CN1265828C - Chinese medicine preparation for curing coronary heart disease and angina pectoris and its preparation method - Google Patents
Chinese medicine preparation for curing coronary heart disease and angina pectoris and its preparation method Download PDFInfo
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Abstract
The present invention relates to traditional Chinese medicine preparation for treating coronary disease and angina pectoris, and a preparation method for the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is formed by extracting effective components of withered components of traditional Chinese medicine based on conventional process steps. Compared with the prior art, the medicine provided by the present invention has simple structure, so the production cost is low. Moreover, the quality can be better controlled. Moreover, the present invention has obvious therapeutic effects. The present invention has the main functions of warming properties, dispelling cold, regulating qi and alleviating pain. The present invention mainly treats diseases such as chest obstruction and cardiodynia (coronary disease and angina pectoris) caused by the loss of qi, chest and back pain, common cold and pain, chest distress, short breath, palmus, even asthma, unable prostration, pale complexion, peripheral coldness, white tongue coating and tight pulse.
Description
Technical field: the present invention is a kind of treatment coronary heart disease, anginal Chinese medicine preparation and preparation method thereof, belongs to technical field of medicaments.
Technical background: coronary heart disease, angina pectoris are commonly encountered diseases, the frequently-occurring diseases in a kind of modern life, conventional Therapeutic Method is to take western medicine, its instant effect, curative effect are more satisfactory, but the problem that exists is: the toxic and side effects of Western medicine is bigger, and its price is also than higher; For the people who suffers from multiple disease, Western medicine uses mutually and causes mutually the discomfort that pins down, causes the people especially easily, influences treatment of diseases in addition; Chinese medicine has the more not available advantages of Western medicine, its toxic and side effects is little, and is cheap, so some pharmaceutical factories of China also produce some Chinese medicine preparation, such as " SUXIAO JIUXIN WAN ", " FUFANG DANSHEN DIWAN " etc., these medicines have their advantage, but also have certain problem: their raw material constitutes more complicated, and the medical material of use is many, so the quality of production is restive, at the ill crowd of different body constitution, region, using a kind of medicine in addition, obviously is not enough.
Summary of the invention: the objective of the invention is to: a kind of manufacture method for the treatment of coronary heart disease, anginal Chinese medicine preparation and this medicine thereof is provided; The medicine that provided constitutes simple especially, so low production cost, quality are controlled easily, its therapeutic effect is obvious in addition; The present invention constitutes like this: this treatment coronary heart disease, anginal Chinese medicine preparation are: get and be made into Chinese medicine preparation after the Chinese medicine Cinnamomum Migao H.W.Li. extracts active ingredient according to conventional operation; Such as: be made into preparations such as powder, granule, drop pill.Specifically: calculate: get Chinese medicine Cinnamomum Migao H.W.Li. 350-600, be equipped with Borneolum Syntheticum 4-15, Rhizoma Chuanxiong 250-500, Bulbus Allii Macrostemonis 250-500 be made into Chinese medicine preparation according to common process according to weight proportion.Say more accurately: calculate: Cinnamomum Migao H.W.Li. 450, Borneolum Syntheticum 9, Rhizoma Chuanxiong 360, Bulbus Allii Macrostemonis 360 are made into Chinese medicine dripping pills according to common process according to weight.Chinese medicine preparation of the present invention is all pharmaceutical preparatioies, comprising: oral formulations, ejection preparation, as: drop pill, oral liquid, sheet, ball, capsule, granular preparation and intramuscular injection, intravenous fluid.The manufacture method of this treatment coronary heart disease, anginal Chinese medicine preparation, calculate according to weight proportion: get Chinese medicine Cinnamomum Migao H.W.Li. 350-600, be equipped with Borneolum Syntheticum 4-15, Rhizoma Chuanxiong 250-500, Bulbus Allii Macrostemonis 250-500 make according to following method: with Cinnamomum Migao H.W.Li. extract quintessence oil, Rhizoma Chuanxiong power is broken into coarse powder, extract Rhizoma Chuanxiong total alkaloids extractum with prior art then, Bulbus Allii Macrostemonis extracts extractum with prior art, Rhizoma Chuanxiong total alkaloids extractum, the Bulbus Allii Macrostemonis extractum that obtains is mixed with Cinnamomum Migao H.W.Li. quintessence oil, the Borneolum Syntheticum of extraction mix the back is made into needs according to common process preparation formulation.
