CN1250600A - Broad-spectrum quick-acting efficient disinfectant and its preparing process - Google Patents
Broad-spectrum quick-acting efficient disinfectant and its preparing process Download PDFInfo
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- CN1250600A CN1250600A CN 98114372 CN98114372A CN1250600A CN 1250600 A CN1250600 A CN 1250600A CN 98114372 CN98114372 CN 98114372 CN 98114372 A CN98114372 A CN 98114372A CN 1250600 A CN1250600 A CN 1250600A
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- disinfectant
- glutaraldehyde
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- metronidazole
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Abstract
This invention discloses a high- and quick-effect wide-spectrum disinfectant and its production method. It is characterized by that the formulated composition by wt.% is: fertifier: alkyl phenol polyethenoxy ether n=10 3.0-20,glutaraldehyde 0.02-3.0; activator: polyoxyethylene aliphatic alcohol ether n=20-25 0.3-5.0; blender: monosodium orthophosphate 0.2-1.0; polymerization inhibitor: hydroquinol 0.02-0.2; buffering agent: propylene glycol 3.0-5.0, metronidazole 0-1.0; and the rest is water, and its prodn. method is: adding ingredients in sequence, mixing, and then filling into package under vacuum.
Description
The present invention relates to efficient, wide spectrum, disinfectant and production method thereof fast.
Since ancient times, human and microorganism community life lives on earth, and harmful pathogenic microorganism is at every moment threatening human beings'health, bring great harmfulness for human environment from bottom to top, even current civilized society also is like this, old infectious disease destroys the evidence, and new infectious disease is comed one after another again.Though traditional disinfectant energy killing microorganism more or less exists such as problems such as excitant, stability, toxicity.For a long time, medical personnel do injection of skin, the preceding prophylactic disinfection of blood sampling with alcohol, the tincture of iodine always, and this sterilization method has continued last 100 years.Yet the relevant expert discovers that this method does not reach satisfied Disinfection Effect at short notice fully, can only be a kind of psychology comfort at most.75% ethanol is invalid to the disinfective action of hepatitis B, with alcohol immersion or the gauze piece wiping lancet that soaks with ethanol, acupuncture needle, blade is not effective disinfectant measure, more intense according to Virology Inst., China Academy of Preventive Medicine Sciences report, hepatitis B virus resistance, contain hepatitis viruse in hepatitis B patient's the serum, with 75% Ethanol Treatment serum,, viral power was reduced slightly, but do not have killing action through 14 days at-5 degree.In recent years, domestic once had the people to check out HBsAg from 75% ethanolic solution.
Hospital is the place that pathogenic microorganism is assembled, microorganism in patient and the pathogen carrier's body can excrete in a variety of forms, pollution ambient air, daily necessities, medicine equipment, water, food, medical worker's clothing, hand etc., hospital is the place of diagnose and treat diseases and patient's rehabilitation, is again simultaneously the place that source of infection, route of transmission and Susceptible population are extensively movable and concentrate.Current, hospital infection has become outstanding public health problem.Hospital inner environment such as room air, sick bed, various body surface all are the potential danger source of infection, it is reported, the incidence of disease of China's virus hepatitis, the corpsman,hospital is higher than about 10 times of resident, see frequently that at home hospital patient's cross-infection takes place and causes the report of malpractice greatly, so it is very urgent to control hospital infectious disease.All can effectively control hospital infectious disease, fast, efficiently kill various pathogenic microorganismss no matter this disinfectant is spraying or wiping, protect vast prescription on individual diagnosis patient, the healthy of personnel and medical worker of accompanying the patient to see a doctor.
China's infectious disease incidence is higher, particularly respiratory tract and enteric infectious disease are in rising trend recently, wherein the incidence of hepatitis rate is high, China has hepatitis b virus carrier 1.2 hundred million people now at present, the existing disease patient 1,400 ten thousand of hepatitis, and wherein quite a few people is just in contaminated environment, the infection scope is constantly enlarged, its reason is removed the virus hepatitis route of transmission and is difficult for cutting off, and outside the restriction source of infection difficulty, neglecting preventions property disinfectant measure also is a big problem.According to investigations, cinema seat hepatitis b surface antigen positive rate is 53.2%, and hair dressing tools hepatitis B positive rate is 27.6%.Popularizing of air-conditioner though bring great convenience to daily life, also causes a large amount of breedings of Legionella, and legionaires' disease patient's (lethality reaches 45%) rarely found in the past and that the state of an illness is very dangerous is sharply increased.The public place of entertainment, working environment and air quality abominable.Cause " modern handle official bussiness compartment syndrome ", this city epidemic disease is familiar with by everybody.
