CN1270697C - Oral nano nourishing emulsion and its preparation method - Google Patents
Oral nano nourishing emulsion and its preparation method Download PDFInfo
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- CN1270697C CN1270697C CNB031485197A CN03148519A CN1270697C CN 1270697 C CN1270697 C CN 1270697C CN B031485197 A CNB031485197 A CN B031485197A CN 03148519 A CN03148519 A CN 03148519A CN 1270697 C CN1270697 C CN 1270697C
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Abstract
The present invention discloses an oral nanometer nourishing emulsion and a preparing method thereof. The method comprises: adding a certain amount of emulsifying agents and vegetable oil into a proper amount of concentrated solution of extracted products of Chinese medicines; uniformly stirring the mixture to form foremilk of the extracted products of the Chinese medicines and obtain an oil phase; adding natural water containing trace elements into a certain quantity of a compound emulsifying agent formed by two emulsifying agents; uniformly stirring the mixture to form an emulsion and obtain an aqueous phase; adding the foremilk oil phase of the extracted products of the Chinese medicines into the aqueous emulsion drop by drop under the condition of high-speed stir; uniformly stirring the mixture to obtain a mixed emulsion; emulsifying the mixed emulsion by using a high-speed shearing method to obtain the uniform primary product of the nourishing emulsion. In the present invention, effective constituents extracted from the Chinese medicines are packed into the nanometer emulsion to reduce the damage of the effective constituents of the Chinese medicines in gastrointestinal tracts of human bodies. Absorption rate and bioavailability of organisms are improved, and simultaneously nutrition level and the effect of nourishing substances are greatly improved by utilizing the synergistic effect of the nutrition of the vegetable oil emulsion and the nanometer emulsion.
Description
Technical field
The present invention relates to the preparation method of Emulsion, promptly adopt edible vegetable oil that Chinese herbal medicine extract such as Herba Artemisiae Scopariae, Herb Gynostemmae Pentaphylli etc. are carried out nano-encapsulated, the product that is obtained is at food, and beverage and medicine aspect have important use to be worth, and belong to the microencapsulation technical field.
Background technology
China has civilized history in several thousand, Chinese medicine occupies an important position therein, part Chinese medicine such as Radix Ginseng, Herba Artemisiae Scopariae, Herb Gynostemmae Pentaphylli etc. have effects such as good blood sugar lowering, blood fat reducing, raising body immunity, and are taken for a long time by people as traditional health food.But it is loaded down with trivial details to exist method on the mode of taking, and dose is big to wait deficiency, and the Chinese medicine product time of staying in vivo that traditional Chinese medicine processing mode is made is short, and targeting is bad.Therefore how to extract effective components of Chinese medicinal and take the suitable mode of taking to become a kind of direction of medicine and health food research and development.Vegetable oil such as Oleum Arachidis hypogaeae semen, soybean oil, Oleum sesami and Semen Juglandis wet goods commonly used are that people are in common knowledge as traditional food already, and its abundant nutritive value also is familiar with by people already.The function that has " benefiting qi and nourishing blood, moistening the lung and resolving the phlegm, intestine moistening " as walnut oil, its Main Ingredients and Appearance is unsaturated fatty acid linoleic acid, oleic acid and alpha-linolenic acid, can reduce low density cholesterol in the blood and the oxidation of low density cholesterol is had inhibitory action, aspect prevention of arterial sclerosis, prevention coronary heart disease and the mastopathy good effect arranged.But the mouthfeel of walnut oil slightly has bitter taste, is subjected to some restrictions when culinary art is edible, and other edible approach is seldom arranged.Therefore occupation mode also is very important for edible vegetable oil is sought out easily and efficiently.It is a kind of good settling mode that vegetable oil and water uniform mixing are made Emulsion, and its Main Ingredients and Appearance of lipomul that uses clinically promptly is soybean oil and Oleum Arachidis hypogaeae semen at present.But the Emulsion that does not combine with Chinese medicine extract.The preparation method of the oral dairy compositions of a kind of cholecalciferol-cholesterol has been described among the Chinese invention patent CN1038386C, said composition comprises cholecalciferol-cholesterol, emulsifying agent, vegetable oil and water, sterilize by raw material, make after the steps such as controlling the water circulation phase, system oil phase and emulsifying, it has the effect of regulating calcium, phosphorus metabolism and formation skeleton oral back, also can be used for treating the plain gland insufficiency of function of first shape.Patent of invention CN1202823A has described a kind of hydrolysis-optimized liplid emulsions, this Emulsion comprises medium chain triglyceride (MCT), vegetable oil and heavy oil, has illustrated that this Emulsion can be used as parenteral nutrition and uses for the patient suffer from disease after disorders post surgery or the wound or inflammation.Patent of invention CN1134273A has described educating of a kind of hair special use and has sent out cosmetics and production method thereof, and it comprises the vegetable oil of the right plant osman grass of eyebrow regrowning blood circulation promoting and blood stasis dispelling and the Emulsion that water is made, the problem of the sufficient nutrition of the new piliation of supply in time.
