CN1241651C - Hemostatic antibiotic products and preparnig method thereof - Google Patents
Hemostatic antibiotic products and preparnig method thereof Download PDFInfo
- Publication number
- CN1241651C CN1241651C CNB031365353A CN03136535A CN1241651C CN 1241651 C CN1241651 C CN 1241651C CN B031365353 A CNB031365353 A CN B031365353A CN 03136535 A CN03136535 A CN 03136535A CN 1241651 C CN1241651 C CN 1241651C
- Authority
- CN
- China
- Prior art keywords
- weight
- hemostatic
- cotton sliver
- thistle extract
- field thistle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/007—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Dispersion Chemistry (AREA)
- Surgery (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention provides a hemostatic antibiotic product in forms of solutions, compresses and bandages. The hemostatic antibiotic product contains 1 to 30.61% weight of cephalanoplos segetum extract and 0.1 to 0.5% weight of benzalkonium chloride and contains 1 to 2% weight of local anaesthetic and/or 0.1 to 0.5% weight of surface acting agent. The present invention also provides a manufacturing method for the hemostatic antibiotic product.
Description
Technical field
The present invention relates to the hemostatic and antibacterial product.The invention still further relates to the method for making described hemostatic and antibacterial product.
Background technology
Field thistle (cephalonoplos segetum) (Herba Cirsii) or wasteland Ji are a kind of medicinal herbs, it is reported, its extract is the Chinese medicine with anastalsis.These medicinal herbs can directly be smashed topical application (Pharmacopoeia of People's Republic of China 1992 English edition the 94th page) to pieces, but the unprocessed medicinal herbs of application are not only unhygienic but also inconvenient.Benzalkonium chloride is a kind of topical antiseptic (The Merck Index, the 11st compiles 1989).Contain concentration in the known anticorrosion binder and be 0.1% to 0.5% benzalkonium chloride (" Bandaid ", India Johson ﹠ Johnson (Johnson and Johnson)).
Summary of the invention
An object of the present invention is to provide the hemostatic and antibacterial product, contain field thistle extract and benzalkonium chloride in the described hemostatic and antibacterial product, and optionally contain local anesthetic and/or surfactant.
Another object of the present invention provides the hemostatic and antibacterial product, contains field thistle extract and benzalkonium chloride in the described hemostatic and antibacterial product, and optionally contains local anesthetic and/or surfactant, and described product price is cheap.
Another object of the present invention provides the method for making the hemostatic and antibacterial product, contains field thistle extract and benzalkonium chloride in the described hemostatic and antibacterial product, and optionally contains local anesthetic and/or surfactant.
Another object of the present invention provides the method for making the hemostatic and antibacterial product, contains field thistle extract and benzalkonium chloride in the described hemostatic and antibacterial product, and optionally contains local anesthetic and/or surfactant, and described method is simple.
The invention provides a kind of hemostatic and antibacterial product, contain the benzalkonium chloride of 1% weight in the described hemostatic and antibacterial product, and optionally contain the surfactant of 1% weight to the local anesthetic of 2% weight and/or 0.1% weight to 0.5% weight to the field thistle extract of 30.61% weight and 0.1% weight to 0.5% weight.
An embodiment of the invention provide a kind of hemostatic and antibacterial product of solution form, and described solution contains the benzalkonium chloride of 1% weight to the field thistle extract of 5.0% weight, 0.1% weight to 0.5% weight, 1% weight surfactant and the solvent to the local anesthetic of 2% weight and/or 0.1% weight to 0.5% weight.
Another embodiment of the invention provides a kind of hemostatic and antibacterial product of compress designs, described compress comprises the expanded cotton sliver or the nonwoven strip of dipping solution, described compress is sealed in pouch or the satchel, and described solution contains the benzalkonium chloride of 1% weight to the field thistle extract of 5.0% weight, 0.1% weight to 0.5% weight, 1% weight surfactant and the solvent to the local anesthetic of 2% weight and/or 0.1% weight to 0.5% weight.
Another embodiment of the invention provides a kind of hemostatic and antibacterial product of form of bandage, expanded cotton sliver or nonwoven strip that described binder has dipping solution and is dried, described solution contain benzalkonium chloride and the solvent of 1.55% weight to the field thistle extract of 30.61% weight, 0.13% weight to 0.18% weight.