Modern society provides height material progress the time for us, and all kinds of infectious diseases are not effectively controlled, just not saying the unscrupulous of century plague AIDS walked crosswise, makes us class and feels simply helpless, the old infectious disease four malaria mankind that stage a comeback again.Last year, the whole world has 5,200 ten thousand people's death, and wherein 1700 die ten thousand deaths in various infectious diseases, account for death toll 1/3rd, whole world hepatitis b virus carrier surpasses 3.5 hundred million people, and last year, (1997) caused 1,100,000 people's death, in addition by also nearly 200,000,000 people of the people of infection with hepatitis C virus.According to World Health Organization's statistics, in about 5,800,000,000 populations in the whole world, the threat that is subjected to new infectious disease over half is arranged.The O-157 Escherichia coli of Japan, the English disease cattle disease, Hong Kong bird flu, everybody is not strange, relevant expert's worry invariably warns, human in the future the most fatal threat be not war and disaster, and bacterium and virus, this paints an alarming picture of the situation just to scare the audience absolutely not.
The sampling observation public telephone, every square centimeter of bacterial population is up to more than 100,000 on the microphone of a public telephone, the hepatitis b surface antigen positive rate is 50%, infectious diseases such as influenza, pharyngitis, tuberculosis, dysentery, hepatitis all might infect thus, a lot of people got hepatitis unconsciously, can not find reason, can only belong to unlucky, unlucky having run into, yet, whether think about it, infectious disease at every moment just with you, a careless phone, Karaoke is lustily sung a song, and perhaps is in trouble.Public telephone may become the source of infection of various diseases, and this is always paid much attention in China in recent years.Phone-specific disinfectant of the present invention is to develop for phone, mobile phone, microphone cleaning-sterilizing, has sterilization, cleaning, taste removal, lasting function, is sprayed on the telephone set surface, stays a room diaphragm, can kill various pathogenic microorganism, removes your trouble and worry.
In family, the pollution of pathogenic microorganism is often ignored by people, thereby cause some infectious disease to propagate within the family, hepatitis B secondary attack rate in family is 23% according to investigations, the secondary attack rate of Eaton agent pneumonia is 63.9%, and other all has familial aggregations is significantly arranged as pulmonary tuberculosis, enteritis, typhoid fever, infectious dermatosis, bacterium, virus are just being hidden in your clothing, food, are being lived, among the row, your health is just compromised.
For these reasons, seek a kind of disinfectant safer, more efficient, that character is more stable and become the target that the world medicine expert constantly pursues, explores.
The purpose of this invention is to provide the sterilization wide spectrum, the speed of killing is fast, valid density is low, the agent of high speed broad-spectrum quick disinfection and the production method thereof of safety non-toxic, stable in properties.
Above-mentioned purpose of the present invention adopts following technical scheme to be achieved:
The basic recipe of disinfectant of the present invention consists of: (following in the weight percent composition)
Hardening agent: alkylphenol polyoxyethylene n=10 3.0-20
Glutaraldehyde 0.02-3.0
Activator: polyoxyethylene aliphatic alcohol ether n=20-25 0.3-5.0
Blender: sodium dihydrogen phosphate 0.2-1.0
Hydroquinone of polymerization retarder 0.02-0.2
Buffer: propane diols 3.0-5.0
Metronidazole 0-1.0
Surplus is a water.
As replenishing of technique scheme, in above-mentioned compound composition, select to add lauric acid diethyl amide, vitamin E, extract solution from aloe, natural flowers and plants essential oil, its addition is respectively 3-5%, 0.3-0.5% by every kind of additive, 2-5% and 0.3-1%.
Described sodium dihydrogen phosphate can be substituted by fatty alcohol citric acid fat.
The production method of product of the present invention is:
The composition activator polyoxyethylene aliphatic alcohol ether (n=20-25) of will filling a prescription is heated to 70-80 ℃, after dissolving, the cooling, be metered into glutaraldehyde (metronidazole), be diluted to prescribed concentration,, add hardening agent alkylphenol polyoxyethylene (n=10) through stirring, add stabilizing agent, polymerization inhibitor and biological extraction liquid, stir and added buffer and blender in 15-30 minute, the reactor of built-in mixture is transferred to vacuum state, and (vacuum-0.08MPa) kept 20 minutes is finished product through vacuum filling.
Because the present invention adopted technique scheme, thereby overcome the easy polymerization of single glutaraldehyde effectively and reduced bioactive defective.It has overcome that traditional chemical type disinfectant excitant is big, poor stability, shortcoming that toxicity is bigger, has efficient, wide spectrum, the effect of pathogenic microbe killing fast, demonstrates powerful sterilization, sterilization effect.
The distinguishing feature of product of the present invention is:
1, fungicidal spectrum is wide: to all thoroughly deactivations of all kinds of bacterial reproduction types, gemma, virus.
2, speed of action is fast: to killing rate ash in the microorganisms such as Escherichia coli, staphylococcus aureus, first, hepatitis type B virus, hay bacillus, black mutation brood cell 5 minutes more than 99.9%.
3, valid density is low: still can kill staphylococcus aureus when concentration is 0.01% (100PPm).Concentration is 0.1% o'clock, kills common bacteria in 1 minute.
4, this product per os, skin toxicology test, true border nontoxic level (acute oral toxicity test: LD 50＞10000mg/kg; Skin irritatin test: average product score value=0.0), safe and harmless to human body.
5, animal (rabbit, small white mouse) long term toxicity test, carcinogenic test, mutagenicity test and reproductive toxicity test be there is no any pathology pathology.
6, stable in properties: be difficult for receiving the influence of mechanism, acid, alkali and other physics, chemical factor, accelerated test, the effective ingredient minimizing is lower than 1%.
Table 1 is the performance comparison of originally disappear agent and common disinfectant.
Table 2 is to form embodiment according to the prescription that embodiment is selected.
Below in conjunction with table 1,2 and embodiment the present invention is described in detail in detail:
The basic recipe of disinfectant of the present invention consists of (forming in weight percent)
Hardening agent: alkylphenol polyoxyethylene n=10 3.0-20
Glutaraldehyde 0.02-3.0
Activator: polyoxyethylene aliphatic alcohol ether n=20-25 0.3-5.0
Blender: sodium dihydrogen phosphate 0.2-1.0
Hydroquinone of polymerization retarder 0.02-0.2
Buffer: propane diols 3.0-5.0
Metronidazole 0-1.0
Surplus is a water.
As replenishing of technique scheme, in above-mentioned compound composition, select to add lauric acid diethyl amide, vitamin E, extract solution from aloe, natural flowers and plants essential oil, its addition is by every kind of additive list, account for total formulation weight composition and be respectively 3-5%, 0.3-0.5%, 2-5% and 0.3-1%.
Described sodium dihydrogen phosphate can be substituted by fatty alcohol citric acid fat.
The production method of product of the present invention is:
By the prescription composition activator polyoxyethylene aliphatic alcohol ether (n=20-25) is heated to 70-80 ℃, after dissolving, the cooling, be metered into glutaraldehyde, (or metronidazole), add pure water and be diluted to prescribed concentration, through stirring, add the molten basic phenol polyethenoxy ether of hardening agent, add stabilizing agent, polymerization inhibitor and biological extraction liquid (above-mentioned substance can be selected to add or do not add), stirred 15-30 minute, add buffer and blender, the reactor of built-in mixture is adjusted to vacuum state (vacuum for-0.08MPa is following) kept 20 minutes, obtain finished product through vacuum filling.
Table 2 the present invention fills a prescription and forms embodiment (forming in weight percent)
Numbering N1 N2 N3 N4 N5
Hardening agent 3.0 57 5.0 20
Glutaraldehyde 0.02 2 2.5 2.0 3.0
Activator 0.30 0.5 0.8 0.35 5.0
(n＝20)?(n＝20)?(n＝20)?(n＝25)?(n＝25)
Blender 0.02 0.6 0.8 1.0 1.0
Polymerization inhibitor 0.02 0.05 0.05 0.2 0.20
Buffer 3.0 4.0 4.0 5 5.0
Metronidazole 0 0.5 0.5 0.8 1.0
Lauric acid diethyl amide 0345
Vitamin E 0 0.3 0.4 0.5
Extract solution from aloe 0235
Natural flowers and plants essential oil 0 0.3 0.5 1
Water: surplus is that water is annotated: 1, hardening agent is alkylphenol polyoxyethylene n=10.
2, activator is selected polyoxyethylene aliphatic alcohol ether for use.
3, polymerization inhibitor is a hydroquinones.
4, buffer is a propane diols.
5, blender is selected fatty alcohol citric acid fat or sodium dihydrogen phosphate for use.
Table 1 disinfectant of the present invention and common disinfectant contrast disinfectant classification representative Disinfection Effect characteristic compare the chlorine bleach powder, two energy kill bacteria bactericidal effects are better, reach but be subject to organic matter
Chlorine monoxid, two breedings, vacuum acid-base value influence can be bleached, and corrosives disinfectant chlorine isouric acid sodium gemma, hepatitis excitant are big, character instability, available chlorine
Virus belongs to more easily forfeiture; Carcinogenic, teratogenesis, mutagenesis are arranged
It is generally invalid to bacterial spore and Hepatitis virus that high effect disinfectants effect alcohols ethanol can be killed
Bacterial propagule disinfectant isopropyl alcohol belongs to the poor efficiency sterilization
The agent quaternary ammonium salt disappears in the bromogeramine, poor efficiency sterilization property is low, colourless, non-stimulated, but antibiotic
The myristylpicolinum bromide toxic agent, low dense spectrum is little, to hepatitis B, that the withered grass brood cell does not have the toxic agent degree is antibacterial, efficient, less stable, incompatibility is many
Concentration sterilization iodine class disinfectant iodine, the middle and high effect of Iodophor disappear this type of disinfectant because of using ionic surface active agent
The toxic agent preparation is subject to antagonistic substance influence in the solution
Easy coloring is subject to organic matter, acid-base value
Influence.The peroxide Peracetic acid high effect disinfectants that disappears easily decomposes, and the character instability has the toxic agent hydrogen peroxide can kill various bleaching and corrosiveness to article, human body is had bigger
Microorganism excitant and toxicity.Aldehyde disinfectant formaldehyde high-efficiency disinfectant has certain excitant, sucks formaldehyde gas
Glutaraldehyde is easily poisoned, the easy polymerization of the dialdehyde aqueous solution,
Oxidation, effective time is short.
The hibitane middle effect disinfectants is to hepatitis B, the withered grass brood cell is invalid, with other anion surfactant antagonism disinfectant high effect disinfectants of the present invention character gentleness, nontoxic, non-stimulated, character
To bacterial reproduction stable (can store more than 2 years under the normal temperature)
Type, fungi, quick, efficient, broad-spectrum bactericidal action can
Gemma, virus are made various formulations.
Have powerful, fast
The speed killing action
Claims (3)
1. efficient, wide spectrum, disinfectant fast is characterized in that its formulation weight percentage composition is:
Hardening agent: alkylphenol polyoxyethylene n=10 3.0-20
Glutaraldehyde 0.02-3.0
Activator: polyoxyethylene aliphatic alcohol ether n=20-25 0.3-5.0
Blender: sodium dihydrogen phosphate 0.2-1.0
Hydroquinone of polymerization retarder 0.02-0.2
Buffer: propane diols 3.0-5.0
Metronidazole 0-1.0
Surplus is a water.
2. efficient, broad-spectrum quick disinfection agent according to claim 1, it is characterized in that: in prescription is formed, select to be added with at least a of following substances: promptly, lauric acid diethyl amide, vitamin E, extract solution from aloe, natural flowers and plants essential oil, it adds percentage by weight and is respectively 3-5%, 0.3-0.5%, 2-5% and 0.3-1%.
3. according to the production method of claim 1 or 2 described products, it is characterized in that: composition activator polyoxyethylene aliphatic alcohol ether (n=20-25) heating of will filling a prescription is 70-80 ℃, dissolving, after the cooling, be metered into glutaraldehyde (metronidazole), be diluted to prescribed concentration, through stirring, add hardening agent alkylphenol polyoxyethylene (n=10), add stabilizing agent, polymerization inhibitor and biological extraction liquid, stir and added buffer and blender in 15-30 minute, the reactor of built-in mixture is transferred to vacuum state, and (vacuum-0.08MPa) kept 20 minutes is finished product through vacuum filling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98114372 CN1250600A (en) | 1998-10-12 | 1998-10-12 | Broad-spectrum quick-acting efficient disinfectant and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98114372 CN1250600A (en) | 1998-10-12 | 1998-10-12 | Broad-spectrum quick-acting efficient disinfectant and its preparing process |
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| Publication Number | Publication Date |
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| CN1250600A true CN1250600A (en) | 2000-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 98114372 Pending CN1250600A (en) | 1998-10-12 | 1998-10-12 | Broad-spectrum quick-acting efficient disinfectant and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997961A (en) * | 2016-07-21 | 2016-10-12 | 南通东华服装有限公司 | Multifunctional antibacterial hand-cleaning sanitizer |
-
1998
- 1998-10-12 CN CN 98114372 patent/CN1250600A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997961A (en) * | 2016-07-21 | 2016-10-12 | 南通东华服装有限公司 | Multifunctional antibacterial hand-cleaning sanitizer |
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