CN1259039C - Huoxiang Zhengqi liquid capsule and its preparation - Google Patents
Huoxiang Zhengqi liquid capsule and its preparation Download PDFInfo
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- CN1259039C CN1259039C CN 03154469 CN03154469A CN1259039C CN 1259039 C CN1259039 C CN 1259039C CN 03154469 CN03154469 CN 03154469 CN 03154469 A CN03154469 A CN 03154469A CN 1259039 C CN1259039 C CN 1259039C
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Abstract
The present invention discloses a Huoxiang Zhengqi liquid capsule with the advantages of high effect, rapid effect taking and stable effect. The Huoxiang Zhengqi liquid capsule is made by filling a Huoxiang Zhengqi preparation emulsion proportionally prepared from all ingredients into a hard gelatin capsule. The Huoxiang Zhengqi capsule preparation has high volatile medicinal component content and rapid effect taking.
Description
Technical field
The present invention relates to a kind of HUOXIANG ZHENGQI JIAONANG, more particularly, relate to the liquid capsule of a kind of ageratum; The invention still further relates to the capsular preparation method of this liquid state.
Background technology
HUOXIANG ZHENGQI RUANJIAONANG comes from Song's " formulary of peaceful benevolent dispensary ", is " damp eliminating panacea " by the ancient Chinese medicine doctor honor, have induce sweat dampness dissipating, QI regulating and in effect.Being used for diseases such as affection of exogenous wind-cold, internal injury humidity hysteresis, the confused weight of headache, abdominal distention, vomiting diarrhea, is indispensable good medicine in summer.Because the advantage of ageratum in treatment used very extensively, it has become a maximum kind of the present dosage form of China, honeyed pill, the watered pill, concentrated pill, tablet, electuary, oral liquid is arranged, contain multiple dosage forms such as pure water preparation, soft capsule, hard capsule.Because we's 60% above flavour of a drug contain volatile ingredient and bringing into play main effect in the sides, and the above-mentioned pure water preparation (HUOXIANG ZHENGQI SHUI) that contains can dissolve volatile ingredient fully with ethanol, curative effect is better, but because mouthfeel is poor, the high stimulating intestine and stomach of alcohol content and be difficult for being accepted by women and child: other dosage forms are low owing to volatile component content, curative effect also can be reduced: soft capsule dosage form then can be wrapped in the ethereal oil soluble components in the softgel shell, be the revolution of Chinese medicine preparation industry, but soft capsule is because the problem that disintegration time prolongs with period of storage is perplexing the performance of curative effect.
Summary of the invention
Purpose of the present invention is exactly in order to overcome the deficiencies in the prior art, the fast liquid capsule of ageratum of a kind of volatility pharmaceutical ingredient content height, curative effect is provided and provides this ageratum liquid capsular preparation method.
The liquid capsule of ageratum of the present invention is made up of ageratum Emulsion and capsule shells, and wherein said ageratum Emulsion is made up of the component of following percentage by weight: ageratum extractum 36-39%, patchouli oil 0.3-0.5%, perilla oil 0.15-0.3%, substrate 55.7-61.3%, surfactant 1.41-2.50%, thickening agent 0.84-2.00%.
Wherein said ageratum extractum is the prepared extractum of ageratum prescription in the HUOXIANG ZHENGQI ZHIJI in the prior art.
Described substrate is vegetable oil and/or Polyethylene Glycol, and preferred molecular weight polyethylene glycol is less than 600.
Described surfactant is cation, anion and nonionic surfactant, is preferably the water soluble surfactant active.Described water soluble surfactant active is the nonionic surfactant.Described nonionic surfactant is preferably lecithin.The percentage by weight of described surfactant comprise Emulsion is preferably 1.9-2.3%.
Described thickening agent is Cera Flava or glyceryl monostearate.
Described ageratum extractum water content is 6-9%.Described extractum accounts for the percentage by weight 37-38% of gained Emulsion.
The liquid capsular preparation method of ageratum of the present invention comprises the following steps:
At first prepare ageratum Emulsion, adopt known method to prepare oil of Herba Pogostemonis, perilla oil and ageratum extractum respectively, vegetable oil and Cera Flava are heated to the 40-60 degree, add ageratum extractum, oil of Herba Pogostemonis and perilla oil then, add gel and make it melt postcooling entirely, add surfactant then to room temperature, stir evenly, grind to form homogeneous latex emulsion then, Emulsion is canned goes into hard capsule, obtains the liquid capsule of ageratum after sealing.
