CN111135315A - High-stability iodine [ iodine ], [ solution ]125I]Preparation method of sealed seed source core - Google Patents

High-stability iodine [ iodine ], [ solution ]125I]Preparation method of sealed seed source core Download PDF

Info

Publication number
CN111135315A
CN111135315A CN202010056820.8A CN202010056820A CN111135315A CN 111135315 A CN111135315 A CN 111135315A CN 202010056820 A CN202010056820 A CN 202010056820A CN 111135315 A CN111135315 A CN 111135315A
Authority
CN
China
Prior art keywords
iodine
seed source
preparation
source core
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010056820.8A
Other languages
Chinese (zh)
Inventor
温冰
周亮
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Chuangyi Biotechnology Co ltd
Original Assignee
Guangzhou Chuangyi Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Chuangyi Biotechnology Co ltd filed Critical Guangzhou Chuangyi Biotechnology Co ltd
Priority to CN202010056820.8A priority Critical patent/CN111135315A/en
Publication of CN111135315A publication Critical patent/CN111135315A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The invention discloses a high stable iodine [ iodine ], [ solution of iodine ]125I]The preparation method of the sealed seed source core comprises the following steps: 1) pretreatment of the silver wire: putting the silver wires into a dilute sulfuric acid solution with the pH value of 0, stirring and soaking, adding a sodium carbonate solution to adjust the pH value to 12, continuously stirring for 4-5h, then filtering, washing and drying; 2) iodine [ 2 ]125I]Adsorption: the pretreated silver wire is added into 150ml of iodine [ iodine ], [ 120- ] -125I]And adding a stabilizer into the mixed solution, reacting for 1-10h, airing the silver wires after the reaction is finished, and placing the silver wires in a titanium tube for sealing. The invention provides a high stable iodine125I]The preparation method of the sealed seed source core has the advantages of low cost, no toxicity, short reaction time, high stability and radioactive iodine125I]The utilization rate of the method is high.