Another embodiment of the invention provides a kind of hemostatic and antibacterial product of form of bandage, expanded cotton sliver or nonwoven strip that described binder has dipping solution and is dried, described solution contains the field thistle extract of 1.55% weight to 30.61% weight, 0.13% weight is to the benzalkonium chloride and the solvent of 0.18% weight, described binder also has the lining that has air-vent, the inner surface of described lining scribbles binding agent, soak on the expanded cotton sliver of medicine or the inner surface that nonwoven strip is bonded to described lining, has noncohesive cover layer on described expanded cotton sliver that soaks medicine or the nonwoven strip, described cover layer is bonded on the inner surface of described lining, have peel strip on described noncohesive cover layer, described peel strip is bonded on the inner surface of described lining.
The invention provides a kind of method of making the hemostatic and antibacterial product of solution form, described method comprise make the Benza of 1% weight to the field thistle extract powder of 5.0% weight, 0.2% weight to 1.0% weight 50%, 1% weight to the local anesthetic of 2% weight and/or 0.1% weight to the surfactant of 0.5% weight and the step of solvent.
The present invention also provides a kind of method of making the hemostatic and antibacterial product of compress designs, described method comprises with expanded cotton sliver of solution impregnation or nonwoven strip, and the expanded cotton sliver bar after will flooding or nonwoven strip be sealed in the step in pouch or the satchel, and described solution contains the Benza of 1% weight to the field thistle extract powder of 5.0% weight, 0.2% weight to 1.0% weight 50%, 1% weight surfactant and the solvent to the local anesthetic of 2% weight and/or 0.1% weight to 0.5% weight.
The present invention also provides a kind of method of making the hemostatic and antibacterial product of form of bandage, and described method comprises:
A) with expanded cotton sliver of solution impregnation or nonwoven strip, described solution contains Benza and the solvent of 1% weight to the field thistle extract powder of 12% weight, 0.05% weight to 0.2% weight 50%, dipping makes the expanded cotton sliver before accompanying medicine is based on dipping on described expanded cotton sliver or the nonwoven strip or the percetage by weight of nonwoven strip be: benzalkonium chloride 180% to 520%, field thistle extract 155% to 255% and
B) 50-110 ℃ of down dry described expanded cotton sliver or nonwoven strip of soaking medicine, so that make solvent evaporation.
The present invention also provides a kind of method of making the hemostatic and antibacterial product of form of bandage, and described method comprises:
A) with expanded cotton sliver of solution impregnation or nonwoven strip, described solution contains Benza and the solvent of 1% weight to the field thistle extract powder of 12% weight, 0.05% weight to 0.2% weight 50%, dipping makes the expanded cotton sliver before accompanying medicine is based on dipping on described expanded cotton sliver or the nonwoven strip or the percetage by weight of nonwoven strip be: benzalkonium chloride 180% to 520%, field thistle extract 155% to 255%
B) 50-110 ℃ of down dry described expanded cotton sliver or nonwoven strip of soaking medicine, so that make solvent evaporation,
C) soak on the expanded cotton sliver of medicine or the inner surface that nonwoven strip is bonded in lining described, described lining has air-vent and scribbles binding agent,
D) on described expanded cotton sliver that soaks medicine or nonwoven strip, provide noncohesive cover layer, and described cover layer is bonded on the inner surface of described lining and
E) on described noncohesive cover layer, provide peel strip, and described peel strip is bonded on the inner surface of described lining.
With known water-tight equipment and known method described expanded cotton sliver or nonwoven strip of soaking medicine (solution) is sealed in pouch or the satchel.For example aluminum film or aluminium foil are made by known material for described pouch or satchel.
Described solvent can be water, ethanol, propanol or ethyl acetate.
Described local anesthetic can be lidocaine hydrochloride or hydrochloric acid benzocaine.
Described surfactant can be PEG (Polyethylene Glycol) 40 or castor oil hydrogenated (cremaphorRH40).
Described lining can comprise cotton, polrvinyl chloride, polyurethane, polyethylene, ethylene vinyl acetate or non-woven fibre.
Described binding agent can be the binding agent of rubber-based or acrylic.
Described noncohesive cover layer can be polyethylene, ethylene vinyl acetate or high density polyethylene (HDPE).
Described peel strip can be siliconised paper or high density polyethylene (HDPE).
The invention provides hemostatic and antibacterial product and manufacture method thereof, described hemostatic and antibacterial product contains the active field thistle extract and the benzalkonium chloride of constant weight percent, and optionally contain local anesthetic and/surfactant of living.This series products does not appear in the newspapers as yet, thereby is new product.This product is effective coagulant and antibacterial.In addition, they is easy to use.Described active matter especially field thistle extract and benzalkonium chloride is cheap.Therefore, product of the present invention is more cheap.Method is simple to make product of the present invention.
Description of drawings
Accompanying drawing 1 is the schematic flow diagram of a dipping systems, and this system is used for making the hemostatic and antibacterial binder according to an embodiment of the invention.
Accompanying drawing 2 is binders of an embodiment of the invention.
The specific embodiment
As shown in Figure 1, described dipping systems is known, and it is worked in known manner.Described dipping systems comprises roller 1, and described roller 1 is used for launching the volume of expanded cotton or non-woven fabrics base material 2a.Groove 3 is equipped with the solution (not shown) of active substance, and described solution contains field thistle extract powder, benzalkonium chloride and solvent.4 and 5 is the eclipsed nip rollers up and down that place in the groove 3, and described nip roller reverse rotation exists engagement mouth or roll gap (not shown) therebetween.6 and 7 is drying ovens.Roller 8 is used for batching the drying volume that soaks the base material 2b behind the medicine.9a-9n, 9p and 9q are deflector roll.10a, 10b and 10c are idler roller.11a, 11b and 11c are respectively the support or the bearing of groove 3, drying oven 6 and 7.When base material 2a passed through the solution that is contained in the groove 3, the medicine that base material 2a is contained field thistle extract and benzalkonium chloride flooded.Engagement mouth between the adjusting nip roller is controlled the percetage by weight of active matter accompanying on the base material.Nip roller has guaranteed that also active matter evenly floods on base material.Process dipping and exsiccant base material are cut into the strip (not shown) of required size on roller 8.
Should be appreciated that and to adopt known other equipment/systems to carry out above-mentioned dipping process of the present invention.
Following experimental example is to explanation of the present invention but not limits the scope of the invention.
Embodiment 1
Benzalkonium chloride, 0.61g sodium chloride, 2g lidocaine hydrochloride and the 96.19g pure water of 1g field thistle extract powder, 0.2g 50% are mixed, thereby make hemostatic and antibacterial solution.
Embodiment 2
Adopt the 97.19g pure water and do not adopt the field thistle extract powder, prepare solution according to the method for embodiment 1.
Benzalkonium chloride, 0.61g sodium chloride, 2g lidocaine hydrochloride, 0.6g cremaphor RH40 and the 95.59g pure water of 1g field thistle extract powder, 0.2g 50% are mixed, thereby make hemostatic and antibacterial solution.
Adopt the 96.59g pure water and do not adopt the field thistle extract powder, prepare solution according to the method for embodiment 1.
Be sealed in the aluminium foil with the solution impregnation nonwoven strip of embodiment 1 to 4 and with it, thereby make compress.
Adopt the blood plasma part of rich platelet and anemia platelet and solution and the corresponding compress thereof of embodiment 1 to 4 to carry out the comparative study of setting time, the result is as shown in table 1.
Table 1
| The embodiment numbering | Average setting time | |
| Platelet rich plasma | Platelet poor plasma | |
| 1 2 3 4 | 4’17” ＞15’ 4’39” ＞15’ | 12’07” ＞15’ 13’46” ＞15’ |
In the dipping systems of accompanying drawing 1, with solution impregnation nonwoven cotton, described solution is for containing the benzalkonium chloride of 1kg field thistle extract powder and 0.05kg 50% in the 98.95kg pure water.The percetage by weight of accompanying active matter is 520% benzalkonium chloride and 163% field thistle extract, the dry nonwoven cotton that soaks medicine in 110 ℃ stove then on the nonwoven cotton.The dried nonwoven cotton that soaks medicine is cut into required size.Detect and find that each cloth that soaks medicine contains the active matter of 1.76% weight.
The cloth that soaks medicine can be used as for example binder, at this moment, this cloth that soaks medicine is wrapped in the affected part or is fixed on the affected part with adhesive tape.Perhaps also the cloth that soaks medicine can be made the binder shown in the accompanying drawing 2, wherein labelling 12 indications is the cloth that soaks medicine.Have passage 14 on the lining 13, and the surface scribbles the binding agent (not shown) within it.The cloth that soaks medicine is bonded on the inner surface of lining.Inviscid cover layer 15 with holes is positioned on the cloth that soaks medicine and is fixed on the inner surface of lining.Peel strip 16a and 16b are positioned on the inviscid cover layer and are fixed on the inner surface of lining.