In the liquid capsular preparation method of ageratum of the present invention, the preparation of ageratum extractum can be closed the ageratum prescription and be fried in shallow oil, and also the composition of ageratum prescription can be prepared into extractum respectively.Preferably with the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis 90-95% alcohol reflux, concentrating under reduced pressure becomes cream (relative density 1.18-1.20), and it is standby to obtain four flavor cream; The Rhizoma Pinelliae cold water soak, bubble is got the Rhizoma Pinelliae to the saturating heart, add Rhizoma Zingiberis again, decocts with water; Poria, Pericarpium Arecae decocting in water merge with Rhizoma Pinelliae liquid, filter, and the mass ratio that is concentrated into above-mentioned three kinds of medical materials and water is 1: 1, and the adjustment of reuse ethanol makes that to contain the alcohol amount be 60%, leaves standstill, and filter, and filtrate is condensed into three cream (relative density 1.30-1.40,80 ℃) of distinguishing the flavor of; Radix Glycyrrhizae extractum is smashed, and adds water and makes its dissolving, transfers to that to contain alcohol amount be 65%, filters, and is condensed into GANGCAO GAO (relative density 1.30-1.40,80 ℃).
Most preferably with the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis 90-95% alcohol reflux secondary (3 hours for the first time, 2 hours for the second time), filtrate merges, and concentrating under reduced pressure becomes cream (relative density 1.18-1.20), and it is standby to obtain four flavor cream; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, changed water 2 times, and bubble is got the Rhizoma Pinelliae to the saturating heart, add Rhizoma Zingiberis 16.46g again, decocted with water secondary (3 hours for the first time, 2 hours for the second time); Poria, Pericarpium Arecae decocting in water secondary (1 hour for the first time, the 2nd time 1 hour), merge with Rhizoma Pinelliae liquid, filter, the mass ratio that is concentrated into above-mentioned three kinds of medical materials and water is 1: 1, and the adjustment of reuse ethanol makes that to contain that alcohol measures be 60%, left standstill 24 hours, filter, filtrate is condensed into three flavor cream (relative density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Radix Glycyrrhizae extractum is smashed, and adds water and makes its dissolving, transfers to that to contain alcohol amount be 65%, filters, be condensed into GANGCAO GAO (to density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30).
The liquid capsule of ageratum of the present invention promptly can reach the curative effect same with soft capsule, and it retains volatile ingredient fully, can reduce disintegration time again, and drug effect is played a role rapidly.
Ageratum of the present invention liquid capsule has kept soft capsule bioavailability height, alcohol-free all advantages, can intuitively find out from following table:
| Dosage form | Pluses and minuses |
| HUOXIANG ZHENGQI WAN (big small honey pill, the watered pill) | Dose is big, children's's dysphagia, and difficult the absorption taken effect slowly, and mouthfeel is bad, and side effect is little |
| HUOXIANG ZHENGQI SHUI | Be tincture, contain ethanol (40-50%), zest is arranged, mouthfeel is poor, side effect is big, narrow application range is not suitable for old age, women, child and unsuitable alcoholic patient.But easily absorb instant effect |
| HUOXIANG ZHENGQI PIAN | Mouthfeel is good, and volatile ingredient easily scatters and disappears, and it is slow to take effect. |
| HUOXIANGZHENGQI KOUFUYE | Oral liquid, soft, nonirritant, be applicable to that old age, women, child reach and should not alcoholic patient take, curative effect reduces after adopting tween emulsifying volatile ingredient, and mouthfeel is poor. |
| The ageratum electuary | Volatile ingredient scatters and disappears and affects the treatment more, and dose is big, and mouthfeel is poor, takes inconvenience. |
| HUOXIANG ZHENGQI JIAONANG | The employing macroporous adsorbent resin extracts, and dose is few, but effective ingredient is lost many, weak curative effect. |
| The ageratum drop pill | Volatile ingredient easily scatters and disappears, and curative effect does not know that market does not see that dose is big, and mouthfeel is bad. |
| HUOXIANG ZHENGQI RUANJIAONANG | Mouthfeel is good, easily absorbs, and instant effect, side effect is little, and disintegration is long. |
