CN1242987C

CN1242987C - Preparation process of organic selenium

Info

Publication number: CN1242987C
Application number: CN 200410016499
Authority: CN
Inventors: 毛建卫; 洪作鹏; 崔艳丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-02-24
Filing date: 2004-02-24
Publication date: 2006-02-22
Anticipated expiration: 2024-02-24
Also published as: CN1560034A

Abstract

The present invention relates to a preparing process of novel organic selenium methionine selenium, which is characterized in that the preparing process of a methionine selenium product is composed of the working procedures of selenium dichloride synthesis, selenium tetrachloride synthesis, methionine salt synthesis, methionine selenium synthesis, drying, crushing, etc., and the novel methionine selenium has high bioavailability, low toxicity, improves the oxidation resistance and the immune function of an organism and regulates internal secretion by enhancing the activity of glutathione peroxidase in tissue cells and plays a remarkable role in enhancing oxidation resistance and the immune efficiency of body fluid, promoting the growth and the development of domestic fowls and animals, improving the quality of muscles, etc.

Description

A kind of preparation technology of organoselenium

Technical field

The present invention relates to a kind of preparation technology of organoselenium selenium methionine.

Background technology

The nutritionist confirms: selenium is one of trace element of needed by human, and selenium can promote that human body grows, and regulates function of human body, strengthens resistance against diseases, prevents and treats Keshan disease, and more than 40 kind of disease such as Kaschin-Beck disease has anti-ageing, antitumous effect.

Selenium is especially one of indispensable trace element in the Mammals growth of animal, China has the area more than 2/3rds to belong to scarce selenium area, in the feed forage grass that produce in these areas, average selenium content is lower than 0.05mg/kg, seriously lacks the selenium area and just accounts for 29%, is processed into mixed feed with these geographic feed forage grasses, the selenium content wretched insufficiency, the selenium deficiency of animal can cause toxicity symptoms such as muscle deterioration, hepatic necrosis, pancreatic necrosis, and yellowish pink simultaneously poor, drip loss increases.Lacking selenium concerning poultry can suffer from white muscle disease, exudative diathesis, poor growth and feather and grow bad, pancreas vacuolation etc.The main path of picked-up selenium is a feed, but the toxic dose of selenium and its nutrition dosage are very approaching, the careless slightly selenosis that easily causes, but all use Sodium Selenite to mend selenium in the past as a kind of additive.Though Sodium Selenite generally adds in feed, the situation that lacks selenium is still quite multiple, and the biological value of Sodium Selenite is low, and scope is little between toxic dose and the requirement, because its toxicity is stronger, brings inconvenience for production and use.On the one hand, inorganic selenium is to absorb by the intestines wall with passive diffusion way to enter liver then, is converted into biological selenium again, and bioavailability is low, and unemployed a large amount of inorganic seleniums are discharged in the environment, cause severe environmental pollution; On the other hand, the using dosage of inorganic selenium is difficult to grasp, and easily causes poisoning, thereby limits its usage quantity, Japan even forbid adding Sodium Selenite.Progressively replace inorganic selenium with organoselenium in the world at present and add, compare with inorganic selenium, the toxicity of organoselenium is less, is convenient to use in feed.Organoselenium is to be absorbed by body by the intestines wall with active transport mechanism, and its specific absorption is higher than inorganic selenium, can reduce the addition in the feed, and can reduce the pollution of selenium to environment.

Organoselenium selenium methionine bioavailability height of the present invention, toxicity is minimum, it act as: (1) selenium methionine in resistance of oxidation, humoral immunization usefulness, promote animal growth and development, to improve aspect effects such as meat quality remarkable.Add selenium methionine in the daily ration and significantly improve growth performance, reduce the muscle drip loss, improve muscle myohaemoglobin, muscle red color, imp content, improve and organize selenium content; (2) selenium methionine improves the resistance of oxidation of body by strengthening the vigor of Selenoperoxidase in the histocyte, reduces the generation of cell endoperoxide, keeps membrane structure and functional integrity, and reduces the drip loss of muscle; Delay the oxidising process of myohaemoglobin simultaneously, produce stable yellowish pink effect; (3) selenium methionine is by improving antioxidant ability of organism and immunity function, endocrine regulation and improve the growth of animals or poultry performance.

Summary of the invention

Operations such as its preparation technology of organoselenium selenium methionine of the present invention is synthetic by dichloride selenium, selenic chloride is synthetic, methionine salt is synthetic, selenium methionine is synthetic, drying, pulverizing are formed.

Dichloride selenium and selenic chloride preparation section are: liquid chlorine reacts through vaporization, drying and selenium powder, generate dichloride selenium, the intact selenium powder of unreacted can separate by microporous membrane to be removed, the intact reactant of unreacted continues to participate in reaction, make selenium powder be able to whole conversions, can be perfect with the reaction that guarantees the back operation, dichloride selenium and chlorine reaction, drying, pulverizing obtain selenic chloride.

