CN1257717C - Medicine for treating pertinacious porking diarrhea and its preparation method - Google Patents
Medicine for treating pertinacious porking diarrhea and its preparation method Download PDFInfo
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- CN1257717C CN1257717C CN 200310104074 CN200310104074A CN1257717C CN 1257717 C CN1257717 C CN 1257717C CN 200310104074 CN200310104074 CN 200310104074 CN 200310104074 A CN200310104074 A CN 200310104074A CN 1257717 C CN1257717 C CN 1257717C
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Abstract
The present invention relates to a medicine for treating refractory dysentery of a piglet, which is characterized in that the present invention is prepared from components of the following parts by weight: 1 to 3 parts of borax which is mixed with adjuvant of 10 parts of hydrochloric acid with a concentration of 5%, and 0.025 part of novocain to be made into an injection, or mixed with adjuvant materials of 1.5 parts of tannic acid and 0.5 part of starch to be made into a tablet, or mixed with adjuvant of 10 parts of hydrochloric acid with a concentration of 5%, and 0.09 part of artificial salt to be made into oral liquid. The medicine of the present invention has the functions of clearing heat, removing toxin, resisting bacteria and relieving dysentery, and the medicine used for treating refractory dysentery of a piglet has a rapid effect and high healing rate. A method for preparing the medicine has the advantages of convenient manufacturing technological flow path and low manufacturing cost. The medicine has the advantages of high efficiency, long acting time, low dose, small toxicity, no side effect, etc.
Description
(1), affiliated technical field
The present invention relates to a kind of Chinese medicine and preparation method thereof, particularly a kind of Chinese medicine for the treatment of intractable baby pig diarrhoea disease and preparation method thereof.
(2), technical background
Baby pig diarrhoea is one of common frdquently encountered disease, and its cause of disease mainly is the diarrhoea by piglet that escherichia coli cause and other animal.Clinical characters is that ash discharge white, yellow green or taupe thin pulp are stuck with paste feces, and the escherichia coli distributed pole is wide, does not present pathogenic effects usually, when resistance reduces, can cause the piglet morbidity.The west veterinary treatment is with medicines such as antibiotic, chemical synthesis preparations.Because the residual poison of antibiotic, chemicals etc. and the appearance of Resistant strain, bring many harmful effects to the development of human and livestock health and pig industry.Injection such as the Chinese medicine compound preparation of present treatment baby pig diarrhoea such as berberine, Herba Andrographis, Radix Isatidis, Herba Houttuyniae, Flos Lonicerae, Herba Portulacae, these medicines are just alleviated baby pig diarrhoea or are treated, and still can't solve the healing problem of intractable baby pig diarrhoea.
(3), summary of the invention
Therefore, still there is demand in vast raise pigs family or large-scale pig farm Chinese medicine preparation that curative effect is better treated intractable baby pig diarrhoea disease.Up to now, also do not find the report of any relevant medicine of the present invention, still belong to initiative.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has found the Chinese medicine injection medicine that the treatment of better curative effect intractable baby pig diarrhoea is arranged finally, thereby has finished the present invention.
The object of the invention just provides a kind of a kind of Chinese medicine injection medicine of quick-acting, efficient, long-acting, treatment intractable baby pig diarrhoea.
Another object of the present invention provides injection, the tablet of above-mentioned Chinese medicine, the preparation method of oral liquid.
The present invention treats the medicine of intractable baby pig diarrhoea disease, purpose is to realize by such technical scheme, it is by following components in part by weight: 1～3 part of Borax, and be equipped with 10 parts of adjuvant 5% hydrochloric acid, 0.025 part of injection of making of novocain or be aided with 10 parts of 5% hydrochloric acid, 0.005 part of berberine, 0.025 part of injection of making of novocain, perhaps be aided with 1.5 parts of tannic acids, 0.5 part of tablet of making of starch, perhaps be aided with 0.09 part of artificial salt, 10 portions of oral liquids of making of 5% hydrochloric acid.
