CN116509955A

CN116509955A - A Chinese medicinal composition for treating coronary heart disease and angina pectoris, and topical patch and method

Info

Publication number: CN116509955A
Application number: CN202310729802.5A
Authority: CN
Inventors: 徐浩; 胡晓美; 郗瑞席
Original assignee: XIYUAN HOSPITAL OF CHINA ACADEMY OF CHINESE MEDICAL SCIENCES
Current assignee: XIYUAN HOSPITAL OF CHINA ACADEMY OF CHINESE MEDICAL SCIENCES
Priority date: 2023-06-19
Filing date: 2023-06-19
Publication date: 2023-08-01

Abstract

The embodiment of the disclosure discloses a traditional Chinese medicine composition for preventing and treating coronary atherosclerotic heart disease stable angina (coronary heart disease angina) and a preparation method of external application thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 40-60 parts of ligusticum wallichii, 40-60 parts of cassia twig, 40-60 parts of allium macrostemon and 10-15 parts of borneol. The external application patch can be prepared from the traditional Chinese medicine composition as a raw material, so that coronary heart disease and angina pectoris can be prevented and treated.

Description

A Chinese medicinal composition for treating coronary heart disease and angina pectoris, and topical patch and method

Technical Field

The present disclosure relates to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition, an external patch and a method for treating coronary heart disease and angina pectoris.

Background

Coronary heart disease is also called coronary atherosclerotic heart disease, and refers to heart disease caused by myocardial ischemia and hypoxia due to stenosis or blockage of a lumen caused by coronary atherosclerosis. The chest stuffiness and pains in traditional Chinese medicine are equivalent to the category of coronary heart disease in modern medicine. Chest stuffiness and pain is a disease in which pain at the Shanzhong acupoints or left chest and other parts is uncomfortable as a main symptom due to heart vessel spasm, stenosis or occlusion, and is often induced by factors such as fatigue, mood swings, satiety and the like. Clinical manifestations of coronary heart disease include angina pectoris, e.g., stable angina pectoris.

The disease name of chest stuffiness and pain is shown in the chapter of the treatment of short qi disease and pulse syndrome of chest stuffiness and pain in the key of jin Kui. Here, "arthralgia, also closed. Zhang Zhongjing is considered as the pathogenesis: when the pulse is too short, the yang is slightly and yin is wiry, i.e. chest stuffiness and pain, so that the pulse is extremely weak. The syndrome of yang deficiency in the upper energizer, chest stuffiness and pain, is also indicated for yin chord. The syndrome of yang deficiency in the upper energizer, which is indicated for chest stuffiness and heart disease, is also indicated for yin chord. The yang is slightly and slightly yin, and the chest yang is blocked and blocked due to deficiency of yang qi, internal cold and excessive yin. "Yu is a person willing to smell five zang organs to relieve pain? The Qibuo is characterized by that it's not only has the channels but also has the functions of stopping at the periphery, making cold qi enter the channels and delay, making qi not go, and making blood less if it is applied to the outside of the pulse, making qi not pass through if it is applied to the inside of the pulse, so that it is easy to break and pain.

The key of the pathogenesis of chest stuffiness and pain is that exogenous pathogenic factors or internal injury cause heart vessel stuffiness, and the disease is located in the heart, but has close relation with the dysfunction of liver, spleen and kidney. The heart governs blood vessels, and depends on liver governs smoothing flow of qi, spleen governs transportation and transformation, and kidneys store essence and water. The disease is in two aspects of deficiency and excess, which are often the symptoms of the deficiency and excess, and deficiency and excess are mixed, and deficiency people are in the form of deficiency of qi and yang; the excessive syndrome is marked by blood stasis and turbid phlegm, and both deficiency and excess are marked by obstruction of heart vessels and pain caused by obstruction.

In the aspect of treating chest stuffiness and pains, according to the pathogenesis of yang-micro yin chord, deficiency people are frequently seen with qi deficiency and yang deficiency; in the case of excess, the recipe is usually to warm yang, activate pulse, activate blood and resolve stasis, which is seen in the excessive presence of blood stasis and turbid phlegm.

The mechanism of the traditional Chinese medicine acupoint application is as follows: the traditional Chinese medicine acupoint application is based on prescription medicines, namely external treatment medicines, namely internal treatment medicines; the principle of external treatment, i.e. the principle of internal treatment. Therefore, the application of the Chinese medicine on the acupoints is firstly distinguished, and then the characteristic of bidirectional regulation of the acupoints is utilized, so that the external Chinese medicine is applied on the acupoints to make the medicine property reach the body along the channels, which is one of the common external treatment methods of 'needle and medicine combination'. Modern medical research has found that the absorption of external traditional Chinese medicines mainly depends on skin and mucous membrane, and acts through local microcirculation into systemic circulation. In addition, the external use of traditional Chinese medicines on the surface is studied by regulating the micro-ecological system of local unbalance and locally regulating the organism so as to finally strengthen body resistance and eliminate evil, thereby treating diseases.

The external use of the traditional Chinese medicine can reduce liver and kidney toxicity possibly caused by oral administration.

The three-volt patch is an important method for preventing and treating various chronic diseases in traditional Chinese medicine, and is used for applying yang-supporting medicines to patients suffering from diseases which are easy to occur or aggravate in winter at the time when the yang qi of the human body is most vigorous in summer according to the principle of nourishing yang in spring and summer in yellow emperor' inner menstruation, so that the effects of supporting yang, dispelling cold, tonifying vital energy and eliminating diseases are exerted.

Therefore, a medicament with clinically proven safety and effectiveness for preventing and treating coronary heart disease and angina pectoris is needed, and a dosage form convenient to use and a proper using method are needed.

Disclosure of Invention

In order to solve the problems in the related art, the embodiment of the disclosure provides a traditional Chinese medicine composition, an external patch and a method for treating coronary heart disease and angina according to the main traditional Chinese medicine syndrome type of coronary heart disease and angina.

In a first aspect, embodiments of the present disclosure provide a Chinese medicinal composition for preventing and treating obstruction of heart vessels (coronary heart disease and angina pectoris) due to chest stuffiness and pains, which is characterized in that,

the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

30-60 parts of ligusticum wallichii, 30-60 parts of cassia twig, 30-60 parts of allium macrostemon and 10-15 parts of borneol.

With reference to the first aspect, in a first implementation manner of the first aspect, the Chinese medicinal composition further includes radix Angelicae sinensis, and the radix Angelicae sinensis is 10-15 parts by weight.

With reference to the first aspect, in a second implementation manner of the first aspect, the traditional Chinese medicine composition further includes an attachment piece, and the attachment piece is 10-15 parts by weight.

In a second aspect, embodiments of the present disclosure provide a medicament, including the traditional Chinese medicine composition of the first aspect, and optionally including pharmaceutically acceptable excipients and/or carriers.

With reference to the second aspect, in a first embodiment of the second aspect, the medicament is in a topical dosage form.

With reference to the first embodiment of the second aspect, in a second embodiment of the second aspect, the topical dosage form is at least one of: powder, ointment, lotion, spray, oil, gel, film, powder or patch.

In a third aspect, embodiments of the present disclosure provide an external application patch for preventing and treating coronary heart disease and angina pectoris, which is characterized in that: the external application patch is prepared from the traditional Chinese medicine composition in the first aspect.

With reference to the third aspect, in a first embodiment of the third aspect, the high-quality traditional Chinese medicine decoction pieces meeting processing standards are taken as raw materials, the traditional Chinese medicine composition is weighed, crushed by adopting a low-temperature high-speed crushing technology, and added with a carrier to prepare paste. The low temperature may be 40 ℃ or lower, and the high speed may be 6000 revolutions or higher. The low temperature may be lower than other temperature values, and the high speed may be higher than other rotation speed values, which is not limited by the present disclosure.

In a fourth aspect, an embodiment of the present disclosure provides an acupoint patch for preventing and treating coronary heart disease and angina pectoris, where the acupoint patch is prepared from the Chinese medicinal composition according to the first aspect.

With reference to the fourth aspect, in a first implementation manner of the fourth aspect, the method includes the steps of:

(1) Weighing the raw materials in the traditional Chinese medicine composition according to parts by weight;

(2) Crushing the raw materials into medicinal powder, and then uniformly mixing the medicinal powder with vegetable oil to obtain paste;

(3) And (3) preparing the paste into a medicinal cake, and placing the medicinal cake on a patch cloth to obtain the acupoint patch.

