CN101397659A - Technique for preparing coating of iodine-125 sealed seed source silver carrier rod - Google Patents
Technique for preparing coating of iodine-125 sealed seed source silver carrier rod Download PDFInfo
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- CN101397659A CN101397659A CNA2007101224599A CN200710122459A CN101397659A CN 101397659 A CN101397659 A CN 101397659A CN A2007101224599 A CNA2007101224599 A CN A2007101224599A CN 200710122459 A CN200710122459 A CN 200710122459A CN 101397659 A CN101397659 A CN 101397659A
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Abstract
The invention relates to a coating preparation technique of iodine-125 sealed seed source silver support rod. A silver rod which is processed beforehand is put into a reaction bottle; NaCl and NaBr mixed aqueous solution and NaI and NaOH mixed aqueous solution are added into the bottle in sequence and evenly mixed; then radioiodine and an oxidizer ICl2 are added into the bottle; the reaction bottle is fixed on a rotation motor and the process of the technique is fulfilled after rotary reaction. The technique adopts ICl2 with relatively low oxidation potential and low molar concentration as the oxidizer which hardly generates any harmful gas when reacts with the silver rod under alkaline condition, thereby reducing the volatilization of the radioiodine, greatly saving production cost, causing no environmental pollution and guaranteeing the working atmosphere of the working staff. The whole preparation process of the source core is fulfilled in one step and only needs 30min to 40min, thus reducing the labor strength of the working staff, improving working efficiency and meeting the requirements of the market.
Description
Technical field
The present invention relates to a kind of preparation technology of medical sealed source of radioactive substance, be specifically related to a kind of technique for preparing coating that is used for the radioactivity iodine-125 sealed seed source silver carrier rod of clinical cancer therapy.
Background technology
Implant between the tissue of tumour and treat close-range treatment in other words, be under the guidance of B ultrasonic or CT, the sealed seed source that will contain radioactive substance is by in implanting device implantation tumour and the surrounding tissue, and the ray kill tumor cell that utilizes radioactive substance to launch reaches the purpose of treatment and tumor remission.This treatment technology both had been applicable to the tumor treatment that maybe can not perform the operation as prostate cancer, the implanted treatment that also can be used for the remaining focus in primary tumo(u)r excision back, for example epidermis, abdominal cavity and thoracic cavity oncotherapy can also be used for the oncotherapy of head, neck, lung and pancreas.Also be applicable to through the residual tumour of external radiotherapy and the tumour of recurrence.Obtained good therapeutic action clinically, toxic side effect is little, obviously is better than the other treatment means, has vast market prospect.Implant the most frequently used radioactive source of treatment technology between the tissue of tumour and be iodine [
125I] sealed seed source, be that the support rod that is adsorbed with the radioactivity iodine-125 is packed in the titanium pipe, two ends are prepared into laser or electron beam sealing, and its structure is as shown in Figure 1.
Usually select the fixedly carrier of iodine-125 of filamentary silver conduct, not only can form the Silver iodide precipitation mainly due to silver with iodine, and be the mark of x ray, so that radioactive seed source is accurately located estimation with therapeutic dose during implanted treatment, the length of silver rod is 3.0mm, diameter is 0.1～0.7mm, is preferably 0.5mm.Though the radioactivity iodine-125 is fixed to the method for carrier many kinds are arranged, the most frequently used is electrochemical plating and chemiadsorption.Shortcomings such as electrochemical plating are owing to complex process, and plant and instrument requires high, and the production cycle is long are seldom used in the preparation of iodine-125 sealed seed source.Therefore, substantially all use chemiadsorption in the preparation of iodine-125 sealed seed source, many associated patents are also arranged, all go on foot in the preparation of the iodine-125 sealed seed source of finishing by two.For example U.S. Patent number 4323055 and the disclosed preparation method of Chinese patent publication number CN1307907 are as the fixing carrier of iodine-125 with silver, with halate (hypochlorite and chlorite) is oxygenant oxidation and chlorination reaction under 6M hydrochloric acid condition, silver rod after the chlorination carried out ion exchange reaction 18～22 hours with the radioactivity iodine-125 in pH10～12, thereby made the source core in iodine-125 seed source.The main deficiency of this method is that hypochlorous acid is not conventional reagent, is difficult to buy, and secondly reaction process produces a large amount of chlorine that pungent odour is arranged.A kind of chemiadsorption that Chinese patent publication number CN 1265924A discloses also is as the fixing carrier of iodine-125 with silver, with the hydrogen peroxide is oxygenant oxidation and chlorination reaction under the hydrochloric acid condition, silver rod after the chlorination carried out ion exchange reaction 18 hours with the radioactivity iodine-125 under pH5, thereby made the source core in iodine-125 grain seed source.The main deficiency of this method is to produce a large amount of oxygen in chlorination reaction process, for the cleaning operation of silver chloride rod brings certain difficulty.