The present invention is to be primary raw material with the Borax, is equipped with above-mentioned adjuvant, can make injection, also can make tablet, can also make oral liquid.Select Borax (to contain Na
2B
4O
710H
2O) Chinese medicine simply can effectively be treated the intractable baby pig diarrhoea.It is cool, slightly poisonous to get the sweet one-tenth of its Borax, the power of heat clearing away, detoxifcation, controlling the disease of intractable baby pig diarrhoea, the time effect of defeating by a surprise move arranged." 10% Borax all has inhibitory action with flat band method to escherichia coli, bacillus pyocyaneus, anthrax bacillus, bacterium flexneri, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, Bacillus proteus and staphylococcus, candida albicans according to " Chinese medicine voluminous dictionary " record; Can also suppress diphtheria corynebacterium, cattle type Brucella, Diplococcus pneumoniae, meningococcus and Hemolytic streptococcus etc. with paper disk method proof Borax, so can effectively treat intractable baby pig diarrhoea disease.
As injection, can be preferably: medicine of the present invention is by 2 parts of Boraxs, 10 parts of 5% hydrochloric acid, 0.025 part of injection of making of novocain.
As injection, can also be preferably: medicine of the present invention is by 2 parts of Boraxs, 10 parts of 5% hydrochloric acid, 0.005 part of berberine, 0.025 part of injection of making of novocain.
As tablet, be preferably: it can be by 2 parts of Boraxs, 1.5 parts of tannic acids, 0.5 part of tablet of making of starch.
As oral liquid, be preferably: it can be by 2 parts of Boraxs, 0.09 part of artificial salt, 10 portions of oral liquids of making of 5% hydrochloric acid.
The step of medicine of the present invention being made the preparation method of injection is:
(1) take by weighing or measure Borax, 5% hydrochloric acid, berberine, novocain by above-mentioned deal than accurately, standby;
(2) Borax is placed glass container, add 5% hydrochloric acid, stirring and dissolving, standby;
(3) novocain is joined in the hydrochloric acid borax soln for preparing in the above-mentioned steps (2), stirring and dissolving, pH value is 6; Filter then, embedding, sterilization, needed injection.
(4) on the hydrochloric acid Borax novocain solution basis that in above-mentioned steps (3), prepares, again berberine is added, stirring and dissolving, pH value is 6; Filter then, embedding, sterilization, another kind of needed injection.
The step of medicine of the present invention being made the preparation method of tablet is:
(1) accurately take by weighing Borax, tannic acid, starch by above-mentioned weight portion, respectively grind and be impalpable powder, standby.
(2) with above-mentioned Borax, tannic acid, 1/4 starch, mixing, granulation, drying add residue 3/4 starch then, mixing, tabletting, oven dry, bottling, needed tablet.
The step of medicine of the present invention being made the preparation method of oral liquid is:
(1) accurately take by weighing or measure Borax, artificial salt, 5% hydrochloric acid by above-mentioned weight portion, standby.
(2) Borax is placed glass container, add 5% hydrochloric acid, stirring and dissolving, standby.
(3) the hydrochloric acid borax soln in the above-mentioned steps (2) is added constantly stirring in the glass container that has filled artificial salt, make the artificial salt dissolving, pH value is 6; Filter then, embedding, sterilization, required oral liquid.
Owing to adopted technique scheme, medicine of the present invention to have the effect of heat clearing away, detoxifcation, antibiotic, dysentery relieving, the sick instant effect of treatment intractable baby pig diarrhoea, cure rate height.It is easy that the preparation method of this medicine has the technological process of production, low cost of manufacture, and have advantages such as efficient, long-acting, that dosage is little, toxicity is little and have no side effect.
(4), the specific embodiment
Below by the test example, further set forth the beneficial effect of medicine of the present invention, these experiments have comprised the pharmacodynamics test and the clinical observation on the therapeutic effect test of medicine of the present invention.
[test example 1] medicine of the present invention is to the external antibacterial observation of baby pig diarrhoea pathogenic bacteria
1. test material
1.1 medicine of the present invention, QINGDAXIAONUO, the happy group in no Xishan lot number 981216; Fluorine group ring, the big bright group in Henan lot number 980112; Enrofloxacin, LIJUNJING, the single new group in Zhejiang lot number 981125.
1.2 strain escherichia coli K
88Provide by the Chongqing City research institute of raising pigs; Dysentery bacterium, bacterium flexneri, Salmonella paratyphi are supplied with by Sichuan Province institute of microbiology.
1.3 conventional reagent and equipment that reagent and equipment Experiment on Microbiology are required
2. method
2.1 preparation for the reagent thing
Get in the 10.00g enrofloxacin adding 100ml distilled water and dissolve, it is standby to be equipped to 10% concentration.Face the time spent get the 10ml test solution with 10 times of distilled water dilutions for examination; Get two the steaming in the water of the big 100ml of adding of 10.00g celebrating and dissolve, it is standby to be made into 10% concentration.Face the time spent get the 10ml test solution with 10 times of distilled water dilutions for examination; Get 10.00g fluorine group with addition of going in the 100ml distilled water to dissolve, it is standby to be made into 10% concentration.Face the time spent get the 10ml test solution with 10 times of distilled water dilutions for examination.
2.2 it is external antibacterial
2.2.1 cup pipe method cut-off directly is 90mm, the flat pair of dish of high 16-17mm behind autoclaving, under the sterile working, injects 2% meat liquid agar culture medium 20ml through heating and melting respectively; Evenly at the bottom of the uncommon dish in stand, place horizontal stand, add respectively again after waiting to solidify and cultivated 18-24h for trying bacterium liquid 4-5ml on culture medium, inserting internal diameter then in each flat pair of dish is 6.0 ± 0.1mm, high 10.0 ± 0.1mm, 3 in external diameter 7.8 ± 0.1mm Oxford cup, supplying reagent liquid to splash into respectively each respectively organizes in the cup of Oxford, be as the criterion with cup full (it is outer to overflow cup), put in 37 ℃ of formula electrothermostats and cultivated 24 hours, use the vernier caliper measurement inhibition zone diameter.
2.2.2 antibacterial intensity criterion by " antibiotic drug inspection " and " Chinese medicine system is recorded with experience " as standard.Be inhibition zone diameter at 8.00mm or followingly be insensitive (one), inhibition zone diameter is low responsive (+) at 8.10-13.00mm, inhibition zone diameter is a medium sensitivity (++) at 13.10-19.00mm, and inhibition zone diameter is extremely sensitive (+++) at 19.10-25.00mm.
2.2.3 doubling dilution is measured the medicine inhibitory potency and is got 11 in the test tube that 13 * 100mm sterilization has tampon, and numbering is arranged on the test tube rack, under the sterile working, add aseptic broth bouillon 2.0ml in every Guan Zhongxian, what add sterilization then in the 1st arm is tried herb liquid 2.0ml, get 2.0ml behind the mixing and put into the 2nd pipe, and the like, take out 2.0ml up to the 9th pipe and discard, make into 1: 2,1: 4,1: 8,1: 16 ... etc. various concentration.The 10th pipe does not add medicine and only adds bacterium in contrast, whether is suitable for bacterial growth so that observe culture medium.Add in the 11st pipe and tried Chinese medicine 2.0ml, whether mixing is got 2.0ml and is discarded, and does not add to be tried bacterium, contaminated so that observation is tried Chinese medicine.Again meat soup has been cultivated the test organisms liquid of 6-8h, be diluted to 10 with aseptic meat soup
-3Concentration is got 0.1ml and is added respectively in above-mentioned 1 one 10 pipes, and permanent the mixing of the rearmounted 37 ℃ of water isolation type electric heating of mixing cultivated the 16-24h observed result in the case.If the meat soup muddiness, the expression bacterial growth (++, +++); If meat soup is limpid fully, expression antibacterial do not grow (--).
3. result
3.1 the outer bacteriostatic test result of cup pipe body of laws, medicine of the present invention is to escherichia coli K
88Inhibition zone diameter is 21.23 ± 1.41mm; To the Shiga bacillus inhibition zone diameter is 20.22 ± 1.24mm; To Fu Shi bacillus inhibition zone diameter is 22.12 ± 1.52mm; To the Salmonella paratyphi inhibition zone diameter is 23.22 ± 1.63mm.Experiment shows that medicine of the present invention is to escherichia coli K
88, dysentery bacterium, bacterium flexneri, Salmonella paratyphi be all extremely sensitive.See table 1 for details.