Description

High-stability iodine [ iodine ], [ solution ]125I]Preparation method of sealed seed source core
Technical Field
The invention relates to the technical field of medical preparation of radioactive substances, in particular to high-stability iodine125I]A preparation method of a sealed seed source core.
Background
At present, radioactive substances are widely applied to various fields such as production, scientific research, medical treatment, biology, laboratories and the like, and particularly, the radioactive substances are widely applied to clinical application at home and abroad as medicines. The implantation of radioactive sealed seed source such as iodine-125, palladium-103, etc. to cure malignant tumor is a minimally invasive therapeutic method, belonging to one kind of near-distance internal radiotherapy. It has the advantages of simple operation, good treatment effect and the like, and has wide prospect in clinical application. This method is widely used in the United states, Europe, and southeast Asia.
The radionuclide iodine [ iodine ] is compared with other radionuclides125I]Has good nuclear properties due to iodine125I]The gamma ray has low energy and is easy to shield, lead with the thickness of 0.25mm can shield more than 99 percent of rays, the tissue range is 17mm, the radioactive damage of normal tissues is small, and the irradiated dose of accompanying personnel and medical personnel is small. Iodine [ 2 ]125I]The sealed seed source has long half-life period, long storage period and clinical use. Iodine [ 2 ]125I]Has good chemical properties, can form stable iodized metal precipitate with a plurality of metal ions (Au, Ag, Cu and the like), and generally selects silver as the fixed iodine [ 2 ]125I]The carrier rod of (1) is convenient for implanting iodine during treatment because silver ions not only form silver iodide precipitate with iodine, but also are markers of X-ray125I]The sealed seed source is accurately positioned and the treatment dosage is estimated. At present, iodine [ 2 ]125I]The sealed seed source is widely used for treating the prostatic cancer in foreign countries, and has certain achievements in the research of treating different types of tumors in other parts, such as malignant glioma, non-small cell lung cancer and the like.
The iodine-125 sealed seed source for treating is prepared through fixing radioactive iodine-125 onto carrier rod, setting in titanium pipe or stainless steel pipe and welding. For example, U.S. Pat. No. 4323055 and Chinese patent publication No. CN1307907 disclose preparation methods using silver as fixed iodine [ iodine ], [ solution ]125I]The carrier of (1) takes halite (hypochlorite and chlorite) as an oxidant to carry out oxidation and chlorination reaction under the condition of 6mol/L hydrochloric acid, and the chloridized silver rod and iodine125I]Performing ion exchange reaction on the sodium chloride aqueous solution at the pH value of 10-12 for 18-22 hours to prepare iodine125I]And sealing the source core of the seed source. However, the method has the advantages of difficult obtainment of raw materials, long reaction time, generation of a large amount of toxic chlorine gas in the reaction process, no harm to the health of personnel and the environment, and the prepared iodine125I]The source core of the sealed seed source is unstable and is not beneficial to clinical application.
Therefore, how to provide a high-stability,Iodine with mild reaction and no pollution125I]A preparation method of a sealed seed source core is an urgent problem to be solved by the technical personnel in the field.
Disclosure of Invention
In view of this, the present invention provides an iodine [ iodine ], [ solution ]125I]The invention adopts proper organic compound or inorganic compound as stabilizer, which not only improves the iodine value125I]The stability of the source core of the sealed seed source is improved, and the radioactive iodine is also improved125I]The utilization ratio of (2).
In order to achieve the purpose, the invention adopts the following technical scheme:
high-stability iodine [ iodine ], [ solution ]125I]The preparation method of the sealed seed source core comprises the following steps:
1) pretreatment of silver wire
Putting the silver wires into a dilute sulfuric acid solution with the pH value of 0, stirring and soaking, adding a sodium carbonate solution to adjust the pH value to 12, continuously stirring for 4-5h, then filtering, washing and drying;
2) iodine [ 2 ]125I]Adsorption
The pretreated silver wire is added into 150ml of iodine [ iodine ], [ 120- ] -125I]And adding a stabilizer into the mixed solution, reacting for 1-10h, airing the silver wires after the reaction is finished, and placing the silver wires in a titanium tube for sealing.
Preferably, the soaking in the step 1) is carried out for 4-6 h.
Preferably, the mass fraction of the sodium carbonate is 10%.
Preferably, the washing step 1) is performed by using ethanol.
Preferably, the iodine [ alpha ], [ alpha ]125I]The mixed solution comprises the following components: 0.06-0.12mol/L of Na+0.05-0.1mol/L iodine and 400-600mCi/ml iodine [ iodine ], [ solution of iodine ] and the like125I]The solvent is water.
Preferably, the stabilizing agent is cuprous chloride with the mass fraction of 1% and 1%, and is added according to the mass ratio of 1: 1.
Preferably, the stabilizer is 20-30ul of chloramine-T with the mass fraction of 10%, 40-50ul of L-tyrosine with the mass fraction of 10% and 20-30ul of sodium metabisulfite with the mass fraction of 10%.
Preferably, the titanium tube has an outer diameter of 0.80-0.85mm, an inner diameter of 0.65-0.70mm and a length of 6.65-6.85 mm.
Preferably, the length of the silver wire is 3.20-3.30mm, and the diameter of the silver wire is 0.45-0.55 mm.
According to the technical scheme, compared with the prior art, the invention has the following beneficial effects:
1. the invention provides a high stable iodine125I]The preparation method of the sealed seed source core adopts conventional reagents, has low cost and no toxicity; the reaction time is short, and the labor intensity is effectively reduced;
2. radioactive iodine [ 2 ]125I]The utilization rate is high, and the average utilization rate can reach 98-99 percent;
3. the dilute sulfuric acid is adopted for activation, so that the dilute sulfuric acid is not easy to volatilize;
4. the invention adopts a stabilizer with proper proportion to improve the radioactive iodine value125I]The utilization rate is increased and the iodine is also increased125I]The stability of the sealed seed source core, the performance of the source core is unchanged after 2 weeks.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
High-stability iodine [ iodine ], [ solution ]125I]The preparation method of the sealed seed source core comprises the following steps:
1) pretreatment of silver wire
Putting the silver wires into a dilute sulfuric acid solution with the pH value of 0, stirring and soaking for 4-6h, adding a sodium carbonate solution with the mass fraction of 10% to adjust the pH value to 12, continuously stirring for 4-5h, then filtering, washing with ethanol, and drying;
2) iodine [ 2 ]125I]Adsorption
Adding the pretreated silver wire intoUp to 120-125I]Mixed liquor (0.06-0.12mol/L Na)+0.05-0.1mol/L iodine and 400-600mCi/ml iodine [ iodine ], [ solution of iodine ] and the like125I]) And then adding a stabilizer, reacting for 1-10h, airing the silver wire after the reaction is finished, and placing the silver wire in a titanium tube for sealing.
Preferably, the stabilizing agent is cuprous chloride with the mass fraction of 1% and 1%, and is added according to the mass ratio of 1: 1.
Preferably, the stabilizer is 20-30ul of chloramine-T with the mass fraction of 10%, 40-50ul of L-tyrosine with the mass fraction of 10% and 20-30ul of sodium metabisulfite with the mass fraction of 10%.
Preferably, the titanium tube has an outer diameter of 0.80-0.85mm, an inner diameter of 0.65-0.70mm and a length of 6.65-6.85 mm.
Preferably, the length of the silver wire is 3.20-3.30mm, and the diameter of the silver wire is 0.45-0.55 mm.
The following examples are provided for the specification of the silver wire and the titanium tube, and the technical parameters according to the specification of the invention can be selected, and other requirements are not particularly limited.
Example 1
High-stability iodine [ iodine ], [ solution ]125I]The preparation method of the sealed seed source core comprises the following steps:
1) pretreatment of silver wire
Putting the silver wires into a dilute sulfuric acid solution with the pH value of 0, stirring and soaking for 4 hours, adding a sodium carbonate solution with the mass fraction of 10% to adjust the pH value to 12, continuously stirring for 4 hours, then filtering, washing by adopting ethanol, and drying;
2) iodine [ 2 ]125I]Adsorption
The pretreated silver wire was added to 120ml of iodine [ iodine ], [ solution ]125I]Mixed solution (0.12mol/L Na)+0.1mol/L iodine and 600mCi/ml iodine [ iodine ], [125I]) And then adding a stabilizer, reacting for 10 hours, airing the silver wire after the reaction is finished, and placing the silver wire in a titanium tube for sealing.
Wherein the stabilizer is cuprous chloride with the mass fraction of 1% and 1%, and is added according to the mass ratio of 1: 1.
The prepared iodine [ iodine ], [ solution ]125I]The average radioactivity of the source core of the seal seed source is 1.312mCi, radioactive iodine125I]The utilization ratio of (2) was 99%.
Example 2
High-stability iodine [ iodine ], [ solution ]125I]The preparation method of the sealed seed source core comprises the following steps:
1) pretreatment of silver wire
Putting the silver wires into a dilute sulfuric acid solution with the pH value of 0, stirring and soaking for 6h, adding a sodium carbonate solution with the mass fraction of 10% to adjust the pH value to 12, continuously stirring for 5h, then filtering, washing with ethanol, and drying;
2) iodine [ 2 ]125I]Adsorption
The pretreated silver wire was added to 150ml of iodine [ iodine ], [ solution ]125I]Mixed solution (0.06mol/L Na)+0.05mol/L of iodine and 400mCi/ml of iodine [ iodine ], [125I]) And then adding a stabilizer, reacting for 2 hours, airing the silver wire after the reaction is finished, and placing the silver wire in a titanium tube for sealing.
Wherein the stabilizer comprises 20ul of chloramine-T with the mass fraction of 10%, 40ul of L-tyrosine with the mass fraction of 10% and 20ul of sodium metabisulfite with the mass fraction of 10%.
The prepared iodine [ iodine ], [ solution ]125I]The average radioactivity of the source core of the seal seed source is 1.287mCi, radioactive iodine125I]The utilization ratio of (2) was 98%.
Example 3
High-stability iodine [ iodine ], [ solution ]125I]The preparation method of the sealed seed source core comprises the following steps:
1) pretreatment of silver wire
Putting the silver wires into a dilute sulfuric acid solution with the pH value of 0, stirring and soaking for 5h, adding a sodium carbonate solution with the mass fraction of 10% to adjust the pH value to 12, continuously stirring for 5h, then filtering, washing with ethanol, and drying;
2) iodine [ 2 ]125I]Adsorption
The pretreated silver wire was added to 140ml of iodine [ iodine ], [ solution ]125I]Mixed solution (0.1mol/L Na)+0.08mol/L iodine and 500mCi/ml iodine [ iodine ], [125I]) And then adding a stabilizer, reacting for 5 hours, airing the silver wire after the reaction is finished, and placing the silver wire in a titanium tube for sealing.
Wherein the stabilizer comprises 25ul of chloramine-T with the mass fraction of 10%, 45ul of L-tyrosine with the mass fraction of 10% and 25ul of sodium metabisulfite with the mass fraction of 10%.
The prepared iodine [ iodine ], [ solution ]125I]The average radioactivity of the source core of the sealed seed source is 1.247mCi, radioactive iodine125I]The utilization ratio of (2) was 99%.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (9)