With reference to the first embodiment of the fourth aspect, in a second embodiment of the fourth aspect, the method further comprises, in a second embodiment,

the medicated cake has a thickness of 2.5-3 cm, a thickness of 5-8 mm, and a weight of 1-1.2 g, and the patch has a thickness of 4.5-7.5 cm×4.5-7.5 cm.

In a fifth aspect, the disclosed embodiments provide a method for improving coronary heart disease symptoms using the traditional Chinese medicine composition of the first aspect, the medicine of the second embodiment of the second aspect to the second aspect, the external application agent of the third aspect, or any one of the acupoint patches of the fourth aspect.

With reference to the fifth aspect, in a first embodiment of the fifth aspect, acupoint patches are used and attached to two Xinshu acupoints of Danzhong.

With reference to the fifth aspect to the first implementation manner of the fifth aspect, in a second implementation manner of the fifth aspect,

the improvement of coronary heart disease symptoms includes at least one of the following: the number of times and degree of the coronary heart disease and angina pectoris.

According to the embodiment of the disclosure, the traditional Chinese medicine composition for preventing and treating chest stuffiness and pain, heart vessel stuffiness (coronary heart disease and angina) is characterized by comprising the following raw materials in parts by weight: 30-60 parts of ligusticum wallichii, 30-60 parts of cassia twig, 30-60 parts of allium macrostemon and 10-15 parts of borneol, thereby preventing and treating coronary heart disease and angina pectoris.

The present disclosure aims at the main pathogenesis of the chest stuffiness and pains patient, adopts the treatment method of "Xuanbi Tongyang, activating blood circulation to dissipate blood stasis", and the formula is described as follows:

according to the principle of "the cold is hot" and "the pain is not relieved", it is the first principal meaning to free the arthralgia and free the yang, activate blood and remove stasis, and the recipe includes Gui Zhi and Xie Bai Wentong heart pulse, chuan Xiong and remove stasis and free the pulse, borneol and promote the flow of qi of Gui Zhi and Xie Bai Xinsan.

Ligusticum wallichii: ligusticum wallichii is pungent, warm, fragrant and dry in nature, can move without being blocked, can promote dispersion, can enter blood system, can reach vertex in upward direction, can reach sea in downward direction, is qi medicine in blood, has wide effects of promoting blood circulation to remove blood stasis, and has the functions of pungent dispersion, ventilation, blood circulation promotion, qi circulation, pain relieving and the like.

Ramulus Cinnamomi: dispel cold and release exterior, warm and unblock meridians. The description of Ben Cao gang mu: treating all wind-cooling rheumatism, bone joint contracture pain, relieving muscle and opening striae, inhibiting liver qi, strengthening spleen and earth, and ironing yin arthralgia. "

Allium macrostemon: xin Wenwei, which is bitter, has the functions of activating yang, dispelling cold, promoting qi and removing stagnation, and is recorded in "true materia medica: xie, wei Xin Zhi san, san Zhi Xiao Zhi Ding from upper cold stagnation; bitter taste can decrease and descending can lead to cold stagnation; the air temperature is then dispersed, and the dispersion can immediately remove the middle-cold stagnation; the body slip is common, and the general one can lead to the immediate resolution of the cold stagnation of the long-term aeipathia, which is healed by the thoracoparalysis and stinging.

Borneol: pungent and bitter taste, cool nature, and good at inducing resuscitation, activating blood and resolving stagnation. Xin Liangkai powder is beneficial to stimulating channels and acupoints, and is less convenient for patients to cool in order to avoid excessive heat and hurt yin and consume qi, and meanwhile, local warm and cool feeling is easy to accept by patients; the medicines are combined together to play the roles of activating yang, dispelling cold, promoting blood circulation and relieving pain.

Chinese angelica root: sweet and pungent in flavor and warm in nature. It enters liver, heart and spleen meridians. Replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Ben Cao Zheng (Ben Cao Zheng): dang Gui is sweet and heavy in flavor, so it can enrich blood, light and pungent in qi, so it can promote blood circulation, tonify middle energizer, nourish middle energizer, and hong Sheng Yao also. The external application has reliable curative effect on different channels and collaterals caused by blood stasis.

Preparing an attaching piece: pungent and sweet in flavor and large in heat. It can warm and tonify heart yang, and dispel heat, and is a strong drug for dispelling yin cold, eliminating rheumatism and relieving pain, and has good therapeutic effect on cold-dampness pain.

Point selection meaning:

the Danzhong acupoint belongs to the conception vessel, and is the qi-flowing function of the pericardium, the eight-meeting acupoint, and has the effects of benefiting upper jiao, relieving chest and diaphragm, reducing qi and dredging collaterals. "Ling Shu-Zhong Lun" records: fu chest and abdomen, guo of zang Fu. For those with the smell of the middle energizer, the heart governs the uterus.

The Xinshu acupoint belongs to the bladder meridian of foot taiyang and is the back Shu acupoint of the heart. The "Jiujiuyi Jing" records "cold and hot heart pain, circulating and leading to pain with the back". Both points are important points for treating chest stuffiness and pain, and the combination of any pulse with the bladder channel, one yin and one yang, and both channels play a role in regulating yin and yang of the whole body.

Winter disease summer treatment:

the winter disease and summer treatment utilizes the concept of nourishing yang in spring and summer, conforms to the advantages of yin and yang coordination of human bodies, changes the condition of disease occurrence, and further promotes yin and yang balance of human bodies, thereby achieving the purpose of curing the disease. The Chinese medicine composition not only accords with the theoretical basis of preventing and treating diseases in the traditional Chinese medicine 'according to time conditions', but also is a concrete embodiment of 'Tian ren' integral appearance. At present, the Sanvo plaster is widely applied to the prevention and treatment of respiratory, digestive, pediatric and other multi-system diseases. In cardiovascular diseases, related researches on acupoint application therapies for treating coronary heart disease, hypertension, heart failure and other diseases are increasing.

In the present disclosure, the three-volt patch for treating winter disease is prepared through double regulation of medicines and channels and collaterals, and has the functions of warming and activating the channels and collaterals, and strengthening the body resistance and consolidating the constitution, thereby achieving the good effect of preventing and treating the angina pectoris of coronary heart disease in winter.

Drawings

Other features, objects and advantages of the present disclosure will become more apparent from the following detailed description of non-limiting embodiments, taken in conjunction with the accompanying drawings. In the drawings:

fig. 1 shows a coronary heart disease angina score table of an embodiment of the present disclosure.

Fig. 2 shows an acupoint diagram of an embodiment of the present disclosure.

Detailed Description

Hereinafter, exemplary embodiments of the present disclosure will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily implement them. In addition, for the sake of clarity, portions irrelevant to description of the exemplary embodiments are omitted in the drawings.

In this disclosure, it is to be understood that terms such as "comprises" or "comprising," etc., are intended to indicate the presence of a tag, number, step, action, component, section or combination thereof disclosed in this specification, and are not intended to exclude the possibility that one or more other tags, numbers, steps, actions, components, sections or combinations thereof are present or added.

Further, it is understood that various changes and modifications of the present invention may be made by those skilled in the art after reading the description of the present invention, and such equivalents are intended to fall within the scope of the claims appended hereto.

In order to facilitate understanding of the technical solution of the present invention, the present invention will be further described below with reference to specific examples.

Example 1: preparation of Chinese medicinal composition, 1 part by weight=1 g

Weighing 30 parts of ligusticum wallichii, 30 parts of cassia twig, 30 parts of allium macrostemon, 10 parts of borneol and 10 parts of Chinese angelica.

Example 2 preparation of a Chinese medicinal composition 1 part by weight=1 g

Weighing 60 parts of ligusticum wallichii, 60 parts of cassia twig, 60 parts of allium macrostemon, 10 parts of borneol and 10 parts of prepared accessory slice.

Example 3 preparation of a Chinese medicinal composition 1 part by weight=1 g

Weighing 30 parts of ligusticum wallichii, 30 parts of cassia twig, 30 parts of allium macrostemon, 15 parts of borneol and 15 parts of Chinese angelica.

Example 4 preparation of a Chinese medicinal composition 1 part by weight=1 g

Weighing 30 parts of ligusticum wallichii, 30 parts of cassia twig, 30 parts of allium macrostemon, 15 parts of borneol and 15 parts of prepared accessory tablet.

Example 5: acupoint plaster

The preparation method comprises the following steps:

taking all the raw materials according to any one of the proportions in the embodiments 1-4, crushing all the raw materials into traditional Chinese medicine powder, and then mixing the traditional Chinese medicine powder with vegetable oil and stirring uniformly; the paste after being stirred evenly is made into medicine cakes with the diameter of about 2.5cm and the thickness of about 5mm, the weight of the medicine cakes is about 1g, and the size of the sticking cloth is about 5cm multiplied by 5cm.

1. Clinical data

1.1 study subjects: the present disclosure collects 230 cases of coronary heart disease patients meeting the inclusion standard in the clinic of the western radix astragali hospital of the academy of Chinese traditional medicine, and the patients taking a doctor in the period of 201x 1 month to 201y 1 month, and the patients are divided into 116 cases of application groups and 114 cases of control groups according to the willingness of the patients. The application group selects the appropriate Chinese medicinal components according to the disease conditions of patients and applies the acupoint patches prepared according to the method of example 5.

1.2 diagnostic criteria: standards are established with reference to the International Association of cardiology and the society and the clinical naming standardization of the world health organization, united states patent group report, naming and diagnosis of ischemic heart disease.

1.3 inclusion criteria: age 18-80 years; meets the diagnosis standard of the coronary heart disease of Western medicine and has any one of the following: (1) a clear history of stale myocardial infarction, or a history of PCI, or a history of coronary bypass. (2) The coronary angiography or coronary CTA result suggests that at least one coronary stenosis is greater than or equal to 50%. (3) The loaded nuclide myocardial scan examination prompts the patients with coronary heart disease and myocardial ischemia. (4) Exercise flat electrocardiogram positive (limited male patient); with typical symptoms of angina pectoris; the subject is informed and voluntarily signs an informed consent.

2. Research method

2.1 study drug: the "winter disease summer treatment" three-volt patch which is developed by Xu Hao professor, chinese medical college of western radix astragali hospital pharmaceutical factory and produced by processing is adopted. The medicine comprises the following components: ligusticum wallichii, allium macrostemon and borneol. The specification of the medicine: the patch is about 5X5cm, the medicine cake is about 1g, and the diameter is about 2.5cm.

2.2, applying acupoints and the method: the patch is applied on the Shanzhong and two Xinshu acupoints. Apply 3 acupoints every first day, apply two Xinshu acupoints every second and third days. During the application, patients are instructed to fast food, such as cold, greasy, spicy, and seafood, mutton, and mushrooms. The specific locations of the two Xinshu acupoints are shown in FIG. 2.

2.3 applying time: according to the traditional Chinese medicine time medical theory, every first day of three volt days is the moment of opening the acupoint, and the application effect is optimal at the moment. The application is started every first volt day, the application is continuously carried out for 3 days, the application is carried out for 1 time a day, each time for 4-6 hours, and the application time can be properly adjusted according to individual differences. Two volts and three volts are the same.

2.4 evaluation of efficacy

2.4.1 angina pectoris curative effect: the treatment of coronary heart disease, angina pectoris and arrhythmia by combining Western and Chinese medicine in 1979 is referred to in "determination criteria for curative effect of coronary heart disease, angina pectoris and Electrocardiogram".

2.4.2 curative effects of Chinese medicine symptoms: recording the traditional Chinese medicine symptoms before and after observation in winter (11 months-2 months).

The symptoms of coronary heart disease and angina pectoris are classified into four grades of no, light, medium and heavy according to different severity, the classification standards are that no is-0, light-2, medium-4 and heavy-6, and the times, duration, pain degree, nitroglycerin dosage and the like of different severity are shown in figure 1. The curative effect judgment refers to the traditional Chinese medicine syndrome curative effect judgment standard of the traditional Chinese medicine new medicine clinical research guiding principle (trial). The effect is shown: the clinical symptoms and signs are obviously improved, and the integral of symptoms is reduced by more than or equal to 70 percent; the traditional Chinese medicine composition has the advantages that clinical symptoms and signs are improved, and the integral of symptoms is reduced by more than or equal to 30%; the clinical symptoms and physical signs are not obviously improved or even aggravated, and the integral of symptoms is reduced by less than 30 percent; weighting: the clinical symptoms and signs are all aggravated, and the integral of symptoms is reduced by <0%.

2.4.3 patient self-evaluation severity of disease: according to the Likett scale, the interval (0-10) is used to represent different severity of illness (0 is asymptomatic, 10 is the most serious illness), patients are asked to select corresponding numbers according to own illness, and the own illness severity of patients is compared before and after observation.

2.5 statistical treatment: statistical processing was performed using the IBM SPSS Statistics 20.0.20.0 software package. First, data are subjected to descriptive statistical analysis: counting data is described in terms of frequency, percentage or composition ratio; the metering data are described in terms of mean.+ -. Standard deviation (. + -.s). The two sets of comparison counting data are checked by X2; the measurement data is in t test in accordance with normal distribution, is in non-parametric test in accordance with normal distribution, gives test statistics and calculates corresponding P value, and has statistical significance that P is less than 0.05. The relevant factors influencing the re-hospitalization in winter are analyzed by adopting a data statistical method such as single factor analysis, binary logics regression and the like.

3. Results of the study

The present disclosure is actually incorporated into 230 patients. 116 cases of the plaster are applied, 4 cases of the plaster are lost, 1 case of the plaster is misreceived (heart failure is combined), and 1 case of the plaster is withdrawn due to adverse reaction; control group 114, 3, 1 by mistake (age > 80 years). Finally 220 patients with coronary heart disease enter the analysis, 110 patients with application group and 110 patients with control group. Wherein, the ages of 108 men and 112 women are 38-80 years, and the average ages are 64.04 +/-9.73 years. The two groups of patients have consistent baseline data such as age, sex, BMI, smoking history, past history, light and heavy grading of angina pectoris, basic medication and the like, and the difference has no statistical significance (P is more than 0.05).

3.1 angina pectoris curative effect: the total effective rate (67.27%) of angina pectoris attacks of patients in the application group in winter is superior to that of the control group (31.82%), and the difference has statistical significance (P is less than 0.05); the total reduction rate (77.40%) of the nitroglycerin in the application group is superior to that of the control group (28.60%), and the difference is statistically significant (P < 0.05), as shown in tables 1 and 2.

Table 1 two groups of angina pectoris winter onset improvement conditions

Table 2 comparison of the amounts of the two groups of nitroglycerin

3.2 efficacy of symptoms in TCM: the total integral of the traditional Chinese medicine symptoms of the two groups of patients after observation is reduced compared with the traditional Chinese medicine symptoms of the two groups of patients after observation, and the improvement degree of the total integral of the traditional Chinese medicine symptoms of the application group is more obvious (P is less than 0.05) compared with the traditional Chinese medicine symptoms of the control group, and the details are shown in Table 3.

Table 3 total integral comparison of symptoms in two groups of patients

Note that: * For the comparison of the difference d of the total integral of the symptoms of the traditional Chinese medicine of the two groups of patients before and after observation, P is less than 0.01.

3.3 comparing the curative effects of angina pectoris of patients with yang deficiency and cold accumulation and non-yang deficiency and cold accumulation: the improvement condition of angina pectoris in winter of the patients with the syndrome of yang deficiency and cold accumulation is superior to that of the patients with the syndrome of non-yang deficiency and cold accumulation, and the difference has statistical significance (P is less than 0.05); the angina pectoris treatment effect of the two groups of patients with the two groups of symptoms of the control group is not obviously different (P is more than 0.05), and the details are shown in Table 4.

Table 4 comparative curative effects of angina pectoris in patients with two groups of yang deficiency and cold coagulation syndromes

Note that: the number of effective cases in the table comprises effective patients; the number of invalid cases includes invalid and aggravated patients.

3.4 binary logistics regression analysis of relevant factors affecting winter re-hospitalization: prior to observation, a total of 57 patients in 220 study subjects were hospitalized for angina in the winter season of the last year (11-2 months). Follow-up after half a year, 18 of them were found to be in hospital again in winter for angina pectoris. The related factors affecting the patients with coronary heart disease and angina pectoris to be hospitalized in winter are analyzed in a single factor way, and the result shows that: the three-volt patch, BMI, blood circulation reconstruction and smoking history are relevant factors for influencing re-hospitalization in winter, P < 0.1 is taken as a screening standard, and the result is taken as a variable for entering binary logics regression analysis, and the three-volt patch is found to be an independent influencing factor [ P <0.01, RR=0.029, 95% CI (0.003,0.312) ] of the re-hospitalization event in winter of coronary heart disease patients, so that the three-volt patch for treating winter diseases and summer has a certain protection effect on reducing the re-hospitalization event in winter caused by angina pectoris of coronary heart disease patients, and the detailed table 5 is shown.

TABLE 5 binary logistics regression analysis of influence factors related to winter re-hospitalization

3.5 related investigation: comparing the evaluation scores of the two groups of patients before and after observation on the severity of the self-illness, the results show that: after observation, the disease severity of both groups of patients is improved, the application group reduces 83 patients, the control group reduces 56 patients, the total improvement rate (75.60%) of the application group is better than the total improvement rate (50.90%) of the control group, and the difference has statistical significance (P is less than 0.05), and the details are shown in Table 6.

TABLE 6 self-assessed severity of disease for two groups of patients

3.6 safety evaluation: no serious adverse reaction event occurs during the application. The patients in 5 cases complain of mild adverse reaction, wherein 3 cases of patients have skin flushing with mild itching after application, 1 case of patients complain of skin abnormal reaction, and the 4 cases of patients can tolerate the skin abnormal reaction without affecting application; another 1 patient was unable to tolerate withdrawal from observation due to allergy to the adhesive tape.

The present invention is not limited to the above-mentioned embodiments, but can be modified or changed in any manner and without departing from the scope of the invention, and the equivalent changes of the invention can be made by those skilled in the art by using the above-mentioned technical matters without departing from the scope of the invention; meanwhile, any equivalent changes, modifications and evolution of the above embodiments according to the essential technology of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A Chinese medicinal composition for treating coronary atherosclerotic heart disease and stable angina pectoris is characterized in that,

2. The Chinese medicinal composition according to claim 1, wherein,

the Chinese medicinal composition also comprises 10-15 parts by weight of Chinese angelica.

3. The Chinese medicinal composition according to claim 2, wherein,

the traditional Chinese medicine composition also comprises an accessory preparation, wherein the accessory preparation is 10-15 parts by weight.

4. A medicament comprising the traditional Chinese medicine composition of any one of claims 1-3, and further comprising pharmaceutically acceptable excipients and/or carriers.

5. The medicament of claim 4, wherein the medicament is in a topical dosage form.

6. The medicament according to claim 5, wherein the external dosage form is at least one of the following: powder, ointment, lotion, spray, oil, gel, film, powder or patch.

7. An external application patch for preventing and treating coronary heart disease and angina pectoris, which is characterized in that: the external application patch is prepared from the traditional Chinese medicine composition as claimed in claims 1-3.

8. The method for producing an external application agent according to claim 7, characterized in that: taking high-quality traditional Chinese medicine decoction pieces meeting processing standards as raw materials, weighing the traditional Chinese medicine composition, crushing by adopting a low-temperature high-speed crushing technology, and adding a carrier to prepare paste.

9. An acupoint patch for preventing and treating coronary heart disease and angina pectoris, characterized in that the acupoint patch is prepared from the traditional Chinese medicine composition as set forth in claims 1-3.

10. The method for preparing an acupoint patch according to claim 9, comprising the steps of:

weighing the raw materials in the traditional Chinese medicine composition according to parts by weight;

crushing the raw materials into traditional Chinese medicine powder at a low temperature and high speed, and then uniformly mixing and stirring the traditional Chinese medicine powder and vegetable oil to obtain paste;

and (3) preparing the paste into a medicinal cake, and placing the medicinal cake on a patch cloth to obtain the acupoint patch.

11. The method according to claim 10, wherein,

the diameter of the medicine cake is 2.5-3 cm, the thickness is 5-8 mm, the weight is 1-1.2 g, and the patch is 4.5-7.5 cm multiplied by 4.5-7.5 cm.

12. Use of the traditional Chinese medicine composition according to claims 1-3, the medicament according to claims 4-6, the external application patch according to claim 7, or any one of the acupoint patches according to claim 9 in the preparation of a medicament for improving chest pain symptoms.

13. The use according to claim 12, characterized in that the kanzhong and the two Xinshu acupoints are applied using an acupoint patch.

14. The use according to claim 13, wherein 3 total of said two Xinzhong and two Xinshu acupoints are applied on the first day of each volt, and only said two Xinshu acupoints are applied on the second and third days.

15. The use according to any one of claims 12-14, wherein,

said improving coronary heart disease symptoms includes improving at least one of: the number of times and degree of the coronary heart disease and angina pectoris.