Table 1 medicine of the present invention is to the bacteriostatic tests of four kinds of dysentery bacillus unit as a result: (N=6)
| The medicine name | Drug level | Inhibition zone diameter (unit: mm) | |||||||
| Escherichia coli K88 X ± SD | Antibacterial intensity | Shiga bacillus X ± SD | Antibacterial intensity | Fu Shi bacillus X ± SD | Antibacterial intensity | Salmonella paratyphi X ± SD | Antibacterial intensity | ||
| Medicine of the present invention | 0.20g/ml | 21.32±1.41 | +++ | 20.22±1.24 | +++ | 22.12±1.52 | +++ | 23.22±1.63 | +++ |
| QINGDAXIAONUO | 1‰ | 0 | Drug resistance | 0 | Drug resistance | 0 | Drug resistance | 7.23±0.81 | Drug resistance |
| The enrofloxacin | 1‰ | 38.17±0.76 | +++ | 7.1±0.82 | Drug resistance | 8.0±0.91 | Drug resistance | 12.23±1.21 | ++ |
| Norfloxacin | 1‰ | 25.31±1.21 | +++ | 7.85±1.63 | Drug resistance | 8.01±0.71 | Drug resistance | 16.13±1.4 | ++ |
| LIJUNJING | 1‰ | 21.31±1.23 | +++ | 29.38±1.43 | +++ | 28.32±1.54 | +++ | 26.71+1.82 | +++ |
3.2 test tube is measured medicine inhibitory potency result of the test, medicine of the present invention is to escherichia coli K
88, dysentery bacterium, bacterium flexneri, Salmonella paratyphi all have stronger inhibitory action, it is to escherichia coli K
88Inhibitory potency is 1: 8; To the dysentery bacterium inhibitory potency is 1: 16; To the bacterium flexneri inhibitory potency is 1: 8; To the Salmonella paratyphi inhibitory potency is that experiment in 1: 32. shows that inhibitory potency all more than 1: 8, sees table 2 for details.
Table 2 medicine of the present invention is to four kinds of bacterial strain inhibitory potency measurement results
| Drug level | Bacterial strain | Test tube number and dilution factor | |||||||||||
| 1 1∶2 | 2 1∶4 | 3 1∶8 | 4 1∶16 | 5 1∶32 | 6 1∶64 | 7 1∶128 | 8 1∶256 | 9 1∶512 | 10 | 11 1∶2 | Tire | ||
| 0.20g/ml | Escherichia coli K88 | - | - | - | + | + | +++ | +++ | +++ | +++ | +++ | - | 1∶8 |
| 0.20g/ml | Shiga bacillus | - | - | - | - | + | + | +++ | +++ | +++ | +++ | - | 1∶16 |
| 0.20g/ml | The Fu Shi bacillus | - | - | - | + | + | +++ | +++ | +++ | +++ | +++ | - | 1∶8 |
| 0.20g/ml | Salmonella paratyphi | - | - | - | - | - | + | + | +++ | +++ | +++ | - | 1∶32 |
The safety and the toxicity test of [test example 2] medicine of the present invention
1. test material
1.1 medicine medicine of the present invention, cyclophosphamide, Hengrui Medicine Co., Ltd., Jiangsu Prov., lot number 991016; Yihong, east, Chongqing chemical reagent work, lot number 980806; The Jim Sa, Shanghai chemical reagent work, lot number 981224.
1.2 the Kunming white mice of the weight of animals 18 ± 2g is supplied with by the Luzhou Medical College Experimental Animal Center; The female large ear rabbit of body weight 4.0 ± 0.2kg (no pregnant) is bought back by the market of farm produce, Rongchang County.
2. method
2.1 mice LD
50Measure
2.2 mice chronic toxicity test
2.3 bone marrow cells in mice mutant test
2.4 mouse sperm distortion test
2.5 the safety testing of medicine of the present invention
3. result
3.1 the acute and chronic toxicity test result, mouse peritoneal injection LD
50, be 2268mg/kg;
Lumbar injection continuous 2
Week laboratory observation, tried the mice end and seen clinical unusually, internal organs do not have the visible pathological changes of naked eyes.
3.2 medicine of the present invention sees table 3 for details to the mouse marrow cell micro nuclear test result
Table 3 medicine of the present invention is to the unit that influences of mouse Bone marrow cells micronucleus rate: (mg/lg, individual, ‰)
3.3 medicine of the present invention sees table 4 for details to mouse marrow cell chromosome aberration test result
Table 4 medicine of the present invention is to the distored unit that influences of mouse marrow cell chromosome: (mg/lg, individual, ‰)
3.4 medicine of the present invention sees table 5 for details to the mouse sperm distortion test result
Table 5 medicine of the present invention is to mouse sperm distortion test unit as a result: (mg/] g, individual, ‰)
3.5 get 3 of does, adopt ear vein slowly to inject the medicine of the present invention of 200mg/kg, survey 1 time every 1h after the administration, survey altogether 3 times, fall 0.2 ℃ than administration precursor relaxing the bowels with purgatives of warm nature.Result of the test, medicine of the present invention does not have influence to normal rabbit body temperature.
