CN102697994A - Weight-losing and fat-reducing traditional Chinese medicine composition - Google Patents

Abstract

The invention discloses a weight-losing and fat-reducing traditional Chinese medicine composition, which is prepared from the following crude drugs in weight percentage: 20-40 percent of lotus leaf, 20-40 percent of hawthorn, 10-30 percent of semen cassia, 5-15 percent of rhizoma alismatis and 5-15 percent of rhizoma atractylodis. The traditional Chinese medicine composition disclosed by the invention has a weight-losing function, a fat-reducing function and a blood pressure-lowering function, is obvious in weight-losing effect and low in recurrence rate and has no toxic and side effects. Meanwhile, as the crude drugs adopted by the composition are medicinal and edible materials, the composition can be used as a health-care food, and a health-care fitness effect is taken after the weight-losing and fat-reducing traditional Chinese medicine composition is orally taken for a long time.

Description

A kind of Weight-reducing and lipid-lowering Chinese medicine composition

Technical field

The present invention relates to the field of Chinese medicines; Be specifically related to a kind of Chinese medicine composition of Weight-reducing and lipid-lowering; More specifically; Relate to compositions with the preparation of integration of edible and medicinal herbs medicinal herbs; Comprise Folium Nelumbinis (Nelumbo nucifera Gaertn.), Fructus Crataegi (Crataegus pinnatifida Bge. Var. major N. E. Br. or Crataegus pinnatifida Bge.), Semen Cassiae (Cassia obtusifolia L. or Cassia tora L.), Rhizoma Alismatis [Alisma orientalis (Sam.)], Rhizoma Atractylodis [Atractylodes lancea (Thunb) DC.], be used for the health care Chinese medicine composition of Weight-reducing and lipid-lowering.

Technical background

The record of just relevant " obesity " in the Huangdi's Internal Classics before more than 2,000 years; It has included the simple property and the Secondary Obesity of modern medicine; Can betide any ages such as child, old people, women's puerperal and climacteric, think that multiple factors such as natural endowment, diet, motion, feelings will can cause cream fat overheap in the body, body weight increases unusually; Dizzy weak, spiritlessness and sparing of words, the clinical symptoms such as short of taking offence less appear simultaneously, thus the generation of causeing fat.Clinical observation confirms, contains the body fertilizer relevant chronic diseases such as cardiovascular and cerebrovascular vessel, atherosclerosis, diabetes, gout, fatty liver that can occur together because of body, and public colony has been constituted serious threat, thereby causes widely and pay close attention to.

Associated description such as " fertile high official ", " dysfunction of vision and hearing is bright for Nian Wushi, body weight " are arranged in " element asks YIN YANG classification of natural phenomena big opinion "; " element is asked the logical deficiency and excess opinion of commenting " points out: " fertile high official, then the disease of fat meat and fine grain also ".

Motherland's traditional medicine is thought: " fertile people's excessive phlegm ", " how wet fertile people is ", " the many deficiency of vital energys of fertile people ", so in " Further Discourses on the Properties of Things " be summed up as fertile people " how wet fertile white man is, fertile white man's excessive phlegm drink "; Jing-Yue Complete Works proposes: " how instead be deficiency of vital energy lid people's body, bone be monarch also, fertile people person is gentle to contain in just, excess of YIN in sun also, and meat becomes with blood, total the moon class all is so fertile people has the deficiency of vital energy more "." a Medical Treasures of the Golden Chamber arthralgia due to stagnation of blood spleen fatiguing disease piece of writing " said: " husband's rank and honour people, the weak bone skin is contained "." Ling Shu Miraculous Pivot or Divine Axis disorder of defensive QI " said: " people has fertilizer, cream is arranged, meat is arranged ... ... popliteal meat is hard, Pi Manzhe, fertilizer.Popliteal meat is not hard, Pi Huanzhe, cream.Skin and flesh does not leave person, meat mutually ", produced " fertilizer, cream, meat " three kinds of clinical pattern of syndrome.Li Dongyuan " Treatise on the spleen and stomach " cloud: " taste are all prosperous, then can eat and fertilizer; Splenogastric asthenia, then anorexia and thin or obesity with poor appetite; Though fertilizer and inability to raise the limbs, be excess syndrome and excess of pathogen also." set forth the substantial connection between obesity and the taste emphatically.Have in the "guide to clinical practice with medical record" " wet from interior life, must its people's fat meat and fine grain wine sweet wine excessive, or it is too many to have a liking for the soup of drinking tea, or eat raw and cold melon and fruit and sweet greasy thing.Its people's color Bai Erfei, muscle is soft ... " say.