Adopt the typical binder (soaking the cloth of medicine) of embodiment 6 to carry out the comparative study of setting time, the result is as shown in table 2:
Table 2
| Test material | The average setting time of platelet rich plasma | The average setting time of platelet poor plasma |
| Be soaked with the nonwoven cotton of the field thistle extract powder of 2.37% weight on the fabric | 5’08” | ＞15’ |
| Be soaked with the nonwoven cotton of the field thistle extract powder of 4.6% weight on the fabric | 8’19” | 11’56” |
| Fabric soil is soaked with the nonwoven cotton of the field thistle extract powder of 7.5% weight | 5’33” | 9’29” |
| Be soaked with the nonwoven cotton of the field thistle extract powder of 19.16% weight on the fabric | 6’20” | 9’17” |
| The binder of | 5’21” | 10’0” |
| The nonwoven cotton of immersion | ＞15’ | ＞15’ |
| The nonwoven cotton | ＞15’ | ＞15’ |
| Be soaked with the nonwoven cotton of the benzalkonium chloride of 0.1% weight | 13’31” | ＞15’ |
Used field thistle extract powder is from Chinese Tianjin pharmaceutical Co. Ltd in the above-mentioned experiment.
In above-mentioned two tables, setting time〉15 ' expression do not have congealing activity.
Table 1 shows, adopts the solution (embodiment 1 and 3) and the corresponding compress of field thistle extract powder to take place to condense, and the solution (embodiment 2 and 4 and corresponding compress) that does not contain the field thistle extract powder does not condense.Table 2 shows that the nonwoven cotton that is soaked with the field thistle extract powder of 2.37% weight condenses to plateletrich blood plasma, is promptly condensed by hematoblastic gathering, but the blood plasma of anemia platelet is not condensed.This shows that it is that final agglomerative factor does not have effect to causing stepwise to condense.The nonwoven cotton of field thistle extract powder that is soaked with big percent such as 4.6%, 7.5% and 19.6% is to the equal show coagulating activity of blood plasma of rich platelet and anemia platelet.The nonwoven cotton of immersion and nonwoven cotton itself all do not have congealing activity for the blood plasma of rich platelet and anemia platelet.The nonwoven cotton that is soaked with the benzalkonium chloride of 0.1% weight has certain congealing activity to plateletrich blood plasma, but the blood plasma of anemia platelet is not had congealing activity.The binder of the embodiment of the invention 6 contains the field thistle extract powder and the benzalkonium chloride of 1.76% weight, this binder all has congealing activity for the blood plasma of rich platelet and anemia platelet, this shows when being used in combination field thistle extract powder and benzalkonium chloride, under the low concentration of 1.76% weight, hematoblastic condensing had synergism, and when the use least concentration is the field thistle extract powder of 2.37% weight separately, demonstrate the stepwise coagulation.
Carry out the antibacterial effect research of the binder of embodiment 6 as follows:
Get size and be about the nonwoven cotton of 15mm * 15mm and the binder sample of embodiment 6, be placed on escherichia coli (E.Coil ATCC 8739), staphylococcus aureus (Staphaureus ATCC 6538), Pseudomonas aeruginosa (Ps Aeruginosa ATCC 9027) and Candida albicans (the C Albicans ATCC 10231) culture through cultivation in 24 hours.Observed result such as table 3 after 48 hours:
Table 3
| Microorganism | The nonwoven cotton | The binder of |
| Escherichia coli ATCC 8739 staphylococcus aureus ATCC 6538 Pseudomonas aeruginosa ATCC 9027 Candida albicans ATCC 10231 | Not having nothing zone, nothing zone, zone does not have regional | Do not have regional 15mm * 15mm zone and do not have nothing zone, zone |
Place the binder of the embodiment 6 on the staphylococcus aureus culture to form the inhibition zone of 15mm * 15mm, this shows that this binder has this antibacterial and suppresses active.
Claims (9)
1. hemostatic and antibacterial product, described hemostatic and antibacterial product contains the benzalkonium chloride of 1% weight to the field thistle extract of 30.61% weight and 0.1% weight to 0.5% weight, and optionally contains the surfactant of 1% weight to the local anesthetic of 2% weight and/or 0.1% weight to 0.5% weight.
