CN1265792C - 含有8－22个碳原子的烷基链的烟酸烷基酯在制备提高受试者瘦素水平的药物中的用途 - Google Patents

含有8－22个碳原子的烷基链的烟酸烷基酯在制备提高受试者瘦素水平的药物中的用途 Download PDF

Info

Publication number
CN1265792C
CN1265792C CNB028061209A CN02806120A CN1265792C CN 1265792 C CN1265792 C CN 1265792C CN B028061209 A CNB028061209 A CN B028061209A CN 02806120 A CN02806120 A CN 02806120A CN 1265792 C CN1265792 C CN 1265792C
Authority
CN
China
Prior art keywords
leptin
nicotinic acid
niacin
purposes
nicotinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028061209A
Other languages
English (en)
Chinese (zh)
Other versions
CN1496260A (zh
Inventor
伊莱恩·雅各布森
迈伦·K·雅各布森
金辉泰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kentucky Research Foundation
University of Arizona
Original Assignee
University of Kentucky Research Foundation
University of Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23047813&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1265792(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Kentucky Research Foundation, University of Arizona filed Critical University of Kentucky Research Foundation
Publication of CN1496260A publication Critical patent/CN1496260A/zh
Application granted granted Critical
Publication of CN1265792C publication Critical patent/CN1265792C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB028061209A 2001-03-08 2002-03-08 含有8－22个碳原子的烷基链的烟酸烷基酯在制备提高受试者瘦素水平的药物中的用途 Expired - Fee Related CN1265792C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27434901P 2001-03-08 2001-03-08
US60/274,349 2001-03-08

Publications (2)

Publication Number Publication Date
CN1496260A CN1496260A (zh) 2004-05-12
CN1265792C true CN1265792C (zh) 2006-07-26

Family

ID=23047813

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028061209A Expired - Fee Related CN1265792C (zh) 2001-03-08 2002-03-08 含有8－22个碳原子的烷基链的烟酸烷基酯在制备提高受试者瘦素水平的药物中的用途

Country Status (12)

Country Link
US (2) US6750234B2 (enExample)
EP (1) EP1365762B1 (enExample)
JP (1) JP5057353B2 (enExample)
CN (1) CN1265792C (enExample)
AT (1) ATE409037T1 (enExample)
CA (1) CA2437844C (enExample)
DE (1) DE60229041D1 (enExample)
DK (1) DK1365762T3 (enExample)
ES (1) ES2315358T3 (enExample)
MX (1) MXPA03008096A (enExample)
PT (1) PT1365762E (enExample)
WO (1) WO2002072092A1 (enExample)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8437251B2 (en) 2005-12-22 2013-05-07 Qualcomm Incorporated Methods and apparatus for communicating transmission backlog information
US8503938B2 (en) 2004-10-14 2013-08-06 Qualcomm Incorporated Methods and apparatus for determining, communicating and using information including loading factors which can be used for interference control purposes
US8514771B2 (en) 2005-12-22 2013-08-20 Qualcomm Incorporated Methods and apparatus for communicating and/or using transmission power information
US8514692B2 (en) 2003-02-24 2013-08-20 Qualcomm Incorporated Methods and apparatus for determining, communicating and using information which can be used for interference control purposes
US8694042B2 (en) 2005-10-14 2014-04-08 Qualcomm Incorporated Method and apparatus for determining a base station's transmission power budget
US8811348B2 (en) 2003-02-24 2014-08-19 Qualcomm Incorporated Methods and apparatus for generating, communicating, and/or using information relating to self-noise
US8965413B2 (en) 2006-04-12 2015-02-24 Qualcomm Incorporated Locating a wireless local area network associated with a wireless wide area network
US9119220B2 (en) 2005-12-22 2015-08-25 Qualcomm Incorporated Methods and apparatus for communicating backlog related information
US9125093B2 (en) 2005-12-22 2015-09-01 Qualcomm Incorporated Methods and apparatus related to custom control channel reporting formats
US9125092B2 (en) 2005-12-22 2015-09-01 Qualcomm Incorporated Methods and apparatus for reporting and/or using control information
US9137072B2 (en) 2005-12-22 2015-09-15 Qualcomm Incorporated Methods and apparatus for communicating control information
US9148795B2 (en) 2005-12-22 2015-09-29 Qualcomm Incorporated Methods and apparatus for flexible reporting of control information
US9191840B2 (en) 2005-10-14 2015-11-17 Qualcomm Incorporated Methods and apparatus for determining, communicating and using information which can be used for interference control
US9338767B2 (en) 2005-12-22 2016-05-10 Qualcomm Incorporated Methods and apparatus of implementing and/or using a dedicated control channel
US9338795B2 (en) 2005-12-22 2016-05-10 Qualcomm Incorporated Methods and apparatus for communicating transmission backlog information
US9451491B2 (en) 2005-12-22 2016-09-20 Qualcomm Incorporated Methods and apparatus relating to generating and transmitting initial and additional control information report sets in a wireless system
US9462604B2 (en) 2005-12-22 2016-10-04 Qualcomm Incorporated Methods and apparatus related to selecting a request group for a request report
US9473265B2 (en) 2005-12-22 2016-10-18 Qualcomm Incorporated Methods and apparatus for communicating information utilizing a plurality of dictionaries
US9544860B2 (en) 2003-02-24 2017-01-10 Qualcomm Incorporated Pilot signals for use in multi-sector cells
US9603102B2 (en) 2003-02-24 2017-03-21 Qualcomm Incorporated Method of transmitting pilot tones in a multi-sector cell, including null pilot tones, for generating channel quality indicators