1. High-stability iodine [ iodine ], [ solution ]125I]The preparation method of the sealed seed source core is characterized by comprising the following steps:
1) pretreatment of silver wire
Putting the silver wires into a dilute sulfuric acid solution with the pH value of 0, stirring and soaking, adding a sodium carbonate solution to adjust the pH value to 12, continuously stirring for 4-5h, then filtering, washing and drying;
2) iodine [ 2 ]125I]Adsorption
The pretreated silver wire is added into 150ml of iodine [ iodine ], [ 120- ] -125I]And adding a stabilizer into the mixed solution, reacting for 1-10h, airing the silver wires after the reaction is finished, and placing the silver wires in a titanium tube for sealing.
2. The method of claim 1High-stability iodine [ alpha ], [ alpha125I]The preparation method of the sealed seed source core is characterized in that the seed source core is soaked for 4-6h in the step 1).
3. The highly stable iodine [ 2 ] according to claim 1125I]The preparation method of the sealed seed source core is characterized in that the mass fraction of the sodium carbonate is 10%.
4. The highly stable iodine [ 2 ] according to claim 1125I]The preparation method of the sealed seed source core is characterized in that ethanol is adopted for washing in the step 1).
5. The highly stable iodine [ 2 ] according to any one of claims 1 to 4125I]The preparation method of the sealed seed source core is characterized in that the iodine [ iodine ], [ solution of iodine ], [ solution125I]The mixed solution comprises the following components: 0.06-0.12mol/L of Na+0.05-0.1mol/L iodine and 400-600mCi/ml iodine [ iodine ], [ solution of iodine ] and the like125I]The solvent is water.
6. The highly stable iodine [ 2 ] according to any one of claims 1 to 4125I]The preparation method of the sealed seed source core is characterized in that the stabilizer is cuprous chloride with the mass fraction of 1% and 1%, and is added according to the mass ratio of 1: 1.
7. The highly stable iodine [ 2 ] according to any one of claims 1 to 4125I]The preparation method of the sealed seed source core is characterized in that the stabilizer is 20-30ul of chloramine-T with the mass fraction of 10%, 40-50ul of L-tyrosine with the mass fraction of 10% and 20-30ul of sodium metabisulfite with the mass fraction of 10%.
8. The highly stable iodine [ 2 ] as defined in claim 5125I]The preparation method of the sealed seed source core is characterized in that the outer diameter of the titanium tube is 0.80-0.85mm, the inner diameter is 0.65-0.70mm, and the length is 6.65-6.85 mm.
9. The method of claim 5Is high stable iodine125I]The preparation method of the sealed seed source core is characterized in that the length of the silver wire is 3.20-3.30mm, and the diameter of the silver wire is 0.45-0.55 mm.
CN202010056820.8A 2020-01-16 2020-01-16 High-stability iodine [ iodine ], [ solution ]125I]Preparation method of sealed seed source core Pending CN111135315A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010056820.8A CN111135315A (en) 2020-01-16 2020-01-16 High-stability iodine [ iodine ], [ solution ]125I]Preparation method of sealed seed source core