Above-mentioned patent is described to be the Emulsion that is applied to aspects such as medicine, cosmetics, does not relate to Chinese medicine extract, and the Emulsion of its generation is conventional Emulsion, and the particle diameter of emulsion particles is micron order (1～100 μ m).
Summary of the invention
The technical problem to be solved in the present invention is intended to provide the preparation method of oral administration nanometer nutrition emulsion, described oral administration nanometer nutrition emulsion is is carrier material with the vegetable oil, the active ingredient of Chinese medicine extraction is rolled into nanoscale Emulsion, making effective components of Chinese medicinal reduce gastrointestinal in human body destroys, the absorbance of enhancing body and bioavailability, utilize the nutrition that vegetable oil Emulsion has itself and the synergism of nano-emulsion simultaneously, improve trophic level to a greater degree, strengthen the effect of nutrient substance.
Oral administration nanometer nutrition emulsion of the present invention is to be made by following materials of weight proportions:
Vegetable oil 7～12;
Emulsifying agent 0.5～0.85;
Chinese medicine extract 2～9.2;
Antibacterial 0.2～0.3;
Antioxidant 0.3～0.5;
Add water to 100%.
Above-described all raw materials are commercially available, and vegetable oil is a purity greater than high-purity vegetable oil of 90%, and antibacterial and antioxidant are food grade.Described water can be the specific natural water that is rich in trace element.
The preparation method of oral administration nanometer nutrition emulsion of the present invention comprises the steps:
The Chinese medicine extract concentrated solution is an amount of, add a certain amount of emulsifying agent and vegetable oil, stirring becomes the Chinese medicine extract colostrum, obtains oil phase;
Add a certain amount of compound emulsifying agent of being made up of two kinds of emulsifying agents in the natural water that contains trace element or other drinking water, stirring becomes Emulsion, obtains water;
Chinese medicine extract colostrum oil phase is dropwise joined in the aqueous emulsion under high-speed stirred, stir, obtain mixed emulsion;
Above-mentioned mixed emulsion with the emulsifying of high speed shear mode, is obtained nutrition emulsion primary product comparatively uniformly;
With the pipeline-type emulsifying machine emulsifying of nutrition emulsion primary product, obtain even, translucent nano nutrient Emulsion; Its form is the light color aqueous solution, has slight opalescence.
With above-mentioned nano nutrient Emulsion add antioxidant, antibacterial, rectify smell agent and coloring agent and remove by filter the part macroparticle after, make dosage forms such as tablet, injection, oral liquid, promptly become oral administration nanometer nutrition emulsion finished product.
The present invention is rolled into nanoscale Emulsion with the active ingredient of Chinese medicine extraction in conjunction with the nutritional labeling in the specific water, the active ingredient that makes Emulsion of the present invention is not by gastrointestinal tract under the destructive prerequisite, arrive surface of cell membrane as early as possible, thereby the absorbance and the bioavailability of very big enhancing body, utilize the nutrition that vegetable oil Emulsion has itself and the synergism of nano-emulsion simultaneously, improve the trophic level of health care to a greater degree, strengthen the nutritive validity of active substance; The present invention not only can be used for nutrient oral liquor, also can be used for the preparation of pharmaceutical emulsion.
Description of drawings
Fig. 1 is the preparation method schematic flow sheet of oral administration nanometer nutrition emulsion of the present invention;
Fig. 2 is the atomic force scanogram of example one Herba Artemisiae Scopariae nano nutrient Emulsion of the present invention in 5.00 * 5.00 mu m ranges.
Fig. 3 is the atomic force scanograms of example two Herb Gynostemmae Pentaphylli nano nutrient Emulsions of the present invention in 2.50 * 2.50 mu m ranges.
