CN1276232A - Chinese medicine preparation for treating viral myocarditis - Google Patents
Chinese medicine preparation for treating viral myocarditis Download PDFInfo
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- CN1276232A CN1276232A CN 99107978 CN99107978A CN1276232A CN 1276232 A CN1276232 A CN 1276232A CN 99107978 CN99107978 CN 99107978 CN 99107978 A CN99107978 A CN 99107978A CN 1276232 A CN1276232 A CN 1276232A
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Abstract
A Chinese medicine for treating viral myocarditis is prepared from 5 Chinese-medicinal materials including astragalus root, ophiopogon root, honeysuckle flower, giant knotweed rhizome, etc through extracting in water and precipitating in a alcohol.
Description
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine oral liquid for the treatment of viral myocarditis.
The sickness rate of viral myocarditis has the trend that increases gradually in recent years.Western modern medicine treatment removes at present and has a rest, and outside augment nutritional and the general supporting treatment, does not still have effective specific therapy, most scholars and then sight turned to Chinese medicine.The Chinese medicine viral myocarditis before 1986, is limited to general report more, has only the single medicinal material Radix Astragali has been carried out the comparatively deep research of system.Before this problem, do not see the systematic study of compound treatment viral myocarditis as yet, more there is not new Chinese medicine preparation for clinical application.From 1986, we began the experiment and the clinical research of the happy health of the heart (Kang Erxin) oral liquid treatment acute viral myocarditis.
Viral myocarditis belongs to sick scope such as the traditional Chinese medical science " cardiopalmus ", " palpitation with a distress feeling ", " thoracic obstruction ", and its morbidity is many by evil poison invasion and attack, going from the exterior into the interior, consumption is hindered healthy energy, sinks into the heart, stops up due to the resistance heart arteries and veins, so " weakened defensive QI, evil poison invasion and attack, impairment of both QI and YIN " is the basic etiology and pathogenesis that causes primary disease, the happy recovery oral liquid of the heart has supplementing QI and nourishing YIN, heat-clearing and toxic substances removing, the function of promoting blood circulation and stopping pain, strengthening vital QI to eliminate pathogenic factors, reinforcement and elimination in combination belongs to deficiency of both QI and YIN so be applicable to viral myocarditis, and evil poison is invaded heart card.Clinical manifestation
Be cardiopalmus, uncomfortable in chest, breathe hard, weak, spontaneous perspiration, xerostomia, night sweat, heating, card shapes such as pharynx discomfort or dried pain; Pale tongue is fat or red, few tongue or BOHUANG (in vain) tongue, and deep pulse counts accurately or slow or knot, generation, urge.
The object of the present invention is to provide a kind ofly carry, taking convenience, curative effect is reliable, and is safe in utilization, no significant discomfort should be demonstrate,proved pure Chinese medicinal preparation with contraindication and preparation method thereof.The present invention is achieved through the following technical solutions; The selection of raw material: (by weight)
Radix Astragali 10-40 10-20 Radix Ophiopogonis Rhizoma Polygoni Cuspidati 10-20
Rhizoma Osmundae 10-20 Flos Lonicerae 10-20 sucrose 10-30 preparation technology:
With the Chinese medicine of the five flavours material in the raw material, all process by official method and to concoct into qualified decoction pieces.Extracting honeysuckle, put and add water 100～250L in the rustless steel jacketed pan, soak after 1-2 hour, open the steam cock heating, a pot inner liquid medicine temperature is remained between 30～80 ℃, warm macerating 2-4 time merges each time filtrate, in the concentrating under reduced pressure device 50 ℃-80kp be concentrated into relative density be about 1.2-1.6 (60 ℃) thick paste standby.Paste-forming rate 15-20%.
Except that Flos Lonicerae, all the other 4 flavor merging place and add water 400～800L in the multipotency extraction pot, open steam cock, decoct three times, merge three times filtrate in the prescription.In the concentrated unit of triple effect, be concentrated into relative density 1.3～1,5, it is standby to get thick paste.
