CN1251674C - Medication combinaton for treating skin disease and preparation technique - Google Patents
Medication combinaton for treating skin disease and preparation technique Download PDFInfo
- Publication number
- CN1251674C CN1251674C CNB2003101033682A CN200310103368A CN1251674C CN 1251674 C CN1251674 C CN 1251674C CN B2003101033682 A CNB2003101033682 A CN B2003101033682A CN 200310103368 A CN200310103368 A CN 200310103368A CN 1251674 C CN1251674 C CN 1251674C
- Authority
- CN
- China
- Prior art keywords
- fat
- skin
- pharmaceutical composition
- present
- moroxydine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a medicine composition for treating dermatosis, which is prepared from moroxydine, lignocaine, sheep seminal vesicle fat, octadecanol, vaseline, glycerine, potassium sorbate, tween 80 and water for injection. Simultaneously, the present invention also discloses preparation technology of the medicine composition for treating dermatosis. The medicine composition of the present invention has the advantages of obvious medicine effect, durable medicine potency, strong sterilization capability, high speed of alleviating itching and pain, obvious curative effect, no toxic side effect, low cost, simple preparation technology, virus resistance and skin metabolism promotion, and is widely suitable for treating various kinds of skin burn, mosquito bite, thorn damage, skin breakage, comedo, acne, herpes, varicella, etc.
Description
Technical field
The present invention relates to dermopathic pharmaceutical composition of a kind of treatment and production technology thereof, particularly relate to a kind of pharmaceutical composition and production technology thereof for the treatment of skin burn and various skin infections.
Technical background
Human body skin burn and by behind virus, the bacterial infection, occur red and swollen, fester, symptom such as pain, pruritus is felt bad.Prior art mainly is to adopt the way of smearing various Chinese medicines or oral western medicine, but effect is not very desirable, and major defect is pain relieving, antipruritic take effect slow, weak effect, leaves scar after the healing.
Summary of the invention
The objective of the invention is to overcome the defective of prior art,, provide a kind of pharmaceutical composition and production technology thereof for the treatment of skin burn and various skin infections by improving prescription and production technology.
The present invention takes following technical scheme.
It is as follows that the present invention treats dermatosis composition of medicine prescription (weight portion):
Metronidazole 20-60 part
Lincomycin 50-150 part
Moroxydine 30-90 part
Lignocaine 40-120 part
Sheep spermary fat 120-360 part
Octadecanol 50-200 part
Vaseline 50-200 part
Glycerol 100-300 part
Potassium sorbate 3-9 part
Tween 80 40-120 part
Water for injection adds to 640-1800 part
Metronidazole in the drug regimen composition formula of the present invention is an anti anaerobic bacteria infection medicine;
But lincomycin both can anti-aerobe also anaerobe resistant.Skin burn and infect in to prevent that especially anaerobic infection from causing deep layer to fester and form scar.Metronidazole and lincomycin merge use can be to the drug resistance of anaerobe resistant;
Moroxydine is an antiviral drugs;
Lignocaine has local anaesthesia pain relieving, itching-relieving action;
Other are the matrix formulations that skin protection is used.
What be worth proposition is that the present invention as main matrix, replaces the main matrix stearic acid in traditional ointment with special sheep spermary fat.Sheep spermary lipid substrate of the present invention has unique curative effect and unique moist, protective effect to human body skin.
The present invention treats the pharmaceutical composition production technology of skin burn and various skin infections:
1, sheep spermary fat preparation: get healthy and strong ram seminal vesicle and remove muscle and connective tissue, clean refining sheep spermary with Klorvess Liquid, levigate to 1 micron diameter suspension in colloid mill, centrifugal, the milky fat flushing that floats over this centrifugal liquid upper strata is a desired fats, filter the centrifugal liquid supernatant with two-layer gauze and obtain sheep spermary fat, freezing standby.
2, take by weighing the heating congruent melting of putting together of sheep spermary fat, octadecanol, vaseline respectively, filter, remove impurity, 40 ℃-60 ℃ of filtrate insulations are standby.
3, measure water for injection, metronidazole, lincomycin, Moroxydine, lignocaine are dissolved fully in wherein, add the potassium sorbate of weighing, stir and make its dissolving, add glycerol, Tween 80 again, stir evenly, be heated to 75 ℃-80 ℃, be incubated standby.
4, in the hydrothermal solution of the filtrate that 2 steps the were made liquid phase that 3 steps of adding make under stirring rapidly, emulsifying is stirred to condensation and promptly gets oil-in-water type (O/W) ointment.