The specific embodiment
Fig. 1 has provided the schematic flow sheet of the method for the invention, and the present invention's two examples given below also are two kinds of products that obtain oral administration nanometer nutrition emulsion of the present invention according to this method, and concrete step is as follows:
(1) the Chinese medicine extract concentrated solution is an amount of, add a certain amount of emulsifying agent and vegetable oil and stir and become the Chinese medicine extract colostrum, obtain oil phase;
(2) add a certain amount of compound emulsifying agent of being made up of two kinds of emulsifying agents in the natural water that contains trace element or other drinking water, stirring becomes Emulsion, obtains water;
(3) Chinese medicine extract colostrum oil phase is dropwise joined in the aqueous emulsion under high-speed stirred, stir, obtain mixed emulsion;
(4) above-mentioned mixed emulsion is used high speed shear mode emulsifying 2～3 times, each 20～50 minutes, vacuum was 0.08mpa, obtained nutrition emulsion primary product comparatively uniformly;
(5) with pipeline-type emulsifying machine emulsifying 1～2 time of nutrition emulsion primary product, each 20～40 minutes, obtain even, translucent nano nutrient Emulsion;
(6) above-mentioned nano nutrient Emulsion is added antioxidant, antibacterial, rectify smell agent and coloring agent and remove by filter the part macroparticle after, promptly become oral administration nanometer nutrition emulsion finished product.
Above-mentioned water can be pure water or mineral water, is preferably the natural groundwater that is rich in trace element that can directly drink.
The preparation of [example 1] Herba Artemisiae Scopariae extract nano nutrient Emulsion
After Herba Artemisiae Scopariae 250 grams add to 1000ml with distilled water, decoct secondary, each 1 hour, intermediate space half an hour filters, and merges secondary filtrate, be concentrated into syrupy shape, put coldly, add 2～3 times of 95% ethanol of its volume, be placed on after the stirring in the refrigerator (4 ℃) and spend the night, filter (adding to 1000ml with distilled water), filtrate adds 0.1% active carbon and boils, filter, add tween 80 5.0ml in the filtrate and stir, to clear and bright, be concentrated into 400ml and obtain the Herba Artemisiae Scopariae extracting solution with No. 4 sand core funnel filters.
Get 8.5 kilograms of refining walnut oils, add 0.28 kilogram of tween 20, add 0.28 kilogram of Arlacel-80, add the Herba Artemisiae Scopariae extracting solution and stir for 4 kilograms, obtain oil phase Herba Artemisiae Scopariae extracting solution colostrum.Drink and use the pure water double centner, add 0.34 kilogram of tween 20, add 0.34 kilogram of Arlacel-80, stir, obtain water.
Under the high-speed stirred of 28000 rev/mins of shearing emulsifiers, oil phase is progressively joined aqueous phase, when vacuum is 0.08mpa, emulsification pretreatment three times, each 40 minutes, after the intermediate space 30 minutes, 23000 rev/mins of emulsifying secondaries of reuse pipeline-type emulsifying machine, each 30 minutes, after the intermediate space 20 minutes, filter, obtain even, translucent Herba Artemisiae Scopariae extract nano nutrient Emulsion, its mean diameter is at 102nm ± 32nm.Measure through CAS Electrical Engineering Research Institute and Military Medical Science Institute, this nano nutrient Emulsion can be directly oral, also can add in the drinking water and drink.Fig. 2 has represented the atomic force scanogram of this Herba Artemisiae Scopariae nano nutrient Emulsion in 5.00 * 5.00 mu m ranges.From Fig. 2, can see even particle distribution, sizableness.Mean diameter is at 102nm ± 32nm.Used instrument is: SPM-9500J3 type atomic force microscope, Japanese SHIMADZU company produces.Take contact scanning, the atmospheric environment imaging.Condition determination is: 20 ℃ of humidity: 40%.Method for making sample is: 3% walnut oil Emulsion drops in fresh mica surface, and nitrogen dries up flattening.
[example 2] Herb Gynostemmae Pentaphylli extract nano nutrient Emulsion
With the 200 gram Herb Gynostemmae Pentaphylli raw materials extractor of packing into, alcoholic solution 420～440 gram heating extraction secondaries with 55% filter, and it is rare to 1000ml with distilled water to merge secondary filtrate, adds 1% active carbon and boils, and filters adding tween 80 5.0ml in the filtrate.After the stirring, to clear and bright, be concentrated into 400ml, obtain Herb Gynostemmae Pentaphylli extract with No. 4 sand core funnel fine straining.