With above thick paste mixing, put and add 70-95% ethanol 20-30L in the alcohol precipitation bucket, stir evenly cold preservation, left standstill 48 hours, the filtering precipitation, decompression recycling ethanol is not to there being the alcohol flavor, and 15 times of amounts of adding distil water stir evenly cold preservation, leave standstill the filtering precipitation 48 hours.
Taking liquid adds coarse filter paper with filter press and filters repeatedly after transferring PH5～7, and medicinal liquid adds sucrose syrup after do not have the observability precipitate, stirs evenly, and adds water to an amount of.
With the medicinal liquid packing that is up to the standards, flowing steam sterilization 30 minutes, promptly.
Happy health (Kang Erxin) is irritated stomach diligently, and the mice maximum tolerated dose is 116.25g crude drug in whole/kg, is equivalent to 116 times of human body consumption.The median lethal dose(LD 50) of intraperitoneal injection of mice is equivalent to more than 20 times of consumption of being grown up greater than 25g crude drug in whole/kg.Toxicity is less.
Happy health (Kang Erxin) is made the rat long term toxicity test diligently, 3 kinds of dosage maximal phases are when 60 times of the human body consumption, continuous irrigation stomach 3 months, with the blank group relatively, the result shows: 3 kinds of dosage treated animals generally in order, body weight increases gradually, the every index of hematology, serum glutamic pyruvic transminase, blood urea nitrogen, blood glucose and each dirty body ratio there is no unusual, and each organ does not see that through histopathological examination pathologic changes.Think thus and irritated stomach for a long time 3 months, do not find toxic reaction to rat.
Since 1987, we have successively carried out following experimentation.
(1), experiment in vitro:
1, extracorporeal antivirus effect experiment:
Had the inclination the liquid effect of keeping of 6 kinds of concentration of happy health (Kang Erxin) 10%, 5%, 1%, 0.5%, 0.1%, 0.05% after 1 hour with containing, show the effect of direct deactivation Cox B3 virus, its deactivation is increased with concentration and is strengthened, and can make virus virulence 1～4.5 logarithm value that descends.
2, to cultivating the protective effect of myocardial cell:
The happy health of the heart (Kang Erxin) has significant protective effect to the rat pulsatile myocardial cell infection herpes simplex virus of cultivating; The mice ventricular muscle cell of cultivating is infected Cox B3 virus significant protective effect is also arranged.Have the inclination in the culture fluid of 3 kinds of variable concentrations of 1: 500,1: 1000,1: 5000 of happy health (Kang Erxin) containing, best with 1: 1000 mass action.Protective rate reaches more than 90%.
(2), experiment in the body:
1, to the protective effect of mice viral myocarditis model:
To the mice after lumbar injection inoculation Cox B3 virus respectively diligently happy health (Kang Erxin) 25ml/kg/d irritate stomach or intraperitoneal injection, connect and handled 10, degeneration, necrosis, a matter occurring with myocardial cell under the light microscopic, cell infiltration is arranged is the myocarditis positive.Result and matched group relatively, its morbid state performance positive rate, myocarditis positive rate, mortality rate all lower (P＜0.05), and there was no significant difference (P＞0.05) between two kinds of medications.With big (50g/kg), in (20g/kg), little (8g/kg) 3 kinds of dosage give and infect the mouse core myositis model that Cox B3 virus forms and irritate stomach, 30 every group.Continuous 14 days, the result: big or middle dosage treatment group morbid state performance incidence rate, mortality rate, myocarditis positive rate were all than model control group low (P＜0.01).Small dose group myocarditis positive rate is lower than model control group (P＜0.01), mortality rate and morbid state performance incidence rate and model control group there was no significant difference.Though three kinds of dosage group morbid state performance incidence rates, mortality rate, myocarditis positive rates have along with dosage increases and downward trend, there was no significant difference between group may be relevant greatly inadequately with sample.