2. hemostatic and antibacterial product as claimed in claim 1, it is the solution form, and described solution contains the benzalkonium chloride of 1% weight to the field thistle extract of 5% weight, 0.1% weight to 0.5% weight, 1% weight surfactant and the solvent to the local anesthetic of 2% weight and/or 0.1% weight to 0.5% weight.
3. hemostatic and antibacterial product as claimed in claim 1, it is a compress designs, described compress comprises the expanded cotton sliver or the nonwoven strip of dipping solution, described compress is sealed in pouch or the satchel, and described solution contains the benzalkonium chloride of 1% weight to the field thistle extract of 5% weight, 0.1% weight to 0.5% weight, 1% weight surfactant and the solvent to the local anesthetic of 2% weight and/or 0.1% weight to 0.5% weight.
4. hemostatic and antibacterial product as claimed in claim 1, it is a form of bandage, expanded cotton sliver or nonwoven strip that described binder has dipping solution and is dried, described solution contain benzalkonium chloride and the solvent of 1.55% weight to the field thistle extract of 30.61% weight, 0.13% weight to 0.18% weight.
5. hemostatic and antibacterial product as claimed in claim 1, it is a form of bandage, expanded cotton sliver or nonwoven strip that described binder has dipping solution and is dried, described solution contains the field thistle extract of 1.55% weight to 30.61% weight, 0.13% weight is to the benzalkonium chloride and the solvent of 0.18% weight, described binder also has the lining that has air-vent, the inner surface of described lining scribbles binding agent, soak on the expanded cotton sliver of medicine or the inner surface that nonwoven strip is bonded to described lining, has noncohesive cover layer on described expanded cotton sliver that soaks medicine or the nonwoven strip, described cover layer is bonded on the inner surface of described lining, have peel strip on described noncohesive cover layer, described peel strip is bonded on the inner surface of described lining.
6. make the method for the hemostatic and antibacterial product of solution form, described method comprise make the Benza of 1% weight to the field thistle extract powder of 5% weight, 0.2% weight to 1.0% weight 50%, 1% weight to the local anesthetic of 2% weight and/or 0.1% weight to the surfactant of 0.5% weight and the step of solvent.
7. make the method for the hemostatic and antibacterial product of compress designs, described method comprises with expanded cotton sliver of solution impregnation or nonwoven strip, and the expanded cotton sliver bar after will flooding or nonwoven strip be sealed in the step in pouch or the satchel, and described solution contains the Benza of 1% weight to the field thistle extract powder of 5% weight, 0.2% weight to 1.0% weight 50%, 1% weight surfactant and the solvent to the local anesthetic of 2% weight and/or 0.1% weight to 0.5% weight.
8. make the method for the hemostatic and antibacterial product of form of bandage, described method comprises:
A) with expanded cotton sliver of solution impregnation or nonwoven strip, described solution contains Benza and the solvent of 1% weight to the field thistle extract powder of 12% weight, 0.05% weight to 0.2% weight 50%, dipping makes the expanded cotton sliver before accompanying medicine is based on dipping on described expanded cotton sliver or the nonwoven strip or the percetage by weight of nonwoven strip be: benzalkonium chloride 180% to 520%, field thistle extract 155% to 255% and
B) 50-110 ℃ of down dry described expanded cotton sliver or nonwoven strip of soaking medicine, so that make solvent evaporation.