The method that the present invention makes drop pill is: get Chinese medicine Cinnamomum Migao H.W.Li. 450 grams, be equipped with Borneolum Syntheticum 9 grams, Rhizoma Chuanxiong 360 grams, Bulbus Allii Macrostemonis 360 grams are made according to following method: Cinnamomum Migao H.W.Li. is extracted quintessence oil with steam distillation, Rhizoma Chuanxiong power is broken into coarse powder, ethanol reduced-pressure backflow with 10 times of amounts 95% extracts secondary then, measured alcohol dipping 2 hours for 6 times for the first time, reflux, extract, 3 hours, measure ethanol for 4 times for the second time, reflux, extract, 2 hours, merge secondary raffinate, decompression recycling ethanol is to about 1.1 (55-60 degrees centigrade) of relative density, get middle level liquid, be evaporated to about 1.2 (55-60 degrees centigrade) of relative density, transferring pH value with ammonia is that three extractions are divided with 6 times of chloroforms in 9 backs, combining extraction liquid, the reclaim under reduced pressure chloroform also is concentrated into relative density 1.01-1.05 (55-60 degree centigrade), extract Rhizoma Chuanxiong total alkaloids extractum, macrostem onion powder is broken into coarse powder, with 6 times of amount 95% alcohol dipping, the reflux, extract, secondary, each 1 hour, be evaporated to relative density 1.12-1.16 (55-60 degree centigrade), extract Bulbus Allii Macrostemonis extractum, with the Rhizoma Chuanxiong total alkaloids extractum that obtains, Bulbus Allii Macrostemonis extractum mixes, the slight fever mix homogeneously, add in the fused Polyethylene Glycol, mixing, add the Cinnamomum Migao H.W.Li. quintessence oil that obtains, move to behind the Borneolum Syntheticum mix homogeneously in the drop pill liquid reservoir, be incubated 90 degrees centigrade, splash in the cooling liquid paraffin after the system of dripping finishes, obtain dropping pill formulation.Compared with prior art: medicine provided by the present invention constitutes simple especially, so low production cost, quality can be reasonable controlled, its therapeutic effect is obvious in addition: its function cures mainly: hot temperature cold expelling, regulating QI to relieve pain, cure mainly by stagnation of YIN-cold, gas lose warm due to obstruction of qi in the chest and cardialgia (angina pectoris); Disease is seen chest pain radiating to the back, the cold pain of sense very, sensation of oppression over the chest with shortness of breath, cardiopalmus, heavy then asthma, can not put down for sleeping in, pale complexion, extreme cold of the limbs, tongue fur is white, tense pulse.
Embodiments of the invention 1: get Chinese medicine Cinnamomum Migao H.W.Li. 450 grams, be equipped with Borneolum Syntheticum 9 grams, Rhizoma Chuanxiong 360 grams, Bulbus Allii Macrostemonis 360 grams are made according to following method: Cinnamomum Migao H.W.Li. is extracted quintessence oil with steam distillation, Rhizoma Chuanxiong power is broken into coarse powder, ethanol reduced-pressure backflow with 10 times of amounts 95% extracts secondary then, measured alcohol dipping 2 hours for 6 times for the first time, reflux, extract, 3 hours, measure ethanol for 4 times for the second time, reflux, extract, 2 hours, merge secondary raffinate, decompression recycling ethanol is to about 1.1 (55-60 degrees centigrade) of relative density, get middle level liquid, be evaporated to about 1.2 (55-60 degrees centigrade) of relative density, transferring pH value with ammonia is that three extractions are divided with 6 times of chloroforms in 9 backs, combining extraction liquid, the reclaim under reduced pressure chloroform also is concentrated into relative density 1.01-1.05 (55-60 degree centigrade), extract Rhizoma Chuanxiong total alkaloids extractum, macrostem onion powder is broken into coarse powder, with 6 times of amount 95% alcohol dipping, the reflux, extract, secondary, each 1 hour, be evaporated to relative density 1.12-1.16 (55-60 degree centigrade), extract Bulbus Allii Macrostemonis extractum, with the Rhizoma Chuanxiong total alkaloids extractum that obtains, Bulbus Allii Macrostemonis extractum mixes, the slight fever mix homogeneously, add in the fused Polyethylene Glycol, mixing, add the Cinnamomum Migao H.W.Li. quintessence oil that obtains, move to behind the Borneolum Syntheticum mix homogeneously in the drop pill liquid reservoir, be incubated 90 degrees centigrade, splash in the cooling liquid paraffin after the system of dripping finishes, obtain dropping pill formulation.
Embodiments of the invention 2: get 35 kilograms of Chinese medicine Cinnamomum Migao H.W.Li., be equipped with 4 kilograms of Borneolum Syntheticums, 250 kilograms of 250 kilograms of Rhizoma Chuanxiongs, Bulbus Allii Macrostemonis make according to following method: with Cinnamomum Migao H.W.Li. extract quintessence oil, Rhizoma Chuanxiong power is broken into coarse powder, extract Rhizoma Chuanxiong total alkaloids extractum with prior art then, Bulbus Allii Macrostemonis extracts extractum with prior art, Rhizoma Chuanxiong total alkaloids extractum, the mixing of Bulbus Allii Macrostemonis extractum that obtains is mixed the back with the Cinnamomum Migao H.W.Li. quintessence oil, the Borneolum Syntheticum that extract be made into oral liquid according to common process.
Embodiments of the invention 3: get Chinese medicine Cinnamomum Migao H.W.Li. 600 gram, be equipped with Borneolum Syntheticum 15 grams, Rhizoma Chuanxiong 500 grams, Bulbus Allii Macrostemonis 500 grams make according to following method: with Cinnamomum Migao H.W.Li. extract quintessence oil, Rhizoma Chuanxiong power is broken into coarse powder, extract Rhizoma Chuanxiong total alkaloids extractum with prior art then, Bulbus Allii Macrostemonis extracts extractum with prior art, Rhizoma Chuanxiong total alkaloids extractum, the mixing of Bulbus Allii Macrostemonis extractum that obtains is mixed the back with the Cinnamomum Migao H.W.Li. quintessence oil, the Borneolum Syntheticum that extract be made into injection according to common process.
Embodiments of the invention 4: get and be made into Chinese medicine preparation as required after Chinese medicine Cinnamomum Migao H.W.Li. 500 grams extract active ingredient according to conventional pharmacy operation.
Drop pill is when taking: every day secondary, each 10.
The thoracic obstruction is felt oppressed with chest, pain, chest pain radiating to the back very then, lose heart, failing to sleep due to dyspnea etc. are the disease of main performance, how by part of the body cavity above the diaphragm housing the heart and lungs YANG QI deficiency, YIN-cold, expectorant is turbid, blood stasis etc. stay and gather in the heart, mechanism of qi must not be declared due to the pain, during primary disease is more common in, the gerontal patient, the thoracic obstruction is principle of treatment with the activating stagnated YANG, the name of the thoracic obstruction is for " interior warp ", the Han dynasty Zhang Zhongjing is established a special piece of writing to its cause of disease in " Medical Treasures of the Golden Chamber ", symptom, treatment waits has carried out comparatively detailed argumentation, later age many of scholars it, the coronary atherosclerotic heart disease of doctor trained in Western medicine, pulmonary heart disease, pneumonia, heart neurosis, occur uncomfortable in chest in the lysises such as pericarditis, the symptom of chest pain, with the thoracic obstruction pathogenesis person of being harmonious, all can control by thoracic obstruction opinion; Etiology and pathogenesis, the generation of the thoracic obstruction is main relevant with factors such as inward invasion of pathogenic cold, improper diet, disorder of emotion, body deficiency due to old age, and it is logical that these factors cause in the heart the QI and blood impatency stop up declaring just, the main cause that heart body is lacked of proper care; The sick position of the thoracic obstruction is mainly at cardiopulmonary, but with the spleen kidney certain relation arranged also, and its pathogenesis has the difference of deficiency and excess, real for cold coagulation, the stagnation of QI, blood stasis, stagnation of phlegm, wetly hold back, emptyly be heart spleen caused by liver and kidney deficiency, functional disorder; Thoracic obstruction clinical manifestation is that simulataneous insufficiency and excessive is to see more, but primary disease be more common in, old healthy energy day by day loses in the void, so deficiency in origin and excess in superficiality is its main pathogenesis; The thoracic obstruction dialectical with distinguish deficiency and excess, specimen is main points; Treatment is rule of treatment with the activating stagnated YANG then, according to the specimen emergency, and the balance medication.The anxious person that falls ill controls its mark earlier; The slow person of morbidity can turn round and look at itself or treating both the principal and secondary aspects of a disease earlier.Excess syndrome is often with blood circulation promoting and blood stasis dispelling, and activating YANG with pungent and warm drugs, dispelling turbid phlegm are main, and then to take a tonic or nourishing food to build up one's health, assistant is with promoting blood circulation to remove obstruction in the collateral for deficiency syndrome.Common pattern of syndrome has: (1) stagnation of QI and blood: card is seen uncomfortable in chest, chest pain such as acupuncture, and localized pain, body of the tongue is purple dim or ecchymosis petechia, hesitant pulse arranged.Control a surname's blood circulation promoting and blood stasis dispelling,
Side's decoction for removing blood stasis; (2) expectorant is turbid is jammed: card sees uncomfortable in chest as stops up and pain, or pain draws the shoulder back of the body, dyspnea with shortness of breath, and cough with copious phlegm, dirty and greasy fur, is controlled a surname's pain sun and lets out turbid, eliminating phlegm relieving accumulation of pathogens rolling pulse; (3) knot in the YIN-cold: card is seen uncomfortable in chest, and chest pain has contrary adverse QI rushing upwards sense under the conscious side of body of patient, cardiopalmus, breathes hard tongue expectorant, white and thin fur, deep and stringy pulse.Control and declare the sending down the abnormal ascending QI that activates yang; Chest pain is violent, and companion's meeting color is pale, cold extremities, and mouth goes out, light red tongue, tongue is white, and the deep-hidden pulse person is for the breast YANG deficiency, yin-cold excess.Control Xuan Wen activate yang gas, relieving spasm to stop pain; See cyanotic lips as double, cold mouthful, cold of the limbs, loose stool and diarrhea is more than, the faint pulse being about to disappear person, the danger that then belongs to the yang-energy sudden collapse is waited, and urgently a section warming YANG takes off admittedly; (4) heart deficiency of the kidney yin: card is seen feeling of oppression and pain over the chest, and cardiopalmus is stolen mouth, dysphoria and insomnia, and soreness of waist and knee, tinnitus, dizziness, red tongue or with purplish patch, thready and rapid pulse or carefully puckery is controlled suitable nourishing YIN for benefiting the kidney, tranquilizing by nourishing the heart; (5) deficiency of both QI and YIN: card is seen sensation of oppression and faint pain in the chest, and time ends when doing, shortness of breath and palpitation, tiredness with no desire to speak, lustreless complexion is had a dizzy spell, meet labor what for, reddish tongue or tongue with indented margins, is controlled a surname's supplementing QI and nourishing YIN, promoting blood circulation to remove obstruction in the collateral at thready and weak pulse without strength or knot generation; (6) deficient and weak YANG QI: card is seen sensation of oppression over the chest with shortness of breath, chest pain radiating to the back very then, and cardiopalmus mouthful goes out fear of cold, and the cold extremities soreness of waist is weak, pale complexion, the lips and nails being pale or purple, pale or dark purple tongue, deep-thready pulse or heavy little desire color are controlled suitable QI invigorating warming YANG, promoting blood circulation to remove obstruction in the collateral.
Prescription provided by the invention cure mainly by stagnation of YIN-cold, gas lose warm due to obstruction of qi in the chest and cardialgia, Zhu Yang is bullied in back of the body Yu that changes one's profession in the heart, cold visitor's back of the body Yu, so hypofunction of YANG QI in chest is chest pain radiating to the back, the beneficial acute breast sun that catches cold is uncomfortable, Lung Qi obstraction is not so sensation of oppression over the chest with shortness of breath is very then breathed heavily and crouched, so sudden and violent cold impairment of YANG is pale complexion, extreme cold of the limbs, white and thin fur, stringy and tense pulse, it is stagnation of YIN-cold, gas loses warm clear proof, controls the hot temperature cold expelling of a surname, regulating QI to relieve pain, because of stagnation of YIN-cold, gas loses warm so control with the suffering temperature of loosing logically, makes that QI and blood is passed unimpeded, pain is from ending.Product provided by the invention can temperature lead to cold expelling so that the hot temperature of rice original text is nontoxic, and regulating QI to relieve pain is so be monarch, and Borneolum Syntheticum is worked hard away and scurried, logical all keys, and the stagnated fire of loosing, reducing swelling and alleviating pain, the power of the logical pain relieving of enhancing rice original text temperature is minister; The hot temperature of Rhizoma Chuanxiong, kind blood-activating and qi-promoting, wind-expelling pain-stopping, because of the QI stagnated by cold blood stasis, Gu Zuo pain relieving with Rhizoma Chuanxiong energy blood-activating and qi-promoting; The Bulbus Allii Macrostemonis warm activating YANG and eliminating stagnation of working