Summary of the invention
Technical problem to be solved by this invention provides that a kind of cost is low, fast and convenient, the technique for preparing coating of the more even more form compact and stable iodine-125 sealed seed source silver carrier rod of radioactivity iodine-125 utilising efficiency and source core.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention, the silver-colored rod of anticipating is packed in the reaction flask, successively add NaBr and NaCl mixed aqueous solution, NaI and NaOH mixed aqueous solution, mix, add radioiodine and oxygenant ICl again
2, reaction flask is fixed on the rotation motor, revolving reaction is promptly.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention, the excellent pre-treatment of described silver are that with excellent heptane, the washing with acetone successively used of silver of cutting, the back is cleaned with deionized water, and drying sealing preservation.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention, in described NaCl and the NaBr mixed aqueous solution, the mol ratio of NaCl and NaBr is 1.2:1～3.5:1.
In described NaCl and the NaBr mixed aqueous solution, the volumetric molar concentration of NaCl is 0.3～10.0mol/l, and the volumetric molar concentration of NaBr is 0.1～5.0mol/l.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention, in described NaI and the NaOH mixed aqueous solution, the mol ratio of NaI and NaOH is 1:1～5:1.
In described NaI and the NaOH mixed aqueous solution, the volumetric molar concentration of NaI is 0.01～0.5mol/l, and the volumetric molar concentration of NaOH is 0.005～0.1mol/L.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention, add two kinds of mixed aqueous solutions after, reaction flask is horizontal by 20～50 degree, rotation mixed 1 minute, rotating speed is 20～60 rev/mins.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention adds the ICl for preparing in advance immediately after described radioiodine joins in the reaction flask
2Solution, reaction flask are horizontal by the rotation of 20～50 degree, and silver-colored rod is drop type stirring up and down voluntarily, and rotating speed is 20～60 rev/mins, revolving reaction 10～40 minutes.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention adds ICl
2The pH value of the mixing solutions behind the solution is 10～13.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention, the activity of the radioiodine of adding are 160%～180% of the excellent apparent activity of each silver.
The technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention, described ICl
2Solution is preparation temporarily before use, and its volumetric molar concentration is 0.005～0.03mol/L.With respect to per 100～600 silver rods, ICl
2The add-on of solution is 0.5～1.8mL.
After the technique for preparing coating of iodine-125 sealed seed source silver carrier rod of the present invention, coating finish, washing coating, and at room temperature placing 15～30 minutes, " ageing " coating is packed into after to be dried in the titanium pipe of getting ready, carries out sealing with laser or electron beam.
The present invention, the ICl of the low volumetric molar concentration that the employing oxidizing potential is lower
2, avoiding in iodination reaction, making iodide ion iodine oxide molecule, and cause the loss of radioactivity iodine-125.Reaction flask horizontal by 20-50 degree rotational oscillation, can make the fully contact of silver rod with 20-60 rev/min rotating speed, and the support rod of preparation is more even.
In the present invention, adopt the ICl of the lower low volumetric molar concentration of oxidizing potential
2Make oxygenant, under alkaline condition,, produce any deleterious gas hardly, reduced the volatilization of radioactivity iodine-125, saved production cost widely, also do not cause environmental pollution, guaranteed producers' Working environment with when reaction silver rod.Simultaneously, whole source core preparation process is finished by a step process, only needs 30-40 minute, has reduced production work personnel's labour intensity widely, enhances productivity, and has satisfied the demand in market.
Description of drawings
Fig. 1 be the most frequently used radioactive source of the present invention be iodine [
125I] the sealed seed source structural representation.
Embodiment
Embodiment 1
The used reagent of present embodiment is analytical pure, is example with 100 silver-colored rods.