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1383540T3 (da) 2000-07-31 2009-08-24 Univ Bar Ilan Fremgangsmdåer og farmaceutiske sammensætninger til sårheling
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
ES2315358T3 (es) * 2001-03-08 2009-04-01 University Of Kentucky Research Foundation Metodo para incrementar los niveles de leptina usando compuestos de acido nicotinico.
AU2003299568B2 (en) * 2002-11-27 2010-07-22 Ampio Pharmaceuticals, Inc. Treatment of diseases and conditions mediated by increased phosphorylation
US7736636B2 (en) * 2003-02-12 2010-06-15 Shaker Mousa Method for treating occlusive vascular diseases & wound healing
CA2535029C (en) 2003-08-07 2013-07-16 Healor Ltd. Pharmaceutical compositions and methods for accelerating wound healing
US8969291B2 (en) 2004-10-08 2015-03-03 Enzo Therapeutics, Inc. Methods for decreasing leptin levels or activity for treating inflammation
JP2006253769A (ja) * 2005-03-08 2006-09-21 National Institute Of Advanced Industrial & Technology 情報処理システムおよび方法
JP4956534B2 (ja) * 2005-06-24 2012-06-20 アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ 女性型脱毛症等の毛髪成長障害の治療方法とそのために有用な組成物
US8367606B2 (en) 2005-08-29 2013-02-05 Healor Ltd. Method and compositions for prevention and treatment of diabetic and aged skin
US20070066512A1 (en) * 2005-09-12 2007-03-22 Dominique Verhelle Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
US7801589B2 (en) 2005-12-22 2010-09-21 Olympus Corporation In-vivo examination method and in-vivo examination apparatus
WO2008026349A1 (fr) * 2006-08-31 2008-03-06 Juridical Foundation Osaka Industrial Promotion Organization Agent thérapeutique destiné au traitement de l'effluvium télogène
DK2120917T3 (da) * 2007-02-28 2014-04-07 Univ Kentucky Res Found Fremgangsmåde til lindring af bivirkninger ved retinsyre-terapi og/eller til forbedring af effektivitet uden at interferere med effektiviteten
EP2523677A2 (en) 2010-01-11 2012-11-21 Healor Ltd. Method for treatment of inflammatory disease and disorder
US11298334B2 (en) * 2016-04-22 2022-04-12 Jc (Wuxi) Company, Inc. Use of isothiocyanate compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4505896A (en) * 1979-04-19 1985-03-19 Elorac, Ltd. Method of treating acne vulgaris and composition
DE3110611A1 (de) * 1981-03-18 1982-10-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen "mitogene der leukozyten und des entzuendungsgewebes:natuerliche leukopoetine zur selektiven anregung der teilung und differenzierung von leukozyten"
GB8330969D0 (en) * 1983-11-21 1983-12-29 Wellcome Found Promoting healing
DE3570598D1 (en) * 1984-11-15 1989-07-06 Nitto Denko Corp Composition for percutaneous administration
US4965252A (en) * 1988-06-28 1990-10-23 Hauser-Kuhrts, Inc. Cholesterol-lowering combination compositions of guar gum and niacin
ATE198830T1 (de) * 1991-03-01 2001-02-15 Univ Florida Verwendung von nikotinanalogen zur behandlung von degenerativen erkrankungen des nervensystems
US5240945A (en) * 1992-02-18 1993-08-31 Warshaw Thelma G Method and compositions for treating acne
US5612382A (en) * 1994-07-15 1997-03-18 Frances B. Fike Composition for percutaneous absorption of pharmaceutically active ingredients
US5496827A (en) * 1994-07-15 1996-03-05 Patrick; Jay Compositions for the transdermal delivery of nutrients
US6068976A (en) * 1995-03-20 2000-05-30 Ligand Pharmaceuticals Incorporated Modulators of ob gene and screening methods therefor
DK0823897T3 (da) * 1995-05-01 2004-12-06 Scarista Ltd Nicotinsyreestere og farmaceutiske præparater indeholdende disse
WO1998052927A1 (en) * 1997-05-19 1998-11-26 Rosemarie Scivoletto Composition for treating skin conditions
AU4672199A (en) * 1998-05-20 1999-12-06 Yale University Modulation of angiogenesis and wound healing
ATE273008T1 (de) * 1998-12-01 2004-08-15 Univ Kentucky Res Found Verwendung von nikotinsäurederivate zur behandlung von dna-schäden bei hautzellen
IT1306141B1 (it) * 1999-05-17 2001-05-30 Giampiero Valletta Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche.
US6326034B1 (en) * 1999-12-22 2001-12-04 Natural Compounds Ltd Natural extracted and synthetic antioxidant compositions
ES2315358T3 (es) * 2001-03-08 2009-04-01 University Of Kentucky Research Foundation Metodo para incrementar los niveles de leptina usando compuestos de acido nicotinico.

