CN1251361A - Process for extracting resveratrol from Chinese medicine giant knotweed root - Google Patents
Process for extracting resveratrol from Chinese medicine giant knotweed root Download PDFInfo
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- CN1251361A CN1251361A CN 99115156 CN99115156A CN1251361A CN 1251361 A CN1251361 A CN 1251361A CN 99115156 CN99115156 CN 99115156 CN 99115156 A CN99115156 A CN 99115156A CN 1251361 A CN1251361 A CN 1251361A
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Abstract
The extraction process of medicinal raw material resveratrol includes the following steps: adding complex enzyme to powdered bushy knotweed root raw material; making zymolysis reaction for 48-72 hr. under the condition of constant temp. to obtain the enzymolyzed raw material; adopting solvent extraction and concentration processes to obtain the intermediate product containing resversatrol, refining to obtain the invented product. It possesses the advantages of rich raw material source, simple process, high yield and low cost.
Description
What the present invention relates to is a kind of extraction process of medicinal raw material trans-resveratrol.
Trans-resveratrol (Resveratrol, 3,5,4 ' trihydroxy-is anti--toluylene), have another name called resvertrol, the pharmacologically active of aspect such as anticancer because of having, antibiotic, anti-inflammatory, antianaphylaxis, anti-oxidant, reducing blood-fat is widely used in fields such as food, healthcare products, makeup.The source of trans-resveratrol mainly is to extract from Pericarpium Vitis viniferae and some beans at present, and content is very limited.The content of the trans-resveratrol in the Pericarpium Vitis viniferae is considered to the highest, also only reaches 0.5～1/0,000.The Resveratrol content that exists with the form of glucoside in China's Chinese medicine giant knotweed of producing of Sichuan, theoretical value is 200 times of Pericarpium Vitis viniferae! And giant knotweed always only uses as Chinese medicinal materials, and consumption seldom causes giant knotweed seriously unsalable, has wasted valuable resource.
The present invention seeks to open up the source of trans-resveratrol, a kind of technology of extracting trans-resveratrol from the Chinese medicine giant knotweed is provided.
The technology of extracting trans-resveratrol from the Chinese medicine giant knotweed of the present invention is characterized in that described extraction process is: add prozyme and carry out enzyme digestion reaction acquisition in 48～72 hours enzymolysis raw material in Powdered giant knotweed raw material under constant temperature; Again with solvent extraction, the concentrated work in-process that obtain to contain trans-resveratrol, again through making with extra care promptly.Extraction process of the present invention is a raw material from containing the very abundant Chinese medicine giant knotweed of polidatin, and the hydrolysis polidatin has the following advantages to extract trans-resveratrol:
1) Chinese medicine giant knotweed plantation easily, cuttage, seed broadcast all can, output height, price are low, convenient sources, follow-up resource is secure.
2) technology is simple and direct, and repeatability is good, and the glucoside hydrolysis is perfect, the product yield height, and quality is good, and cost is low.Enlarge experiment through three batches and show that the trans-resveratrol extract yield reaches more than 85% in the giant knotweed.Product is checked through Chinese medical courses in general institute medicine, and purity reaches 99.63%, 99.68%, 99.78% respectively.Be higher than 1.7 percentage points of international indicators, reach the requirement of Sigma's standard substance purity more than 99.5%.
3) facility investment is few, and cost is low, three-waste free pollution, production safety.
Following is embodiments of the invention.
Fig. 1 is a process flow sheet of the present invention
Referring to Fig. 1, get the Chinese medicine giant knotweed and mill to Powdered, add prozyme and under constant temperature, carried out enzyme digestion reaction 70 hours, contain the work in-process of trans-resveratrol about 30% behind the acquisition enzymolysis raw material with solvent extraction, concentrated acquisition, again through the refining trans-resveratrol that promptly gets.