Get 10.2 kilograms of refined soybean oils, add 0.42 kilogram of tween 20, add 0.42 kilogram of Arlacel-60, add 5 kilograms of Herb Gynostemmae Pentaphylli extract, stir, obtain the colostrum of oil phase Herb Gynostemmae Pentaphylli extract.
Drink and use the pure water double centner, add 0.52 kilogram of tween 20, add 0.52 kilogram of Arlacel-60, stir, obtain water.
Under the high-speed stirred of 28000 rev/mins of shearing mulsers, oil phase is progressively joined aqueous phase, vacuum is 0.08mpa, with shearing emulsifying agent emulsifying three times, each 30 minutes, after the intermediate space 30 minutes, 23000 rev/mins of emulsifyings of reuse pipeline-type emulsifying machine three times, each 30 minutes, after the intermediate space 20 minutes, filter, obtain even, translucent Herb Gynostemmae Pentaphylli extract nano nutrient Emulsion, measure its mean diameter 96nm ± 42nm through CAS Electrical Engineering Research Institute and Military Medical Science Institute.This nano nutrient Emulsion can be directly oral, also can add drink-service in the drinking water.Fig. 3 has represented the atomic force scanogram of Herb Gynostemmae Pentaphylli nano nutrient Emulsion in 2.50 * 2.50 mu m ranges.From Fig. 3, can see even particle distribution, sizableness.Mean diameter is at 96nm ± 42nm.Used instrument is: SPM-9500J3 type atomic force microscope, Japanese SHIMADZU company produces.Take contact scanning, the atmospheric environment imaging.Condition determination is: 20 ℃ of humidity are: 40%.Method for making sample is: 3% walnut oil Emulsion drops in fresh mica surface, and nitrogen dries up flattening.
The present invention at first makes colostrum with vegetable oil and Chinese medicine extract, is distributed under high-speed stirred then in the relatively large water, again through becoming uniform nano nutrient Emulsion after high speed shear and two kinds of emulsification methods processing of pipeline emulsifying.
The high speed shear mulser rotating speed that this adopted is greater than 25000 rev/mins, and the pipeline-type emulsifying machine rotating speed is greater than 20000 rev/mins, and vacuum is 0.08mpa.
After being wrapping to Chinese medicine extract in the nano nutrient Emulsion, can prolong their holdup times in vivo greatly, make it exempt from gastrointestinal tract and destroy and slow-releasing and certain tissue target tropism's (as liver, spleen etc.) are arranged, improve their body absorption rate and bioavailability.
Nano nutrient Emulsion of the present invention is with opalescent stable dispersion for half, can do infinite dilution with water, add entry after, particularly add the natural groundwater that is rich in trace element that can directly drink after, have very high stability.Room temperature is placed after 1 year its mean diameter and is changed and be no more than 2%.This nano nutrient Emulsion is measured average largest diameter 120nm-130nm through Military Medical Science Institute, average diameter 96nm is nano-emulsion, except that can do oral, also available the present invention prepares drug injection, in food, pharmaceuticals industry comparatively wide application prospect is arranged.
It should be noted last that: above embodiment is the unrestricted technical scheme of the present invention in order to explanation only, although the present invention is had been described in detail with reference to the foregoing description, those of ordinary skill in the art is to be understood that: still can make amendment or be equal to replacement the present invention, and not breaking away from any modification or partial replacement of the spirit and scope of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (2)
1, a kind of preparation method of oral administration nanometer nutrition emulsion comprises:
After Herba Artemisiae Scopariae 250 grams add to 1000ml with distilled water, decoct secondary, each 1 hour, intermediate space half an hour filters, and merges secondary filtrate, be concentrated into syrupy shape, put coldly, add 2～3 times of 95% ethanol of its volume, be placed on 4 ℃ of refrigerator overnight after the stirring, add to 1000ml with distilled water and filter, filtrate adds 0.1% active carbon and boils, filter, add tween 80 5.0ml in the filtrate and stir, to clear and bright, be concentrated into 400ml and obtain the Herba Artemisiae Scopariae extracting solution with No. 4 sand core funnel filters;
Get 8.5 kilograms of refining walnut oils, add 0.28 kilogram of tween 20, add 0.28 kilogram of Arlacel-80, add the Herba Artemisiae Scopariae extracting solution and stir for 4 kilograms, obtain oil phase Herba Artemisiae Scopariae extracting solution colostrum; Drink and use the pure water double centner, add 0.34 kilogram of tween 20, add 0.34 kilogram of Arlacel-80, stir, obtain water;
Under the high-speed stirred of 28000 rev/mins in emulsification pretreatment machine, oil phase is progressively joined aqueous phase, when vacuum is 0.08mpa, emulsification pretreatment three times, each 40 minutes, after the intermediate space 30 minutes, 23000 rev/mins of emulsifying secondaries of reuse pipeline-type emulsifying machine, each 30 minutes, intermediate space was after 20 minutes, filter, obtain even, translucent Herba Artemisiae Scopariae extract nano nutrient Emulsion.