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9603102B2 (en) 2003-02-24 2017-03-21 Qualcomm Incorporated Method of transmitting pilot tones in a multi-sector cell, including null pilot tones, for generating channel quality indicators
US8514692B2 (en) 2003-02-24 2013-08-20 Qualcomm Incorporated Methods and apparatus for determining, communicating and using information which can be used for interference control purposes
US8811348B2 (en) 2003-02-24 2014-08-19 Qualcomm Incorporated Methods and apparatus for generating, communicating, and/or using information relating to self-noise
US9544860B2 (en) 2003-02-24 2017-01-10 Qualcomm Incorporated Pilot signals for use in multi-sector cells
US8503938B2 (en) 2004-10-14 2013-08-06 Qualcomm Incorporated Methods and apparatus for determining, communicating and using information including loading factors which can be used for interference control purposes
US8989084B2 (en) 2005-10-14 2015-03-24 Qualcomm Incorporated Methods and apparatus for broadcasting loading information corresponding to neighboring base stations
US8694042B2 (en) 2005-10-14 2014-04-08 Qualcomm Incorporated Method and apparatus for determining a base station's transmission power budget
US9191840B2 (en) 2005-10-14 2015-11-17 Qualcomm Incorporated Methods and apparatus for determining, communicating and using information which can be used for interference control
US9137072B2 (en) 2005-12-22 2015-09-15 Qualcomm Incorporated Methods and apparatus for communicating control information
US9338795B2 (en) 2005-12-22 2016-05-10 Qualcomm Incorporated Methods and apparatus for communicating transmission backlog information
US9125093B2 (en) 2005-12-22 2015-09-01 Qualcomm Incorporated Methods and apparatus related to custom control channel reporting formats
US9125092B2 (en) 2005-12-22 2015-09-01 Qualcomm Incorporated Methods and apparatus for reporting and/or using control information
US8437251B2 (en) 2005-12-22 2013-05-07 Qualcomm Incorporated Methods and apparatus for communicating transmission backlog information
US9148795B2 (en) 2005-12-22 2015-09-29 Qualcomm Incorporated Methods and apparatus for flexible reporting of control information
US9161313B2 (en) 2005-12-22 2015-10-13 Qualcomm Incorporated Methods and apparatus for communicating and/or using transmission power information
US8514771B2 (en) 2005-12-22 2013-08-20 Qualcomm Incorporated Methods and apparatus for communicating and/or using transmission power information
US9338767B2 (en) 2005-12-22 2016-05-10 Qualcomm Incorporated Methods and apparatus of implementing and/or using a dedicated control channel
US9119220B2 (en) 2005-12-22 2015-08-25 Qualcomm Incorporated Methods and apparatus for communicating backlog related information
US9451491B2 (en) 2005-12-22 2016-09-20 Qualcomm Incorporated Methods and apparatus relating to generating and transmitting initial and additional control information report sets in a wireless system
US9462604B2 (en) 2005-12-22 2016-10-04 Qualcomm Incorporated Methods and apparatus related to selecting a request group for a request report
US9473265B2 (en) 2005-12-22 2016-10-18 Qualcomm Incorporated Methods and apparatus for communicating information utilizing a plurality of dictionaries
US8830827B2 (en) 2005-12-22 2014-09-09 Qualcomm Incorporated Methods and apparatus for communicating transmission backlog information
US9572179B2 (en) 2005-12-22 2017-02-14 Qualcomm Incorporated Methods and apparatus for communicating transmission backlog information
US9578654B2 (en) 2005-12-22 2017-02-21 Qualcomm Incorporated Methods and apparatus related to selecting reporting alternative in a request report
US8965413B2 (en) 2006-04-12 2015-02-24 Qualcomm Incorporated Locating a wireless local area network associated with a wireless wide area network