Current, there are many moneys to contain the diet products of Folium Nelumbinis on the market, the data of literatures of losing weight about Folium Nelumbinis is a lot, but all is the prescription of piecing together much wherein, and no principle-method-recipe-medicines can be sayed.Even some directly steeps boiled water, and effective ingredient is difficult to stripping, does not meet the decocting for Chinese herbal medicine standard, can't play the effect of Weight-reducing and lipid-lowering.

Summary of the invention

The purpose of this invention is to provide a kind of theory of Chinese medical science that meets, have the health care Chinese medicine composition of fat reducing and weight reducing function, this compositions has Weight-reducing and lipid-lowering, buck functionality.

Technical scheme of the present invention is following:

A kind of Weight-reducing and lipid-lowering Chinese medicine composition is characterized in that, is processed by following bulk drugs, and the percentage by weight of each crude drug is: Folium Nelumbinis 20-40%, Fructus Crataegi 20-40%, Semen Cassiae 10-30%, Rhizoma Alismatis 5-15%, Rhizoma Atractylodis 5-15%.

Described Weight-reducing and lipid-lowering Chinese medicine composition is characterized in that, is processed by following bulk drugs, and the percentage by weight of each crude drug is:

Folium Nelumbinis 30%, Fructus Crataegi 30%, Semen Cassiae 20%, Rhizoma Alismatis 10%, Rhizoma Atractylodis 10%.

Method for preparing may further comprise the steps:

(1) takes by weighing Folium Nelumbinis by formula proportion, Fructus Crataegi, Semen Cassiae, Rhizoma Alismatis, Rhizoma Atractylodis;

(2) crude drug that takes by weighing is soaked 30-60 minute after, decoct secondary again, for the first time add 15-17 times of water, decoct after 1.5-2.5 hour; Filter to collect filtrating, with adding 10-13 times of water gaging in the medicinal residues again, decoct 1.5-2.5 hour once more after; Filter, collect filtrating

(3) merge twice filtrating, after stirring, leave standstill, getting supernatant, to be evaporated to relative density be 1.10-1.15, spray drying, and pack gets final product every bag of 3-5g.

The crowd of being suitable for: overweight people, hyperlipidemia, hyperpietic.

Instructions of taking: directly take after mixing it with water every day 2-3 time, each 1 bag with warm water.

Compositions of the present invention can also be processed various other dosage forms, like pill, extractum, capsule, tablet or decoction.

Side of the present invention separates:

" fertile people's excessive phlegm ".The traditional Chinese medical science thinks that the main cause that causes fat is that yang-energy can not be failed cloth, so that water-damp not being transformed, gathers humidifying expectorant because of stagnation of dampness due to deficiency of the spleen, and fat liquid deposition is gathered into cream, and cream fat is piled up, and shows as the fat swelling of figure for a long time and then.In the treatment, method is worked as the spleen strengthening and damp drying, drains away the mud and bring in fresh water.So-called stranguria treating and diuresis inducing, drying dampness to eliminate phlegm is wanted for it.

" the Folium Nelumbinis fat-reducing makes us thin bad ".The Compendium of Material Medica record: " Folium Nelumbinis rises and sends out yang-energy, the degrease weight reducing, and dissipating blood stasis blood, Flos Nelumbinis relieving palpitation benefit color is preserved youthful looks and is made light of one's life by commiting suicide ".The so-called liter sent out yang-energy, rises actually to send out the spleen sun.Spleen governing muscles, main extremity, main fortuneization.The strong fortune of spleen sun, vital essence overflows, so refreshing bright body is strong.Folium Nelumbinis goes out mud and does not dye, and lid is because of the merit of ascending the clear and descending the turbid.Modern pharmacological research confirms; The Flavonoid substances that is rich in the Folium Nelumbinis; Be the scavenger of most of oxygen-derived free radicals, can improve the vigor of SOD (superoxide dismutase), reduce the generation of MDA (MDA malonaldehyde) and 0X-LDL (OxLDL ELISA); It can increase coronary flow, and experimental myocardial infarction is had antagonism; Acute myocardial ischemia there is protective effect; Treatment coronary heart disease, hypertension etc. there is remarkable result; To reducing diastolic pressure, prevent and treat arrhythmia, cardiovascular diseases etc. and also play an important role.In addition, the alkaloid of another big type of active substance oslim flowers and plants in the Folium Nelumbinis, physiologically active is remarkable, has effects such as tangible blood fat reducing, antiviral.The modern pharmacology test confirms that contained nuciferine has the effect that brings high blood pressure down with blood fat reducing in the Folium Nelumbinis.As for the principle of Folium Nelumbinis fat-reducing, after being to take these article, can on the human body intestinal wall, form one deck fat isolating membrane, can stop the absorption of fat effectively, thereby fundamentally lose weight, and controlling body weight bounce-back effectively;