Pharmaceutical composition property of medicine performance of the present invention is rapid, and the efficacy of a drug is lasting, and sterilizing power is strong, particularly the deep skin anaerobe there is good killing effect, antipruritic pain relieving is fast, and the curative effect height is cured the no cicatrix in back, have no side effect, cost is low, and production technology is simple, and has antivirus action, stimulating cellular growth promotes the effect of skin metabolism.
Using method: directly be applied in ill skin surface, every day three times.
The specific embodiment
Below the specific embodiment of the present invention is done to describe in further detail.
Embodiment 1
Prescription: metronidazole 30g
Lincomycin 50g
Moroxydine 40g
Lignocaine 40g
Sheep spermary fat 360g
Octadecanol 150g
Vaseline 200g
Glycerol 120g
Potassium sorbate 9g
Tween 80 100g
Water for injection 1000g
Production technology:
1, get 500 in healthy and strong ram seminal vesicle, remove muscle and connective tissue, Klorvess Liquid 7kg with 0.154mol/L concentration washs at twice, wash with 4.5kg for the first time, use for the second time 2.5kg drip washing, the Klorvess Liquid of reuse 7.5kg 0.154mol/L concentration and refining sheep spermary mix, in colloid mill, be milled to the 1 micron grain liquid that suspends, this suspension in refrigerated centrifuger with under 4500 rev/mins and-2 ℃ of temperature centrifugal 45 minutes, the milky fat that floats over the centrifugal liquid upper strata filters the supernatant with two-layer gauze, the milky fat on the gauze is stayed in collection, and is freezing standby.
2, take by weighing sheep spermary fat 360g, octadecanol 150g, the vaseline 200g common fusing of heating of putting together respectively,, remove impurity with four layers of filtered through gauze, filtrate be incubated 60 ℃ standby.
3, measure 100ml water for injection (fresh), metronidazole 30g, lincomycin 50g, Moroxydine 40g, lignocaine 40g are dissolved wherein, stirring and dissolving is complete, add potassium sorbate 9g, stirring makes its dissolving, adds glycerol 120g again, Tween 80 amount 100g stirs evenly, and heat tracing to 80 is ℃ standby.
4, in the aqueous solution of the filtrate that 2 steps the were made liquid phase that 3 steps of adding make under stirring rapidly, be incubated 75 ℃, emulsifying is stirred to condensation and promptly gets ointment.
5, quality determination qualified after, 1000 of fills, the packing, enter the storehouse.
Skin infection diseases such as pharmaceutical composition of the present invention can be widely used in that various skin burns, mosquito bite, stab, broken skin and acne, acne, herpes, chickenpox.
The clinical use observed result of the ointment that makes sees the following form.The clinical efficacy standard:
Cure: pruritus is ended, and it is normal that skin lesion recovers, and drug withdrawal is not recurrence after 3 months;
Produce effects: pruritus is ended, and it is normal that skin lesion recovers substantially;
Take a turn for the better: pruritus alleviates, and it is unstable, flickering that skin lesion recovers;
Invalid: medication did not have any effect in 3 days.
| The dermatosis title | Therapeutic effect | Total effective rate | ||||
| Case load | Cure | Produce effects | Take a turn for the better | Invalid | ||
| Burn | 57 | 30 | 10 | 10 | 7 | 88％ |
| Mosquito is bitten | 91 | 50 | 20 | 13 | 8 | 91％ |
| Stab, break skin | 11 | 8 | 1 | 1 | 1 | 91％ |
| Acne | 26 | 17 | 4 | 4 | 1 | 96％ |
| Acne | 152 | 70 | 60 | 20 | 2 | 97％ |
| Herpes | 33 | 30 | 1 | / | 2 | 94％ |
| Chickenpox | 37 | 5 | 21 | 8 | 3 | 92％ |
Embodiment 2
Prescription: metronidazole 60g
Lincomycin 100g
Moroxydine 80g
Lignocaine 80g
Sheep spermary lipase 37 20g
Octadecanol 300g
Vaseline 400g
Glycerol 240g
Potassium sorbate 18g
Tween 80 100g
Water for injection 2000g
Production technology is with embodiment 1.
Claims (3)
1, the dermopathic pharmaceutical composition of a kind of treatment is characterized in that each raw material weight proportioning is as follows:
Metronidazole 20-60 part
Lincomycin 50-150 part
Moroxydine 30-90 part
Lignocaine 40-120 part
Sheep spermary fat 120-360 part
Octadecanol 50-200 part
Vaseline 50-200 part
Glycerol 100-300 part
Potassium sorbate 3-9 part
Tween 80 40-120 part
Water for injection adds to 640-1800 part.
2, the production technology of the dermopathic pharmaceutical composition of the described treatment of claim 1 is characterized in that comprising the steps:
(1) get healthy and strong ram seminal vesicle and remove muscle and connective tissue, clean with Klorvess Liquid, levigate in colloid mill, centrifugal, filter, collect sheep spermary fat, freezing standby;
(2) take by weighing the heating congruent melting of putting together of sheep spermary fat, octadecanol, vaseline, filter, remove impurity, 40 ℃-60 ℃ of filtrate insulations are standby;
(3) measure water for injection, metronidazole, lincomycin, Moroxydine, lignocaine dissolving in wherein, are added potassium sorbate fully, stir and make its dissolving, add glycerol, Tween 80 again, stir evenly, be heated to 75 ℃-80 ℃, be incubated standby;
In the hydrothermal solution of the filtrate liquid phase that adding (3) step makes under stirring rapidly that (4) (2) step is made, emulsifying is stirred to condensation and promptly makes ointment.
3, the production technology of the dermopathic pharmaceutical composition of treatment according to claim 2 is characterized in that sheep spermary is milled to the 1 micron grain liquid that suspends in colloid mill, in refrigerated centrifuger with under 4500 rev/mins ,-2 ℃ temperature centrifugal 45 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101033682A CN1251674C (en) | 2003-10-31 | 2003-10-31 | Medication combinaton for treating skin disease and preparation technique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101033682A CN1251674C (en) | 2003-10-31 | 2003-10-31 | Medication combinaton for treating skin disease and preparation technique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1539430A CN1539430A (en) | 2004-10-27 |
| CN1251674C true CN1251674C (en) | 2006-04-19 |
Family
ID=34333266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101033682A Expired - Fee Related CN1251674C (en) | 2003-10-31 | 2003-10-31 | Medication combinaton for treating skin disease and preparation technique |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1251674C (en) |
-
2003
- 2003-10-31 CN CNB2003101033682A patent/CN1251674C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1539430A (en) | 2004-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101062343A (en) | External application Chinese traditional medicine for treating dermatoma, tinea, wart and herpes | |
| CN1943600A (en) | Medicinal composition containing American cockroach and its ethanol extract and new use | |
| CN1272038C (en) | Preparation of Chinese medicinal suppository for treating female chronic cervicitis | |
| CN1903289A (en) | Gel for treating hemorrhoidal anus and rectum diseases, and its prepn. method | |
| CN1883599A (en) | Chinese medicinal composition for treating women's episioitis or colpitis and method for preparing same | |
| CN1251674C (en) | Medication combinaton for treating skin disease and preparation technique | |
| CN1772127A (en) | Detoxicating and blood circulation promoting ointment and its prepn | |
| CN101053612A (en) | External applied traditional Chinese medicine vagina cleaning agent for curing gynecopathy and vagina cleaning ointment thereof | |
| CN1279952C (en) | Medicine for treating burns and scalds | |
| CN1084196C (en) | Burn ointment | |
| CN111939194A (en) | Traditional Chinese medicine formula for treating breast tumor and uterine tumor and preparation method thereof | |
| CN1296084C (en) | Externally applied medicine for treating chronic dermatopathy | |
| CN1330365C (en) | Compound preparation its preparing method and use | |
| CN1127970C (en) | Ointment for treating burn and its preparing process | |
| CN1172701C (en) | Medicine for curing herpes zoster | |
| CN1285351C (en) | Ointment for treating breach of skin | |
| CN101053636A (en) | Medicinal composition for treating prostate and its preparation method and application | |
| CN1923230A (en) | Medicine for treating rheumatism and rheumatoid disease, and its preparation method | |
| CN1076864A (en) | Skin health-care liquid | |
| CN1247216C (en) | External used Chinese medicinal ointment for scald and its preparation | |
| CN1253194C (en) | Externally used Shueryin lotion for treating colpitis and its preparation | |
| CN1528418A (en) | Chinese medicine for treating pelvis, nephritis and kidney injury and preparing method thereof | |
| CN100502940C (en) | Healing agent for intestinal mucosal injury and its preparation method | |
| CN1239180C (en) | Medicine for treating piles | |
| CN1839882A (en) | Medicament composition for treating tinea pedis and tinea corporis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |