CN1238989A - Medicine for curing infantile malnutrition and its preparing process - Google Patents
Medicine for curing infantile malnutrition and its preparing process Download PDFInfo
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- CN1238989A CN1238989A CN99114840A CN99114840A CN1238989A CN 1238989 A CN1238989 A CN 1238989A CN 99114840 A CN99114840 A CN 99114840A CN 99114840 A CN99114840 A CN 99114840A CN 1238989 A CN1238989 A CN 1238989A
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Abstract
A medicine for curing infantile malnutrition is prepared from 15 Chinese-medicinal materials including white atractylodes rhizome, lotus seed, white peony root, tangerine peel, parched germinated barley, etc. through distilling tangerine peel and white atractylodes rhizome, collecting volatile oil, cold storage, decocting others in water, filtering decoction, concentrating, and mixing. It features stable properties and high curative effect.
Description
The present invention relates to a kind of pharmaceutical composition that cures mainly infantile malnutrition, particularly relating to a kind of is the pharmaceutical composition that raw material is made with the vegetable Chinese herbal medicine.
Children are infant especially, and digestive organs are tender and lovely, and taste are lacked of proper care easily.Its clinical symptoms is weak, anorexia, hyperhidrosis, disposition restless with anxiety and stool abnormity etc., and the traditional Chinese medical science is called " infantile malnutrition ", is child's commonly encountered diseases and frequently-occurring disease, has a strong impact on growth of children.The exploitation of children also is nowhere near in the prior art, though the medicine of some treatment infantile malnutrition is also arranged so far, effect is not fairly obvious: the child who has is difficult for absorbing, and side effect is big; What have takes inconvenience, feeds difficulty; The price that has is high, can't popularize.
The object of the present invention is to provide a kind of have spleen invigorating suppressing the hyperactive liver, digesting and appetizing, benefiting QI and nourishing blood function, treat infantile malnutrition and iron deficiency anemia and vitamin D deficiency, can obviously improve the pure natural therapeutic agent of the main clinic symptoms and the main clinical Signs of infant.Its commodity are called sharp youngster's health-care composition (oral liquid).
Another object of the present invention provides the preparation method of this therapeutic agent.
Technical solution of the present invention is based on motherland's medical science to pathogenetic understanding of infantile malnutrition and Therapeutic Principle, with reference to the modern pharmacological research achievement, adopts multiple high-quality Chinese crude drug, uses the refining pure natural oral formulations that forms of high-tech means.
Medicine of the present invention is made by following component: (consumption is a weight portion)
The Rhizoma Atractylodis Macrocephalae 7～11 Semen Nelumbinis 7～11 Radix Paeoniae Albas 5～11
Concha Ostreae (calcined) 3～7 Os Draconis 3～7 Pericarpium Citri Reticulataes 3～7
Fructus Hordei Germinatus (parched) 4～8 Fructus Setariae Germinatus (parched) 4～8 moxibustion Endothelium Corneum Gigeriae Galli 1～5
Radix Glehniae 7～11 Radix Stellariaes 4～8 Semen Platycladi 1～5
Vinegar Fructus Toosendan (parched) 1～5 Fructus Jujubae 3～7 Radix Glycyrrhizaes 1～5
Mel 8～12
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
The Rhizoma Atractylodis Macrocephalae 8～10 Semen Nelumbinis 8～10 Radix Paeoniae Albas 6～9
Concha Ostreae (calcined) 4～6 Os Draconis 4～6 Pericarpium Citri Reticulataes 4～6
Fructus Hordei Germinatus (parched) 5～7 Fructus Setariae Germinatus (parched) 5～7 moxibustion Endothelium Corneum Gigeriae Galli 2～4
Radix Glehniae 8～10 Radix Stellariaes 5～7 Semen Platycladi 2～4
Vinegar Fructus Toosendan (parched) 2～4 Fructus Jujubaes 4～6 Radix Glycyrrhizaes 2～4
Mel 9～11
Optimum weight (part) proportioning of preparation medicine of the present invention is:
The Rhizoma Atractylodis Macrocephalae 9 Semen Nelumbinis 9 Radix Paeoniae Albas 7
Concha Ostreae (calcined) 5 Os Draconis 5 Pericarpium Citri Reticulataes 5
Fructus Hordei Germinatus (parched) 6 Fructus Setariae Germinatus (parched) 6 moxibustion Endothelium Corneum Gigeriae Galli 3
Radix Glehniae 9 Radix Stellariaes 6 Semen Platycladi 3
Vinegar Fructus Toosendan (parched) 3 Fructus Jujubaes 5 Radix Glycyrrhizaes 3
Mel 10
Above-mentioned each component is made medicine production method of the present invention is:
1, the medical material that is up to the standards is cleaned removal impurity, the foreign body and the person of going mouldy take by weighing medical material by prescription;
2, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae adopted steam distillation 1～5 hour, collected volatile oil, and the volatile oil yield is 1～1.5 ‰, and volatile oil cold preservation is standby;
3, getting Semen Nelumbinis, the Radix Paeoniae Alba, Concha Ostreae (calcined), Os Draconis, Fructus Hordei Germinatus (parched), Fructus Setariae Germinatus (parched), moxibustion Endothelium Corneum Gigeriae Galli, Radix Glehniae, Radix Stellariae, Semen Platycladi, vinegar Fructus Toosendan (parched), Fructus Jujubae, Radix Glycyrrhizae and above-mentioned distilled 2 flavor medical materials merges, add in the multipotency extraction pot, with water boiling and extraction 2～4 times, each extraction time is 1～3 hour, the addition of water is 15～5 times, and the water extract filters;
4, the water extract uses the triple effect concentrator to be concentrated into the runny plaste relative density to be 1.05～1.20 (60 ℃ of heat are surveyed), to move in the settling vat after cooling, and adding 90～95% ethanol to solution, to contain the alcohol amount be 40～65%, left standstill 24 hours, filters; Decompression filtrate recycling ethanol to runny plaste relative density is 1.05～1.25 (60 ℃ of heat are surveyed), puts and treats coldly usefulness;
5, preparation oral liquid:
1. add tween in the volatile oil, volatile oil: tween=1: 0.5, add 100 times of distilled water again, stir evenly;
2. Mel is put in the caldron, boils the back and is incubated half an hour, filtered through gauze;
3. with receive behind the precipitate with ethanol runny plaste, the Mel of refining, volatile oil aqueous solution and an amount of distilled water put in the caldron, stir, add distilled water again to ormal weight, stir evenly, adjusting PH is 5.7～6.8, leaves standstill after 24 hours and filters with filter press, after the inspection of semifinished product is qualified, stand-by;
4. packing, medicinal liquid is distributed into the mixture of 50 milliliters of specifications respectively by scheduling of production, or the oral liquid of 10 milliliters of specifications, rolls lid; At 115 ℃, sterilization is 30 minutes under the condition of 0.105 MPa with oral liquid; Carry out strict lamp inspection, qualified labeling, outer package, warehouse-in promptly gets required finished product after the assay was approved.
Product character: rufous liquid, sweet in the mouth, little hardship, gas perfume (or spice).
Instructions of taking: oral, 2 years old with 5 milliliters next time, 2～10 years old one time 10 milliliters, 10 years old with last 15 milliliters, three times on the one.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the present invention is according to tcm theory, and The spleen and stomach provide the material basis of the acquired, and main transporting and transforming nutrients from foodstuff and defeated cloth are precise and tiny, are source of generating QI and blood, and this product focuses on function of spleen and stomach regulating, holds up the fortune spleen invigorating, reaches the purpose of strengthening the body resistance.It has the spleen invigorating suppressing the hyperactive liver, digesting and appetizing, the function of benefiting QI and nourishing blood.The children's who cures mainly due to insufficiency of the spleen is weak, anorexia, hyperhidrosis, disposition restless with anxiety, diseases such as stool abnormity.Take for a long time, can promote children's upgrowth and development.It is raw material that the present invention selects the natural edible-plant medicine for use, and each component meets the pharmaceutical control law regulation.Utilize the common infantile malnutrition of comprehensive function treatment of the Chinese medicine of respectively distinguishing the flavor of, easily absorbed by the child, evident in efficacy, there is not chemical sweeting agent, nontoxic to human body;
2, the present invention need not to decoct, and mouthfeel is moderate, and oneself takes the child, or feeds all very convenient to infant;
3, compared with similar products, have the good outstanding advantage of product stability, investigate, again the experimental study of stability being carried out through relative method and accelerated test through nearly 5 years room temperature reserved sample observing method, presentation of results this product is steady quality at normal temperatures, and the operating period can reach more than 3 years.In addition, the present invention compares with similar research aspect the quality control of preparation, maintain the leading position, adopt high pressure liquid chromatograph (HPLC) that drug content is measured, make method of quality control more accurate, fast and reappear, the modernization of Chinese medicine preparation, scientific detection have been realized.
