CN1273173C - New use of medicine for preventing and treating radiative damage - Google Patents
New use of medicine for preventing and treating radiative damage Download PDFInfo
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- CN1273173C CN1273173C CN 02134695 CN02134695A CN1273173C CN 1273173 C CN1273173 C CN 1273173C CN 02134695 CN02134695 CN 02134695 CN 02134695 A CN02134695 A CN 02134695A CN 1273173 C CN1273173 C CN 1273173C
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Abstract
The present invention relates to a new purpose of a medicine for treating and preventing radiation injury. The medicine is prepared from figwort root, rehmannia root, ophiopogon root, isatis root, oldenlandia, raw astragalus root, glossy privet fruit, lucid ganoderma and green tea by a certain proportion. The present invention can lower the mortality of mice irradiated by a lethal dose of radiant rays, improve the life quality of mice and increase the immune functions of tumor-bearing mice, and the present invention has synergic antitumor effects with radiant rays.
Description
[technical field]
The present invention relates to a kind of being used for the treatment of and the purposes of preventing the radiation injury medicine.
[background technology]
Radiation claims lonizing radiation again, and radiation therapy claims radiotherapy again.Radiotherapy is one of main means of treatment of cancer, and many cancer patients can obtain curing with radiotherapy, but the staff who accepts the patient of radiation cure or contact radiation for a long time also can be subjected to the infringement or the damage of radiation, toxic and side effects occurs.People are seeking radioprotectant for a long time, but do not find out the toxic and side effects due to treatment of an ideal medicine usefulness and the prevention radiation so far yet.
Theory of Chinese medical science thinks that lonizing radiation belong to the heresy of pyretic toxicity, and tumour patient easily causes body body fluid impaired after accepting radiotherapy, and pyretic toxicity is crossed Sheng.Disharmony between QI and blood, taste imbalance and caused by liver and kidney deficiency appear in severe patient.Xerostomia, pharyngalgia, mucous membrane of oropharynx and skin ulceration can appear, symptoms such as tired power, spontaneous perspiration.Therefore, to the toxicity due to the radiation moisturize to promote the production of body fluid, heat-clearing and toxic substances removing, help that cold fills blood, medicine among the nourishing the liver and kidney.
[summary of the invention]
The invention provides a kind of being used for the treatment of and the application that prevents the radiation injury medicine, the composition of this medicine and the component of each composition are:
Radix Scrophulariae 8-14, Radix Rehmanniae 8-14, Radix Ophiopogonis 8-14, Radix Isatidis 6-10, Herba Hedyotidis Diffusae 5-9, Radix Astragali 7-11, Fructus Ligustri Lucidi 7-11, Ganoderma 5-7, green tea 2-4.
The invention provides a kind of Chinese medicine preparation, be used for the treatment of radiation according to due to toxicity;
The present invention shows by mouse experiment, can effectively reduce mortality of mice behind the lethal dose irradiation with radiation, improves life quality;
The present invention experiment showed, with tumor-bearing mice can not offset the killing effect of radiation to tumor cell, on the contrary, with radiation the synergistic antitumor effect is arranged;
The present invention experiment showed, the immunologic function that can improve tumor-bearing mice and plays antitumor action with tumor-bearing mice;
The present invention presses body surface area and calculates, 10 times of personnel selection consumptions; Press kilogram weight and calculate 100 times of dose singles of personnel selection consumption to observing 7 days behind the mouse stomach, mice has no poisoning manifestations.It is inferior on every Saturdays that the present invention gavages rat with two dosage of height, in continuous 12 weeks, bone marrow and hepatic and renal function do not had any toxicity damage.
[specific embodiment]
Be medicine of the present invention (trade name is radiation recovery oral liquid or capsule, tablet, pill, Emulsion, the dissolved granule) testing data relevant below with function.