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010056820.8A CN111135315A (en) 2020-01-16 2020-01-16 High-stability iodine [ iodine ], [ solution ]125I]Preparation method of sealed seed source core

Publications (1)

Publication Number Publication Date
CN111135315A true CN111135315A (en) 2020-05-12

Family

ID=70526251

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010056820.8A Pending CN111135315A (en) 2020-01-16 2020-01-16 High-stability iodine [ iodine ], [ solution ]125I]Preparation method of sealed seed source core

Country Status (1)

Country Link
CN (1) CN111135315A (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李天星 等主编: "《现代临床医学免疫学检验技术》", 30 September 2014, 北京：军事医学科学出版社 *

Similar Documents

Publication Publication Date Title
CN101797392B (en) Palladium-103 and io-125 compound sealed seed source, source core and source core preparation method
Chakravarty et al. An electro-amalgamation approach to isolate no-carrier-added 177Lu from neutron irradiated Yb for biomedical applications
CN109384806B (en) A [ 2 ]18F]Novel preparation method of FBPA (FBPA)
US6143431A (en) Production of Palladium-103
CN111135315A (en) High-stability iodine [ iodine ], [ solution ]125I]Preparation method of sealed seed source core
CN101401944B (en) Method of preparing iodine-125 sealing seed source core
CN101880873B (en) Preparation process of 103Pd sealed seed source core
CN101397659A (en) Technique for preparing coating of iodine-125 sealed seed source silver carrier rod
CN103550796B (en) Method for preparing iodine-125 sealed seed source core
KR101426422B1 (en) Iodine seed for treatment of eye disease and cancer, and the method for preparation thereof
Cardoso et al. Highly efficient method for production of radioactive silver seed cores for brachytherapy
CN1246042C (en) Preparation method of therapy used iodine-125 sealed seed source core
Lee et al. Surface treatments of silver rods with enhanced iodide adsorption for I-125 brachytherapy seeds
RU2436179C1 (en) Start target composition on basis of radium, and manufacturing method thereof
CN106540282B (en) A kind of preparation method of -103 sealed seed source source core of palladium
CN105920627A (en) Method for preparing iodine [<125>I] sealed seed source core
Zhang et al. Preparation of iodine-125 seed Part I
Fan et al. Preparation of 125I seed sources for implantation therapy of prostate cancer
WO2023171617A1 (en) Method for producing radiolabeled aryl compound by electrolytic oxidation reaction
Saidi et al. Application of Cyclotrons in Brachytherapy
Lee et al. Adsorption of iodide on silver rods for 125 I seed preparation
RU2332735C1 (en) Method of production of carrier-free radionuclide palladium-103
LEBEDEVA et al. PRINCIPLES DEVELOPMENT OF 103Pd REACTOR PRODUCTION TECHNOLOGY AND PALLADIUM SEED CORE PRODUCTION TECHNOLOGY BY ELECTROCHEMICAL PLATING RA KUZNETSOV, VM RADCHENKO, VA TARASOV, NN ANDREICHUK
BR102014027720A2 (en) process of direct fixation of radioactive iodine on silver substrate to manufacture brachytherapy supplies
RU2398774C2 (en) Method for synthesis of 3'-iodofolic acid and 3'-bromofolic acid labelled with radioactive isotopes of iodine and bromine

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination