CN1246042C - Preparation method of therapy used iodine-125 sealed seed source core - Google Patents
Preparation method of therapy used iodine-125 sealed seed source core Download PDFInfo
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- CN1246042C CN1246042C CN 200410019966 CN200410019966A CN1246042C CN 1246042 C CN1246042 C CN 1246042C CN 200410019966 CN200410019966 CN 200410019966 CN 200410019966 A CN200410019966 A CN 200410019966A CN 1246042 C CN1246042 C CN 1246042C
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Abstract
The present invention discloses a preparing method of an iodine-125 sealed seed source core for treatment, which comprises the following steps: (1) a silver rod, a water solution potassium ferricyanide and a water solution of soluble alkali chloride are put into a reaction container to carry out an oscillating reaction for 3 to 8 hours, the chloridized silver rod is taken out and washed 1 to 3 times with deionized water, and then the silver rod is dried; (2) a water solution of alkali metal iodide, a water solution of alkali metal bromide, the chloridized silver rod and a water solution of radioactive sodium iodide are put into the reaction container to carry out an oscillating reaction for 8 to 10 hours at a pH value of 8 to 10, and the iodine-125 sealed seed source core for treatment is obtained. Because an oxidizing agent used in the present invention is potassium ferricyanide whose oxidizing power is weak, the chlorination reaction of the silver rod is gentle and no gas is generated in the reaction process, a precipitation layer of silver chloride forming on the surface of the silver rod is uniform, compact, firm and not easy to desquamate. The method of the present invention has no environmental pollution, the iodine-125 sealed seed source core is stable in normal light rays, and therefore, the working environment for workers is improved.
Description
Technical field
The invention belongs to the preparation method of medical radioactive sealed seed source source core, particularly, relate to a kind of radioactive sealed seed that is used for tumor implanted treatment preparation method of core in a steady stream.
Background technology
Implanting treatment between tissue is with around radioactive seed source implantation tumour or the tumor, utilizes the seed core ray kill cancer cell of emitting in a steady stream, reaches treatment and alleviates the purpose of disease.Implant treatment between tissue and be used for the treatment of various entity tumors,, obtained and surgical operation, therapeutic effect that outer radiotherapy is identical as carcinoma of prostate, breast carcinoma, hepatocarcinoma, cerebroma and ovarian cancer etc.Implantation is divided into temporary implantation and permanent implanted between tissue, and permanent implanted being meant no longer taken out radioactive seed source implantation tumour position, and temporary implantation is meant radioactive seed source implantation tumour position, takes out after treatment a period of time.Implant treatment between permanent tissue and adopt seed source short by the half-life and that the low radionuclide of ray energy is prepared into usually, as I-125 and Pd-103 seed source.Treatment is that sealing is made in the titanium of packing into pipe or the stainless steel tube with radioactivity iodine-125 immobilization carrier rod with the iodine-125 sealed seed source.The general silver of selecting is as the fixing carrier of iodine-125, and this is because silver not only can form silver iodide with iodine to be precipitated, and is the mark of x ray, so that the radioactive seed source source core is accurately located estimation with therapeutic dose during implanted treatment.Generally, the length of silver rod is 3.0mm, and diameter is 0.1～0.7mm, is preferably 0.5mm.The method that the radioactivity iodine-125 is fixed on the silver-colored rod adopts chemiadsorption usually, and it was finished by two steps.This method technology and equipment are simple, and production process is controlled, to accomplish scale production.U.S. Patent number 4323055 and Chinese patent publication number 1307907, (application number is 01105242.2) disclosed preparation method all is as the fixing carrier of iodine-125 with silver, with halate (hypochlorite and chlorite) is oxidant oxidation and chlorination reaction under 6M hydrochloric acid condition, silver rod after the chlorination carried out ion-exchange reactions 18～22 hours with the radioactivity iodine-125 in pH10～12, thereby made the source core in iodine-125 seed source.The main deficiency of this method is that hypochlorous acid is not conventional reagent, is difficult to buy, and secondly is, produces a large amount of chlorine that penetrating odor is arranged in course of reaction, and environment is polluted.A kind of chemiadsorption that Chinese patent publication number CN 1265924A discloses also is as the fixing carrier of iodine-125 with silver, with the hydrogen peroxide is oxidant oxidation and chlorination reaction under the hydrochloric acid condition, silver rod after the chlorination carried out ion-exchange reactions 18 hours with the radioactivity iodine-125 under pH5, thereby made the source core in iodine-125 grain seed source.The main deficiency of this method is to produce a large amount of oxygen in chlorination reaction process, for the cleaning operation of silver chloride rod brings certain difficulty.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of preparation method for the treatment of with iodine-125 sealed seed source source core is provided, technical scheme of the present invention is summarized as follows:
A kind of preparation method for the treatment of with iodine-125 sealed seed source source core, form by following steps:
(1) in reaction vessel, put into silver rod, potassium ferricyanide aqueous solution and soluble alkali metal aqueous chloride solution, the excellent number of described silver is 100 with the ratio of potassium ferricyanide aqueous solution volume, soluble alkali metal aqueous chloride solution volume: 0.1mL～12mL:1mL～10mL, the concentration of described potassium ferricyanide aqueous solution is 1mg/mL～100mg/mL, the concentration of described soluble alkali metal aqueous chloride solution is 0.1mol/L～6mol/L, oscillating reactions 3～8 hours, silver rod after the taking-up chlorination, with washed with de-ionized water 1～3 time, dry;
(2) in reaction vessel, put into silver-colored rod and radioiodination sodium water solution after alkaline metal iodide aqueous solution, alkali metal bromide aqueous solution, the chlorination, the radioactivity of silver-colored excellent number after the described chlorination and alkaline metal iodide aqueous solution volume, alkali metal bromide aqueous solution volume, radioiodination sodium water solution is 100: 0.05mL～17mL:0.05mL～17mL:10～400mci, and the concentration of described alkaline metal iodide aqueous solution is 1mg/mL～100mg/mL; The concentration of described alkali metal bromide aqueous solution is 1mg/mL～150mg/mL, and in pH=8～10, oscillating reactions 8～10 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
In the reaction of (2) step, the mol ratio of control alkaline metal iodide and alkali metal bromide is 1: 2～1: 5.Preferably 1: 2.5～1: 3.
The diameter of described silver rod is that 0.1～0.7mm, length are 2.0～3.5mm, and preferably the diameter of silver rod is that 0.5mm, length are 3.0mm.
Described soluble alkali metal chloride is sodium chloride or potassium chloride or cesium chloride.
The pH=9 of described (2) step reaction.
The duration of oscillation of described (2) step reaction is 9 hours.
Described alkaline metal iodide is sodium iodide or potassium iodide, and described alkali metal bromide is potassium bromide or sodium bromide.
Because the used oxidant of the present invention is the potassium ferricyanide, oxidability wants weak with respect to sodium hypochlorite and hydrogen peroxide, do not produce any gas in the chlorination reaction gentleness of silver rod and the course of reaction, the silver nitride precipitation layer that forms on the excellent surface of silver is promptly evenly fine and close again, firm difficult drop-off, overcome and produced deleterious gas chlorine pollution on the environment in the prior art in the chlorination reaction process, also overcome the generation that is unfavorable for the gas oxygen of iodination reaction of the prior art, also overcome course of reaction simultaneously and produced of the influence of a large amount of gases tectal compactness of silver chloride and fastness.
The pH that iodination reaction of the prior art has elects 8～12 as, the pH that has elects 3～5 as, iodide ion is oxidation easily under acid condition, and iodine is easily brought into play, and can influence the utilization rate of iodine-125 like this, also can cause environmental pollution, therefore, the present invention is chosen in pH and 8～10 carries out iodination reaction, the experiment proved that, oscillating reactions is 8～10 hours with this understanding, and the utilization rate of iodine-125 is greater than 98%.
Because silver halide is a heliosensitivity, easily decomposes at ordinary ray, the heliosensitivity of Silver monobromide is the most responsive, is silver chloride and silver iodide secondly.The source core of the method preparation of prior art just forms the photosensitive stronger silver iodide precipitation of one deck on silver-colored face, silver-colored rod after the iodate can not be operated under ordinary ray, should under darkroom or HONGGUANG, operate, so that reduce the decomposition of silver iodide when operation, minimizing pollutes environment, reduces the utilization rate of iodine-125.The present invention must add iodized salt and Bromide before iodination reaction, so that on the excellent surface of silver, form the mixed precipitation layer of Silver monobromide and silver iodide, Zhi Bei iodo-1 25 sealed seed source source cores are stable under ordinary ray like this, for this reason, treatment of the present invention need not carried out in the darkroom of costliness with the preparation and the processing of iodine-125 sealed seed source source core, has improved staff's working environment simultaneously greatly.
The present invention has produced beyond thought effect.
The specific embodiment
Reaction principle of the present invention is, surface with oxidant potassium ferricyanide silver oxide rod, form silver ion at silver surface, the silver ion of silver surface and the reaction of soluble alkali metal chloride generate silver nitride precipitation, silver-colored rod after the chlorination places radioactivity iodine-125 solution to carry out iodination reaction, must add alkaline metal iodide and alkali metal bromide mixed liquor in iodination reaction, form the mixed precipitation layer of silver iodide and Silver monobromide on silver rod surface.
Concrete reaction as:
The present invention is further illustrated below in conjunction with specific embodiment:
Embodiment 1
(1) (φ 0.5 * 3mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 1mL 10mg/mL, add 4mL 2mol/L sodium-chloride water solution, mix homogeneously, oscillating reactions 5 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod, use washed with de-ionized water three times, dry standby;
(2) in reaction bulb, add 0.2mL 10mg/mL IodineSodium Solution and 0.2mL 20mg/mL sodium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 100mCi IodineSodium Solution, regulate pH to 10 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 9 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
The utilization rate of iodine-125 is greater than 98%..
The utilization rate of iodine-125=(activity of iodine-125 in the activity one reaction back solution of input iodine-125) ÷ drops into activity * 100% of iodine-125
The utilization rate of iodine-125 in table 1 iodination reaction
| Response time (h) | 4 | 5 | 7 | 8 | 9 | 10 | 12 | 19 |
| Drop into the activity (mCi) of iodine-125 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
| The activity (mCi) of iodine-125 in the solution of reaction back | 15 | 9 | 5 | 2 | 1.5 | 1.5 | 1.0 | 2.0 |
| Utilization rate (%) | 85％ | 91％ | 95％ | 98％ | 98.5％ | 98.5％ | 99％ | 98％ |
Embodiment 2
(1) (φ 0.1 * 3mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 12mL 1mg/mL, add 1mL 6mol/L sodium-chloride water solution, mix homogeneously, oscillating reactions 8 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod,, dry standby with washed with de-ionized water twice;
(2) in reaction bulb, add 0.05mL 100mg/mL IodineSodium Solution and 0.05mL 150mg/mL sodium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 200mCi IodineSodium Solution, regulate pH to 8 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 10 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
Embodiment 3
(1) (φ 0.7 * 3.5mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 0.0mL 100mg/mL, add the 10mL0.1mol/L potassium chloride solution, mix homogeneously, oscillating reactions 3 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod,, dry standby with washed with de-ionized water twice;
(2) in reaction bulb, add 17mL 1mg/mL liquor kalii iodide and 17mL 1mg/mL potassium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 10mCi IodineSodium Solution, regulate pH to 9 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 8 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
Embodiment 4
(1) (φ 0.7 * 2mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 1mL 30mg/mL, add 4mL 2mol/L cesium chloride aqueous solution, mix homogeneously, oscillating reactions 5 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod, use washed with de-ionized water three times, dry standby;
(2) in reaction bulb, add 15mL 1mg/mL IodineSodium Solution and 1mL 30mg/mL sodium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 400mCi IodineSodium Solution, regulate pH to 9 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 9 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
Embodiment 5
(1) (φ 0.5 * 3mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 2mL 10mg/mL, add 4mL 2mol/L sodium-chloride water solution, mix homogeneously, oscillating reactions 5 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod, use washed with de-ionized water three times, dry standby;
(2) in reaction bulb, add 15mL 1mg/mL IodineSodium Solution and 10.3mL 2mg/mL sodium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 200mCi IodineSodium Solution, regulate pH to 9 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 9 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
Embodiment 6
(1) (φ 0.5 * 3mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 2mL 10mg/mL, add 4mL 2mol/L sodium-chloride water solution, mix homogeneously, oscillating reactions 6 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod, use washed with de-ionized water three times, dry standby;
(2) in reaction bulb, add 15mL 1mg/mL IodineSodium Solution and 10.3mL 2mg/mL sodium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 200mCi IodineSodium Solution, regulate pH to 9 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 9 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
Embodiment 7
(1) (φ 0.5 * 3mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 2mL 10mg/mL, add 4mL 2mol/L sodium-chloride water solution, mix homogeneously, oscillating reactions 6 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod, use washed with de-ionized water three times, dry standby;
(2) in reaction bulb, add 15mL 1mg/mL IodineSodium Solution and 12.87mL 2mg/mL sodium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 200mCi IodineSodium Solution, regulate pH to 9 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 9 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
Embodiment 8
(1) (φ 0.5 * 3mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 2mL 10mg/mL, add 4mL 2mol/L sodium-chloride water solution, mix homogeneously, oscillating reactions 6 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod, use washed with de-ionized water three times, dry standby;
(2) in reaction bulb, add 15mL 1mg/mL IodineSodium Solution and 15.45mL 2mg/mL sodium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 200mCi IodineSodium Solution, regulate pH to 9 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 9 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
Embodiment 9
(1) (φ 0.5 * 3mm) cleans with acetone with 100 silver rods, the reaction bulb of packing into, the potassium ferricyanide solution that adds 2mL 10mg/mL, add 4mL 2mol/L sodium-chloride water solution, mix homogeneously, oscillating reactions 6 hours, form the silver nitride precipitation of one deck densification on silver rod surface, take out the silver rod, use washed with de-ionized water three times, dry standby;
(2) in reaction bulb, add 15mL 1mg/mL IodineSodium Solution and 25.75mL 2mg/mL sodium bromide solution earlier, add the silver rod after 100 chlorinations again, add the 200mCi IodineSodium Solution, regulate pH to 9 with 0.01mol/LNaOH solution, mix homogeneously, oscillating reactions 9 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
Claims (7)
1. treat the preparation method of using iodine-125 sealed seed source source core for one kind, it is characterized in that forming by following steps:
(1) in reaction vessel, put into the silver rod, potassium ferricyanide aqueous solution and soluble alkali metal aqueous chloride solution, the diameter of described silver rod is 0.1～0.7mm, length is 2.0～3.5mm, excellent number of described silver and potassium ferricyanide aqueous solution volume, the ratio of soluble alkali metal aqueous chloride solution volume is 100: 0.1mL～12mL: 1mL～10mL, the concentration of described potassium ferricyanide aqueous solution is 1mg/mL～100mg/mL, the concentration of described soluble alkali metal aqueous chloride solution is 0.1mol/L～6mol/L, oscillating reactions 3～8 hours, silver rod after the taking-up chlorination, with washed with de-ionized water 1～3 time, dry;
(2) in reaction vessel, put into silver-colored rod and radioiodination sodium water solution after alkaline metal iodide aqueous solution, alkali metal bromide aqueous solution, the chlorination, the radioactivity of silver-colored excellent number after the described chlorination and alkaline metal iodide aqueous solution volume, alkali metal bromide aqueous solution volume, radioiodination sodium water solution is 100: 0.05mL～17mL: 0.05mL～17mL: 10～400mci, and the concentration of described alkaline metal iodide aqueous solution is 1mg/mL～100mg/mL; The concentration of described alkali metal bromide aqueous solution is 1mg/mL～150mg/mL, the mol ratio of described alkaline metal iodide and alkali metal bromide is 1: 2～1: 5, regulate pH=8～10 with NaOH solution, oscillating reactions 8～10 hours promptly obtains medical treatment with iodine-125 sealed seed source source core.
2. a kind of preparation method for the treatment of with iodine-125 sealed seed source source core according to claim 1, the mol ratio that it is characterized in that described alkaline metal iodide and alkali metal bromide is 1: 2.5～1: 3.
3. a kind of preparation method for the treatment of with iodine-125 sealed seed source source core according to claim 1 is characterized in that the diameter of described silver rod is that 0.5mm, length are 3.0mm.
4. a kind of preparation method for the treatment of with iodine-125 sealed seed source source core according to claim 1 is characterized in that described soluble alkali metal chloride is sodium chloride or potassium chloride or cesium chloride.
5. a kind of preparation method for the treatment of with iodine-125 sealed seed source source core according to claim 1 is characterized in that the pH=9 that described (2) step reacts.
6. a kind of preparation method for the treatment of with iodine-125 sealed seed source source core according to claim 1 is characterized in that the duration of oscillation of described (2) step reaction is 9 hours.
7. a kind of preparation method for the treatment of with iodine-125 sealed seed source source core according to claim 1 is characterized in that described alkaline metal iodide is sodium iodide or potassium iodide, and described alkali metal bromide is potassium bromide or sodium bromide.
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| CN 200410019966 CN1246042C (en) | 2004-07-12 | 2004-07-12 | Preparation method of therapy used iodine-125 sealed seed source core |
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| CN 200410019966 CN1246042C (en) | 2004-07-12 | 2004-07-12 | Preparation method of therapy used iodine-125 sealed seed source core |
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| CN1246042C true CN1246042C (en) | 2006-03-22 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102011120A (en) * | 2009-09-08 | 2011-04-13 | 郝迈琦 | Process for preparing silver based iodine-plated-125 source rod |
| CN101905028B (en) * | 2010-07-08 | 2012-02-01 | 北京智博高科生物技术有限公司 | Method for preparing iodine [1251] sealed seed source core |
| CN103550796B (en) * | 2013-09-25 | 2015-02-25 | 阎尔坤 | Method for preparing iodine-125 sealed seed source core |
| CN105920627B (en) * | 2016-07-01 | 2019-07-30 | 上海欣科医药有限公司 | A kind of iodine [125I] sealed seed source source core preparation method |
| CN106139175A (en) * | 2016-07-13 | 2016-11-23 | 江苏华益科技有限供公司 | A kind of Novel silver-based absorption iodine [125i] preparation method of sealed seed source |
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