Fructus Crataegi has the effect that comparatively significantly reduces blood cholesterol and three YOUGAN fat content, and lipase can promote steatolysis in the Fructus Crataegi, and Crataegolic acid can improve the albuminolysis enzymatic activity, digestive effect;

The Semen Cassiae bitter in the mouth is slightly cold, and the effect of loosening bowel to relieve constipation is arranged, and modern pharmacological research shows that the effect that reduces serum cholesterol and triglyceride is arranged;

The Rhizoma Alismatis regulating fluid apssage, promoting diuresis to eliminate damp pathogen.The modern pharmacology result of the test shows that Rhizoma Alismatis has blood fat reducing, AFL and anti-obesic action.Its fat-soluble part has tangible cholesterol reducing effect and study of anti-atherogenic effect to experimental hypercholesterolemia rabbit; By wherein separate Alisol A, B and Alisol A, B, the acetas of C; Except that alisol B, apparent cholesterol reducing effect is arranged all.Rabbit experiment shows that Rhizoma Alismatis extract is not only effective to the fatty liver that the low protein diet that is added with cholesterol causes, and can suppress the rising of cholesterolemia and have to alleviate atherosclerotic tendency, is a kind of blood fat reducing, lipotropic active drug.Decoct is irritated stomach has inhibitory action to the rat obesity that sodium glutamate causes, fat Mus is lost weight, and the Lee's index reduces, and fat index also reduces; To serum triglycerides content, Rhizoma Alismatis all can reduce normal and fat Mus

Rhizoma Atractylodis are drying damp and strengthening spleen, and " pearl sac " is alleged: " full non-this of all damp-edema can not remove ", " Wan Shi gynecological " Rhizoma Atractylodis are led the expectorant ball to cure mainly MBV with this especially few, and amenorrhea is infertile, obesity, and abundant expectoration is weak to wait disease.

Chinese prescription of the present invention, through 658 routine obese patient's clinic trial, effective percentage reaches 95%, takes Chinese medicinal components of the present invention, and the obese patient is in fat-reducing, and health does not have other senses of discomfort, and full of vitality during taking, diet is normal.After the fat-reducing, cut out, body weight does not rebound; On probation through 400 routine hyperpietics, the patient take one week the back blood pressure significantly reduced, took continuously 1 month, after cut out, blood pressure still can remain on range of normal value.

 

Beneficial effect of the present invention:

1, Chinese prescription of the present invention, the medicine source is extensive, is easy to get, low price, preparation technology is simple;

2, Chinese prescription of the present invention has fat-reducing, and multiple efficacies such as blood fat reducing, blood pressure lowering are compared with existing fat-reducing on the market, have low price, and health is had no side effect, and fat-reducing effect is obvious.Relapse rate is low;

3, because the raw medicinal material that this compositions adopts all is the integration of edible and medicinal herbs material, therefore can be used as health food, take for a long time, play the effect of health-care.

The following example only supplies to set forth usefulness, is not to be used for limiting effective range of the present invention.

The specific embodiment

Embodiment 1

Prescription:

Title consumption (g)

Folium Nelumbinis 600

Fructus Crataegi 1200

Semen Cassiae 600

Rhizoma Alismatis 150

Rhizoma Atractylodis 450.

Method for preparing: get the Folium Nelumbinis of above-mentioned weight, Fructus Crataegi, Semen Cassiae, Rhizoma Alismatis, Rhizoma Atractylodis, decocte with water secondary; For the first time add 16 times of water, soaked 1 hour, decocted 2 hours, filter and collect filtrating, adding 12 times of water gagings in the medicinal residues; Decocted 2 hours, and filtered, collect filtrating, merge twice filtrating and mix, leave standstill; Getting supernatant, to be evaporated to relative density be 1.10-1.15 (50 ℃), and spray drying adds steviosin 2g, adds dextrin and makes into 1000g in right amount, uses 30% alcohol granulation; 60 ℃ of dryings, granulate, pack promptly gets every packed 3g.