HUOXIANG ZHENGQI YE capsule of the present invention stores that disintegrate has bigger advantage than soft capsule dosage form after 1 year.Following table is: HUOXIANG ZHENGQI RUANJIAONANG and sol capsule are stored contrast disintegration after a year:
| HUOXIANG ZHENGQI RUANJIAONANG | The HUOXIANG ZHENGQI YE capsule | |||
| Before the storage | After the storage | Before the storage | After the storage | |
| Sample 1 | 10 minutes | More than 60 minutes | 8 minutes | 20 minutes |
| Sample 2 | 11 minutes | More than 60 minutes | 9 minutes | 25 minutes |
| Sample 3 | 12 minutes | More than 60 minutes | 10 minutes | 24 minutes |
The liquid capsule of ageratum of the present invention adopts the hard capsule fill, compares with the soft capsule dosage form volatile oil content, and content is basicly stable before and after storing, show that liquid capsule and soft capsule have the function of identical reservation volatile effective component, seal tightly, identical with soft capsule, thus guarantee curative effect.Following table is: HUOXIANG ZHENGQI RUANJIAONANG and liquid capsule are stored volatile oil content (ml/100g content) comparison after a year:
| HUOXIANG ZHENGQI RUANJIAONANG | The HUOXIANG ZHENGQI YE capsule | |||
| Before the storage | After the storage | Before the storage | After the storage | |
| Sample 1 | 0.33 | 0.33 | 0.35 | 0.34 |
| Sample 2 | 0.34 | 0.33 | 0.33 | 0.32 |
| Sample 1 | 0.33 | 0.32 | 0.32 | 0.30 |
The liquid capsule of ageratum had both kept former special efficacy, can solve soft capsule disintegrate problem again, provided another new carrier for the oil-soluble medicine fill simultaneously.And improved image appearance, made it unusual, improved patient's degree of recognition.Following table is: HUOXIANG ZHENGQI RUANJIAONANG and the contrast of sol capsule appearance stability:
| Outward appearance | The content character | Filling process | |
| Soft capsule | Stable, small part is from the seam leakage of oil. | Former emulsifying process, easily layering. | Need wine to wash after the fill, oven dry etc. influence one of disintegrate factor. |
| Liquid capsule | Stable, seal tightly no leakage of oil. | Emulsifying process is good, and is not stratified, good fluidity. | Do not need wine to wash after the fill, oven dry etc. |
The liquid capsule of ageratum has onset time faster, solves patient's misery faster, and general curative effect is higher than soft capsule.Following table is: the contrast of HUOXIANG ZHENGQI RUANJIAONANG and liquid capsule clinical onset of action time and curative effect:
| Average onset time (h) | The total effects contrast | |||
| Significantly effectively | Effectively | Invalid | ||
| Soft capsule | 9-72 | 61.82％ | 26.36％ | 11.82％ |
| Liquid capsule | 4-36 | 62％ | 30％ | 8％ |
The key factor that influences the usefulness of capsule preparations is the selection of surfactant, and the present invention has investigated commercially available conventional surfactant for this reason, mainly comprises zwitterionic surfactant, investigates with settling ratio coefficient and preparation stability.(surface-active contents is 2.00%):
| Total grain number | Leakage of oil grain number | Distortion grain number | Oil spill rate % | Deformation rate % | |
| Zwitterionic surfactant (lecithin) | 1500 | 0 | 0 | 0 | 0 |
| Zwitterionic surfactant (betanin aminoacid) | 1500 | 12 | 18 | 0.8 | 1.2 |
| Anion surfactant class (triethanolamine soap) | 1500 | 15 | 15 | 0.1 | 0.1 |
| Anhydro sorbitol fatty acid ester (span 20) | 1500 | 15 | 24 | 1.0 | 1.6 |
| Polyethenoxy sorbitan fatty acid ester (Tween 80) | 1500 | 18 | 6 | 1.2 | 0.4 |
| Polyoxyethylene fatty acid ester class (Myrij) | 1500 | 12 | 6 | 0.8 | 0.4 |
| Polyoxyethylene aliphatic alcohol ether class (Brij) | 1500 | 6 | 18 | 0.4 | 1.2 |
| Polyoxyethylene-polyoxypropylene copolymer analog (pluronic) | 1500 | 12 | 18 | 0.8 | 1.2 |
Following table is: the settling ratio coefficient (10cm, 600turnpermin) (surface-active contents is 2.00%):
| The settling ratio coefficient | |
| Zwitterionic surfactant (lecithin) | 0.9286 |
| Zwitterionic surfactant (betanin aminoacid) | 0.8165 |
| Anion surfactant class (triethanolamine soap) | 0.7695 |
| Anhydro sorbitol fatty acid ester (span 20) | 0.7231 |
| Polyethenoxy sorbitan fatty acid ester (Tween 80) | 0.7061 |
| Polyoxyethylene fatty acid ester class (Myrij) | 0.5002 |
| Polyoxyethylene aliphatic alcohol ether class (Brij) | 0.5041 |
| Polyoxyethylene-polyoxypropylene copolymer analog (pluronic) | 0.5437 |
Because the toxicity of water soluble ionic surfactant is big, and zwitterionic surfactant or nonionic shape surfactant toxicity are very little, take all factors into consideration various factors, surfactant of the present invention is preferably zwitterionic surfactant.