For verifying that the present invention is to treatment of diseases effects such as infantile malnutrition, the present invention has done the clinical observation of 601 routine systems through Traditional Chinese Medicine University Of Guangzhou clinical pharmacology base, wherein: 404 examples are organized in treatment, matched group 197 examples, Patients with iron deficiency anemia 272 examples, vitamin D deficiency patient 329 examples.
Treatment infantile malnutrition clinical recovery rate is 8.2%, and obvious effective rate is 36.1%, and effective percentage is 46.0%, and total effective rate is 90.3%; And contrast medicine ginseng Siberian cocklebur Rhizoma Atractylodis Macrocephalae electuary clinical recovery is 4.6%, and obvious effective rate is 14.2%, and effective percentage is 40.6%, total effective rate 59.4%.Learn by statistics and handle, difference has the meaning (P＜0.01) of highly significant.
The different sick clinical efficacy results that plant show that sharp youngster's recovery oral liquid treatment Patients with iron deficiency anemia clinical recovery is 14.1%, and wherein obvious effective rate is 44.3%, and effective percentage is 23.8%; And contrast medicine ginseng Siberian cocklebur Rhizoma Atractylodis Macrocephalae electuary clinical recovery is 10.3%, and obvious effective rate is 29.9%, and effective percentage is 17.2%.Learn by statistics and handle, difference has the meaning (P＜0.01) of highly significant.Treatment vitamin d deficiency rickets patient clinical recovery rate is 3.2%, and obvious effective rate is 29.2%, and effective percentage is 64.8%; The matched group obvious effective rate is 1.8%, and effective percentage is 59.1% (P＜0.01).
Clinical test results shows, the effect that the present invention has spleen invigorating, suppressing the hyperactive liver, helps digestion, its total effects and all be better than contrasting medicine ginseng Siberian cocklebur Rhizoma Atractylodis Macrocephalae electuary for the disease kind curative effect of iron deficiency anemia, vitamin D deficiency; Can obviously improve patient's main clinic symptoms and main clinical Signs, clinical practice safety has no side effect.
Embodiment
Take by weighing raw material (kilogram) by following proportioning:
The Rhizoma Atractylodis Macrocephalae 9 Semen Nelumbinis 9 Radix Paeoniae Albas 7
Concha Ostreae (calcined) 5 Os Draconis 5 Pericarpium Citri Reticulataes 5
Fructus Hordei Germinatus (parched) 6 Fructus Setariae Germinatus (parched) 6 moxibustion Endothelium Corneum Gigeriae Galli 3
Radix Glehniae 9 Radix Stellariaes 6 Semen Platycladi 3
Vinegar Fructus Toosendan (parched) 3 Fructus Jujubaes 5 Radix Glycyrrhizaes 3
Mel 10
Production method is as follows:
Take by weighing the medical material that is up to the standards by prescription; Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae adopted steam distillation 3 hours, collected volatile oil, and the volatile oil yield is 1.2 ‰, and volatile oil cold preservation is standby; Get in Semen Nelumbinis, the Radix Paeoniae Alba, Concha Ostreae (calcined), Os Draconis, Fructus Hordei Germinatus (parched), Fructus Setariae Germinatus (parched), moxibustion Endothelium Corneum Gigeriae Galli, Radix Glehniae, Radix Stellariae, Semen Platycladi, vinegar Fructus Toosendan (parched), Fructus Jujubae, the Radix Glycyrrhizae adding multipotency extraction pot, with water boiling and extraction 3 times, each extraction time is 2 hours, the addition of water is 9 times, and the water extract filters; It is 1.10 (60 ℃ of heat are surveyed) that the water extract uses the triple effect concentrator to be concentrated into the runny plaste relative density, moves in the settling vat after cooling, and it is 55% that ethanol to the solution of adding 90～95% contains the alcohol amount, leaves standstill 24 hours, filters; Decompression filtrate recycling ethanol to runny plaste relative density is 1.15 (60 ℃ of heat are surveyed), puts and treats coldly usefulness; Add tween in the volatile oil, volatile oil: tween=1: 0.5, add 100 times of distilled water again, stir evenly; Mel is put in the caldron, boils the back and is incubated half an hour, filtered through gauze; With receive behind the precipitate with ethanol runny plaste Mel volatile oil aqueous solution and an amount of distilled water refined put in the caldron, stir, add distilled water again to ormal weight, stir evenly, adjusting PH is 6.2, leaves standstill after 24 hours and filters with filter press, after the inspection of semifinished product is qualified, stand-by; Medicinal liquid is distributed into the mixture of 50 milliliters of specifications respectively by scheduling of production, or the oral liquid of 10 milliliters of specifications, rolls lid; At 115 ℃, sterilization is 30 minutes under the condition of 0.105 MPa with oral liquid; Carry out strict lamp inspection, qualified labeling, outer package, warehouse-in promptly gets required finished product after the assay was approved.
Claims (6)
1, a kind of medicine for the treatment of children's infantile malnutrition symptom is characterized in that it is the medicament of being made by the following weight proportion raw material
The Rhizoma Atractylodis Macrocephalae 7～11 Semen Nelumbinis 7～11 Radix Paeoniae Albas 5～11
Concha Ostreae (calcined) 3～7 Os Draconis 3～7 Pericarpium Citri Reticulataes 3～7
Fructus Hordei Germinatus (parched) 4～8 Fructus Setariae Germinatus (parched) 4～8 moxibustion Endothelium Corneum Gigeriae Galli 1～5
Radix Glehniae 7～11 Radix Stellariaes 4～8 Semen Platycladi 1～5
Vinegar Fructus Toosendan (parched) 1～5 Fructus Jujubae 3～7 Radix Glycyrrhizaes 1～5
Mel 8～12
2, the medicine of treatment children's infantile malnutrition symptom according to claim 1, wherein the weight proportion of each raw material is
The Rhizoma Atractylodis Macrocephalae 8～10 Semen Nelumbinis 8～10 Radix Paeoniae Albas 6～9
Concha Ostreae (calcined) 4～6 Os Draconis 4～6 Pericarpium Citri Reticulataes 4～6
Fructus Hordei Germinatus (parched) 5～7 Fructus Setariae Germinatus (parched) 5～7 moxibustion Endothelium Corneum Gigeriae Galli 2～4
Radix Glehniae 8～10 Radix Stellariaes 5～7 Semen Platycladi 2～4
Vinegar Fructus Toosendan (parched) 2～4 Fructus Jujubaes 4～6 Radix Glycyrrhizaes 2～4
Mel 9～11
3, the medicine of treatment children's infantile malnutrition symptom according to claim 1, the weight proportion that wherein is equipped with raw material is
The Rhizoma Atractylodis Macrocephalae 9 Semen Nelumbinis 9 Radix Paeoniae Albas 7
Concha Ostreae (calcined) 5 Os Draconis 5 Pericarpium Citri Reticulataes 5
Fructus Hordei Germinatus (parched) 6 Fructus Setariae Germinatus (parched) 6 moxibustion Endothelium Corneum Gigeriae Galli 3
Radix Glehniae 9 Radix Stellariaes 6 Semen Platycladi 3
Vinegar Fructus Toosendan (parched) 3 Fructus Jujubaes 5 Radix Glycyrrhizaes 3
Mel 10
4,, it is characterized in that described medicament is a said dosage form on any pharmaceutics according to the medicine of claim 1 or 2 or 3 described treatment children's infantile malnutrition symptoms.
5, the medicine of treatment children's infantile malnutrition symptom according to claim 4 is characterized in that described medicament is oral liquid or mixture.
6, the preparation method of the medicine of the described treatment infantile malnutrition of claim 5 is characterized in that adopting following processing step:
1. the medical material that is up to the standards is cleaned removal impurity, the foreign body and the person of going mouldy take by weighing medical material by prescription;
2. Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae adopted steam distillation 1～5 hour, collected volatile oil, and the volatile oil yield is 1～1.5 ‰, and volatile oil cold preservation is standby;
3. get Semen Nelumbinis, the Radix Paeoniae Alba, Concha Ostreae (calcined), Os Draconis, Fructus Hordei Germinatus (parched), Fructus Setariae Germinatus (parched), moxibustion Endothelium Corneum Gigeriae Galli, Radix Glehniae, Radix Stellariae, Semen Platycladi, vinegar Fructus Toosendan (parched), Fructus Jujubae, Radix Glycyrrhizae and distilled Pericarpium Citri Reticulatae, Rhizoma Atractylodis Macrocephalae merging, add in the multipotency extraction pot, with water boiling and extraction 2～4 times, each extraction time is 1～3 hour, the addition of water is 15～5 times, and the water extract filters;
4. the water extract uses the triple effect concentrator to be concentrated into the runny plaste relative density to be 1.05～1.20 (60 ℃ of heat are surveyed), to move in the settling vat after cooling, and adding 90～95% ethanol to solution, to contain the alcohol amount be 40～65%, left standstill 24 hours, filters; Decompression filtrate recycling ethanol to runny plaste relative density is 1.05～1.25 (60 ℃ of heat are surveyed), puts and treats coldly usefulness; 5. prepare oral liquid: add tween, volatile oil in the volatile oil: tween=1: 0.5, add 100 times of distilled water again, stir evenly; Mel is put in the caldron, boils the back and is incubated half an hour, filtered through gauze; With receive behind the precipitate with ethanol runny plaste, the Mel of refining, volatile oil aqueous solution and an amount of distilled water put in the caldron, stir, add distilled water again to ormal weight, stir evenly, adjusting PH is 5.7～6.8, leaves standstill after 24 hours and filters with filter press, after the inspection of semifinished product is qualified, stand-by; Medicinal liquid is distributed into the mixture of 50 milliliters of specifications respectively by scheduling of production, or the oral liquid of 10 milliliters of specifications, rolls lid; At 115 ℃, sterilization is 30 minutes under the condition of 0.105 MPa with oral liquid; Carry out strict lamp inspection, qualified labeling, outer package, warehouse-in promptly gets required finished product after the assay was approved.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99114840A CN1069836C (en) | 1999-04-29 | 1999-04-29 | Medicine for curing infantile malnutrition and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99114840A CN1069836C (en) | 1999-04-29 | 1999-04-29 | Medicine for curing infantile malnutrition and its preparing process |
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| Publication Number | Publication Date |
|---|---|
| CN1238989A true CN1238989A (en) | 1999-12-22 |
| CN1069836C CN1069836C (en) | 2001-08-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99114840A Expired - Lifetime CN1069836C (en) | 1999-04-29 | 1999-04-29 | Medicine for curing infantile malnutrition and its preparing process |
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| Country | Link |
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| CN (1) | CN1069836C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416123A (en) * | 2011-11-21 | 2012-04-18 | 四川豪运药业股份有限公司 | Traditional Chinese medicinal composition for invigorating spleen and helping digestion and preparation method thereof |
| CN108783309A (en) * | 2018-07-11 | 2018-11-13 | 绩溪县老胡家生态农业专业合作社 | A kind of preparation method of appetizing dried bamboo shoots |
-
1999
- 1999-04-29 CN CN99114840A patent/CN1069836C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416123A (en) * | 2011-11-21 | 2012-04-18 | 四川豪运药业股份有限公司 | Traditional Chinese medicinal composition for invigorating spleen and helping digestion and preparation method thereof |
| CN108783309A (en) * | 2018-07-11 | 2018-11-13 | 绩溪县老胡家生态农业专业合作社 | A kind of preparation method of appetizing dried bamboo shoots |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1069836C (en) | 2001-08-22 |
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Effective date of registration: 20100506 Address after: 650118 national hi tech Industrial Development Zone, Yunnan, Kunming Patentee after: Yunnan Baiyao Group Corp., Ltd. Address before: 650032 Yunnan Province, Kunming City West Road No. 51 Patentee before: Inst. of Yunnan Baiyao Group Co., Ltd. |
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