Embodiment 2

Title consumption (g)

Folium Nelumbinis 1200

Fructus Crataegi 600

Semen Cassiae 600

Rhizoma Alismatis 450

Rhizoma Atractylodis 150,

Method for preparing: get the Folium Nelumbinis of above-mentioned weight, Fructus Crataegi, Semen Cassiae, Rhizoma Alismatis, Rhizoma Atractylodis, decocte with water secondary; For the first time add 16 times of water, soaked 1 hour, decocted 2 hours, filter and collect filtrating, adding 12 times of water gagings, decocted 2 hours in the medicinal residues; Filter, collect filtrating, merge twice filtrating and mix, leave standstill, getting supernatant, to be evaporated to relative density be 1.10-1.15 (50 ℃), spray drying; Use 30% alcohol granulation, 60 ℃ of dryings, granulate, tabletting promptly gets, every heavy 0.48g.

Embodiment 3

Title consumption (g)

Folium Nelumbinis 90

Fructus Crataegi 90

Semen Cassiae 30

Rhizoma Alismatis 45

Rhizoma Atractylodis 45,

Method for preparing: get the Folium Nelumbinis of above-mentioned weight, Fructus Crataegi, Semen Cassiae, Rhizoma Alismatis, Rhizoma Atractylodis, decocte with water secondary; For the first time add 16 times of water, soaked 1 hour, decocted 2 hours, filter and collect filtrating, adding 12 times of water gagings in the medicinal residues; Decocted 2 hours, and filtered, collect filtrating, merge twice filtrating and mix, leave standstill; Getting supernatant, to be evaporated to relative density be 1.20-1.30 (50 ℃), puts coldly, adds 4 times of water gagings, stirs, and leaves standstill; Get supernatant, add the 2g steviosin, be diluted with water to 1000ml, bottling promptly gets every bottled 10ml.

Embodiment 4

Title consumption (g)

Folium Nelumbinis 90

Fructus Crataegi 90

Semen Cassiae 90

Rhizoma Alismatis 15

Rhizoma Atractylodis 15

Method for preparing: get Folium Nelumbinis, Fructus Crataegi, Semen Cassiae, Rhizoma Alismatis, Rhizoma Atractylodis, the decocte with water secondary adds 16 times of water for the first time, soaks 1 hour, decocts 2 hours; For the second time add 12 times of water gagings, decocted 2 hours, filtration is put coldly, and getting supernatant, to be evaporated to relative density be 1.20-1.30 (50 ℃); Put coldly, add 4 times of water gagings, stir, leave standstill, get supernatant; Add the 2g steviosin, be diluted with water to 1000ml, bottling promptly gets every bottled 10ml.

Embodiment 5

Title consumption (g)

Folium Nelumbinis 90

Fructus Crataegi 90

Semen Cassiae 60

Rhizoma Alismatis 30

Rhizoma Atractylodis 30,

Method for preparing: get Folium Nelumbinis, Fructus Crataegi, Semen Cassiae, Rhizoma Alismatis, Rhizoma Atractylodis, the decocte with water secondary adds 16 times of water for the first time, soaks 1 hour, decocts 2 hours; For the second time add 12 times of water gagings, decocted 2 hours, filtration is put coldly, and getting supernatant, to be evaporated to relative density be 1.20-1.30 (50 ℃); Put coldly, add 4 times of water gagings, stir, leave standstill, get supernatant; Add the 20g steviosin, be diluted with water to 10000ml, bottling promptly gets every bottled 100ml.

Test data

1, with this experimentation of product of present embodiment 5 to the rat antiobesity action:

Get 30 of Wistar rats, be divided into 3 groups at random.Normal group gives common Mus material, and other two groups give the moulding Mus by 20g/ rat and expect that after 3 weeks of moulding, begin test, experimental group gives 2ml/kg embodiment 5 products.During the administration, each is organized rat and quantitatively gives common Mus material every day, and drinking-water is not limit.Weigh weekly 1 time, after taking medicine continuously 30 days.See table 1.

Table 1 rat body weight change list

Group	Average weight g before the moulding	Average weight g after the moulding	Whole last average weight g
				Normal group	188.2	191.2	190.3
Model group	185.7	227.1	233.7
				Experimental group	190.5	228.6	195.1

Experimental result shows: the present invention has fat-reducing effect preferably.

Effect embodiment 2

The present invention is to the experimentation that influences of rat fat, use be embodiment 5 products.

Get 30 of SD rats, male and female half and half are divided into 3 groups at random.Normal group gives common Mus material, all feeds high lipid food for other two groups, after 4 weeks of modeling, begins test; Every morning, experimental group gives 2ml/kg embodiment 5 products, and each is organized rat and quantitatively gives common Mus material every day, and drinking-water is not limit, and continuous 30 days, blood fat was surveyed in docking blood sampling in the 31st day.See table 2.