One: the making of radiation health preparation
Choose superior Radix Scrophulariae 11 gram, the Radix Rehmanniae 11 grams, Radix Ophiopogonis 11 gram, Radix Isatidis 8 grams, Herba Hedyotidis Diffusae 7 grams, Radix Astragali 9 grams, Fructus Ligustri Lucidi 9 grams, Ganoderma 6 grams, green tea 3 grams, soaked 1-2 hour, execute water-bath and decoct, water-bath is concentrated into the 2.5g/ml crude drug, uses for zoopery.
Two: the radiation health is to the protective effect of irradiation with radiation animal
Method: get 100 individual weight 18-22 gram Kunming mouse, be divided into 5 groups, 20 every group.Do not make irradiation with radiation, gavage normal saline for the 1st group.The 2-5 group is accepted single 7.5Gy's (lethal dose) respectively
60The total irradiation of Co gamma-rays.The 2nd group gavages normal saline subsequently, and the 3rd, 4,5 group gavages basic, normal, high radiation recovery oral liquid respectively, every day 1 time, and continuous 30 days, observe and write down ordinary circumstance and the dead animal number of animal, calculate the protection index by following formula:
The result:
Table 1 radiation health is to the protective effect of irradiation with radiation animal
| Group | Dosage g/kg | Observe 30 days survival rate | The The average survival time natural law (X ± SD) | K | The P value | ||
| The laboratory animal number | The live animal number is arranged | Survival rate (%) | |||||
| The matched group list is put 1 group of group radiation health *2 groups of radiation health *3 groups of radiation health * | 30ml(NS) 30ml(NS) 37.18 52.5 75.0 | 20 20 20 20 20 | 20 0 9 10 14 | 100 0 45 50 70 | 30±0 12.5±8.1 21.5±8.9 20.9±9.6 24.8±8.3 | - - 1.73 1.68 1.99 | - - ＜0.01 ＜0.01 ＜0.01 |
*Medicament protection group: add after radiation shines and use the radiation health
Three: the collaborative anti-tumor effect of radiation health and radiation
Method: get 7-9 days rat liver cancer ascitic type ascites of growth under aseptic condition, (cell content is about 10 * 10 to become cell suspension with physiological water by 1: 1 dilution proportion
6Individual/ml) at the approaching right armpit subcutaneous vaccination 0.2ml of every Mus.Be divided into 4 groups after the inoculation at random.Every group 20, the 1st group of negative matched group do not made irradiation with radiation, gavages NS every day, totally 10 days; Do not make irradiation with radiation for the 2nd group, gavage the radiation health every day 1 time, totally 10 times; The 3rd group of usefulness
60CO gamma-rays total irradiation 1.5Gy per two days 1 time, totally 5 times, gavages NS every day 1 time, totally 10 times; The 4th group of usefulness
60CO gamma-rays total irradiation 1.5Gy, per two days 1 time, totally 5 times.Add every day with the radiation health and gavage totally 10 times 1 time.Put to death animal on the 11st day, and stripped out the tumor piece and weigh, calculate every group of average tumor body weight, calculate tumour inhibiting rate (IR) by following formula
The result:
The collaborative anti-tumor effect of table 2 radiation health and radiation
| Group | Drug dose (g/g) | Number of animals | Body weight (g) | Average tumor is heavy | Tumour inhibiting rate (%) | The P value | ||
| Beginning | The result | Beginning | The result | |||||
| 1 2 3 4 | 30ml NS 75 30ml NS * 75 * | 20 20 20 20 | 18 20 20 20 | 21.5 21.4 21.4 21.5 | 28.0 28.3 22.3 23.4 | 2.14 1.07 0.74 0.392 | - 50.0 65.4 81.7 | - ＜0.01 ＜0.01 ＜0.01 |
*Accept
60Co radiation gamma 1.5Gy * 5 times
Four: the antitumaous effect of radiation health and centralizing function
Method: get 7-9 days rat liver cancer ascitic type ascites of growth under aseptic condition, (cell content is about 10 * 10 to become cell suspension with normal saline by 1: 1 dilution proportion