hard, circulation of qi promoting intestinal stasis relieving be for making, and four medicines share can hot temperature cold expelling, regulating QI to relieve pain, and the cold gas that looses is logical, and blood is capable prosperous without obstacle, so obstruction of qi in the chest and cardialgia is from only.In the present invention: monarch drug rice original text, Xin Wen is nontoxic, the logical cold expelling of temperature, promoting the circulation of QI to relieve pain, to because of air-cooled pathogen, visitor's stagnation of QI due to the thoracic dorsal is pained, is its choice drug; In the prior art, the rice original text generally is to cooperate, be made into the medicine with other function to use with other medicines, but independent use, particularly yet there are no report as treatment coronary heart disease, anginal Chinese medicine preparation, by our discovering, this flavor medicine has treatment coronary heart disease, anginal function really; If be equipped with the ministerial drug Borneolum Syntheticum, then: logical all keys, loose stagnated fire, reducing swelling and alleviating pain strengthen meter merit of original text pain relieving; The adjuvant drug Rhizoma Chuanxiong, Xin Wen, blood-activating and qi-promoting, wind-expelling pain-stopping, stagnation of YIN-cold, QI-blood circulation is not smooth, so cooperate monarch-minister drug to strengthen the logical analgesic drug effect of temperature with Rhizoma Chuanxiong; And the messenger drug Bulbus Allii Macrostemonis, arduous temperature, the warming YANG eliminating stagnation, circulation of qi promoting intestinal stasis relieving, priming reach the disease event for making.
Claims (3)
1, a kind of treatment coronary heart disease, anginal Chinese medicine preparation is characterized in that: get crude drug Cinnamomum Migao H.W.Li. 350-600 by weight, be equipped with Borneolum Syntheticum 4-15, Rhizoma Chuanxiong 250-500 and Bulbus Allii Macrostemonis 250-500 be made into Chinese medicine preparation according to common process.
2, according to the described treatment coronary heart disease of claim 1, anginal Chinese medicine preparation, it is characterized in that: calculate: Cinnamomum Migao H.W.Li. 450, Borneolum Syntheticum 9, Rhizoma Chuanxiong 360 and Bulbus Allii Macrostemonis 360 are made into Chinese medicine dripping pills according to common process according to weight.
3, a kind of preparation method for the treatment of coronary heart disease, anginal Chinese medicine preparation as claimed in claim 1, it is characterized in that: with Cinnamomum Migao H.W.Li. extract quintessence oil, Rhizoma Chuanxiong power is broken into coarse powder, extract Rhizoma Chuanxiong total alkaloids extractum with prior art then, Bulbus Allii Macrostemonis extracts extractum with prior art, Rhizoma Chuanxiong total alkaloids extractum, the mixing of Bulbus Allii Macrostemonis extractum that obtains is mixed the back with the Cinnamomum Migao H.W.Li. quintessence oil, the Borneolum Syntheticum that extract make drop pill, oral liquid or injection according to common process.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03135734 CN1265828C (en) | 2003-08-29 | 2003-08-29 | Chinese medicine preparation for curing coronary heart disease and angina pectoris and its preparation method |
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| CN 03135734 CN1265828C (en) | 2003-08-29 | 2003-08-29 | Chinese medicine preparation for curing coronary heart disease and angina pectoris and its preparation method |
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| CN1265828C true CN1265828C (en) | 2006-07-26 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708274B (en) * | 2009-12-23 | 2014-03-05 | 贵州益佰制药股份有限公司 | Quality control method of pill preparation for treating chest impediment and cardialgia |
| CN102475830B (en) * | 2010-11-29 | 2013-12-25 | 贵州益佰制药股份有限公司 | Medicinal composition for treating coronary disease and angina pectoris, preparation method thereof and preparation thereof |
| CN104587145A (en) * | 2013-10-30 | 2015-05-06 | 贵州益佰制药股份有限公司 | Application of qi regulating and blood activating preparation in preparation of drug for prevention and treatment of acute coronary syndrome |
| CN107536938B (en) * | 2016-06-23 | 2020-12-18 | 贵州益佰制药股份有限公司 | Application of qi regulating and blood circulation promoting preparation in preparation of medicine for treating or preventing renal damage |
| CN114073740B (en) * | 2020-08-12 | 2022-11-15 | 贵州益佰制药股份有限公司 | Preparation method of dripping pills for regulating qi and activating blood circulation |
| CN116509955A (en) * | 2023-06-19 | 2023-08-01 | 中国中医科学院西苑医院 | A Chinese medicinal composition for treating coronary heart disease and angina pectoris, and topical patch and method |
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