With the silver-colored rod of the well cutting square quartzy bottle of 30mL of packing into, use 5mL heptane and acetone ultrasonic cleaning 5 minutes respectively, with washed with de-ionized water 3 times, dry.Add the NaCl (3.5mol/l) of 5mL and the mixed aqueous solution of NaBr (1mol/l), the mol ratio of NaCl and NaBr is 3.5:1, the NaI (0.05mol/l) and NaOH (0.01mol/L) mixed aqueous solution that add the 1.5mL of existing preparation then, the mol ratio of NaI and NaOH is 5:1, reaction flask is fixed on the rotation motor, horizontal by 20 degree, with 60 rev/mins rotating speed rotations 1 minute, stop, add the radioactivity iodine-125 solution of 100mCi (the silver-colored excellent apparent activity of preparing is 0.6mCi), add the ICl that the 1.8ml volumetric molar concentration is 0.005mol/l again
2The aqueous solution, conditioned reaction pH value is 10, again with reaction flask fixedly on the rotation motor, horizontal by 20 degree, 60 rev/mins of rotating speeds, revolving reaction 10 minutes takes out supernatant liquor, with washed with de-ionized water 2 times, acetone cleans 1 time, at room temperature places 20 minutes " ageing " coating, in the titanium pipe of getting ready of packing into after to be dried, with laser or electron beam sealing, standby.Merge scavenging solution and supernatant liquor, and with the radioactive activity of this mixed solution of activity measurement and silver rod, calculate the utilization ratio of iodine-125 by following formula:
The gross activity activity of the utilization ratio of iodine-125=silver rod/(radioactive activity of the gross activity activity+mixed solution of silver rod) * 100%, the utilization ratio that obtains this embodiment is 98.5%.
Embodiment 2
With the silver-colored rod of the well cutting square quartzy bottle of 30mL of packing into, use 5mL heptane and acetone ultrasonic cleaning 5 minutes respectively, with washed with de-ionized water 3 times, dry.Add the NaCl (2.4mol/l) of 5mL and the mixed aqueous solution of NaBr (2.0mol/l), the mol ratio of NaCl and NaBr is 1.2:1, the NaI (0.3mol/l) and NaOH (0.1mol/L) mixed aqueous solution that add the 1.5mL of existing preparation then, the mol ratio of NaI and NaOH is 3:1, reaction flask is fixed on the rotation motor, horizontal by 50 degree, with 20 rev/mins rotating speed rotations 1 minute, stop, add the radioactivity iodine-125 solution of 100mCi (the silver-colored excellent apparent activity of preparing is 0.6mCi), add the ICl that the 0.5mL volumetric molar concentration is 0.03mol/l again
2The aqueous solution, conditioned reaction pH value is 13, again with reaction flask fixedly on the rotation motor, rotating speed is 20 rev/mins, horizontal by 50 degree, revolving reaction 20 minutes takes out supernatant liquor, with washed with de-ionized water 2 times, acetone cleans 1 time, at room temperature places 15 minutes " ageing " coating, in the titanium pipe of getting ready of packing into after to be dried, with laser or electron beam sealing, standby.The utilization ratio that calculates iodine-125 is 99%.
Embodiment 3
With the silver-colored rod of the well cutting square quartzy bottle of 30mL of packing into, use 5mL heptane and acetone ultrasonic cleaning 5 minutes respectively, with washed with de-ionized water 3 times, dry.Add the NaCl (4.0mol/l) of 5mL and the mixed aqueous solution of NaBr (2.0mol/l), the mol ratio of NaCl and NaBr is 2:1, the NaI (0.05mol/l) and NaOH (0.05mol/L) mixed aqueous solution that add the 1.5mL of existing preparation then, the mol ratio of NaI and NaOH is 1:1, reaction flask is fixed on the rotation motor, horizontal by 30 degree, with 40 rev/mins rotating speed rotations 1 minute, stop, add the radioactivity iodine-125 solution of 100mCi (the silver-colored excellent apparent activity of preparing is 0.6mCi), add the ICl that the 1.0ml volumetric molar concentration is 0.01mol/l again
2The aqueous solution, conditioned reaction pH value is 12, again with reaction flask fixedly on the rotation motor, horizontal by 30 degree, 40 rev/mins of rotating speeds, revolving reaction 40 minutes takes out supernatant liquor, with washed with de-ionized water 2 times, acetone cleans 1 time, at room temperature places 30 minutes " ageing " coating, in the titanium pipe of getting ready of packing into after to be dried, with laser or electron beam sealing, standby.Merge scavenging solution and supernatant liquor, and with the radioactive activity of this mixed solution of activity measurement and silver rod, the utilization ratio of calculating iodine-125 is 99%.
Claims (13)
1, a kind of technique for preparing coating of iodine-125 sealed seed source silver carrier rod, it is characterized in that it being that the silver-colored rod of anticipating is packed in the reaction flask, successively add NaCl and NaBr mixed aqueous solution, NaI and NaOH mixed aqueous solution, mix, add radioiodine and oxygenant ICl again
2, reaction flask is fixed on the rotation motor, revolving reaction is promptly.
2, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 1 is characterized in that, the excellent pre-treatment of described silver is that with excellent heptane, the washing with acetone successively used of silver of cutting, the back is cleaned with deionized water, and drying sealing preservation.
3, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 1 is characterized in that, in described NaCl and the NaBr mixed aqueous solution, the mol ratio of NaCl and NaBr is 1.2:1～3.5:1.
4, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 3 is characterized in that, in described NaCl and the NaBr mixed aqueous solution, the volumetric molar concentration of NaCl is 0.3～10.0mol/l, and the volumetric molar concentration of NaBr is 0.1～5.0mol/l.
5, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 1 is characterized in that, in described NaI and the NaOH mixed aqueous solution, the mol ratio of NaI and NaOH is 1:1～5:1.
6, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 5, it is characterized in that, in described NaI and the NaOH mixed aqueous solution, the volumetric molar concentration of NaI is 0.01～0.5mol/l, and the volumetric molar concentration of NaOH is 0.005～0.1mol/L.
7, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 1 is characterized in that, add two kinds of mixed aqueous solutions after, reaction flask is horizontal by 20～50 degree, rotation mixed 1 minute, rotating speed is 20～60 rev/mins.
8, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 1 is characterized in that, adds the ICl for preparing in advance after described radioiodine joins in the reaction flask immediately
2Solution, reaction flask are horizontal by the rotation of 20～50 degree, and silver-colored rod is drop type stirring up and down voluntarily, and rotating speed is 20～60 rev/mins, revolving reaction 10～40 minutes.
9, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 8 is characterized in that, adds ICl
2The pH value of the mixing solutions behind the solution is 10～13.
10, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 1 is characterized in that, the activity of the radioiodine of adding is 160%～180% of the excellent apparent activity of each silver.
11, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 1 is characterized in that, described ICl
2Solution is preparation temporarily before use, and its volumetric molar concentration is 0.005～0.03mol/L.
12, according to the technique for preparing coating of claim 1 or 11 described iodine-125 sealed seed source silver carrier rods, it is characterized in that, with respect to per 100～600 silver rods, ICl
2The add-on of solution is 0.5～1.8mL.
13, the technique for preparing coating of iodine-125 sealed seed source silver carrier rod according to claim 1, it is characterized in that, after coating finishes, successively with deionized water and washing with acetone coating, and at room temperature placed 15～30 minutes, " ageing " coating is packed into after to be dried in the titanium pipe of getting ready, carries out sealing with laser or electron beam.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101224599A CN101397659A (en) | 2007-09-26 | 2007-09-26 | Technique for preparing coating of iodine-125 sealed seed source silver carrier rod |
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| CNA2007101224599A CN101397659A (en) | 2007-09-26 | 2007-09-26 | Technique for preparing coating of iodine-125 sealed seed source silver carrier rod |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102011120A (en) * | 2009-09-08 | 2011-04-13 | 郝迈琦 | Process for preparing silver based iodine-plated-125 source rod |
| CN103550796A (en) * | 2013-09-25 | 2014-02-05 | 阎尔坤 | Method for preparing iodine-125 sealed seed source core |
| CN105920627A (en) * | 2016-07-01 | 2016-09-07 | 上海欣科医药有限公司 | Method for preparing iodine [<125>I] sealed seed source core |
| CN106139175A (en) * | 2016-07-13 | 2016-11-23 | 江苏华益科技有限供公司 | A kind of Novel silver-based absorption iodine [125i] preparation method of sealed seed source |
-
2007
- 2007-09-26 CN CNA2007101224599A patent/CN101397659A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102011120A (en) * | 2009-09-08 | 2011-04-13 | 郝迈琦 | Process for preparing silver based iodine-plated-125 source rod |
| CN103550796A (en) * | 2013-09-25 | 2014-02-05 | 阎尔坤 | Method for preparing iodine-125 sealed seed source core |
| CN105920627A (en) * | 2016-07-01 | 2016-09-07 | 上海欣科医药有限公司 | Method for preparing iodine [<125>I] sealed seed source core |
| CN105920627B (en) * | 2016-07-01 | 2019-07-30 | 上海欣科医药有限公司 | A kind of iodine [125I] sealed seed source source core preparation method |
| CN106139175A (en) * | 2016-07-13 | 2016-11-23 | 江苏华益科技有限供公司 | A kind of Novel silver-based absorption iodine [125i] preparation method of sealed seed source |
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Open date: 20090401 |