The change list of table 2 rat fat (mmd/L is meansigma methods)

Group	TC	TG	HDL-C	LDL-C
					Normal group	2.15	0.55	1.17	1.03
Model group	5.31	0.75	1.19	3.88
					Experimental group	2.71	0.62	1.09	1.77

Experimental result shows: the present invention is more obvious to the blood fat influence of rat.

Model case

1, Lee, man, 36 years old.January 11 2011 first visit date.The main hyperlipidemia of stating, fat several years history, height 174cm, body weight 107kg, lipid examination prompting on January 8th, 2011 serum total cholesterol 5.06mmol/L, triglyceride 1.96 mmol/L, high density lipoprotein 0.72 mmol/L, low density lipoprotein, LDL 4.14 mmol/L.Once took multiple lowering blood-fat and reducing weight product, effect is not remarkable.Recommend to take the embodiment of the invention 1 granule through the people, 3 times on the 1st, 1 time 1 bag, boiled water is taken after mixing it with water.Take the back check of 2 weeks continuously: body weight 100kg, blood fat serum analysis T-CHOL 4.17 mmol/L, triglyceride 1.58 mmol/L, high density lipoprotein 0.94 mmol/L, low density lipoprotein, LDL 3.36 mmol/L.Continued to take 2 weeks, check result prompting: body weight 93kg, serum total cholesterol 4.28 mmol/L, triglyceride 1.12 mmol/L, HDL1 .26 mmol/L, low density lipoprotein, LDL 2.80 mmol/L.Suggestion continued to take 1 month, consolidated curative effect, followed up a case by regular visits to not recurrence after 1 year.

2, fourth, woman, 17 years old.June 18 2011 first visit date.4 years histories of Simple Obesity, body weight 89kg, it is multiple once to take diet products, keeps on a diet poor effect simultaneously.Recommend to take the embodiment of the invention 1 granule 3 times on the 1st through the people, 1 time 1 bag, take 2 week back body weight 84kg.Continued to take 2 weeks, body weight 80kg, suggestion renews takes 1-2 month, the back check of 6 weeks, body weight 67kg follows up a case by regular visits to body weight after 1 year and reaches normal value, not recurrence.

3, Wang certain, man, 59 years old.July 4 2011 first visit date.In year surplus hypertension, the hyperlipidemia medical history 10, the figure is fat, check result prompting: body weight 87kg; Blood pressure 180mmHg/118mmHg; Blood fat is analyzed: serum total cholesterol 4.69 mmol/L, three YOUGAN fat, 2.30 mmol/L, high density lipoprotein 0.94 mmol/L, low density lipoprotein, LDL 3.29 mmol/L.Take the embodiment of the invention 1 granule, 3 times on the 1st, 1 time 1 bag; Continuous 2 weeks back check: body weight 84.5kg, blood pressure 142mmHg/90mmHg, serum total cholesterol 4.06 mmol/L; Triglyceride 1.46, HDL1 .23 mmol/L, low density lipoprotein, LDL 3.07 mmol/L.Continued to take 1 month, and consolidated and follow up a case by regular visits to body weight after 1 year and reach normal value, not recurrence.

Claims (3)

1. a Weight-reducing and lipid-lowering Chinese medicine composition is characterized in that, is processed by following bulk drugs, and the percentage by weight of each crude drug is: Folium Nelumbinis 20-40%, Fructus Crataegi 20-40%, Semen Cassiae 10-30%, Rhizoma Alismatis 5-15%, Rhizoma Atractylodis 5-15%.

2. Weight-reducing and lipid-lowering Chinese medicine composition according to claim 1 is characterized in that, is processed by following bulk drugs, and the percentage by weight of each crude drug is:

Folium Nelumbinis 30%, Fructus Crataegi 30%, Semen Cassiae 20%, Rhizoma Alismatis 10%, Rhizoma Atractylodis 10%.

3. according to claim 1 or claim 2 the method for preparing of Weight-reducing and lipid-lowering Chinese medicine composition is characterized in that, may further comprise the steps:

(1) takes by weighing Folium Nelumbinis by formula proportion, Fructus Crataegi, Semen Cassiae, Rhizoma Alismatis, Rhizoma Atractylodis;

(2) crude drug that takes by weighing is soaked 30-60 minute after, decoct secondary again, for the first time add 15-17 times of water, decoct after 1.5-2.5 hour; Filter to collect filtrating, with adding 10-13 times of water gaging in the medicinal residues again, decoct 1.5-2.5 hour once more after; Filter, collect filtrating

(3) merge twice filtrating, after stirring, leave standstill, getting supernatant, to be evaporated to relative density be 1.10-1.15, spray drying, and pack gets final product the 3-5g/ bag.