Also Published As

Publication number Publication date
DE60229041D1 (de) 2008-11-06
EP1365762A1 (en) 2003-12-03
EP1365762B1 (en) 2008-09-24
ES2315358T3 (es) 2009-04-01
EP1365762A4 (en) 2005-05-25
US20040198776A1 (en) 2004-10-07
PT1365762E (pt) 2008-11-27
WO2002072092A1 (en) 2002-09-19
MXPA03008096A (es) 2005-10-05
US6750234B2 (en) 2004-06-15
CA2437844C (en) 2007-05-15
JP2004519488A (ja) 2004-07-02
HK1065941A1 (en) 2005-03-11
US20020128298A1 (en) 2002-09-12
CN1496260A (zh) 2004-05-12
ATE409037T1 (de) 2008-10-15
DK1365762T3 (da) 2008-11-17
CA2437844A1 (en) 2002-09-19
JP5057353B2 (ja) 2012-10-24

Similar Documents

Publication Publication Date Title
CN1265792C (zh) 含有8－22个碳原子的烷基链的烟酸烷基酯在制备提高受试者瘦素水平的药物中的用途
Bo et al. A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial
Witte et al. Arginine physiology and its implication for wound healing
AU2005316295B2 (en) Method for extending lifespan and delaying the onset of age-related disease
US5955059A (en) Use of locally applied DNA fragments
EP0722324B1 (en) Pharmaceutical composition for immunoenhancement therapy
JP2007145865A (ja) 抗新生物剤としての酪酸、酪酸塩、および誘導体の生理学的に安定な組成物
US8778995B2 (en) Use of hydroxyoleic acid and related compounds in the manufacture of drugs
Shi et al. Supplemental L‐arginine enhances wound healing following trauma/hemorrhagic shock
CN111643669A (zh) 谷氨酰胺酶抑制剂在制备治疗银屑病的药物中的应用
Tessari Changes in protein, carbohydrate, and fat metabolism with aging: possible role of insulin
US20080125489A1 (en) Methods and compositions for the treatment and prevention of lung disease
WO2022077276A1 (zh) 烟酰胺单核苷酸与发酵乳杆菌联合在制备缓解皮肤光老化制剂中的应用
Tong et al. Differential effects of retinoids on DNA synthesis in calcium-regulated murine epidermal keratinocyte cultures
HK1065941B (en) Use of a nicotinic acid alkyl ester containing an alkyl chain from 8 to 22 carbon atoms for the preparation of a medicament for increasing leptin levels in a subject
US8048923B2 (en) Treatment of polyglutamine disorders caused by expanding genomic CAG nucleotides
US6303648B1 (en) Methods and compositions for the treatment and prevention of lung disease
Desai et al. Branched-chain amino acid administration in surgical patients: effects on amino acid and fuel substrate profiles
Shechter et al. Suspensions of pro-drug insulin greatly prolong normoglycemic patterns in diabetic rats
TWI672145B (zh) 預防及／或治療代謝疾病的醫藥組合物及其用途
CN117653642A (zh) 格列本脲促进nad+水平的用途
AU2004246895A1 (en) Methods of treating obesity and related disorders using tellurium and selenium compounds
CN114539092A (zh) 一种燕麦麸酚酰胺生物碱及其制备方法与在制备止痒产品中的应用
Yanıcoglu et al. Effects of Prostaglandin Inhibitation, Electrical Stimulation and Local Heating on Skeletal Muscle Atrophy
Wing The Immunomodulatory Effect of Methimazole on Inbred Mice

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1065941

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1065941

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060726

Termination date: 20210308