3.6 medicine of the present invention is transferred to PH7 with sodium chloride, get 3 of does, get medicine of the present invention 2 (0.05-0.1ml) and splash in every rabbit conjunctiva of left eye capsule, stop 2min; Splash into the contrast of equivalent normal saline with right eye.Observe 3h.Result of the test, medicine of the present invention does not have hyperemia, edema, secretions to rabbit conjunctival.
3.7 get 3 of does, the hair at two ears middle part cut light.Left side ear middle part subcutaneous injection medicine 0.1ml of the present invention, the normal saline of auris dextra middle part subcutaneous injection equivalent is observed 3h.Result of the test, medicine of the present invention are injected down rabbit and are had no stimulation.
3.8 get 3 of does, medicine 1ml of the present invention is injected hunkers quadriceps femoris position, the left and right back of rabbit respectively, 1-3d puts to death rabbit, vertically cuts injection site muscle, observes to have or not hyperemia, edema, degeneration or necrosis etc.Result of the test, medicine of the present invention is non-stimulated to the intramuscular injection of rabbit leg portion.
The antiinflammatory action observation of [test example 3] medicine of the present invention
1. test material
1.1 medicine medicine of the present invention, Oleum Tiglii is provided by the Chinese medicine institute; Agar strip, the honest and clean Sargassum in Guangdong processing factory, lot number 011016.
1.2 the reagent preparation takes by weighing agar strip 1g, puts into beaker adding distil water 100ml, heating for dissolving is prepared 1% agar system inflammation liquid then, and it is standby to bottle; Measure Oleum Tiglii 2ml, dehydrated alcohol 20ml, distilled water 5ml, ether 73ml all puts into the beaker stirring and evenly mixing, and it is standby to bottle.
1.3 animal Wistar rat, kunming mice are supplied with by the Luzhou Medical College Experimental Animal Center.
2. method
2.1 rat paw edema method
[1,2]With 10 healthy male rats of 150-180g body weight, be divided into medicine of the present invention (experiment) group, solvent (contrast) group, lumbar injection medicine of the present invention, solvent liquid 1.0ml/kg respectively at random.Cause inflammation in the right back sufficient plantar subcutaneous injection 1% agar solution 0.1ml of rat behind the 10min.Cause scorching back every 1h with miking swelling limb thickness, be contrast with the left back sufficient sole of the foot, be the swelling degree with the difference of left and right sides metapedes sole of the foot thickness, 1-5h pedal swelling degree after the record administration.Biometrics is handled, and with matched group zero difference is arranged relatively.
The method 2.2 mouse ear swells
[1,2]With 20 male mices of 18 ± 2g body weight, be divided into medicine of the present invention (experiment) group, solvent (contrast) group at random.Every Mus left side ear is coated with 2% Oleum Tiglii, and auris dextra is made blank, distinguishes lumbar injection medicine of the present invention, solvent liquid 1.0ml/kg for two groups behind 30min, behind the 4h mice is put to death.Cut two ears along the auricle baseline, lay round auricle at same position respectively, weigh with ten thousand/photoanalysis with 9.0mm diameter card punch, with the heavy difference of (left ear weigh an auris dextra heavy) left and right sides ear as the swelling rate.Biometrics is handled, and with matched group zero difference is arranged relatively.
3. result
3.1 rat paw edema result of the test sees table 6 for details
Table 6 invention medicine is to the influence of normal rat paw edema
| Group | N | Different time pedal swelling degree (mm) (X ± SE) | ||||
| 1 | 2 | 3 | 4 | 5 | ||
| Medicine of the present invention | 5 | 5.1±0.4 ※ | 8.2±0.5 ※※ | 9.5±0.8 ※※※ | 9.2±0.9 ※※※ | 8.7±0.7 ※※ |
| Solvent | 5 | 7.5±0.6 | 10.4±0.6 | 14.7±.4 | 13.3±0.5 | 12.1±0.9 |
In the table: compare " ※ " expression p＜0.05 with matched group, " ※ ※ " represents p＜0.01, and " ※ ※ ※ " represents p＜0.001.
3.2 the mice ear result of the test sees table 7 for details
Table 7 medicine of the present invention is to the influence of normal mice ear
| Group | N | The swelling rate |
| Medicine of the present invention | 10 | 1.27±0.4 ※※ |
| Solvent | 10 | 1.73±0.3 |
In the table: compare with matched group. " ※ ※ " represents p＜0.01.