The specific embodiment
Below in conjunction with embodiment the present invention is described further, but is not to be used for limiting protection scope of the present invention.
Embodiment 1:
According to become a full member the record in the preparation of the 5th 16 pages of HUOXIANG ZHENGQI RUANJIAONANG of new drug standard, prepare Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Rhizoma Pinelliae, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, Rhizoma Zingiberis ten medical material simply, wherein Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis 90-95% alcohol reflux secondary is (3 hours for the first time, 2 hours for the second time), filtrate merges, concentrating under reduced pressure becomes cream (relative density 1.18-1.20), and it is standby to obtain four flavor cream; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, changed water 2 times, and bubble is got the Rhizoma Pinelliae to the saturating heart, add Rhizoma Zingiberis 16.46g again, decocted with water secondary (3 hours for the first time, 2 hours for the second time); Poria, Pericarpium Arecae decocting in water secondary (1 hour for the first time, the 2nd time 1 hour), merge with Rhizoma Pinelliae liquid, filter, the mass ratio that is concentrated into above-mentioned three kinds of medical materials and water is 1: 1, and the adjustment of reuse ethanol makes that to contain that alcohol measures be 60%, left standstill 24 hours, filter, filtrate is condensed into three flavor cream (relative density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Radix Glycyrrhizae extractum is smashed, and adds water and makes its dissolving, transfers to that to contain alcohol amount be 65%, filters, and is condensed into GANGCAO GAO (relative density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Salad oil 252g and Cera Flava 8.1g are heated to 50 degree, add four flavor cream 135g, three flavor cream 21.6g, GANGCAO GAO 12.6g, oil of Herba Pogostemonis 1.35g, perilla oil 0.68g then, adding gel aluminium stearate 7.42g makes it melt postcooling entirely to room temperature, (mass ratio is 0.654: 1 to add surfactant glyceryl monostearate-span (80) then, the HLB value is 5) 11.25g, stir evenly, stir, grind to form homogeneous latex emulsion then, Emulsion is canned goes into hard capsule, obtains the liquid capsule of ageratum after sealing.
Embodiment 2:
According to become a full member the record in the preparation of the 5th 16 pages of HUOXIANG ZHENGQI RUANJIAONANG of new drug standard, prepare Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Rhizoma Pinelliae, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, Rhizoma Zingiberis ten medical material simply, wherein the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis 90-95% alcohol reflux secondary is (3 hours for the first time, 2 hours for the second time), filtrate merges, concentrating under reduced pressure becomes cream (relative density 1.18-1.20), and it is standby to obtain four flavor cream; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, changed water 2 times, and bubble is got the Rhizoma Pinelliae to the saturating heart, add Rhizoma Zingiberis 16.46g again, decocted with water secondary (3 hours for the first time, 2 hours for the second time); Poria, Pericarpium Arecae decocting in water secondary (1 hour for the first time, the 2nd time 1 hour), merge with Rhizoma Pinelliae liquid, filter, the mass ratio that is concentrated into above-mentioned three kinds of medical materials and water is 1: 1, and the adjustment of reuse ethanol makes that to contain that alcohol measures be 60%, left standstill 24 hours, filter, filtrate is condensed into three flavor cream (relative density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Radix Glycyrrhizae extractum is smashed, and adds water and makes its dissolving, transfers to that to contain alcohol amount be 65%, filters, be condensed into GANGCAO GAO (to density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Salad oil 247.05g and Cera Flava 10.35 are heated to 60 degree, add four flavor cream 139.5, three flavor cream 22.05g, GANGCAO GAO 15.25g, oil of Herba Pogostemonis 1.35g, perilla oil 0.68g then, adding gel aluminium stearate 9g makes it melt postcooling entirely to room temperature, (mass ratio is 0.654: 1 to add surfactant span 20-sorbester p17 then, the HLB value is 5) 4.5g, stir evenly, stir, grind to form homogeneous latex emulsion then, Emulsion is canned goes into hard capsule, obtains the liquid capsule of ageratum after sealing.
Embodiment 3:
Adopt the technology of embodiment 1 to add each material according to recipe quantity in the following table.Unit in the table: gram
| Prescription 1 | Prescription 2 | Prescription 3 | Prescription 4 | Prescription 5 | |
| Four flavor cream | 135.00 | 139.50 | 141.75 | 144.00 | 144.00 |
| Three flavor cream | 21.60 | 22.05 | 23.40 | 24.30 | 23.18 |
| GANGCAO GAO | 12.60 | 15.25 | 15.30 | 13.50 | 16.20 |
| Oil of Herba Pogostemonis | 1.35 | 1.35 | 1.80 | 1.80 | 20.25 |
| Perilla oil | 0.68 | 0.68 | 0.90 | 0.90 | 1.35 |
| Salad oil | 252.00 | 247.05 | 220.05 | 220.05 | 216.00 |
| Cera Flava | 8.10 | 10.35 | 9.90 | 9.00 | 11.25 |
| Glyceryl monostearate-sorbester p17 (mass ratio is 2: 3, and the HLB value is 4) | 11.25 | 0.00 | 31.50 | 0.00 | 18.00 |
| Span 20-sorbester p17 (mass ratio is 0.654: 1, and the HLB value is 5) | 0.00 | 4.50 | 0.00 | 13.50 | 0.00 |
| Aluminium stearate | 7.42 | 9.00 | 4.95 | 22.05 | 18.00 |
Embodiment 4:
According to become a full member the record in the preparation of the 5th 16 pages of HUOXIANG ZHENGQI RUANJIAONANG of new drug standard, prepare Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Rhizoma Pinelliae, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, Rhizoma Zingiberis ten medical material simply, wherein Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis 90-95% alcohol reflux secondary is (3 hours for the first time, 2 hours for the second time), filtrate merges, concentrating under reduced pressure becomes cream (relative density 1.18-1.20), and it is standby to obtain four flavor cream; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, changed water 2 times, and bubble is got the Rhizoma Pinelliae to the saturating heart, add Rhizoma Zingiberis 16.46g again, decocted with water secondary (3 hours for the first time, 2 hours for the second time); Poria, Pericarpium Arecae decocting in water secondary (1 hour for the first time, the 2nd time 1 hour), merge with Rhizoma Pinelliae liquid, filter, the mass ratio that is concentrated into above-mentioned three kinds of medical materials and water is 1: 1, and the adjustment of reuse ethanol makes that to contain that alcohol measures be 60%, left standstill 24 hours, filter, filtrate is condensed into three flavor cream (relative density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Then behind the drying under reduced pressure (60-80 ℃ ,-0.08Pa 8h), pulverized 80 mesh sieves; Obtain three flavor cream powder of fluffy exquisiteness; Radix Glycyrrhizae extractum is smashed, and adds water and makes its dissolving, transfers to that to contain alcohol amount be 65%, filters, and is condensed into GANGCAO GAO (relative density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Then behind the drying under reduced pressure (60-80 ℃ ,-0.08Pa 8h), pulverized 80 mesh sieves; Obtain the GANGCAO GAO powder of fluffy exquisiteness; Salad oil 225g and Cera Flava 40.5g are heated to 70 degree, add four flavor cream 135g, three flavor cream powder 16.65g, Radix Glycyrrhizae cream powder 11.25g, oil of Herba Pogostemonis 2.25g, perilla oil 0.68g then, add gel aluminium stearate 7.02g, make it melt postcooling entirely to room temperature, add surfactant phosphatidase 11 1.66g then, stir evenly, stir, grind to form homogeneous latex emulsion then, Emulsion is canned goes into hard capsule, obtains the liquid capsule of ageratum after sealing.
