CN1255351A - Decrustation ointment for burn and its preparing process - Google Patents
Decrustation ointment for burn and its preparing process Download PDFInfo
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- CN1255351A CN1255351A CN98123208A CN98123208A CN1255351A CN 1255351 A CN1255351 A CN 1255351A CN 98123208 A CN98123208 A CN 98123208A CN 98123208 A CN98123208 A CN 98123208A CN 1255351 A CN1255351 A CN 1255351A
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Abstract
A decrustation ointment for treating burn and vasculitis is prepared from 12 Chinese-medicinal materials including gypsum, arnebia root, sufflower, peach kernel, Chinese angelica root, etc. Its advantages are high decrustation effect on level I, II and III of burn, and convenient application.
Description
It is main, the double vasculitic new drug of controlling that decrustation ointment for burn of the present invention relates to a kind of treatment burn, belongs to pure Chinese medicine compound ointment formulation.The invention still further relates to the manufacture method of this medicine.
Burn is to be acted on due to the human body by heating power, electric energy or radiation, chemistry etc., with heat injury for seeing more.If treatment is dealt with improperly, will cause and disable even threat to life, bring serious economy and social problem for family, society.At present, in the world burn more than the shallow III degree is not still had ideal medicine, particularly the burn medicine decrustation is not still had ideal Therapeutic Method.In existing numerous burn medicine, some burn medicines are disclosed as the Chinese patent communique, CN1065014, CN1068495, CN1075038, CN1079163 etc. owing to many reasons such as prescription and making, only have certain curative effect to I, II degree burn, but burn more than the shallow III degree is not still had desirable curative effect, the burn medicine decrustation is not still had desirable therapy.
The object of the present invention is to provide a kind ofly both had desirable curative effect to I, II degree burn, also especially the medicine decrustation especially of burning more than the shallow III degree was all had the burn treating ointment of special efficacy simultaneously.Another object of the present invention also is to provide the preparation method of this burn ointment.
The objective of the invention is to realize that by following technical proposals a kind of treatment burn is main, the double vasculitic medicine of controlling, be the medicament of being made by the following weight proportion raw material.
Gypsum Fibrosum 40-80 part Radix Arnebiae (Radix Lithospermi) 20-40 part Flos Carthami 30-50 part Semen Persicae 30-50 part
Radix Angelicae Sinensis 40-60 part Borneolum Syntheticum 7-15 part Moschus 1-3 part dried Alumen 10-20 part
Cera Flava 10-22 part Colophonium 15-25 part Oleum Verniciae fordii 250-500 part Oleum Sesami 250-500 part
Decrustation ointment for burn preferred weight proportioning of the present invention is:
7.5 parts of 60 parts of Borneolum Syntheticums of 40 parts of Radix Angelicae Sinensis of 40 parts of Semen Persicaes of 25 parts of Flos Carthamis of 60 portions of Radix Arnebiae (Radix Lithospermi)s of Gypsum Fibrosum
350 parts in 350 parts of Oleum Sesami of 12.5 parts of Oleum Verniciae fordii of 20 parts of Colophonium of 12.5 parts of Cera Flavas of 1.5 parts of dried Alumens of Moschus
The preparation method of decrustation ointment for burn of the present invention is:
A, take by weighing each raw material by formula proportion;
B, Borneolum Syntheticum, Moschus, dried Alumen, Cera Flava, Colophonium are put into a watt cylinder, add Oleum Verniciae fordii again, Oleum Sesami is mixed, and adds a cover and seals with wax, and goes into loess after 4 years, it is standby to take out medicinal liquid (being called for short the medicinal liquid that is unearthed);
C, the medicinal liquid that is unearthed add Gypsum Fibrosum, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Semen Persicae, Radix Angelicae Sinensis again, make medicine ointment with lapping-in method.
This medicament is an ointment, its exquisiteness, thickness, infiltration, heat radiation, clean wound, steady, nontoxic, non-stimulated, the not mould corruption of film, and hardening by being cooled, meet thermal softening, meeting water is milky white liquid, no slag, outward appearance is brown, gloss, and the salted cake fried in sesame oil abnormal smells from the patient is arranged.Be pure Chinese medicine compound ointment formulation, temporary called after decrustation ointment for burn (being " multiple-effect spirit burn ointment " originally).