The efficacy of medicine observing of [experimental example 4] Drug therapy baby pig diarrhoea disease of the present invention
1. test material
1.1 medicine medicine of the present invention, norfloxacin, North China pharmacy group, lot number 991208; LIJUNJING, southwestern pharmacy group, lot number 990824.
1.2 it is treatment target that the clinical case of sucking the milk piglet that Rongchang County sow that pig farm and peasant household raise produced is planted by so-and-so in case source.
2. method
2.1 case diagnosis will be put the primary disease pilosity after birth age in 1-2 week suck the milk piglet.Present unexpected dysentery, ash discharge white, yellow green or taupe pulpous state loose stool, body temperature and appetite do not have obvious change, or loss of appetite.
2.2 every each intramuscular injection 2-4ml of dosage medicine group of the present invention injects twice every day, continuous use three days; Every each intramuscular injection norfloxacin 30mg/kg of Western medicine group, LIJUNJING 30mg/kg injects twice every day, continuous use three days.
2.3 after the criterion of therapeutical effect medication in five days dysentery stop, feces recovers attitude, appetite is recovered the normal recovery from illness that is; After the medication in five days dysentery stop, feces does not return to normal, appetite increases to effectively, after the medication in five days dysentery do not subtract, the feces character does not change, sb.'s illness took a turn for the worse or death is invalid.
3. result
Medicine of the present invention shows that to the sick treatment of baby pig diarrhoea observed result Chinese drug-treated group is treated 542 examples, 483 examples of fully recovering, and cure rate is 89.11%; Effective 49 examples, effective percentage are 9.04%; Invalid 10 examples, inefficiency are 1.85%.The sick total effective rate of Drug therapy baby pig diarrhoea of the present invention reaches 98.15%, and Chinese drug-treated group is Duoed 26.59 percentage points than the treatment total effective rate of Western medicine group, the remarkable p of poor heteropole＜0.01.Auspiciously see Table 8.
Table 8 medicine of the present invention is to the therapeutic outcome of baby pig diarrhoea
| Group | N/P | Recovery from illness | Effectively | Invalid | Total effective rate (%) | |||
| Head | ％ | Head | ％ | Head | ％ | |||
| Chinese drug-treated group | 542 | 483 | 89.11 | 49 | 9.04 | 10 | 1.85 | 98.15 |
| The Western medicine group | 524 | 167 | 31.68 | 209 | 39.88 | 58 | 28.44 | 71.56 |
| In: the west | ＜0.01 | |||||||
Come further to set forth the preparation method of medicine of the present invention by the following examples.
The injection preparation process of [embodiment 1] medicine of the present invention is as follows:
(1) take by weighing or measure 2 parts of Boraxs, 10 parts of 5% hydrochloric acid, 0.005 part of berberine, novocain 0.025 minute by above-mentioned deal than accurately, standby;
(2) Borax is placed glass container, add 5% hydrochloric acid, stirring and dissolving, standby;
(3) novocain is joined in the hydrochloric acid borax soln for preparing in the above-mentioned steps (2), stirring and dissolving, pH value is 6; Filter then, embedding, sterilization, needed injection.
(4) on the hydrochloric acid Borax novocain solution basis that in above-mentioned steps (3), prepares, again berberine is added, stirring and dissolving, pH value is 6; Filter then, embedding, sterilization, another kind of needed injection.
The preparation tablets step of [embodiment 2] medicine of the present invention is as follows:
(1) accurately take by weighing 2 parts of Boraxs, 1.5 parts of tannic acids, 0.5 part of starch by above-mentioned weight portion, respectively grind and be impalpable powder, standby.
(2) with above-mentioned Borax, tannic acid, 1/4 starch, mixing, granulation, drying add residue 3/4 starch then, mixing, tabletting, oven dry, bottling, needed tablet.
The oral liquid preparation process of [embodiment 3] medicine of the present invention is as follows:
(1) take by weighing or measure 2 parts of Boraxs, 0.09 part of artificial salt, 10 parts of 5% saline solutions by above-mentioned deal than accurately, standby;
(2) Borax is placed glass container, add 5% hydrochloric acid, stirring and dissolving, standby;
(3) the hydrochloric acid borax soln in the above-mentioned steps (2) is added constantly stirring in the glass container that has filled artificial salt, make the artificial salt dissolving, pH value is 6; Filter then, embedding, sterilization, required oral liquid.