The methionine salt preparation section is: methionine(Met) is dissolved in water, adds that alkali lye reacts, concentrates, drying obtains methionine salt.

The selenium methionine preparation section is: methionine salt and selenic chloride are added respectively in water solvent or the organic solvent react, reaction PH can be controlled between the 2-9, preferred PH is between the 4.5-8, temperature of reaction is-10 ℃-100 ℃, preferred temperature is between 0 ℃-50 ℃, reaction times is between 0.5-10 hour, the preferred reaction time is between 1-5 hour, reaction solvent is the aqueous solution or alcohol, ether, ketone, organic solvents such as amine, the preferred alcohol of institute is methyl alcohol, or ethanol, or Virahol, reactant carries out drying again through filtering or concentrating, pulverizing obtains the selenium methionine product.

Advantage of the present invention:

Organoselenium selenium methionine preparation cost of the present invention is low, and product toxicity is little, the biological value height.According to the application test result, adopt organoselenium selenium methionine of the present invention as fodder additives, use back growth of animal effect to compare with mixed feeds such as general organoselenium, inorganic seleniums, pig, chicken average weight gain improve significantly, the trunk dressing percentage improves 5%, obviously improves meat, egg product matter; Improve bright fragrance nucleotide content in the pork, improve pig flesh flavor, improve lean ratio, obviously improve than general organoselenium, inorganic selenium biological value, toxicity significantly descends, and quality improving is big, and result of use is remarkable.

Embodiment

Embodiment 1

Liquid chlorine reacts through vaporization, drying and selenium powder 160g, generates dichloride selenium, and dichloride selenium and chlorine reaction, drying, pulverizing obtain selenic chloride 405g.

Methionine(Met) 1180g is dissolved in water, adds that alkali lye reacts, concentrates, drying obtains methionine salt 1270g.

Methionine salt 1270g and selenic chloride 405g added in the entry respectively react, reaction PH is controlled at 6-7, and temperature of reaction is 5 ℃, and the reaction times is 2 hours, and reactant is through filtering and concentrating, carries out drying again, pulverizes and obtain selenium methionine product 1170g.

Embodiment 2

Liquid chlorine reacts through vaporization, drying and selenium powder 80g, generates dichloride selenium, and the intact selenium powder of unreacted can be removed by the microporous membrane separation, returns continuation and participates in reaction, and dichloride selenium and chlorine reaction, drying, pulverizing obtain selenic chloride 215g.

Methionine(Met) 590g is dissolved in water, adds that alkali lye reacts, concentrates, drying obtains methionine salt 635g.

Methionine salt 635g and selenic chloride 215g added in the Virahol respectively react, reaction PH is controlled between the 5-7, and temperature of reaction is 20 ℃, and the reaction times is 3 hours, reactant is through filtering and concentrating, carries out drying again, pulverizes and obtain selenium methionine product 605g.

Claims

1, a kind of preparation technology of organoselenium selenium methionine, synthetic by dichloride selenium, selenic chloride synthetic, methionine salt synthetic, selenium methionine is synthetic, dry, pulverizing process is formed, step is as follows:

(1) liquid chlorine reacts through vaporization, drying and selenium powder, generates dichloride selenium, and dichloride selenium and chlorine reaction, drying, pulverizing obtain selenic chloride;

(2) methionine(Met) is dissolved in water, adds that alkali lye reacts, concentrates, drying obtains methionine salt;

(3) methionine salt and selenic chloride are added respectively in water solvent or the organic solvent react, reaction PH is controlled between the 2-9, and temperature of reaction is-10 ℃-100 ℃, and the reaction times is 0.5-10 hour, reactant is through filtering or concentrating, and carries out drying again, pulverizes and obtain the selenium methionine product.

2, the preparation technology of selenium methionine according to claim 1, it is characterized in that adopting in the dichloride selenium synthesis technique microporous membrane separation technology, carry out the intact reactants separate of dichloride selenium intermediate and unreacted, the intact reactant of unreacted continues to participate in reaction, make selenium powder be able to whole conversions, can be perfect with the reaction that guarantees the back operation.

3, the preparation technology of selenium methionine according to claim 1, it is characterized in that reacting PH is between the 4.5-8.

4, the preparation technology of selenium methionine according to claim 1 is characterized in that temperature of reaction is between 0 ℃-50 ℃.

5,, it is characterized in that the reaction times is between 1-5 hour according to the preparation technology of claim 1 or 4 described selenium methionines.

6, the preparation technology of selenium methionine according to claim 1 is characterized in that described reaction organic solvent is alcohol.

7, the preparation technology of selenium methionine according to claim 6 is characterized in that described alcohol is: methyl alcohol, ethanol, Virahol a kind of.