Decrustation ointment for burn of the present invention shows through animal experiment and clinical test results: this decrustation ointment for burn has pain relieving, decrustation, protect wound, four is anti-(impervious, antiinflammatory, anticoagulant, anti-sense) and optimize three and be worth Quality Controls (1: 20-1: 4-1: 0.1) and blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting, comprehensive functions such as heat-clearing and toxic substances removing, not only to I, II degree burn has desirable curative effect, and especially burn more than the shallow III degree there is special efficacy, and Unihub decrustation, its big or small wound surface normal healing does not have scar function return rate can reach 100%, and its dark III degree has the life decrustation function that injures tendon 2/3 to repair substantially.Through clinical trial with facts have proved that this medicine has following ten big characteristics: 1. pain relieving: painless rate reached 100% after wound was treated medicine; 2. impervious: no edema rate reaches 100% behind the early stage medicine, edema (skin is stayed in its bubble sterilization tapping) person is arranged, short its recovery; 3. antiinflammatory: the inflammatory reaction control rate reaches 80-100% behind the kitchen range machine medicine; 4. anticoagulant (anastalsis that contains mutual restriction): activity ratio such as thrombolytic reaches 100% behind the kitchen range machine medicine; 5. anti-sense: do not reach 100% to more having infection rate behind the early stage medicine, wherein the infected's kitchen range machine can be changed corruption and carries pus, and the wound surface inflammation alleviates, and General Symptoms takes a turn for the better, and quickens slough and separates (decrustation), promotes healing; 6. burning crust: skin crust (dark II degree corium deep layer is impaired), eschar (shallow III degree, holostrome skin lesion have a small amount of sweat duct survival under its parabiosis and the corium), charcoal crust (carbonization), it on average is respectively decrustation in 7,9,15 days.7. protect wound: the kitchen range machine protects the wound rate with biomembrane (medicine film) and reaches 80-100%; 8. three values: the epithelium and the granulation tissue growth ratio of kitchen range machine size wound surface are peak value 1: 20-normal value 1: 4-threshold value 1: 0.1, the Quality Control rate reaches 100%.9. dosage form: the dosage form of this product is a water-soluble ointment, treats comprehensive optimization both for wound, does not emphasize the sterile working again.10. therapy: strengthened the adaptability of occlusive dressing greatly, enlarged the scope of application, both optimized traditional wrapping method, replaced the deficiency of therapies such as exposure again.
In addition, this product all has the effect that As the medicine took effect, the symptoms lessened to the vasculitis of connective tissue pathological changes and its acute-chronic purulent focus (contain vomica drain with) and face burns (containing imbedibility) with unearthed medicinal liquid.
1993-1996, the inventor compared test with decrustation ointment for burn and Pekinese's moist expose burn ointment.Exempt from 10 with family, cause into shallow III degree (eschar) with electric energy, treatment group application decrustation ointment for burn, its cure rate reaches 100%, is optimum with comparing 1: 0 (P<0.01).Please Medical Colleges Of Guilin do acute toxicity testing and skin irritation test to decrustation ointment for burn in 1998, the result shows that decrustation ointment for burn is to the LD of mouse stomach
50Greater than per kilogram of body weight 12.8 grams, no poisoning manifestations.Disposable with decrustation ointment for burn to the Cavia porcellus medication, its Cavia porcellus intact skin and the equal nonirritant of damaged skin.
Antibacterial tests: artificially with strain to 6 Kunming kind white mice wound surface, cause infection, the result shows that the treatment group obviously is better than matched group (P<0.05) with antibiotic, the antiinflammation of decrustation ointment for burn; Health test: 1996-1998 is put in box-packed each 10 box of this product 70-400g in county, the office of the Municipal Commission of Science and Technology, after 3 years as a result this sample gloss as before, not mould corruption, dry; Physicochemical identification: this product brown, soft, fine and smooth, the thickness of matter, in dissolving more than 42 ℃, but solute can keep focal drug effect constant in 24 hours, and meeting water (cold water or hot water) is milky white liquid, no slag.And do not emphasize the sterile working; The heat radiation test: divide 1,2 group, every group is the II degree wound surface at three places 1%, and it is all fixed with decrustation ointment for burn and four layers of yarn pad glue boron, and then on 2 groups of yarn pads, add thin film and cover, as a result 1 group 4 days all wound more, with 2 groups relatively be optimum, the heat radiation appropriateness of visible decrustation ointment for burn wound treatment; Protect the wound test: the medicine film applies wound and reduces amount of infusion 50%; Permeability test: emerge 1 minute the time from sweat duct when wound surface causes severe pain, oozing of blood and body fluid, after 30 seconds, its pain sensation and exudate all stop with decrustation ointment for burn; The defat test: this product is substrate with oils, and its comprehensive saponification defat is a water-soluble ointment, all presents milky white liquid so this product is met hot and cold water, there is no slag.Outer this, this product and burn cream both domestic and external (as local specialties such as the U.S.) are done controlled trial, the result shows that every index of medicine of the present invention is optimum (P<0.01).
Clinical drug of the present invention is used 884 examples, and wherein to the decrustation of shallow III degree (eschar) Unihub, normal healing does not have scar, and the function return rate reaches 100%, has the life decrustation function that injures tendon 2/3 to repair substantially to dark III degree, and return rate reaches 100%, and no sequel.Medicine of the present invention significantly is better than various burn cream.