Embodiment 5:
According to become a full member the record in the preparation of the 5th 16 pages of HUOXIANG ZHENGQI RUANJIAONANG of new drug standard, prepare Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Rhizoma Pinelliae, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, Rhizoma Zingiberis ten medical material simply, wherein Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis 90-95% alcohol reflux secondary is (3 hours for the first time, 2 hours for the second time), filtrate merges, concentrating under reduced pressure becomes cream (relative density 1.18-1.20), and it is standby to obtain four flavor cream; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, changed water 2 times, and bubble is got the Rhizoma Pinelliae to the saturating heart, add Rhizoma Zingiberis 16.46g again, decocted with water secondary (3 hours for the first time, 2 hours for the second time); Poria, Pericarpium Arecae decocting in water secondary (1 hour for the first time, the 2nd time 1 hour), merge with Rhizoma Pinelliae liquid, filter, the mass ratio that is concentrated into above-mentioned three kinds of medical materials and water is 1: 1, and the adjustment of reuse ethanol makes that to contain that alcohol measures be 60%, left standstill 24 hours, filter, filtrate is condensed into three flavor cream (relative density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Get condensed cream spray drying (75-90 ℃) then; Obtain three flavor cream powder of fluffy exquisiteness; Radix Glycyrrhizae extractum is smashed, and adds water and makes its dissolving, transfers to that to contain alcohol amount be 65%, filters, and is condensed into GANGCAO GAO (relative density 1.30-1.40,80 ℃; Under the room temperature condition, relative density 1.10-1.30); Get condensed cream spray drying (75-90 ℃) then; Obtain the GANGCAO GAO powder of fluffy exquisiteness; Salad oil 139g and Cera Flava 31.5g are heated to 80 degree, add four flavor cream 139.5g, three flavor cream powder 16.2g, Radix Glycyrrhizae cream powder 11.7g, oil of Herba Pogostemonis 1.80g, perilla oil 0.90g then, add gel aluminium stearate 5.40g, make it melt postcooling entirely to room temperature, add surfactant phospholipid 9.00g then, stir evenly, stir, grind to form homogeneous latex emulsion then, Emulsion is canned goes into hard capsule, obtains the liquid capsule of ageratum after sealing.
Embodiment 6:
Adopt the technology of embodiment 5 to add each material according to recipe quantity in the following table.
Unit in the table: gram
| Prescription 6 | Prescription 7 | Prescription 8 | |
| Four flavor cream | 135.00 | 139.50 | 144.00 |
| Three flavor cream powder | 16.65 | 16.20 | 15.75 |
| The GANGCAO GAO powder | 11.25 | 11.70 | 12.15 |
| Oil of Herba Pogostemonis | 2.25 | 1.80 | 1.35 |
| Perilla oil | 0.68 | 0.90 | 1.12 |
| Salad oil | 225.00 | 234.00 | 243.00 |
| Cera Flava | 40.50 | 31.50 | 22.50 |
| Phospholipid | 11.66 | 9.00 | 6.34 |
| Aluminium stearate | 7.02 | 5.40 | 3.78 |
Claims (12)
1. the liquid capsule of an ageratum, it is characterized in that, it is made up of ageratum Emulsion and capsule shells, and described ageratum Emulsion is made up of following by weight percentage: ageratum extractum 36-39%, patchouli oil 0.3-0.5%, perilla oil 0.15-0.30%, substrate 55.7-61.3%, surfactant 1.41-2.50%, thickening agent 0.84-2.00%.
2. the liquid capsule of ageratum according to claim 1, it is characterized in that described ageratum Emulsion is made up of following by weight percentage: ageratum extractum 37-38%, patchouli oil 0.3-0.5%, perilla oil 0.15-0.30%, substrate 55.7-61.3%, surfactant 1.9-2.3%, thickening agent 0.84-2.00%.