2, a kind of preparation method of oral administration nanometer nutrition emulsion comprises:
With the 200 gram Herb Gynostemmae Pentaphylli raw materials extractor of packing into, alcoholic solution 420～440 gram heating extraction secondaries with 55% filter, and it is rare to 1000ml with distilled water to merge secondary filtrate, adds 1% active carbon and boils, and filters adding tween 80 5.0ml in the filtrate; After the stirring, to clear and bright, be concentrated into 400ml, obtain Herb Gynostemmae Pentaphylli extract with No. 4 sand core funnel fine straining;
Get 10.2 kilograms of refined soybean oils, add 0.42 kilogram of tween 20, add 0.42 kilogram of Arlacel-60, add 5 kilograms of Herb Gynostemmae Pentaphylli extract, stir, obtain the colostrum of oil phase Herb Gynostemmae Pentaphylli extract;
Drink and use the pure water double centner, add 0.52 kilogram of tween 20, add 0.52 kilogram of Arlacel-60, stir, obtain water;
Under the high-speed stirred of 28000 rev/mins of shearing mulsers, oil phase is progressively joined aqueous phase, vacuum is 0.08mpa, with shearing emulsifying agent emulsifying three times, and each 30 minutes, after the intermediate space 30 minutes, 23000 rev/mins of emulsifyings of reuse pipeline-type emulsifying machine three times, each 30 minutes, intermediate space was after 20 minutes, filter, obtain even, translucent Herb Gynostemmae Pentaphylli extract nano nutrient Emulsion.
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Families Citing this family (10)
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| CN101816444A (en) * | 2010-04-22 | 2010-09-01 | 王京南 | Walnut oil fat emulsion oral solution or beverage and preparation method |
| CN101869298A (en) * | 2010-06-02 | 2010-10-27 | 王京南 | Compound walnut and linseed oil fat emulsion oral solution, beverage and preparation method |
| CN103736070B (en) * | 2014-01-23 | 2014-09-10 | 江西美媛春药业股份有限公司 | Xiangsha (Chinese character) oral emulsion for nourishing stomach and preparation method thereof |
| CN104824181A (en) * | 2015-05-31 | 2015-08-12 | 安庆市孝柱食品科技有限公司 | Low-sugar sunflower seed oil emulsion |
| CN104957273A (en) * | 2015-05-31 | 2015-10-07 | 安庆市孝柱食品科技有限公司 | Low-sugar soybean oil emulsion |
| CN104939093A (en) * | 2015-05-31 | 2015-09-30 | 安庆市孝柱食品科技有限公司 | Low-sugar semen trichosanthis oil emulsion |
| CN104824180A (en) * | 2015-05-31 | 2015-08-12 | 安庆市孝柱食品科技有限公司 | Low-sugar sunflower seed oil emulsion |
| CN104840612A (en) * | 2015-05-31 | 2015-08-19 | 安庆市孝柱食品科技有限公司 | Low-sugar tea oil emulsion |
| CN105963343B (en) * | 2016-05-14 | 2019-11-19 | 运城学院 | A kind of compound Codonopsis pilosula total saposins immune polysaccharide nano emulsion composition and preparation method thereof |
| CN107496604A (en) * | 2017-09-28 | 2017-12-22 | 贵州航生态农牧科技开发有限公司 | A kind of camellia oil nanometer emulsion oral liquid and preparation method thereof |
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