9. the method for the hemostatic and antibacterial product of manufacturing form of bandage as claimed in claim 8, described method also comprises:
C) soak on the expanded cotton sliver of medicine or the inner surface that nonwoven strip is bonded in lining described, described lining has air-vent and scribbles binding agent,
D) on described expanded cotton sliver that soaks medicine or nonwoven strip, provide noncohesive cover layer, and described cover layer is bonded on the inner surface of described lining and
E) on described noncohesive cover layer, provide peel strip, and described peel strip is bonded on the inner surface of described lining.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031365353A CN1241651C (en) | 2003-05-22 | 2003-05-22 | Hemostatic antibiotic products and preparnig method thereof |
| PCT/IN2004/000141 WO2004103264A2 (en) | 2003-05-22 | 2004-05-21 | Hemostatic antibacterial composition and products incorporating the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031365353A CN1241651C (en) | 2003-05-22 | 2003-05-22 | Hemostatic antibiotic products and preparnig method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1548167A CN1548167A (en) | 2004-11-24 |
| CN1241651C true CN1241651C (en) | 2006-02-15 |
Family
ID=33459838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031365353A Expired - Fee Related CN1241651C (en) | 2003-05-22 | 2003-05-22 | Hemostatic antibiotic products and preparnig method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1241651C (en) |
| WO (1) | WO2004103264A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888266A (en) * | 2014-03-06 | 2015-09-09 | 李平 | Haemostasis and antibiosis band, and production method and application thereof |
| US10039830B2 (en) * | 2016-03-04 | 2018-08-07 | Cetylite Industries, Inc. | Topical anesthetic composition |
| CN108939130A (en) * | 2017-05-21 | 2018-12-07 | 衢州玛济克医疗科技有限公司 | A kind of bedsore medical dressing and its production method |
| CN108853557A (en) * | 2018-07-23 | 2018-11-23 | 衢州玛济克医疗科技有限公司 | A kind of wet erythema medical dressing of infant and its production method |
| CN108904859A (en) * | 2018-07-23 | 2018-11-30 | 衢州玛济克医疗科技有限公司 | A kind of hemorrhoid medical dressing and its production method |
| CN110339390A (en) * | 2019-08-12 | 2019-10-18 | 中国中医科学院中药研究所 | A kind of compounding adhesive bandage and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3249707B2 (en) * | 1995-05-10 | 2002-01-21 | 花王株式会社 | Lipolysis accelerator |
| JPH09208483A (en) * | 1996-01-30 | 1997-08-12 | Kao Corp | Preparation composition for external use for skin and bath agent composition |
-
2003
- 2003-05-22 CN CNB031365353A patent/CN1241651C/en not_active Expired - Fee Related
-
2004
- 2004-05-21 WO PCT/IN2004/000141 patent/WO2004103264A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004103264A3 (en) | 2005-02-17 |
| CN1548167A (en) | 2004-11-24 |
| WO2004103264A2 (en) | 2004-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602004002717T2 (en) | Leaf-shaped wound dressing of microbial cellulose containing PHMB for chronic wounds | |
| US20190125924A1 (en) | Absorbent, breathable and pathogen blocking/killing wound care dressing and fabrication thereof | |
| CN1241651C (en) | Hemostatic antibiotic products and preparnig method thereof | |
| RU149063U1 (en) | ANTI-MICROBIAL ACTION BAND FOR HEALING | |
| CN109289084A (en) | A kind of surface of a wound antibacterial liquid dressing and preparation method thereof | |
| CN107050048A (en) | A kind of cold compress patch and preparation method thereof | |
| CN1833649A (en) | Jixuedai gel with action of promoting wound reunion, and prepn. thereof | |
| US20060134096A1 (en) | Compositions and methods for medical use of graphene-containing compositions | |
| CN1805739A (en) | Anti-inflammatory analgesic adhesive patch | |
| Ibrahim et al. | Antimicrobial Property of Water and Ethanol Extract Chlorella vulgaris: A Value-Added Advantage for a New Wound Dressing Material. | |
| CN104771779A (en) | Functional dressing and preparation method thereof | |
| Chuysinuan et al. | Preparation and characterization of electrospun polyacrylonitrile fiber mats containing Garcinia mangostana | |
| CN105664226A (en) | Medical composite dressing and preparation method thereof | |
| CN1317042C (en) | Biologic external application medicine for curing wound | |
| CN1833693A (en) | Red medicine gel for treating traumatic injury and its prepn. method | |
| Gergeroglu et al. | Functional composite nanofibers derived from natural extract of Satureja hortensis | |
| CN110869062A (en) | Film for topical application in the treatment of skin lesions and method for obtaining and applying same | |
| KR102173192B1 (en) | Manufacturing Method Of Trnasdermal Patch With Improved Durability | |
| US20100034872A1 (en) | Adhesive patch for protecting and treating viral cutaneous lesions | |
| CN113476641A (en) | Composite nanofiber membrane containing periplaneta americana herb residue polysaccharide and preparation method and application thereof | |
| CN1076866A (en) | A kind of smoke clearing agent | |
| CN1103288A (en) | Local anaesthetic and its preparing method | |
| CN113846419B (en) | Antibacterial and disinfectant nanofiber medical dressing and preparation method thereof | |
| CN1192770C (en) | Wet keeping dressing for wound medicine | |
| CN1254278C (en) | Medical ointment, film and tincture |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060215 Termination date: 20130522 |