3. the liquid capsule of ageratum according to claim 1 and 2 is characterized in that described substrate is vegetable oil and Polyethylene Glycol.
4. the liquid capsule of ageratum according to claim 3 is characterized in that described molecular weight polyethylene glycol is less than 600.
5. the liquid capsule of ageratum according to claim 1 is characterized in that described surfactant is the water soluble surfactant active.
6. the liquid capsule of ageratum according to claim 5 is characterized in that described water soluble surfactant active is an amphoteric ionic surfactant.
7. the liquid capsule of ageratum according to claim 6 is characterized in that described amphoteric ionic surfactant is a lecithin.
8. the liquid capsule of ageratum according to claim 1 is characterized in that described thickening agent is Cera Flava or glyceryl monostearate.
9. the liquid capsule of ageratum according to claim 1 is characterized in that described ageratum extractum water content is 6-9%.
10. the liquid capsular preparation method of the ageratum of a claim 1, it is characterized in that, it comprises the following steps: to adopt known method to prepare oil of Herba Pogostemonis, perilla oil and ageratum extractum respectively, 225-252 is restrained vegetable oil and 8.1-40.5 gram Cera Flava be heated to the 40-60 degree, add ageratum extractum, oil of Herba Pogostemonis and perilla oil then, adding gel makes it melt postcooling entirely to room temperature, add surfactant then, stir evenly, grind to form homogeneous latex emulsion then, Emulsion is filled into hard capsule, obtains the liquid capsule of ageratum after sealing.
11. the liquid capsular preparation method of ageratum according to claim 10, it is characterized in that, described ageratum extract making method is: with the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis 90-95% alcohol reflux, concentrating under reduced pressure becomes cream relative density 1.18-1.20, and it is standby to obtain four flavor cream; The Rhizoma Pinelliae cold water soak, bubble is got the Rhizoma Pinelliae to the saturating heart, add Rhizoma Zingiberis again, decocts with water; Poria, Pericarpium Arecae decocting in water merge with Rhizoma Pinelliae liquid, filter, and the mass ratio that is concentrated into above-mentioned three kinds of medical materials and water is 1: 1, and the adjustment of reuse ethanol makes that to contain the alcohol amount be 60%, leaves standstill, and filters, and filtrate is condensed into three flavor cream, 80 degree survey relative density 1.30-1.40; Radix Glycyrrhizae extractum is smashed, and adds water and makes its dissolving, transfers to that to contain alcohol amount be 65%, filters, and is condensed into GANGCAO GAO 80 degree and surveys relative density 1.30-1.40.
12. the liquid capsular preparation method of ageratum according to claim 11, it is characterized in that, described ageratum extract making method is: with the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis 90-95% alcohol reflux secondary, 3 hours for the first time, 2 hours for the second time, filtrate merges, and concentrating under reduced pressure becomes cream relative density 1.18-1.20, and it is standby to obtain four flavor cream; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, changed water 2 times, and bubble is got the Rhizoma Pinelliae to the saturating heart, add Rhizoma Zingiberis 16.46g again, decocts with water secondary, and 3 hours for the first time, 2 hours for the second time; Poria, Pericarpium Arecae decocting in water secondary, 1 hour for the first time, 1 hour for the second time, merge with Rhizoma Pinelliae liquid, filter, the mass ratio that is concentrated into above-mentioned three kinds of medical materials and water is 1: 1, the adjustment of reuse ethanol makes that to contain alcohol amount be 60%, left standstill 24 hours, and filtered, filtrate is condensed into three flavor cream, 80 degree and surveys relative density 1.30-1.40; Radix Glycyrrhizae extractum is smashed, and adds water and makes its dissolving, transfers to that to contain alcohol amount be 65%, filters, and is condensed into GANGCAO GAO 80 degree and surveys relative density 1.30-1.40.
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| CN 03154469 CN1259039C (en) | 2003-09-30 | 2003-09-30 | Huoxiang Zhengqi liquid capsule and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101474324B (en) * | 2007-12-31 | 2013-01-09 | 天津中新药业集团股份有限公司达仁堂制药厂 | Ageratum soft capsule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474324B (en) * | 2007-12-31 | 2013-01-09 | 天津中新药业集团股份有限公司达仁堂制药厂 | Ageratum soft capsule and preparation method thereof |
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