Claims (1)
1. a technology of extracting trans-resveratrol from the Chinese medicine giant knotweed is characterized in that described extraction process is: add prozyme and carry out enzyme digestion reaction acquisition in 48～72 hours enzymolysis raw material in Powdered giant knotweed raw material under constant temperature; Again with solvent extraction, the concentrated work in-process that obtain to contain trans-resveratrol, again through making with extra care promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99115156A CN1090603C (en) | 1999-09-24 | 1999-09-24 | Process for extracting resveratrol from Chinese medicine giant knotweed root |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99115156A CN1090603C (en) | 1999-09-24 | 1999-09-24 | Process for extracting resveratrol from Chinese medicine giant knotweed root |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1251361A true CN1251361A (en) | 2000-04-26 |
| CN1090603C CN1090603C (en) | 2002-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99115156A Expired - Fee Related CN1090603C (en) | 1999-09-24 | 1999-09-24 | Process for extracting resveratrol from Chinese medicine giant knotweed root |
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| CN (1) | CN1090603C (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100340536C (en) * | 2002-12-31 | 2007-10-03 | 曹庸 | Technology of super critical caron dioxide extraction of resveratrol from polygonum cuspidatum |
| CN101628858A (en) * | 2009-08-11 | 2010-01-20 | 张守力 | Preparation process of resveratrol |
| CN101628859A (en) * | 2009-08-11 | 2010-01-20 | 张守力 | Extraction method of resveratrol |
| CN1896256B (en) * | 2006-06-29 | 2010-07-28 | 大连理工大学 | Method for converting resveratrolside into resveratrol by microbion |
| CN101255449B (en) * | 2008-03-20 | 2010-12-29 | 山东大学 | Use of beta-glucosidase in preparation of resveratrol by transforming polydatin |
| CN101721488B (en) * | 2009-12-08 | 2011-11-09 | 湖南省中药提取工程研究中心有限公司 | Pharmaceutical composition for treating liver diseases and prepration method thereof |
| CN101709024B (en) * | 2009-11-06 | 2012-11-28 | 淮阴工学院 | Method for extracting and purifying resveratrol from polygonum cuspidatum |
| CN101628857B (en) * | 2009-05-16 | 2013-01-02 | 花垣恒远植物生化有限责任公司 | Production technique for extracting resveratrol from giant knotweed |
| CN102596211B (en) * | 2009-12-29 | 2015-06-24 | 韩国韩医学研究院 | Compositions and functional foods for treating and preventing obesity using polygonum cuspidatum butanol fraction and ethyl acetate fraction |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61171427A (en) * | 1985-01-24 | 1986-08-02 | Osaka Chem Lab | Substance for preventing thrombosis or the like |
-
1999
- 1999-09-24 CN CN99115156A patent/CN1090603C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100340536C (en) * | 2002-12-31 | 2007-10-03 | 曹庸 | Technology of super critical caron dioxide extraction of resveratrol from polygonum cuspidatum |
| CN1896256B (en) * | 2006-06-29 | 2010-07-28 | 大连理工大学 | Method for converting resveratrolside into resveratrol by microbion |
| CN101255449B (en) * | 2008-03-20 | 2010-12-29 | 山东大学 | Use of beta-glucosidase in preparation of resveratrol by transforming polydatin |
| CN101628857B (en) * | 2009-05-16 | 2013-01-02 | 花垣恒远植物生化有限责任公司 | Production technique for extracting resveratrol from giant knotweed |
| CN101628858A (en) * | 2009-08-11 | 2010-01-20 | 张守力 | Preparation process of resveratrol |
| CN101628859A (en) * | 2009-08-11 | 2010-01-20 | 张守力 | Extraction method of resveratrol |
| CN101709024B (en) * | 2009-11-06 | 2012-11-28 | 淮阴工学院 | Method for extracting and purifying resveratrol from polygonum cuspidatum |
| CN101721488B (en) * | 2009-12-08 | 2011-11-09 | 湖南省中药提取工程研究中心有限公司 | Pharmaceutical composition for treating liver diseases and prepration method thereof |
| CN102596211B (en) * | 2009-12-29 | 2015-06-24 | 韩国韩医学研究院 | Compositions and functional foods for treating and preventing obesity using polygonum cuspidatum butanol fraction and ethyl acetate fraction |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1090603C (en) | 2002-09-11 |
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