Now lifting several cases is described below:
Example one, Luo, man 4 years old, 3 groups on liberation road, Xinning County metal and stone town.Because of boiled water is scalded limbs, 4 days (980 yuan of medical fees) of local treatment, infection fever.Look into: 39.2 ℃ of body temperature, kitchen range holds: wound surface has 1-3 the medicine crust that coin is thick, under the crust pus is arranged, the gross area 30%, the sterilization back finds that wound surface develops into similar honeycomb group inflammation, as right upper arm and chest fluid portion is that shallow III degree accounts for 2%, and the back of the body, buttocks and both thighs have dark II degree to account for 8%, surplusly accounts for 20% for shallow II degree, treat with the decrustation ointment for burn wound, suit the medicine to the illness and the whole body supporting treatment in conjunction with conventional Chinese medicine and western medicine, body temperature is reduced to normally after 24 hours, and General Symptoms is separated kind, 35 days normal healings of wound surface do not have scar, and function is normal again.685 yuan of medical fees.
Example two: foxtail millet so-and-so, man 32 years old, 3 groups in He Lian village, town, field, the pool, Shaoyang County.Because of gunpowder burn limbs are gone to a doctor.Kitchen range holds: hair, eyebrow, vibrissa all burn up, and face are impaired, and wound surface is penetrated the black eschar of some Kong Quncheng of burning by spark, shape chalybeate emery cloth, the crust district analgesia of head, neck, breast and upper and lower extremities, still district accounts for 38% and is shallow III degree, kitchen range machine edema is very serious, and there is severe pain at positions such as wound week, and vesicle string district accounts for 32% and is the II degree, the gross area 70%, treat with the decrustation ointment for burn wound, suit the medicine to the illness and whole body supporting treatment, 29 days normal healings in conjunction with Chinese medicine and western medicine, wound surface does not have scar, and the face function is all repaired.362 yuan of medical fees.
Example three: Zhang, man, 49 years old, the cadre of Qianyang county Party school.Because of the left parotid gland carcinoma glanular cell, once 9 years successively in the city, six recurrences of provincial hospital excision, the inventor injects the tumor base November 8 nineteen eighty-two with homemade chemical agent and reaches cheekbone shell medicine and cut, and makes that the left facial part wound surface is long-pending to account for 1%, is dark III degree.With decrustation ointment for burn 82 days, wound surface normal healing, wound scar light is thin, no sufferings, no hypertrophy, do not have fortune and hinder (being called for short good scar), after follow up a case by regular visits to and do not recur in 16 years.101 examples are controlled in such chemical burn altogether, through with letters and calls, are good scar.
1978-1998, this medicine are on Tang Tian city, Shaoyang County, Hunan Province hospital, Xinning County HUANGLONG hospital and other places, and be clinical openly on probation to all kinds of burns, has been subjected to medical circle and patient's popular welcome and praise because of the curative effect highly significant.Successively there are how tame news unit such as " Hunan science and technology newspaper ", Hunan television station, Journal of Traditional Chinese Medicine, Chinese combination of Chinese and Western medicine magazine and newpapers and periodicals to report.And the international medical science academic conference in ' 96, international Chinese medicine in year Hong Kong, ' 98 and combination of Chinese and Western medicine academic exchange conference exchange and prize-winning glass, bonus.Invite Hunan Inst of Traditional Chinese Medicine He Shi, county three grade expert professors to this drug effect should set up the project assessment by Xinning County health bureau, county State Scientific and Technological Commission tissue in June, 1996, and unanimously adopted, and this medicine has now caused the very big concern and the attention of medical circle at home and abroad.
Embodiment: select for use quality to meet the raw material of Chinese medicine of Chinese Pharmacopoeia regulation, take by weighing Gypsum Fibrosum 60Kg by prescription, Radix Arnebiae (Radix Lithospermi) 25Kg, Flos Carthami 40Kg, pink 40Kg, Radix Angelicae Sinensis 60Kg, Borneolum Syntheticum 7.5Kg, Moschus 1.5Kg, dried Alumen 12.5Kg, Cera Flava 20kg, Colophonium 12.5kg, Oleum Verniciae fordii 350Kg, Oleum Sesami 350Kg.Borneolum Syntheticum, Moschus, peak wax, dried Alumen, Colophonium are put into watt cylinder and Oleum Verniciae fordii, Oleum Sesami mixing, add a cover and seal with wax, go into loess 3 chis, cover after 4 years, take out standby.Above unearthed medicinal liquid is added Gypsum Fibrosum, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Semen Persicae, Radix Angelicae Sinensis again, make the externally-applied ointment medicament with lapping-in method.Pack with medical type toothpaste type plastic tube, mark medicine name, cure mainly, function, usage, consumption etc.