2, to the influence of mouse immune function:
Motive happy health (Kang Erxin) 25ml/kg/d, lumbar injection is after 3 days continuously, and testing result shows: the happy health of the heart (Kang Erxin) can improve the mouse lymphocyte conversion ratio.Motive happy health (Kang Erxin) 25ml/kg/d, continuous irrigation stomach can make the mice serum interferon content that infects Cox B3 virus increase (P＜0.001) after 7 days, the active obviously rising (P＜0.001) of natural killer cell.The effect that strengthens body immunity is arranged.
3, to the influence of the non-specific damage of rat heart muscle:
Motive happy health (Kang Erxin) oral liquid 5ml/kg/d, the continuous irrigation stomach is used isoproterenol 5mg/kg subcutaneous injection after 1 week, logotype caused myocardium non-specific damage model on the 2nd, the happy health of motive (Kang Erxin) is irritated 7 mouthfuls in stomach continuously again, measure heart merit parameter, the result shows that the happy health of the heart (Kang Erxin) can make myocardium shrinkage function and diastolic function improve, and improves the reserve of heart.Do cardiac muscular tissue's section, the light microscopy checking result shows: the happy health of the heart (Kang Erxin) has the repair that promotes the non-specific damage of rat heart muscle.
(3), to the influence of characteristic of disease myocarditis patient's left heart function and insufficiency of heart-QI integral exponential:
Give the each 20ml of the 30 happy health of the oral heart of routine acute viral myocarditis patient (Kang Erxin) oral liquids, every day 3 times.Continuous 2 weeks back check STI shows PEP, and ICT shortens, PEP/LVET, and ICT/LVET reduces, and left systolic heart improves (P is all＜0.05).Compare there was no significant difference (P＞0.05) with Western medicine group with Comprehensive Treatments such as inosine, coenzyme Q10s; And PEP/LVET and insufficiency of heart-QI primary symptom integral exponential be proportionate (r=0.87, P＜0.01).After showing careful happy health (Kang Erxin) oral liquid treatment, myocarditis patient is when cardiac function recovers, and the primary symptom of insufficiency of heart-QI also is improved.
Embodiment:
Radix Astragali 30kg 18kg Radix Ophiopogonis Rhizoma Polygoni Cuspidati 18kg
Rhizoma Osmundae 18kg Flos Lonicerae 18kg sucrose 20kg makes 100,000 milliliters of oral liquids
With the Chinese medicine of the five flavours material in the prescription, all process by official method and to concoct into qualified decoction pieces.Extracting honeysuckle is put and is added water 180L in the rustless steel jacketed pan, soaks after 1 hour, opens the steam cock heating, a pot inner liquid medicine temperature is remained between 50-60 ℃, warm macerating 3 times, 72 hours after-filtration of warm macerating first; For the second time add water 160L, warm macerating 12 hours filters; Add water 140L for the third time, warm macerating 12 hours filters; Merge three times filtrate, in the concentrating under reduced pressure device 60 ℃-70kp be concentrated into relative density be about 1.4 (60 ℃) the about 3.0L of thick paste standby.Paste-forming rate about 17%.
Except that Flos Lonicerae, all the other 4 flavor merging place and add water 600L in the multipotency extraction pot, soak after 1 hour, open steam cock, decoct three times, decoct 1 hour for the first time, filter in the prescription; Second and third time all adds water 450L, decocts 0.5 hour, filters; Merge three times filtrate.In the concentrated unit of triple effect, be concentrated into relative density 1.3～1.5, get about thick paste 14.5kg.Paste-forming rate about 17.6%.
To add 95% ethanol 24L in the alcohol precipitation bucket to raise the cream mixing, to put, and make to contain the alcohol amount and control to 54～55%, stir evenly, 5～10 ℃ of cold preservations were left standstill 48 hours, the filtering precipitation, decompression (70kg) is reclaimed ethanol to not having alcohol flavor, 15 times of amounts of adding distil water, 90L, stir evenly, 5～10 ℃ of cold preservations were left standstill 48 hours, the filtering precipitation.
Taking liquid adds coarse filter paper with filter press and filters repeatedly after transferring PH5～7, and medicinal liquid adds sucrose syrup (making with 20kg sucrose), eats Fructus Citri tangerinae essence 100g after do not have the observability precipitate, stirs evenly, and adds water to 100,000 ml.
With the medicinal liquid packing that is up to the standards, flowing steam sterilization 30 minutes, promptly.
Claims (5)
1, a kind of Chinese medicine is characterized in that said composition made by the medicine of following weight parts:
Radix Astragali 10-40 10-20 Radix Ophiopogonis Rhizoma Polygoni Cuspidati 10-20
Rhizoma Osmundae 10-20 Flos Lonicerae 10-20
2, Chinese medicine as claimed in claim 1 is characterized in that said composition made by the medicine of following weight parts:
Radix Astragali Rhizoma Polygoni Cuspidati 18 30 Radix Ophiopogonis 18
Rhizoma Osmundae 18 Flos Loniceraes 18
3, compositions as claimed in claim 1 or 2 is characterized in that said composition is dosage forms such as oral liquid, injection, pill, capsule.
4, a kind of preparation method for the treatment of the oral liquid of viral myocarditis is characterized in that crude drug is:
Radix Astragali 10-40 10-20 Radix Ophiopogonis Rhizoma Polygoni Cuspidati 10-20
Rhizoma Osmundae 10-20 Flos Lonicerae 10-20
Preparation technology
With the Chinese medicine of the five flavours material in the raw material, all process by official method and to concoct into qualified decoction pieces.Extracting honeysuckle, put and add water 100～250L in the rustless steel jacketed pan, soak after 1-2 hour, open the steam cock heating, a pot inner liquid medicine temperature is remained between 30～80 ℃, warm macerating 2-4 time merges each time filtrate, in the concentrating under reduced pressure device 50 ℃-80kp be concentrated into relative density be about 1.2-1.6 (60 ℃) thick paste standby.Paste-forming rate 15-20%,
Except that Flos Lonicerae, all the other 4 flavor merging place and add water 400～800L in the multipotency extraction pot, open steam cock, decoct three times, merge three times filtrate in the prescription.In the concentrated unit of triple effect, be concentrated into relative density 1.3～1,5, it is standby to get thick paste,
With above thick paste mixing, put and add 70-95% ethanol 20-30L in the alcohol precipitation bucket, stir evenly cold preservation, left standstill 48 hours, the filtering precipitation, decompression recycling ethanol is not to there being the alcohol flavor, and 15 times of amounts of adding distil water stir evenly cold preservation, left standstill 48 hours, the filtering precipitation,
Taking liquid adds coarse filter paper with filter press and filters repeatedly after transferring PH5～7, and medicinal liquid adds sucrose syrup after do not have the observability precipitate, stirs evenly, and adds water to 10-12 ten thousand ml,
With the medicinal liquid packing that is up to the standards, flowing steam sterilization 30 minutes, promptly.