Claims (8)
1. medicine for the treatment of the intractable baby pig diarrhoea is characterized in that it is a component by following deal: 1～3 part of Borax, and be equipped with 10 parts of adjuvant 5% hydrochloric acid, 0.025 part of novocain; Perhaps be equipped with 10 parts of adjuvant 5% hydrochloric acid, 0.005 part of berberine, 0.025 part of novocain; Perhaps be equipped with 1.5 parts of adjuvant tannic acids, 0.5 part of starch; Perhaps be equipped with 0.09 part of adjuvant artificial salt, 5% hydrochloric acid is made for 10 parts.
2. the medicine of treatment intractable baby pig diarrhoea as claimed in claim 1 is characterized in that: it is by 2 parts of the Boraxs of deal, 10 parts of 5% hydrochloric acid, 0.025 part of injection of making of novocain.
3. the medicine of treatment intractable baby pig diarrhoea as claimed in claim 1 is characterized in that: it is by 2 parts of the Boraxs of deal, 0.005 part of berberine, 0.025 part of novocain, 10 parts of injections of making of 5% hydrochloric acid.
4. the medicine of treatment intractable baby pig diarrhoea as claimed in claim 1 is characterized in that: it is by 2 parts of the Boraxs of deal, 1.5 parts of tannic acids, 0.5 part of tablet of making of starch.
5. the medicine of treatment intractable baby pig diarrhoea as claimed in claim 1 is characterized in that: it is by 2 parts of the Boraxs of deal, 0.09 part of artificial salt, and 5% hydrochloric acid is made oral liquid for 10 parts.
6. as the process for preparing medicine of claim 1 or 3 described treatment intractable baby pig diarrhoeas, its step is as follows:
(1) take by weighing or measure Borax, 5% hydrochloric acid, berberine, novocain by above-mentioned deal than accurately, standby;
(2) Borax is placed glass container, add 5% hydrochloric acid, stirring and dissolving, standby;
(3) novocain is joined in the hydrochloric acid borax soln for preparing in the above-mentioned steps (2), stirring and dissolving, pH value is 6; Filter then, embedding, sterilization, needed injection;
(4) on the hydrochloric acid Borax novocain solution basis that in above-mentioned steps (3), prepares, again berberine is added, stirring and dissolving, pH value is 6; Filter then, embedding, sterilization, another kind of needed injection.
7. as the medicine of claim 1 or 4 described treatment intractable baby pig diarrhoeas, its preparation process is as follows:
(1) accurately take by weighing Borax, tannic acid, starch by above-mentioned weight portion, respectively grind and be impalpable powder, standby;
(2) with above-mentioned Borax, tannic acid, 1/4 starch, mixing, granulation, drying add residue 3/4 starch then, mixing, tabletting, oven dry, bottling, needed tablet.
8. the medicine of claim 1 or 5 described treatment intractable baby pig diarrhoeas, its preparation process is as follows:
(1) take by weighing or measure Borax, artificial salt, 5% saline solution by above-mentioned deal than accurately, standby;
(2) Borax is placed glass container, add 5% hydrochloric acid, stirring and dissolving, standby;
(3) the hydrochloric acid borax soln in the above-mentioned steps (2) is added constantly stirring in the glass container that has filled artificial salt, make the artificial salt dissolving, pH value is 6; Filter then, embedding, sterilization, required oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310104074 CN1257717C (en) | 2003-12-19 | 2003-12-19 | Medicine for treating pertinacious porking diarrhea and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310104074 CN1257717C (en) | 2003-12-19 | 2003-12-19 | Medicine for treating pertinacious porking diarrhea and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1628697A CN1628697A (en) | 2005-06-22 |
| CN1257717C true CN1257717C (en) | 2006-05-31 |
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| CN 200310104074 Expired - Fee Related CN1257717C (en) | 2003-12-19 | 2003-12-19 | Medicine for treating pertinacious porking diarrhea and its preparation method |
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| CN (1) | CN1257717C (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107095059A (en) * | 2017-05-18 | 2017-08-29 | 佛山市高明区生产力促进中心 | It is a kind of to be effective against the feed for nursing that lower dysentery occurs for piglet |
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| Publication number | Publication date |
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| CN1628697A (en) | 2005-06-22 |
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