Claims (4)
1, a kind of treatment burn is the main and double vasculitic medicine of controlling, and it is characterized in that it is the medicament of being made by the following weight proportion raw material.
Gypsum Fibrosum 40-80 part Radix Arnebiae (Radix Lithospermi) 20-40 part Flos Carthami 30-50 part Semen Persicae 30-50 part
12.5 parts of Radix Angelicae Sinensis 40-60 part Borneolum Syntheticum 7-15 part Moschus 1-3 part dried Alumens
20 parts of Colophonium 15-25 of Cera Flava part Oleum Verniciae fordii 250-500 part Oleum Sesami 250-500 part
2, a kind of treatment burn according to claim 1 is the main and double vasculitic medicine of controlling, and it is characterized in that the weight proportion of its preferred each raw material is:
7.5 parts of 60 parts of Borneolum Syntheticums of 40 parts of Radix Angelicae Sinensis of 40 parts of Semen Persicaes of 25 parts of Flos Carthamis of 60 portions of Radix Arnebiae (Radix Lithospermi)s of Gypsum Fibrosum
350 parts in 350 parts of Oleum Sesami of 12.5 parts of Oleum Verniciae fordii of 20 parts of Colophonium of 12.5 parts of Cera Flavas of 1.5 parts of dried Alumens of Moschus
3, treatment burn according to claim 1 and 2 is the main and double vasculitic medicine of controlling, it is characterized in that this medicament is an ointment, exquisiteness, thickness, infiltration, heat radiation, clean wound, steady, nontoxic, non-stimulated, the not mould corruption of film, harden by being cooled, meet thermal softening, chance water is milky white liquid, no slag, and outward appearance is a brown, gloss has the salted cake fried in sesame oil abnormal smells from the patient.
4, a kind of treatment burn according to claim 1 and 2 is the main and double vasculitic medicine of controlling, and its preparation is characterised in that:
A, take by weighing each raw material by formula proportion;
B, Borneolum Syntheticum, Moschus, Cera Flava, dried Alumen, Colophonium are gone in watt cylinder, add Oleum Verniciae fordii, Oleum Sesami mixing again, add a cover and seal with wax, go into loess after 4 years, it is standby to take out medicinal liquid;
C, the medicinal liquid that is unearthed add Gypsum Fibrosum, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Semen Persicae, Radix Angelicae Sinensis again, make medicine ointment with lapping-in method.
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CN98123208A CN1067902C (en) | 1998-11-30 | 1998-11-30 | Decrustation ointment for burn and its preparing process |
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CN98123208A CN1067902C (en) | 1998-11-30 | 1998-11-30 | Decrustation ointment for burn and its preparing process |
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CN1255351A true CN1255351A (en) | 2000-06-07 |
CN1067902C CN1067902C (en) | 2001-07-04 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102198159A (en) * | 2011-06-08 | 2011-09-28 | 李会珍 | Medicament for the treatment of burns and sore and ulcer diseases, and wound plaster made of the same |
CN102343073A (en) * | 2011-09-21 | 2012-02-08 | 王丽娟 | Medicament for treating vasculitis and cerebral infarction |
CN104117088A (en) * | 2013-04-26 | 2014-10-29 | 张勇 | Liquid wound dressing used for wound healing and preparation method thereof |
CN112716997A (en) * | 2021-02-25 | 2021-04-30 | 陈小杰 | A Chinese medicinal composition for treating skin burn and scald, and its preparation method |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1044973C (en) * | 1993-11-05 | 1999-09-08 | 郑州铁路分局医院 | Burn ointment |
CN1108122A (en) * | 1994-12-20 | 1995-09-13 | 刘磊 | Medicinal prepn. for treating scald and its prepn. method |
CN1046419C (en) * | 1995-04-24 | 1999-11-17 | 刘景文 | Burn and scald curing ointment |
-
1998
- 1998-11-30 CN CN98123208A patent/CN1067902C/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102198159A (en) * | 2011-06-08 | 2011-09-28 | 李会珍 | Medicament for the treatment of burns and sore and ulcer diseases, and wound plaster made of the same |
CN102343073A (en) * | 2011-09-21 | 2012-02-08 | 王丽娟 | Medicament for treating vasculitis and cerebral infarction |
CN104117088A (en) * | 2013-04-26 | 2014-10-29 | 张勇 | Liquid wound dressing used for wound healing and preparation method thereof |
CN112716997A (en) * | 2021-02-25 | 2021-04-30 | 陈小杰 | A Chinese medicinal composition for treating skin burn and scald, and its preparation method |
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Publication number | Publication date |
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CN1067902C (en) | 2001-07-04 |
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