromium trichloride (CrCl
36H
2O) 600 micrograms, zinc sulphate hydrate (ZnSO
47H
2O) 25 milligrams.Giving earlier soaks more than 8 hours.Above-mentioned additive and the smart powder of 120 gram wheat faces, yeast powder and amount of water are mixed, knead, cutting, cook, are processed into steamed bun.
Embodiment 6:
Additive formulations: 100 milligrams of hydroxyethylcellulose 20 grams, chromic nitrate 600 micrograms, zinc chloride.Giving earlier soaks more than 8 hours.Above-mentioned additive and 250 gram flour, yeast powder and amount of water are mixed, knead, cutting, cook, are processed into steamed bun.
Claims (9)
1, a kind of food additive for diabetic comprises cellulose, chromium compound and zinc compound, it is characterized in that food additives are made by following component: (weight %)
Elemental chromium 0.00001-0.01
Element zinc 0.001-0.5
Surplus is a water-soluble cellulose except that trivalent inorganic chromium compound and zinc compound weight.
2, food additive for diabetic according to claim 1 is characterized in that preferred (weight %) proportioning for preparing food additives of the present invention is:
Elemental chromium 0.0007-0.005
Element zinc 0.01-0.2
Surplus is water-soluble cellulose (except that trivalent inorganic chromium compound and a zinc compound weight).
3,, it is characterized in that the best (weight %) proportioning of food additives of the present invention is according to claim 1 and/or 2 described food additive for diabetic:
Elemental chromium 0.001
Element zinc 0.06
Surplus is water-soluble cellulose (except that trivalent inorganic chromium compound and a zinc compound weight).
4,, it is characterized in that said water-soluble cellulose comprises brown (sea) phycocolloid and derivative, other polysaccharide or natural plant gum, semisynthetic fibre element according to claim 1,2 or 3 described food additive for diabetic.
5, food additive for diabetic according to claim 4 is characterized in that said brown (sea) phycocolloid and derivative thereof are one or more in brown (sea) phycocolloid, brown (sea) mosanom, brown (sea) potassium alginate, brown (sea) ammonium alginate, brown (sea) calcium alginate, brown (sea) propylene glycol alginate, brown (sea) alginic acid triethanolamine, brown (sea) alginic acid dibutyl amine, agar and the carragheen.
6, food additive for diabetic according to claim 4, it is characterized in that said other polysaccharide or natural plant gum comprise Glucomannan, mannosan, araboxylan, tamarind seed polysaccharide glue, glucan, pectin, natural gum, edible gelatin, Arabic gum, sesbania gum, xanthans, bean gum and guanidine glue.
7, food additive for diabetic according to claim 4 is characterized in that said semisynthetic fibre element comprises sodium cellulosate, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethylcellulose, methylethylcellulose.
8,, it is characterized in that said inorganic chromium can select one or more from chromium trichloride, chrome green, chromic nitrate, chromic acetate and nicotinic acid chromium according to claim 1,2 or 3 food additive for diabetic of stating.
9,, it is characterized in that said zinc can select one or more from zinc sulfate, zinc acetate, zinc chloride, zinc lactate, orotic acid-arginine zinc, zinc citrate, zinc gluconate, licorzinc, amino-acid zinc and zinc albuminate according to claim 1,2 or 3 described food additive for diabetic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00111268A CN1284297A (en) | 2000-08-08 | 2000-08-08 | Food additive for diabetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00111268A CN1284297A (en) | 2000-08-08 | 2000-08-08 | Food additive for diabetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1284297A true CN1284297A (en) | 2001-02-21 |
Family
ID=4581193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00111268A Pending CN1284297A (en) | 2000-08-08 | 2000-08-08 | Food additive for diabetic |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1284297A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102077936A (en) * | 2010-09-20 | 2011-06-01 | 王强 | Special sea dietary food for diabetics |
| CN101380115B (en) * | 2008-10-27 | 2011-11-16 | 买世禄 | Production method of health food rich in glucose sugar tolerance factor chrome |
| US8283338B2 (en) | 2007-11-30 | 2012-10-09 | Kao Corporation | GIP secretion inhibitor |