5, preparation method as claimed in claim 4 is characterized in that:
Raw material medicaments in part by weight is: Radix Astragali 30kg 18kg Radix Ophiopogonis Rhizoma Polygoni Cuspidati 18kg Rhizoma Osmundae 18kg Flos Lonicerae 18kg sucrose 20kg
With the Chinese medicine of the five flavours material in the prescription, all process by official method and to concoct into qualified decoction pieces, extracting honeysuckle, put and add water 180L in the rustless steel jacketed pan, soak after 1 hour, open the steam cock heating, a pot inner liquid medicine temperature is remained between 50-60 ℃, warm macerating 3 times, 72 hours after-filtration of warm macerating first; For the second time add water 160L, warm macerating 12 hours filters; Add water 140L for the third time, warm macerating 12 hours filters; Merge three times filtrate, in the concentrating under reduced pressure device 60 ℃-70kp be concentrated into relative density be about 1.4 (60 ℃) the about 3.0L of thick paste is standby, paste-forming rate is about 17%,
Except that Flos Lonicerae, all the other 4 flavor merging place and add water 600L in the multipotency extraction pot, soak after 1 hour, open steam cock, decoct three times, decoct 1 hour for the first time, filter in the prescription; Second and third time all adds water 450L, decocts 0.5 hour, filters; Merge three times filtrate.In the concentrated unit of triple effect, be concentrated into relative density 1.3～1.5, get about thick paste 14.5kg.Paste-forming rate is about 17.6%,
To add 95% ethanol 24L in the alcohol precipitation bucket to raise the cream mixing, to put, and make to contain the alcohol amount and control to 54～55%, stir evenly, 5～10 ℃ of cold preservations were left standstill 48 hours, filtering precipitation, decompression (70kg) reclaim ethanol to not having alcohol flavor, 15 times of amounts of adding distil water, 90L, stir evenly, 5～10 ℃ of cold preservations were left standstill 48 hours, the filtering precipitation
Taking liquid adds rag paper with filter press and filters repeatedly after transferring PH5～7, and medicinal liquid is not after have the observability precipitate, add sucrose syrup (making), edible Fructus Citri tangerinae essence 100g, stir evenly, add water to 100,000 ml with 20kg sucrose, with the medicinal liquid packing that is up to the standards, flowing steam sterilization 30 minutes, promptly.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99107978 CN1276232A (en) | 1999-06-07 | 1999-06-07 | Chinese medicine preparation for treating viral myocarditis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 99107978 CN1276232A (en) | 1999-06-07 | 1999-06-07 | Chinese medicine preparation for treating viral myocarditis |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085241B (en) * | 2007-06-29 | 2010-06-16 | 纪一楠 | Internal-applied traditional Chinese medicinal composition for treating viral myocarditis |
| CN102166432A (en) * | 2010-02-26 | 2011-08-31 | 太极集团重庆涪陵制药厂有限公司 | Method for extracting morphine from opium |
| CN102166441A (en) * | 2010-02-26 | 2011-08-31 | 太极集团重庆涪陵制药厂有限公司 | Solid-liquid separation method for replacing conventional alcohol deposition standing separation of Chinese medicaments |
| CN104940566A (en) * | 2015-07-21 | 2015-09-30 | 戚红艳 | Drug for treating infantile viral myocarditis |
| CN105267298A (en) * | 2014-07-25 | 2016-01-27 | 高晓燕 | Pediatric myocarditis treating formula |
-
1999
- 1999-06-07 CN CN 99107978 patent/CN1276232A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085241B (en) * | 2007-06-29 | 2010-06-16 | 纪一楠 | Internal-applied traditional Chinese medicinal composition for treating viral myocarditis |
| CN102166432A (en) * | 2010-02-26 | 2011-08-31 | 太极集团重庆涪陵制药厂有限公司 | Method for extracting morphine from opium |
| CN102166441A (en) * | 2010-02-26 | 2011-08-31 | 太极集团重庆涪陵制药厂有限公司 | Solid-liquid separation method for replacing conventional alcohol deposition standing separation of Chinese medicaments |
| CN102166432B (en) * | 2010-02-26 | 2013-04-17 | 太极集团重庆涪陵制药厂有限公司 | Method for extracting morphine from opium |
| CN105267298A (en) * | 2014-07-25 | 2016-01-27 | 高晓燕 | Pediatric myocarditis treating formula |
| CN104940566A (en) * | 2015-07-21 | 2015-09-30 | 戚红艳 | Drug for treating infantile viral myocarditis |
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