6Individual/ml) at the approaching right armpit subcutaneous vaccination 0.2ml of every Mus.Be divided into negative control group after the inoculation at random, basic, normal, high three the dosage groups of radiation health.Gastric infusion after 24 hours, every day 1 time, continuous 10 days.Drug withdrawal 24 hours is got blood from the eye chamber, surveys the T lymhocyte transformation rate, puts to death animal subsequently, strips out spleen, thymus and tumor piece, calculates tumour inhibiting rate (IR) by following formula
The result:
Table 3 radiation health is to the inhibitory action of rat liver cancer
| Group | Dosage (g/kg) | Number of animals | Body weight change (g) | On average seriously ill (X ± SD) | Press down sick rate (%) | The P value | |
| Before | After | ||||||
| 3 groups of 2 groups of radiation health of 1 group of radiation health of NS matched group radiation health | 30ml 37.8 52.5 75.0 | 13 13 13 13 | 13 13 13 13 | +7.9 +6.7 +7.6 +8.3 | 1.37±0.49 0.67±0.29 0.65±0.23 0.60±0.20 | - 51.1 52.6 56.2 | - ＜0.01 ＜0.01 ＜0.01 |
Table 4: the radiation health is to the influence of tumor-bearing mice body weight, spleen weight, thymus weight, spleen index and thymus index
| Group | Body weight (g) | Spleen heavy (mg) | The P value | Thymus heavy (mg) | The P value | Spleen index | The P value | Thymus index | The P value | |
| Before | After | |||||||||
| 3 groups of 2 groups of radiation of 1 group of radiation of NS radiation | 22.4±0.8 22.6±0.9 22.9±0.9 22.5±1.0 | 30.3±3.9 29.4±3.1 30.6±2.4 30.7±1.9 | 148.5±45.3 141.2±23.4 17.0±51.1 18.3±72.1 | ＞0.05 ＞0.06 ＞0.05 | 56.9±14.8 80.8±12.1 82.1±21.1 87.0±15.0 | - ＜0.001 ＜0.001 ＜0.001 | 4.9 4.9 5.6 6.0 | - ＞0.05 ＞0.05 ＞0.05 | 1.9 2.7 2.7 2.8 | - ＜0.001 ＜0.001 ＜0.001 |
Annotate: numeral is the meansigma methods of every group of 13 animals in the table
Table 5 radiation health is to the influence of tumor-bearing mice lymhocyte transformation rate
| Group | Dosage (g/kg) | Lymphocyte transformation (%) (n=13, x ± SD) | The P value |
| 3 groups of 2 groups of radiation health of 1 group of radiation health of NS radiation health | 30ml 37.8 52.5 75.0 | 24.22±16.89 47.16±16.87 48.07±25.57 50.86±22.19 | - ＜0.01 ＜0.01 ＜0.01 |
Claims (1)
1, the application of a kind of pharmaceutical preparation in the medicine of preparation treatment and prevention radiation injury is characterized in that described pharmaceutical preparation made by the following weight proportion raw material: Radix Scrophulariae 8-14, Radix Rehmanniae 8-14, Radix Ophiopogonis 8-14, Radix Isatidis 6-10, Herba Hedyotidis Diffusae 5-9, Radix Astragali 7-11, Fructus Ligustri Lucidi 7-11, Ganoderma 5-7, green tea 2-4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02134695 CN1273173C (en) | 2002-09-07 | 2002-09-07 | New use of medicine for preventing and treating radiative damage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02134695 CN1273173C (en) | 2002-09-07 | 2002-09-07 | New use of medicine for preventing and treating radiative damage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1421243A CN1421243A (en) | 2003-06-04 |
| CN1273173C true CN1273173C (en) | 2006-09-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 02134695 Expired - Fee Related CN1273173C (en) | 2002-09-07 | 2002-09-07 | New use of medicine for preventing and treating radiative damage |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148038A (en) * | 2015-10-28 | 2015-12-16 | 粘琦玉 | Traditional Chinese medicine pills for treating adverse reactions after CT examination and preparation method |
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- 2002-09-07 CN CN 02134695 patent/CN1273173C/en not_active Expired - Fee Related
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| CN1421243A (en) | 2003-06-04 |
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Granted publication date: 20060906 Termination date: 20100907 |