| US8338389B2 (en) | 2009-06-17 | 2012-12-25 | Kao Corporation | Agent for preventing or ameliorating obesity |
| CN105982087A (en) * | 2015-02-26 | 2016-10-05 | 北京福寿星绿色食品科技有限责任公司 | Traditional Chinese medicine eggs capable of reducing blood sugar and making method |
| CN107094893A (en) * | 2016-02-23 | 2017-08-29 | 天津阿尔发保健品有限公司 | A kind of chromium-rich milk powder |
| CN108125978A (en) * | 2017-12-29 | 2018-06-08 | 广州润虹医药科技股份有限公司 | A kind of chitin fiber composition and preparation method thereof |
| CN108366610A (en) * | 2015-11-27 | 2018-08-03 | 倍佳有限公司 | Food supplement and composition for treating metabolic syndrome |
-
2000
- 2000-08-08 CN CN00111268A patent/CN1284297A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8283338B2 (en) | 2007-11-30 | 2012-10-09 | Kao Corporation | GIP secretion inhibitor |
| CN101380115B (en) * | 2008-10-27 | 2011-11-16 | 买世禄 | Production method of health food rich in glucose sugar tolerance factor chrome |
| US8338389B2 (en) | 2009-06-17 | 2012-12-25 | Kao Corporation | Agent for preventing or ameliorating obesity |
| CN102077936A (en) * | 2010-09-20 | 2011-06-01 | 王强 | Special sea dietary food for diabetics |
| CN102077936B (en) * | 2010-09-20 | 2013-04-24 | 王强 | Special sea dietary food for diabetics |
| CN105982087A (en) * | 2015-02-26 | 2016-10-05 | 北京福寿星绿色食品科技有限责任公司 | Traditional Chinese medicine eggs capable of reducing blood sugar and making method |
| CN108366610A (en) * | 2015-11-27 | 2018-08-03 | 倍佳有限公司 | Food supplement and composition for treating metabolic syndrome |
| CN107094893A (en) * | 2016-02-23 | 2017-08-29 | 天津阿尔发保健品有限公司 | A kind of chromium-rich milk powder |
| CN108125978A (en) * | 2017-12-29 | 2018-06-08 | 广州润虹医药科技股份有限公司 | A kind of chitin fiber composition and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100579395C (en) | Instant nutritive gruel having a function of stabilizing body blood sugar after meal and method for preparing the same | |
| CN109221898A (en) | A kind of grain dust and its preparation method and application containing xylo-oligosaccharide | |
| CN106360310A (en) | Composition for dropping after meal blood sugar and application thereof | |
| CA2517172C (en) | Therapeutic compositions | |
| CN107212256A (en) | A kind of meal replacement powder with function of blood sugar reduction and preparation method thereof | |
| CN111887370A (en) | Uric acid-reducing ocean fish oligopeptide-chitosan oligosaccharide solid beverage | |
| CN108208802A (en) | A kind of special diet of suitable patients with diabetes mellitus and preparation method thereof | |
| CN108813590A (en) | A kind of low GI formula food of suitable diabetic and preparation method thereof | |
| CN102113652A (en) | Special dietary extruded rice applicable to patients suffering from 'five-high' metabolic syndrome and preparation method thereof | |
| CN1284297A (en) | Food additive for diabetic | |
| CN107198246A (en) | A kind of health composition and a kind of health care preparation | |
| WO2002040035A1 (en) | Remedies for diabetes | |
| CN112956695A (en) | Oat beta-glucan composition and preparation method and application thereof | |
| CN1161801A (en) | Formular of food and medicine containing glucose tolerance factor chromium and processing technology thereof | |
| CN101953867B (en) | Petroleum ether extract of saussurea involucrate, application preparation method and application thereof | |
| CN1148476A (en) | Sugar-reducing health-care food additive and preparing method thereof | |
| JP2004149471A (en) | Hypoglycemic agent | |
| CN103549008B (en) | Liquid dairy product rich in cellulose | |
| CN102907681A (en) | Production method of konjak and highland barley high-fiber slimming food | |
| CN1286503C (en) | A Chinese medicinal composition with blood sugar and blood lipid reducing effects, and its preparation method | |
| CN113498844A (en) | A composition formula for regulating metabolic diseases with oat bran as base material and its preparation method | |
| CN102150779A (en) | Health food for regulating and stabilizing blood sugar and preparation method thereof | |
| CN110638041A (en) | Food for improving blood sugar and application thereof | |
| TW202034790A (en) | Bitter gourd peptide composition | |
| CN113662188A (en) | Functional food suitable for diabetes patients and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| AD01 | Patent right deemed abandoned | ||
| C20 | Patent right or utility model deemed to be abandoned or is abandoned |